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M. thermoresistible (build 8) TH_0233 (-)

annotation: CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN
coordinates: 507709 - 508842
length: 378

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0233--100% (378)CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2999c-1e-13968.32% (382) hypothetical protein Mb2999c
M. gilvum PYR-GCKMflv_4213-1e-13565.89% (384) Dak phosphatase
M. tuberculosis H37RvRv2974c-1e-13968.32% (382) hypothetical protein Rv2974c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3279c-1e-11353.65% (397) putative phosphatase/kinase
M. marinum MMMAR_1741-1e-14068.30% (388) hypothetical protein MMAR_1741
M. avium 104MAV_3819-1e-13666.50% (394) DAK2 domain-containing protein
M. smegmatis MC2 155MSMEG_2402-1e-14970.26% (390) dihydroxyacetone kinase
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_2154-1e-14166.06% (386) Dak phosphatase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4213|M.gilvum_PYR-GCK          ---------------MSARRLDASTLRRWAHDAVAALISHTDEINRLNVF
Mvan_2154|M.vanbaalenii_PYR-1       ---------------MSARRLDASALRHWAHAAVADLISHTDEINQLNVF
MSMEG_2402|M.smegmatis_MC2_155      ---------------MSARRLDASALRDWAHTAVGDLITHTDEINRLNVF
TH_0233|M.thermoresistible__bu      --------------------------------------------------
Mb2999c|M.bovis_AF2122/97           ---------MG----TADRPLDASALRDWAHAVVSDLILHIDEINRLNVF
Rv2974c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1741|M.marinum_M               ---------MG----TTERPLDALALRDWAHTGVSDLITHLDEINRLNVF
MAV_3819|M.avium_104                MAAQRRWVTLGSSWTSHDRPLDAAALRDWAHTAVSDLITHIDEINRLNVF
MAB_3279c|M.abscessus_ATCC_199      ---------------MRLSVLDSAALLDWARASVEGLISRSDEINRLNVF
                                                                                      

Mflv_4213|M.gilvum_PYR-GCK          PVADADTGTNMLFTMRAAWAQADS-DAADD----------VTAITAALAA
Mvan_2154|M.vanbaalenii_PYR-1       PVADADTGTNMLFTMRAAWAEADSCDAGDD----------VTAVAAALAG
MSMEG_2402|M.smegmatis_MC2_155      PVADADTGTNMLFTMRSAWAHADA-QSGGD----------VAQVASALAA
TH_0233|M.thermoresistible__bu      --------------------------------------------------
Mb2999c|M.bovis_AF2122/97           PVADSDTGVNMLFTMRAAVVEADLHANS------QADAEDVARVAAALAA
Rv2974c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1741|M.marinum_M               PVADSDTGANMLFTMRSALAQVDSTGGAGPEHPEDPEHRDVAQVAAALAA
MAV_3819|M.avium_104                PVADSDTGANMLFTMRSALAELQAAGGPG----------CVARAAAALST
MAB_3279c|M.abscessus_ATCC_199      PVADADTGTNMLFTMRSAVNAAEALGEGAT----------VAQVAAALAR
                                                                                      

Mflv_4213|M.gilvum_PYR-GCK          GALRGARGNSGVILSQILRALAEVTAEAAEERGGVLSEVTGEMLAAALRH
Mvan_2154|M.vanbaalenii_PYR-1       GALHGARGNSGVILSQILRAVAEVTASAAEDRDGVLADITGPLLSSALRH
MSMEG_2402|M.smegmatis_MC2_155      GALQGARGNSGVILSQILLGLAEVITSAAADRGGDLLDVDGPLFGAALRH
TH_0233|M.thermoresistible__bu      --------------------------------------------------
Mb2999c|M.bovis_AF2122/97           GALNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWR
Rv2974c|M.tuberculosis_H37Rv        --MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWR
MMAR_1741|M.marinum_M               GALNGARGNSGVILSQILRGVSDVTDSAAAG--QPLAAIDAALLAAALWR
MAV_3819|M.avium_104                GALNGARGNSGVILSQILRGVADVTATAAARAGGQLAHIEAAVLGAALQR
MAB_3279c|M.abscessus_ATCC_199      GAVHGARGNSGVILSQIVRGIADAAD--------DQDAIGAEVVRRALRQ
                                                                                      

Mflv_4213|M.gilvum_PYR-GCK          AVTLVVASMG-EAVPGTIVSVLHDAAAAAEDAVCGQADLAAVVVACTQAA
Mvan_2154|M.vanbaalenii_PYR-1       AVTLVVTSMG-EAVPGTIVSVLHDAAEAAEEAVSAEAELADVVAACAHAA
MSMEG_2402|M.smegmatis_MC2_155      GVALVAVSMG-DPVPGTIVTVLQAAADAAEKCVVGGADLAEVAASAADAA
TH_0233|M.thermoresistible__bu      -----------------------------------------VVSTAAEAA
Mb2999c|M.bovis_AF2122/97           GVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--EGLAGAVTAAGDAA
Rv2974c|M.tuberculosis_H37Rv        GVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--EGLAGAVTAAGDAA
MMAR_1741|M.marinum_M               GVELVITSMGGEEVPGTIVSVLRAAAVAVRQCADAGEGLAAAVAAAGDAA
MAV_3819|M.avium_104                GVELVIASMGGEEIPGTIVSVLRAAATAVAQCARAGEGVTAAVIAAGDAA
MAB_3279c|M.abscessus_ATCC_199      ASQFVIASMS-TPVEGTIVSVLAAAADAADDAQS--DDLPVLVTTAADAA
                                                                              . :. .**

Mflv_4213|M.gilvum_PYR-GCK          AAALDRTPTQLDVLADAGVVDAGGRGLLVLLDALSAILTGELTRRQVYLP
Mvan_2154|M.vanbaalenii_PYR-1       GAALDRTPTQLDVLADAGVVDAGGRGLVVLLDALCATLTGHAPRRGVYQP
MSMEG_2402|M.smegmatis_MC2_155      ATALERTPQQLDVLAEAGVVDSGGRGLLVLLDAMTATITGHAPRRPAYTP
TH_0233|M.thermoresistible__bu      VVALEKTPEQLDVLARAGVVDAGGRGFVALLDALTLTLTGQLPYRPEYRP
Mb2999c|M.bovis_AF2122/97           VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEP
Rv2974c|M.tuberculosis_H37Rv        VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEP
MMAR_1741|M.marinum_M               VVALEKTPEQLDVLADAGVVDAGGRGLLVLLDALRSTITGAAPARSVYEP
MAV_3819|M.avium_104                VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRTTITGQAPARTVYRL
MAB_3279c|M.abscessus_ATCC_199      VSALEKTPKQLDVLADNGVVDAGARGLVVILDALVSVVAGELPSRREYSP
                                      **::** ******  *.**:*.**::.:***:   : *  . *  *  

Mflv_4213|M.gilvum_PYR-GCK          DPKHAAGAAAP----------------PSPTPGFEVMYLLSDCDAENVEQ
Mvan_2154|M.vanbaalenii_PYR-1       SPNKSSAPSSA----------------AHATPSFEVMYLLADCHAEDIEK
MSMEG_2402|M.smegmatis_MC2_155      APPRATASSSVSARAGVPADDV----APTQVPQFEVMYLLSGCAPEAVEH
TH_0233|M.thermoresistible__bu      APPEPAVTTPA----------------APAPPQFEVMYLLSGCDARGVER
Mb2999c|M.bovis_AF2122/97           SPRALPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQ
Rv2974c|M.tuberculosis_H37Rv        SPRALPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQ
MMAR_1741|M.marinum_M               APRSPALGVGV----------------PAPIPQFEVMYLLAGCDAAAADT
MAV_3819|M.avium_104                APRTAAPEAAA----------------PRPAPQFEVMYRLDDCAPAAADA
MAB_3279c|M.abscessus_ATCC_199      SPPKNAPSQVWVAGPGRGGGGLNLDPPRELPPEFEVMYLLCGCDELQIAD
                                     *   .                         * ***** *  *       

Mflv_4213|M.gilvum_PYR-GCK          LRARLDALGDSVAIAASGFGEAG---AGHYSVHVHADDAGAAVEAGLAVG
Mvan_2154|M.vanbaalenii_PYR-1       LRAALEELGDSIAIAASGFGEAGGAGPGHYSVHVHADDAGAAVEAGLAVG
MSMEG_2402|M.smegmatis_MC2_155      LRAGLEQIGESVAIATSGG--------DRYSVHVHVDDAGAAVEAGLAVG
TH_0233|M.thermoresistible__bu      LRRRLSEIGESVAVAASGS--------GGYSVHVHCDDAGGAVEAGLACG
Mb2999c|M.bovis_AF2122/97           LRDRLKELGESVAIAAAPP--------DSYSVHVHTDDAGAAVEAGLAVG
Rv2974c|M.tuberculosis_H37Rv        LRDRLKELGESVAIAAAPP--------DSYSVHVHTDDAGAAVEAGLAVG
MMAR_1741|M.marinum_M               LRDRLSELGDSVAIAAAPS--------ESYSVHVHTDDAGAAVEAGLAAG
MAV_3819|M.avium_104                LRDRLTELGDSVGIASAPSSAQ-----HTYSVHVHTDDAGAAVEAGLAAG
MAB_3279c|M.abscessus_ATCC_199      LRAQLDAMGDSIAIAGDGE--------MGHSVHAHVNDAGAAIEAGMKFG
                                    **  *  :*:*:.:*              :***.* :***.*:***:  *

Mflv_4213|M.gilvum_PYR-GCK          TLSRIQITSLHGGADRSSAG---SWGRERAVLAVVDGEGAEELFVGEGAA
Mvan_2154|M.vanbaalenii_PYR-1       SLSRIQITSLSGGGDRHPAG---GWSRQRAVLAVVDGDGAESLFTGEGAE
MSMEG_2402|M.smegmatis_MC2_155      TLNRIQITALTGSGGSRPSG---GWERERAVLAVVDGDGGAELFAGEGAH
TH_0233|M.thermoresistible__bu      VPSRIQITALSGG-AAHPAA---GWSRERAALAVVDGDGAAELFATEGAH
Mb2999c|M.bovis_AF2122/97           RVSRIVISALGSGTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGEGAC
Rv2974c|M.tuberculosis_H37Rv        RVSRIVISALGSGTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGEGAC
MMAR_1741|M.marinum_M               RLSKIVISALSSGTTALAAG---GWTRQRAVLAVVDGDGAAELFAAEGAC
MAV_3819|M.avium_104                RLSRIVISALSSGGPGLPAG---GWTRERAVLAVVDGDGAAGLFSGEGAC
MAB_3279c|M.abscessus_ATCC_199      TPQSIQISSLRGGLDVPGGGHHDGRHRHRRVLALAEGDGAATLFSSEGAQ
                                      . * *::* ..     ..   .  * * .**:.:*:*.  **  *** 

Mflv_4213|M.gilvum_PYR-GCK          VLRT-----EPGVEISAQQLLHALVKTGAAQVMVLPNGYVAAEEIVAGCA
Mvan_2154|M.vanbaalenii_PYR-1       ILRP-----QSDVPVSAQQLLHALVNTGAAQVMVLPNGYVAAEEIVAGCA
MSMEG_2402|M.smegmatis_MC2_155      VLRP-----EADEPVSAKQLLRALVDVGAAQVMVLPNGYVAAEELVAGCT
TH_0233|M.thermoresistible__bu      VLRR-----DPDTPVTAQQLLRALVDTGAGQVMVLPNGYVAAEELVAGCT
Mb2999c|M.bovis_AF2122/97           VLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCT
Rv2974c|M.tuberculosis_H37Rv        VLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCT
MMAR_1741|M.marinum_M               VLRPGAGAAAPASDLSAHQLVRAVVDTGAAQVMVLPNGYVAVEELVAGCT
MAV_3819|M.avium_104                VLQRDPAAADPVTTISAHQLMRAVVDTGAAQVMVLPNGYVAAEELVAGCT
MAB_3279c|M.abscessus_ATCC_199      VLRVD------EPPASAKRLLDAVVDSGAHQIMVLPNGLMAAEELVAVCA
                                    :*:            :*::*: *:*. ** ::****** :*.**:** *:

Mflv_4213|M.gilvum_PYR-GCK          VAADWGIDLVPIPTGSMVQGLAALAVHDPGHRLVDDGYTMARAGAAARFG
Mvan_2154|M.vanbaalenii_PYR-1       VASDWGIDMVPVPTGSMVQGLAALAVHDPERRLVDDGYTMARAAAGARHG
MSMEG_2402|M.smegmatis_MC2_155      AAIGWGIDVVPVPAGSMVQGLAALAVHDAARQAVDDGYTMARAAAGARHG
TH_0233|M.thermoresistible__bu      AAISWGIDVVPVPAASMVQGLAALAVHDPGRHAVDDGYTMAGAAADTRHG
Mb2999c|M.bovis_AF2122/97           AAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHG
Rv2974c|M.tuberculosis_H37Rv        AAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHG
MMAR_1741|M.marinum_M               AAIGWGVDVVPVPTGSMVQGLAALAVHDPASQAVDDGYIMARAAGAARHG
MAV_3819|M.avium_104                AAIGWGIDVVPIPTESMVQGLAALAVHDTGRQAVDDGYTMARAAGAARHG
MAB_3279c|M.abscessus_ATCC_199      AARGWGITVIPLPSASMAQGLAALAVHDPERMAVDDSYTMARAAGATRFG
                                    .* .**: ::*:*: **.**********.    ***.* ** *.. :*.*

Mflv_4213|M.gilvum_PYR-GCK          SVRIAAEDALTWAGACRPGDGLGITGDEVVVVGDDIVSAATGLIDLLLAA
Mvan_2154|M.vanbaalenii_PYR-1       TVRVAAEEALTWAGACKPGDGLGIAGDEVVIVGADVVAAGAGLIDLMLAA
MSMEG_2402|M.smegmatis_MC2_155      SVRVATEEALTWAGACKPGDGLGIAGDEVLIVGPDVTAAAAGLIDLLLAA
TH_0233|M.thermoresistible__bu      SVRVATEQALTWAGPCGPGDGLGIAGGEVLIVGRDIASAAMGLIDLLLGG
Mb2999c|M.bovis_AF2122/97           SVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAS
Rv2974c|M.tuberculosis_H37Rv        SVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAS
MMAR_1741|M.marinum_M               SVRIATETALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAP
MAV_3819|M.avium_104                SVRIATETALTWAGSCRPGDGLGIAGGEVLIVAADAVGAAIGLLDLLLAS
MAB_3279c|M.abscessus_ATCC_199      LVRVATERALTWSGTCEPGDAMGIIGDEVLVLNHDIANATKALVSIMLSS
                                     **:*:: ****:*.* ***.:** *.**:::  * . *  .*:.::*. 

Mflv_4213|M.gilvum_PYR-GCK          GGELVTVLTGDGVESE--------VGAALAEHVHHNHLGAELVTFHTGHR
Mvan_2154|M.vanbaalenii_PYR-1       GGELVTVLTGDGVGPE--------IGEALAEHVHHHHPGTDLVTFHTGHR
MSMEG_2402|M.smegmatis_MC2_155      GGELITVLTGHGVDSA--------VGEALQAHVHDKHLGVELVTYHTGHR
TH_0233|M.thermoresistible__bu      GGDLATVLVGEGVDPA--------VAERLRDHVHRNHPGTELSVYHTGHR
Mb2999c|M.bovis_AF2122/97           GGDLVTVLIGAGVTED--------VAVVLERHVHDHHPGTELVSYRTGHR
Rv2974c|M.tuberculosis_H37Rv        GGDLVTVLIGAGVTED--------VAVVLERHVHDHHPGTELVSYRTGHR
MMAR_1741|M.marinum_M               GGDLVTVLIGAGIDDDE---RIARLVESLERHMHDHHPGTELVIYRTGHR
MAV_3819|M.avium_104                GGDLVTVLLGAGLDADGSDAHAGAVVDILEEHMHDHHPGTELVTYRTGHH
MAB_3279c|M.abscessus_ATCC_199      GGELVTVLLSDEVDDS--------LAESLIEHTRSHHGGVEVMIYRTGQH
                                    **:* *** .  :           :   *  * : :* *.::  ::**::

Mflv_4213|M.gilvum_PYR-GCK          ADALLIGVE
Mvan_2154|M.vanbaalenii_PYR-1       VDALVIGVE
MSMEG_2402|M.smegmatis_MC2_155      GDALLIGVE
TH_0233|M.thermoresistible__bu      GDALLIGVE
Mb2999c|M.bovis_AF2122/97           GDALLIGVE
Rv2974c|M.tuberculosis_H37Rv        GDALLIGVE
MMAR_1741|M.marinum_M               GDALLIGVE
MAV_3819|M.avium_104                GDVLLIGVE
MAB_3279c|M.abscessus_ATCC_199      TDVVHIGVE
                                     *.: ****