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TRGRKKPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVGSAVELPEPAPAKPATGGD EAPAAADNEAAAEPPLTIDIRPALGDPADVAKTLVAEARSGVDVVRLVAGDPLSIDSVLAEVHAVTRTQV AFEILPGLASSTAVPAYAGLPPGSAHTVADVRGDVDWAALAAAPGPLILHATPTHVPDAAKALIEHGLAD QTLVAVTAQGTTCAQRTVETTLASLIDGVPVDANDPHGPMTGALVLTIGRVVAGRSKLNWWESRALYGWT VLVPRTKDQAGEMSDKLVGYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEK FAEFGLDARAFSGVKIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEFPPYDDVFDPVNRVLLPRAD IATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKTGGFDAVCFTSSSTVRNLVGIAGKPHARTI VACIGPKTAETAVEFGLRVDVQPETAAVGPLVEALAEHAARLRTEGALPPPRKKSRRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3991c | - | - | 100% (549) | uroporphyrin-III C-methyltransferase |
M. abscessus ATCC 19977 | MAB_3143c | - | 2e-19 | 31.54% (241) | multifunctional siroheme synthase CysG/uroporphyrin-III |
M. abscessus ATCC 19977 | MAB_2196 | - | 7e-11 | 25.19% (266) | precorrin-4 C11-methyltransferase CobM |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0524 | hemD | 0.0 | 75.13% (567) | uroporphyrin-III C-methyltransferase HemD |
M. gilvum PYR-GCK | Mflv_0065 | - | 0.0 | 79.23% (568) | uroporphyrinogen III synthase HEM4 |
M. tuberculosis H37Rv | Rv0511 | hemD | 0.0 | 75.13% (567) | uroporphyrin-III C-methyltransferase HemD |
M. leprae Br4923 | MLBr_02420 | hemD | 0.0 | 76.70% (558) | putative uroporphyrin-III C-methyltransferase |
M. marinum M | MMAR_0844 | hemD | 0.0 | 77.82% (559) | uroporphyrin-III C-methyltransferase HemD |
M. avium 104 | MAV_4638 | hemD | 0.0 | 77.31% (542) | uroporphyrinogen-III synthase |
M. smegmatis MC2 155 | MSMEG_0954 | hemD | 0.0 | 77.07% (567) | uroporphyrinogen-III synthase |
M. thermoresistible (build 8) | TH_0267 | cysG | 1e-166 | 67.57% (441) | PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD |
M. ulcerans Agy99 | MUL_4600 | hemD | 0.0 | 77.64% (559) | uroporphyrin-III C-methyltransferase HemD |
M. vanbaalenii PYR-1 | Mvan_0846 | - | 0.0 | 77.89% (570) | uroporphyrinogen III synthase HEM4 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0065|M.gilvum_PYR-GCK -------------------------------------------MSLRGRK Mvan_0846|M.vanbaalenii_PYR-1 -------------------------------------------MSLRGRK Mb0524|M.bovis_AF2122/97 --------------------------------------------MTRGRK Rv0511|M.tuberculosis_H37Rv --------------------------------------------MTRGRK MAV_4638|M.avium_104 -------------------------------------------------- MMAR_0844|M.marinum_M -------------------------------------------MMTRGRK MUL_4600|M.ulcerans_Agy99 --------------------------------------------MTRGRK MLBr_02420|M.leprae_Br4923 --------------------------------------MVGATMTTRGRK MAB_3991c|M.abscessus_ATCC_199 --------------------------------------------MTRGRK MSMEG_0954|M.smegmatis_MC2_155 MGGADSLTKVGGADAAVAVVGAAEGSVGAAESPASDPQPRESSSRSRSRK TH_0267|M.thermoresistible__bu -------------------------------------------------- Mflv_0065|M.gilvum_PYR-GCK NKPGRITFVGSGPGDPGLLTSRARAVLANAALVFTDPDVPEAVRALVGSE Mvan_0846|M.vanbaalenii_PYR-1 GKPGRITFVGSGPGDPGLLTTRARAVLAHAALVFTDPDVPEAVLELVGSE Mb0524|M.bovis_AF2122/97 PRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTD Rv0511|M.tuberculosis_H37Rv PRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTD MAV_4638|M.avium_104 --------MGSGPGDPGLLTARAAAVLANAALVFTDPDVPEPVLALIGKD MMAR_0844|M.marinum_M PRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGND MUL_4600|M.ulcerans_Agy99 PRPGRITYVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPESVLALIGND MLBr_02420|M.leprae_Br4923 LRPGRITFVGAGPGAPGLLTAQAVAVLANAALVFIDPDVPEPVLALIGKD MAB_3991c|M.abscessus_ATCC_199 -KPGRILFVGSGPGDPGLLTVRARAVLTGATVAFTDPDVPQAVLDLVG-- MSMEG_0954|M.smegmatis_MC2_155 VKPGRITFVGSGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTD TH_0267|M.thermoresistible__bu --------VGAGPGDPGLLTTKAQTILAHAALVFTDPDVPEAVKTLIGTN :*:*** ***** :* ::*: * :.* *****:.* *:* Mflv_0065|M.gilvum_PYR-GCK LPPPSGPLPP------VAD-AAPKTAAAGADQPASQDAAPADAAKTAKAA Mvan_0846|M.vanbaalenii_PYR-1 LPPPSGPLPP------VAAGAAPKPADAVVKQDADAAEKPAEGSK---AA Mb0524|M.bovis_AF2122/97 LPPVSGPAP-----------AEPVAGNGDAAGGGSA-QEHGRAAS----- Rv0511|M.tuberculosis_H37Rv LPPVSGPAP-----------AEPVAGNGDAAGGGSA-QEHGRAAS----- MAV_4638|M.avium_104 LPPVSGPAP-----------AEPAP-NGEGAG-----SEQGQAQP----- MMAR_0844|M.marinum_M LPPVSGPAP-----------ATAVADNADAATGGPAEGESDQAVP----- MUL_4600|M.ulcerans_Agy99 LPPVSGPAP-----------ATAVADNADAATGGPAEGESDQAVP----- MLBr_02420|M.leprae_Br4923 LPPVSGPAP-----------AGPAAVTAGRAADGTLEGDHYQAAP----- MAB_3991c|M.abscessus_ATCC_199 -SAVELPEP-----------APAKPATGGDEAPAAADNEAAAEPP----- MSMEG_0954|M.smegmatis_MC2_155 LPPAAGPAPA------KKNDKADKATDKSDKSDKADKADDAKSDD----- TH_0267|M.thermoresistible__bu LPPLVGPAPARPVKSGAKSDAKAAGAKSDAKATDAKSDAKAAKADDKDAV .. * * Mflv_0065|M.gilvum_PYR-GCK EDAVIPGGPDVRPALGDPAEVAKTLAHEARTGVDVVRLVAGDPLSNDSVI Mvan_0846|M.vanbaalenii_PYR-1 EDAVIPGGPDVRPALGDPVEVAKTLATEARTGVDVVRLVAGDPLSIDSVI Mb0524|M.bovis_AF2122/97 --AVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVI Rv0511|M.tuberculosis_H37Rv --AVVSGGPDIRPALGDPADVAKTLTAEARSGVDVVRLVAGDPLTVDAVI MAV_4638|M.avium_104 --AVISGGPDIRPALGDPAEVAKTLTAEARTGVDVVRLVAGDPLTVDAVI MMAR_0844|M.marinum_M --AVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVI MUL_4600|M.ulcerans_Agy99 --AVVSSGPDIRPALGDPTEVAKTLTAEARSGADVVRLVAGDPMSVDAVI MLBr_02420|M.leprae_Br4923 --MVMSGGADIRPALGDPTEVAKTLTAEARSGVDVVRLVAGDPLTVDAVI MAB_3991c|M.abscessus_ATCC_199 --LTI----DIRPALGDPADVAKTLVAEARSGVDVVRLVAGDPLSIDSVL MSMEG_0954|M.smegmatis_MC2_155 -PAVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGDPLSVDAVI TH_0267|M.thermoresistible__bu EEEDICRGPEIRPALGDPAEVAKTVAAEARSGSDVVRLIAGDPLSVDAVI : ::*******.:****:. *** * :****:****:: *:*: Mflv_0065|M.gilvum_PYR-GCK TEVNALAKTQLSFEIVPGLPGTSAVPTYAGLPLGSSHTVADVRG---DVD Mvan_0846|M.vanbaalenii_PYR-1 TEINALAKTQLNFEIVPGLPGTSAVPTYAGLPLGSSHTVADVRDP--NVD Mb0524|M.bovis_AF2122/97 SEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTD Rv0511|M.tuberculosis_H37Rv SEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVADVRIDPENTD MAV_4638|M.avium_104 TEVNAIARSHLHIEIVPGLAPTNAVPTYAGLPLGSSHTMADVRGD---VD MMAR_0844|M.marinum_M AEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD---VD MUL_4600|M.ulcerans_Agy99 AEVNAITRSHLQIEILPGLAATSAVPTYAGLPLGSAHTVADVRGD---VD MLBr_02420|M.leprae_Br4923 AEVNAVARTNLQIEIVPGLVTSSVVPTYAGLPLGSSHTVADVRGD---VD MAB_3991c|M.abscessus_ATCC_199 AEVHAVTRTQVAFEILPGLASSTAVPAYAGLPPGSAHTVADVRGD---VD MSMEG_0954|M.smegmatis_MC2_155 TEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGD---VD TH_0267|M.thermoresistible__bu NEITALARTQLTFEIVPGLPQTTAVPTYAGLPLGSTHTVADVRGD---VD *: *:::::: :**:*** :..**:***** **:**:**** .* Mflv_0065|M.gilvum_PYR-GCK WAALAAAPGPLILHATPSHLPEAARTLIEYGLAESTPAVVTANGTTCQQR Mvan_0846|M.vanbaalenii_PYR-1 WAALAAAPGPLILHATASHLPEAARTLIEYGLADSTPAVVTANGTTCQQR Mb0524|M.bovis_AF2122/97 WDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR Rv0511|M.tuberculosis_H37Rv WDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR MAV_4638|M.avium_104 WEALAAAPGPLILQATASHLADAARTLIEHELAENTPCVVTAHGTTCQQR MMAR_0844|M.marinum_M WEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQR MUL_4600|M.ulcerans_Agy99 WEALAAAPGPLILQATASHLADAARTLVEHELADTTPCVVTAHGTTCQQR MLBr_02420|M.leprae_Br4923 WEALAAAPGPLILQATASHLADAAHILIDHGLDDATPCVVTAQGTTCQQR MAB_3991c|M.abscessus_ATCC_199 WAALAAAPGPLILHATPTHVPDAAKALIEHGLADQTLVAVTAQGTTCAQR MSMEG_0954|M.smegmatis_MC2_155 WAALAAAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTCQQR TH_0267|M.thermoresistible__bu WGALAAAPGPLILQATASHLSDAANTLIEYGLADTTPVVVTTNGTTCQQR * ***********:**.:*:.::*. *::: * : * .**::**** ** Mflv_0065|M.gilvum_PYR-GCK SVETTLAGLLDKAALAG------TEPAGPLTG------TLVVTIGRTVAN Mvan_0846|M.vanbaalenii_PYR-1 SIETTLGGLLDKAVLDKP---AVAEPAGPLTG------TLVVTLGRTVAH Mb0524|M.bovis_AF2122/97 SVETTLQGLTDPAVLGA------TDPACSANGRDSQAGPLIVTIGKTVTS Rv0511|M.tuberculosis_H37Rv SVETTLQGLTDPAVLGA------TDPACSANGRDSQAGPLIVTIGKTVTS MAV_4638|M.avium_104 SIETTLQGLTDSAVLGG------TDPAGPLTG------PLVVTIGKTVSA MMAR_0844|M.marinum_M SVETTLQGLTDPAILGG------TDPAGPLTG------PLVVTIGKTVSN MUL_4600|M.ulcerans_Agy99 SVETTLQGLTDPAILGG------TDPAGPLTG------PLVVTIGKTVSN MLBr_02420|M.leprae_Br4923 SVETTLEGLADSAVLVG------TDTAGPLTG------PLVVTIGKTVTS MAB_3991c|M.abscessus_ATCC_199 TVETTLASLIDGVPVDA------NDPHGPMTG------ALVLTIGRVVAG MSMEG_0954|M.smegmatis_MC2_155 SVETTLVGLTDKTVVEKP---AGSELLGPLTG------PLVVTIGKTVAN TH_0267|M.thermoresistible__bu SVEASLATMGDKATLAGLEPPGGAPAEGPHTG------NLVVTIGKTVTN ::*::* : * . : . .* *::*:*:.*: Mflv_0065|M.gilvum_PYR-GCK RAKLNWWESRALYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEP Mvan_0846|M.vanbaalenii_PYR-1 RAKLNWWESRALYGWTVLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEP Mb0524|M.bovis_AF2122/97 RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP Rv0511|M.tuberculosis_H37Rv RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP MAV_4638|M.avium_104 RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPIEVPTIAVEP MMAR_0844|M.marinum_M RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP MUL_4600|M.ulcerans_Agy99 RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVAP MLBr_02420|M.leprae_Br4923 RARLNWWESRALYGWTVLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEP MAB_3991c|M.abscessus_ATCC_199 RSKLNWWESRALYGWTVLVPRTKDQAGEMSDKLVGYGALPVEVPTIAVEP MSMEG_0954|M.smegmatis_MC2_155 RAKLNWWESRALYGWTVLVPRTKDQAGEMSERLVTHGALPIEVPTIAVEP TH_0267|M.thermoresistible__bu RAKLNWWESRALYGWTVLVPRTREQAGEMSEKLVAHGALPMEVPTISVEP *::*******************::******::*. :****:*****:* * Mflv_0065|M.gilvum_PYR-GCK PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV Mvan_0846|M.vanbaalenii_PYR-1 PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV Mb0524|M.bovis_AF2122/97 PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGV Rv0511|M.tuberculosis_H37Rv PRSPAQMERAVKGLVDGRFQWIVFTSTNAVRAVWEKFGEFGLDARAFSGV MAV_4638|M.avium_104 PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV MMAR_0844|M.marinum_M PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV MUL_4600|M.ulcerans_Agy99 PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV MLBr_02420|M.leprae_Br4923 PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFGEFGLDARAFSGV MAB_3991c|M.abscessus_ATCC_199 PRSPAQMERAVKGLVDGRYQWVVFTSTNAVRAVWEKFAEFGLDARAFSGV MSMEG_0954|M.smegmatis_MC2_155 PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGV TH_0267|M.thermoresistible__bu PRSPAQMERAVKGLVDGRYQWVVFTSTNSVRAVWEKFKEFGLDARAFSGV ******************:**:******:******** ************ Mflv_0065|M.gilvum_PYR-GCK KIACVGQATAEKVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV Mvan_0846|M.vanbaalenii_PYR-1 KIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV Mb0524|M.bovis_AF2122/97 KIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRV Rv0511|M.tuberculosis_H37Rv KIACVGESTADRVRAFGISPELVPSGEQSSLGLLDDFPPYDSVFDPVNRV MAV_4638|M.avium_104 KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDDFPLYDSVFDPVNRV MMAR_0844|M.marinum_M KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNRV MUL_4600|M.ulcerans_Agy99 KIACVGESTADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSIFDPVNRV MLBr_02420|M.leprae_Br4923 KIACVGEATADRVRAFGISPELVPAGEQSSLGLLDEFPPYDSVFDPVNRV MAB_3991c|M.abscessus_ATCC_199 KIACVGQATADKVRAFGINPELVPAGEQSSLGLLDEFPPYDDVFDPVNRV MSMEG_0954|M.smegmatis_MC2_155 KIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRV TH_0267|M.thermoresistible__bu KIACVGQATADRVRAFGINPELVPSGEQSSLGLLEEFPPYDDVFDPVNRV ******::**::******.*****:*********::** **.:******* Mflv_0065|M.gilvum_PYR-GCK LLPRADIATETLAEGLRELGWEIEDVTAYRTVRAAPPPAHTREMIKTGGF Mvan_0846|M.vanbaalenii_PYR-1 LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIKTGGF Mb0524|M.bovis_AF2122/97 LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF Rv0511|M.tuberculosis_H37Rv LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIKTGGF MAV_4638|M.avium_104 LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAETREMIKTGGF MMAR_0844|M.marinum_M LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGF MUL_4600|M.ulcerans_Agy99 LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAATREMIKTGGF MLBr_02420|M.leprae_Br4923 LLPRADIATETLAEGLRGCGWEIEDVTAYRTVRAAPPPAATREMIKTGGF MAB_3991c|M.abscessus_ATCC_199 LLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPAAQTREMIKTGGF MSMEG_0954|M.smegmatis_MC2_155 LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGF TH_0267|M.thermoresistible__bu LLPRADIAXXX--------------------------------------- ******** Mflv_0065|M.gilvum_PYR-GCK DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPE Mvan_0846|M.vanbaalenii_PYR-1 DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPE Mb0524|M.bovis_AF2122/97 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPD Rv0511|M.tuberculosis_H37Rv DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPD MAV_4638|M.avium_104 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE MMAR_0844|M.marinum_M DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE MUL_4600|M.ulcerans_Agy99 DAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPE MLBr_02420|M.leprae_Br4923 DAVCFTSSSTVRNLVGIAGKPHARTVIACIGPKTAETASEFGLRVDVQPE MAB_3991c|M.abscessus_ATCC_199 DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAVEFGLRVDVQPE MSMEG_0954|M.smegmatis_MC2_155 DAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPE TH_0267|M.thermoresistible__bu -------------------------------------------------- Mflv_0065|M.gilvum_PYR-GCK VAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR Mvan_0846|M.vanbaalenii_PYR-1 VAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR Mb0524|M.bovis_AF2122/97 TAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR Rv0511|M.tuberculosis_H37Rv TAAIGPLVDALAEHAARLRAEGALPPPRKKSRRR MAV_4638|M.avium_104 TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR MMAR_0844|M.marinum_M TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR MUL_4600|M.ulcerans_Agy99 TAAVGPLVDALAEHAARLRAEGALPPPRKKSRRR MLBr_02420|M.leprae_Br4923 TAAVGPLVDALAEHVARLRAEGALPPPRKKSRRR MAB_3991c|M.abscessus_ATCC_199 TAAVGPLVEALAEHAARLRTEGALPPPRKKSRRR MSMEG_0954|M.smegmatis_MC2_155 TAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR TH_0267|M.thermoresistible__bu ----------------------------------