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M. thermoresistible (build 8) TH_0267 (cysG)

annotation: PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)
coordinates: 606588 - 607922
length: 445

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0267cysG-100% (445)PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM)
M. thermoresistible (build 8)TH_1981cysG27e-1926.84% (272) POSSIBLE MULTIFUNCTIONAL ENZYME SIROHEME SYNTHASE CYSG:
M. thermoresistible (build 8)TH_0443cobM5e-0728.03% (157) Probable precorrin-4 C11-methyltransferase CobM

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0524hemD1e-17570.50% (444) uroporphyrin-III C-methyltransferase HemD
M. gilvum PYR-GCKMflv_0065-0.075.68% (444) uroporphyrinogen III synthase HEM4
M. tuberculosis H37RvRv0511hemD1e-17570.50% (444) uroporphyrin-III C-methyltransferase HemD
M. leprae Br4923MLBr_02420hemD1e-17471.43% (441) putative uroporphyrin-III C-methyltransferase
M. abscessus ATCC 19977MAB_3991c-1e-16667.57% (441) uroporphyrin-III C-methyltransferase
M. marinum MMMAR_0844hemD1e-17972.56% (441) uroporphyrin-III C-methyltransferase HemD
M. avium 104MAV_4638hemD1e-17670.98% (441) uroporphyrinogen-III synthase
M. smegmatis MC2 155MSMEG_0954hemD0.078.10% (443) uroporphyrinogen-III synthase
M. ulcerans Agy99MUL_4600hemD1e-17972.34% (441) uroporphyrin-III C-methyltransferase HemD
M. vanbaalenii PYR-1Mvan_0846-0.074.43% (442) uroporphyrinogen III synthase HEM4

CLUSTAL 2.0.9 multiple sequence alignment


Mb0524|M.bovis_AF2122/97            --------------------------------------------MTRGRK
Rv0511|M.tuberculosis_H37Rv         --------------------------------------------MTRGRK
MAV_4638|M.avium_104                --------------------------------------------------
MMAR_0844|M.marinum_M               -------------------------------------------MMTRGRK
MUL_4600|M.ulcerans_Agy99           --------------------------------------------MTRGRK
MLBr_02420|M.leprae_Br4923          --------------------------------------MVGATMTTRGRK
MAB_3991c|M.abscessus_ATCC_199      --------------------------------------------MTRGRK
Mflv_0065|M.gilvum_PYR-GCK          -------------------------------------------MSLRGRK
Mvan_0846|M.vanbaalenii_PYR-1       -------------------------------------------MSLRGRK
MSMEG_0954|M.smegmatis_MC2_155      MGGADSLTKVGGADAAVAVVGAAEGSVGAAESPASDPQPRESSSRSRSRK
TH_0267|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mb0524|M.bovis_AF2122/97            PRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTD
Rv0511|M.tuberculosis_H37Rv         PRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTD
MAV_4638|M.avium_104                --------MGSGPGDPGLLTARAAAVLANAALVFTDPDVPEPVLALIGKD
MMAR_0844|M.marinum_M               PRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGND
MUL_4600|M.ulcerans_Agy99           PRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGND
MLBr_02420|M.leprae_Br4923          LRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKD
MAB_3991c|M.abscessus_ATCC_199      -KPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVG--
Mflv_0065|M.gilvum_PYR-GCK          NKPGRITFVGSGPGDPGLLTSRARAVLANAALVFTDPDVPEAVRALVGSE
Mvan_0846|M.vanbaalenii_PYR-1       GKPGRITFVGSGPGDPGLLTTRARAVLAHAALVFTDPDVPEAVLELVGSE
MSMEG_0954|M.smegmatis_MC2_155      VKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTD
TH_0267|M.thermoresistible__bu      --------VGAGPGDPGLLTTKAQTILAHAALVFTDPDVPEAVKTLIGTN
                                            :*:*** ***** :* ::*: * :.* *****:.*  *:*  

Mb0524|M.bovis_AF2122/97            LPPVSGPAP-----------AEPVAGNGDAAGGGSA-QEHGRAAS-----
Rv0511|M.tuberculosis_H37Rv         LPPVSGPAP-----------AEPVAGNGDAAGGGSA-QEHGRAAS-----
MAV_4638|M.avium_104                LPPVSGPAP-----------AEPAP-NGEGAG-----SEQGQAQP-----
MMAR_0844|M.marinum_M               LPPVSGPAP-----------ATAVADNADAATGGPAEGESDQAVP-----
MUL_4600|M.ulcerans_Agy99           LPPVSGPAP-----------ATAVADNADAATGGPAEGESDQAVP-----
MLBr_02420|M.leprae_Br4923          LPPVSGPAP-----------AGPAAVTAGRAADGTLEGDHYQAAP-----
MAB_3991c|M.abscessus_ATCC_199      -SAVELPEP-----------APAKPATGGDEAPAAADNEAAAEPP-----
Mflv_0065|M.gilvum_PYR-GCK          LPPPSGPLPP------VAD-AAPKTAAAGADQPASQDAAPADAAKTAKAA
Mvan_0846|M.vanbaalenii_PYR-1       LPPPSGPLPP------VAAGAAPKPADAVVKQDADAAEKPAEGSK---AA
MSMEG_0954|M.smegmatis_MC2_155      LPPAAGPAPA------KKNDKADKATDKSDKSDKADKADDAKSDD-----
TH_0267|M.thermoresistible__bu      LPPLVGPAPARPVKSGAKSDAKAAGAKSDAKATDAKSDAKAAKADDKDAV
                                     ..   * *                                         

Mb0524|M.bovis_AF2122/97            --AVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVI
Rv0511|M.tuberculosis_H37Rv         --AVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVI
MAV_4638|M.avium_104                --AVISGGPDIRPALGDPAEVAKTLTAEARTGVDVVRLVAGDPLTVDAVI
MMAR_0844|M.marinum_M               --AVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVI
MUL_4600|M.ulcerans_Agy99           --AVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVI
MLBr_02420|M.leprae_Br4923          --MVMSGGADIRPALGDPTEVAKTLTAEARSGVDVVRLVAGDPLTVDAVI
MAB_3991c|M.abscessus_ATCC_199      --LTI----DIRPALGDPADVAKTLVAEARSGVDVVRLVAGDPLSIDSVL
Mflv_0065|M.gilvum_PYR-GCK          EDAVIPGGPDVRPALGDPAEVAKTLAHEARTGVDVVRLVAGDPLSNDSVI
Mvan_0846|M.vanbaalenii_PYR-1       EDAVIPGGPDVRPALGDPVEVAKTLATEARTGVDVVRLVAGDPLSIDSVI
MSMEG_0954|M.smegmatis_MC2_155      -PAVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGDPLSVDAVI
TH_0267|M.thermoresistible__bu      EEEDICRGPEIRPALGDPAEVAKTVAAEARSGSDVVRLIAGDPLSVDAVI
                                        :    ::*******.:****:. *** * :****:****:: *:*:

Mb0524|M.bovis_AF2122/97            SEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTD
Rv0511|M.tuberculosis_H37Rv         SEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTD
MAV_4638|M.avium_104                TEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGD---VD
MMAR_0844|M.marinum_M               AEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD---VD
MUL_4600|M.ulcerans_Agy99           AEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD---VD
MLBr_02420|M.leprae_Br4923          AEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVRGD---VD
MAB_3991c|M.abscessus_ATCC_199      AEVHAVTRTQVAFEILPGLASSTAVPAYAGLPPGSAHTVADVRGD---VD
Mflv_0065|M.gilvum_PYR-GCK          TEVNALAKTQLSFEIVPGLPGTSAVPTYAGLPLGSSHTVADVRG---DVD
Mvan_0846|M.vanbaalenii_PYR-1       TEINALAKTQLNFEIVPGLPGTSAVPTYAGLPLGSSHTVADVRDP--NVD
MSMEG_0954|M.smegmatis_MC2_155      TEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGD---VD
TH_0267|M.thermoresistible__bu      NEITALARTQLTFEIVPGLPQTTAVPTYAGLPLGSTHTVADVRGD---VD
                                     *: *:::::: :**:***  :..**:***** **:**:****     .*

Mb0524|M.bovis_AF2122/97            WDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR
Rv0511|M.tuberculosis_H37Rv         WDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR
MAV_4638|M.avium_104                WEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQR
MMAR_0844|M.marinum_M               WEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQR
MUL_4600|M.ulcerans_Agy99           WEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQR
MLBr_02420|M.leprae_Br4923          WEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQR
MAB_3991c|M.abscessus_ATCC_199      WAALAAAPGPLILHATPTHVPDAAKALIEHGLADQTLVAVTAQGTTCAQR
Mflv_0065|M.gilvum_PYR-GCK          WAALAAAPGPLILHATPSHLPEAARTLIEYGLAESTPAVVTANGTTCQQR
Mvan_0846|M.vanbaalenii_PYR-1       WAALAAAPGPLILHATASHLPEAARTLIEYGLADSTPAVVTANGTTCQQR
MSMEG_0954|M.smegmatis_MC2_155      WAALAAAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTCQQR
TH_0267|M.thermoresistible__bu      WGALAAAPGPLILQATASHLSDAANTLIEYGLADTTPVVVTTNGTTCQQR
                                    * ***********:**.:*:.::*. *::: * : *  .**::**** **

Mb0524|M.bovis_AF2122/97            SVETTLQGLTDPAVLGA------TDPACSANGRDSQAGPLIVTIGKTVTS
Rv0511|M.tuberculosis_H37Rv         SVETTLQGLTDPAVLGA------TDPACSANGRDSQAGPLIVTIGKTVTS
MAV_4638|M.avium_104                SIETTLQGLTDSAVLGG------TDPAGPLTG------PLVVTIGKTVSA
MMAR_0844|M.marinum_M               SVETTLQGLTDPAILGG------TDPAGPLTG------PLVVTIGKTVSN
MUL_4600|M.ulcerans_Agy99           SVETTLQGLTDPAILGG------TDPAGPLTG------PLVVTIGKTVSN
MLBr_02420|M.leprae_Br4923          SVETTLEGLADSAVLVG------TDTAGPLTG------PLVVTIGKTVTS
MAB_3991c|M.abscessus_ATCC_199      TVETTLASLIDGVPVDA------NDPHGPMTG------ALVLTIGRVVAG
Mflv_0065|M.gilvum_PYR-GCK          SVETTLAGLLDKAALAG------TEPAGPLTG------TLVVTIGRTVAN
Mvan_0846|M.vanbaalenii_PYR-1       SIETTLGGLLDKAVLDKP---AVAEPAGPLTG------TLVVTLGRTVAH
MSMEG_0954|M.smegmatis_MC2_155      SVETTLVGLTDKTVVEKP---AGSELLGPLTG------PLVVTIGKTVAN
TH_0267|M.thermoresistible__bu      SVEASLATMGDKATLAGLEPPGGAPAEGPHTG------NLVVTIGKTVTN
                                    ::*::*  : * . :             . .*       *::*:*:.*: 

Mb0524|M.bovis_AF2122/97            RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP
Rv0511|M.tuberculosis_H37Rv         RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP
MAV_4638|M.avium_104                RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPIEVPTIAVEP
MMAR_0844|M.marinum_M               RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP
MUL_4600|M.ulcerans_Agy99           RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVAP
MLBr_02420|M.leprae_Br4923          RARLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP
MAB_3991c|M.abscessus_ATCC_199      RSKLNWWESRALYGWTVLVPRTKDQAGEMSDKLVGYGALPVEVPTIAVEP
Mflv_0065|M.gilvum_PYR-GCK          RAKLNWWESRALYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEP
Mvan_0846|M.vanbaalenii_PYR-1       RAKLNWWESRALYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEP
MSMEG_0954|M.smegmatis_MC2_155      RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEP
TH_0267|M.thermoresistible__bu      RAKLNWWESRALYGWTVLVPRTREQAGEMSEKLVAHGALPMEVPTISVEP
                                    *::*******************::******::*. :****:*****:* *

Mb0524|M.bovis_AF2122/97            PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGV
Rv0511|M.tuberculosis_H37Rv         PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGV
MAV_4638|M.avium_104                PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV
MMAR_0844|M.marinum_M               PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV
MUL_4600|M.ulcerans_Agy99           PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV
MLBr_02420|M.leprae_Br4923          PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV
MAB_3991c|M.abscessus_ATCC_199      PRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGV
Mflv_0065|M.gilvum_PYR-GCK          PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV
Mvan_0846|M.vanbaalenii_PYR-1       PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV
MSMEG_0954|M.smegmatis_MC2_155      PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV
TH_0267|M.thermoresistible__bu      PRSPAQMERAVKGLVDGRYQWVVFTSTNSVRAVWEKFKEFGLDARAFSGV
                                    ******************:**:******:******** ************

Mb0524|M.bovis_AF2122/97            KIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRV
Rv0511|M.tuberculosis_H37Rv         KIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRV
MAV_4638|M.avium_104                KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPLYDSVFDPVNRV
MMAR_0844|M.marinum_M               KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNRV
MUL_4600|M.ulcerans_Agy99           KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNRV
MLBr_02420|M.leprae_Br4923          KIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSVFDPVNRV
MAB_3991c|M.abscessus_ATCC_199      KIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEFPPYDDVFDPVNRV
Mflv_0065|M.gilvum_PYR-GCK          KIACVGQATAEKVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV
Mvan_0846|M.vanbaalenii_PYR-1       KIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV
MSMEG_0954|M.smegmatis_MC2_155      KIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRV
TH_0267|M.thermoresistible__bu      KIACVGQATADRVRAFGINPELVPSGEQSSLGLLEEFPPYDDVFDPVNRV
                                    ******::**::******.*****:*********::** **.:*******

Mb0524|M.bovis_AF2122/97            LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF
Rv0511|M.tuberculosis_H37Rv         LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF
MAV_4638|M.avium_104                LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGF
MMAR_0844|M.marinum_M               LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGF
MUL_4600|M.ulcerans_Agy99           LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGF
MLBr_02420|M.leprae_Br4923          LLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGF
MAB_3991c|M.abscessus_ATCC_199      LLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKTGGF
Mflv_0065|M.gilvum_PYR-GCK          LLPRADIATETLAEGLRELGWEIEDVTAYRTVRAAPPPAHTREMIKTGGF
Mvan_0846|M.vanbaalenii_PYR-1       LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGF
MSMEG_0954|M.smegmatis_MC2_155      LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGF
TH_0267|M.thermoresistible__bu      LLPRADIAXXX---------------------------------------
                                    ********                                          

Mb0524|M.bovis_AF2122/97            DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPD
Rv0511|M.tuberculosis_H37Rv         DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPD
MAV_4638|M.avium_104                DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE
MMAR_0844|M.marinum_M               DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE
MUL_4600|M.ulcerans_Agy99           DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE
MLBr_02420|M.leprae_Br4923          DAVCFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPE
MAB_3991c|M.abscessus_ATCC_199      DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPE
Mflv_0065|M.gilvum_PYR-GCK          DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPE
Mvan_0846|M.vanbaalenii_PYR-1       DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPE
MSMEG_0954|M.smegmatis_MC2_155      DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPE
TH_0267|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mb0524|M.bovis_AF2122/97            TAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR
Rv0511|M.tuberculosis_H37Rv         TAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR
MAV_4638|M.avium_104                TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR
MMAR_0844|M.marinum_M               TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR
MUL_4600|M.ulcerans_Agy99           TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR
MLBr_02420|M.leprae_Br4923          TAAVGPLVDALAEHVARLRAEGALPPPRKKSRRR
MAB_3991c|M.abscessus_ATCC_199      TAAVGPLVEALAEHAARLRTEGALPPPRKKSRRR
Mflv_0065|M.gilvum_PYR-GCK          VAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR
Mvan_0846|M.vanbaalenii_PYR-1       VAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR
MSMEG_0954|M.smegmatis_MC2_155      TAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR
TH_0267|M.thermoresistible__bu      ----------------------------------