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NGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGVEVPGTIVSVLR AAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPAR AVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDA GAAVEAGLAVGRVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPA ADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQ AVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASGG DLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2974c | - | - | 100% (470) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2999c | - | 0.0 | 100.00% (470) | hypothetical protein Mb2999c |
| M. gilvum PYR-GCK | Mflv_4213 | - | 1e-156 | 62.89% (477) | Dak phosphatase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3279c | - | 1e-121 | 51.43% (490) | putative phosphatase/kinase |
| M. marinum M | MMAR_1741 | - | 0.0 | 82.18% (477) | hypothetical protein MMAR_1741 |
| M. avium 104 | MAV_3819 | - | 0.0 | 77.02% (483) | DAK2 domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2402 | - | 1e-168 | 65.91% (484) | dihydroxyacetone kinase |
| M. thermoresistible (build 8) | TH_0233 | - | 1e-139 | 68.32% (382) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2154 | - | 1e-158 | 62.50% (480) | Dak phosphatase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2974c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2999c|M.bovis_AF2122/97 ---------MG----TADRPLDASALRDWAHAVVSDLILHIDEINRLNVF
MMAR_1741|M.marinum_M ---------MG----TTERPLDALALRDWAHTGVSDLITHLDEINRLNVF
MAV_3819|M.avium_104 MAAQRRWVTLGSSWTSHDRPLDAAALRDWAHTAVSDLITHIDEINRLNVF
Mflv_4213|M.gilvum_PYR-GCK ---------------MSARRLDASTLRRWAHDAVAALISHTDEINRLNVF
Mvan_2154|M.vanbaalenii_PYR-1 ---------------MSARRLDASALRHWAHAAVADLISHTDEINQLNVF
MSMEG_2402|M.smegmatis_MC2_155 ---------------MSARRLDASALRDWAHTAVGDLITHTDEINRLNVF
TH_0233|M.thermoresistible__bu --------------------------------------------------
MAB_3279c|M.abscessus_ATCC_199 ---------------MRLSVLDSAALLDWARASVEGLISRSDEINRLNVF
Rv2974c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2999c|M.bovis_AF2122/97 PVADSDTGVNMLFTMRAAVVEADLHANS------QADAEDVARVAAALAA
MMAR_1741|M.marinum_M PVADSDTGANMLFTMRSALAQVDSTGGAGPEHPEDPEHRDVAQVAAALAA
MAV_3819|M.avium_104 PVADSDTGANMLFTMRSALAELQAAGGPG----------CVARAAAALST
Mflv_4213|M.gilvum_PYR-GCK PVADADTGTNMLFTMRAAWAQADS-DAADD----------VTAITAALAA
Mvan_2154|M.vanbaalenii_PYR-1 PVADADTGTNMLFTMRAAWAEADSCDAGDD----------VTAVAAALAG
MSMEG_2402|M.smegmatis_MC2_155 PVADADTGTNMLFTMRSAWAHADA-QSGGD----------VAQVASALAA
TH_0233|M.thermoresistible__bu --------------------------------------------------
MAB_3279c|M.abscessus_ATCC_199 PVADADTGTNMLFTMRSAVNAAEALGEGAT----------VAQVAAALAR
Rv2974c|M.tuberculosis_H37Rv --MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWR
Mb2999c|M.bovis_AF2122/97 GALNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWR
MMAR_1741|M.marinum_M GALNGARGNSGVILSQILRGVSDVTDSAAAG--QPLAAIDAALLAAALWR
MAV_3819|M.avium_104 GALNGARGNSGVILSQILRGVADVTATAAARAGGQLAHIEAAVLGAALQR
Mflv_4213|M.gilvum_PYR-GCK GALRGARGNSGVILSQILRALAEVTAEAAEERGGVLSEVTGEMLAAALRH
Mvan_2154|M.vanbaalenii_PYR-1 GALHGARGNSGVILSQILRAVAEVTASAAEDRDGVLADITGPLLSSALRH
MSMEG_2402|M.smegmatis_MC2_155 GALQGARGNSGVILSQILLGLAEVITSAAADRGGDLLDVDGPLFGAALRH
TH_0233|M.thermoresistible__bu --------------------------------------------------
MAB_3279c|M.abscessus_ATCC_199 GAVHGARGNSGVILSQIVRGIADAAD--------DQDAIGAEVVRRALRQ
Rv2974c|M.tuberculosis_H37Rv GVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--EGLAGAVTAAGDAA
Mb2999c|M.bovis_AF2122/97 GVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--EGLAGAVTAAGDAA
MMAR_1741|M.marinum_M GVELVITSMGGEEVPGTIVSVLRAAAVAVRQCADAGEGLAAAVAAAGDAA
MAV_3819|M.avium_104 GVELVIASMGGEEIPGTIVSVLRAAATAVAQCARAGEGVTAAVIAAGDAA
Mflv_4213|M.gilvum_PYR-GCK AVTLVVASMG-EAVPGTIVSVLHDAAAAAEDAVCGQADLAAVVVACTQAA
Mvan_2154|M.vanbaalenii_PYR-1 AVTLVVTSMG-EAVPGTIVSVLHDAAEAAEEAVSAEAELADVVAACAHAA
MSMEG_2402|M.smegmatis_MC2_155 GVALVAVSMG-DPVPGTIVTVLQAAADAAEKCVVGGADLAEVAASAADAA
TH_0233|M.thermoresistible__bu -----------------------------------------VVSTAAEAA
MAB_3279c|M.abscessus_ATCC_199 ASQFVIASMS-TPVEGTIVSVLAAAADAADDAQS--DDLPVLVTTAADAA
. :. .**
Rv2974c|M.tuberculosis_H37Rv VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEP
Mb2999c|M.bovis_AF2122/97 VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEP
MMAR_1741|M.marinum_M VVALEKTPEQLDVLADAGVVDAGGRGLLVLLDALRSTITGAAPARSVYEP
MAV_3819|M.avium_104 VIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRTTITGQAPARTVYRL
Mflv_4213|M.gilvum_PYR-GCK AAALDRTPTQLDVLADAGVVDAGGRGLLVLLDALSAILTGELTRRQVYLP
Mvan_2154|M.vanbaalenii_PYR-1 GAALDRTPTQLDVLADAGVVDAGGRGLVVLLDALCATLTGHAPRRGVYQP
MSMEG_2402|M.smegmatis_MC2_155 ATALERTPQQLDVLAEAGVVDSGGRGLLVLLDAMTATITGHAPRRPAYTP
TH_0233|M.thermoresistible__bu VVALEKTPEQLDVLARAGVVDAGGRGFVALLDALTLTLTGQLPYRPEYRP
MAB_3279c|M.abscessus_ATCC_199 VSALEKTPKQLDVLADNGVVDAGARGLVVILDALVSVVAGELPSRREYSP
**::** ****** *.**:*.**::.:***: : * . * *
Rv2974c|M.tuberculosis_H37Rv SPRALPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQ
Mb2999c|M.bovis_AF2122/97 SPRALPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQ
MMAR_1741|M.marinum_M APRSPALGVGV----------------PAPIPQFEVMYLLAGCDAAAADT
MAV_3819|M.avium_104 APRTAAPEAAA----------------PRPAPQFEVMYRLDDCAPAAADA
Mflv_4213|M.gilvum_PYR-GCK DPKHAAGAAAP----------------PSPTPGFEVMYLLSDCDAENVEQ
Mvan_2154|M.vanbaalenii_PYR-1 SPNKSSAPSSA----------------AHATPSFEVMYLLADCHAEDIEK
MSMEG_2402|M.smegmatis_MC2_155 APPRATASSSVSARAGVPADDV----APTQVPQFEVMYLLSGCAPEAVEH
TH_0233|M.thermoresistible__bu APPEPAVTTPA----------------APAPPQFEVMYLLSGCDARGVER
MAB_3279c|M.abscessus_ATCC_199 SPPKNAPSQVWVAGPGRGGGGLNLDPPRELPPEFEVMYLLCGCDELQIAD
* . * ***** * *
Rv2974c|M.tuberculosis_H37Rv LRDRLKELGESVAIAAAPP--------DSYSVHVHTDDAGAAVEAGLAVG
Mb2999c|M.bovis_AF2122/97 LRDRLKELGESVAIAAAPP--------DSYSVHVHTDDAGAAVEAGLAVG
MMAR_1741|M.marinum_M LRDRLSELGDSVAIAAAPS--------ESYSVHVHTDDAGAAVEAGLAAG
MAV_3819|M.avium_104 LRDRLTELGDSVGIASAPSSAQ-----HTYSVHVHTDDAGAAVEAGLAAG
Mflv_4213|M.gilvum_PYR-GCK LRARLDALGDSVAIAASGFGEAG---AGHYSVHVHADDAGAAVEAGLAVG
Mvan_2154|M.vanbaalenii_PYR-1 LRAALEELGDSIAIAASGFGEAGGAGPGHYSVHVHADDAGAAVEAGLAVG
MSMEG_2402|M.smegmatis_MC2_155 LRAGLEQIGESVAIATSGG--------DRYSVHVHVDDAGAAVEAGLAVG
TH_0233|M.thermoresistible__bu LRRRLSEIGESVAVAASGS--------GGYSVHVHCDDAGGAVEAGLACG
MAB_3279c|M.abscessus_ATCC_199 LRAQLDAMGDSIAIAGDGE--------MGHSVHAHVNDAGAAIEAGMKFG
** * :*:*:.:* :***.* :***.*:***: *
Rv2974c|M.tuberculosis_H37Rv RVSRIVISALGSGTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGEGAC
Mb2999c|M.bovis_AF2122/97 RVSRIVISALGSGTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGEGAC
MMAR_1741|M.marinum_M RLSKIVISALSSGTTALAAG---GWTRQRAVLAVVDGDGAAELFAAEGAC
MAV_3819|M.avium_104 RLSRIVISALSSGGPGLPAG---GWTRERAVLAVVDGDGAAGLFSGEGAC
Mflv_4213|M.gilvum_PYR-GCK TLSRIQITSLHGGADRSSAG---SWGRERAVLAVVDGEGAEELFVGEGAA
Mvan_2154|M.vanbaalenii_PYR-1 SLSRIQITSLSGGGDRHPAG---GWSRQRAVLAVVDGDGAESLFTGEGAE
MSMEG_2402|M.smegmatis_MC2_155 TLNRIQITALTGSGGSRPSG---GWERERAVLAVVDGDGGAELFAGEGAH
TH_0233|M.thermoresistible__bu VPSRIQITALSGG-AAHPAA---GWSRERAALAVVDGDGAAELFATEGAH
MAB_3279c|M.abscessus_ATCC_199 TPQSIQISSLRGGLDVPGGGHHDGRHRHRRVLALAEGDGAATLFSSEGAQ
. * *::* .. .. . * * .**:.:*:*. ** ***
Rv2974c|M.tuberculosis_H37Rv VLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCT
Mb2999c|M.bovis_AF2122/97 VLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCT
MMAR_1741|M.marinum_M VLRPGAGAAAPASDLSAHQLVRAVVDTGAAQVMVLPNGYVAVEELVAGCT
MAV_3819|M.avium_104 VLQRDPAAADPVTTISAHQLMRAVVDTGAAQVMVLPNGYVAAEELVAGCT
Mflv_4213|M.gilvum_PYR-GCK VLRT-----EPGVEISAQQLLHALVKTGAAQVMVLPNGYVAAEEIVAGCA
Mvan_2154|M.vanbaalenii_PYR-1 ILRP-----QSDVPVSAQQLLHALVNTGAAQVMVLPNGYVAAEEIVAGCA
MSMEG_2402|M.smegmatis_MC2_155 VLRP-----EADEPVSAKQLLRALVDVGAAQVMVLPNGYVAAEELVAGCT
TH_0233|M.thermoresistible__bu VLRR-----DPDTPVTAQQLLRALVDTGAGQVMVLPNGYVAAEELVAGCT
MAB_3279c|M.abscessus_ATCC_199 VLRVD------EPPASAKRLLDAVVDSGAHQIMVLPNGLMAAEELVAVCA
:*: :*::*: *:*. ** ::****** :*.**:** *:
Rv2974c|M.tuberculosis_H37Rv AAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHG
Mb2999c|M.bovis_AF2122/97 AAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHG
MMAR_1741|M.marinum_M AAIGWGVDVVPVPTGSMVQGLAALAVHDPASQAVDDGYIMARAAGAARHG
MAV_3819|M.avium_104 AAIGWGIDVVPIPTESMVQGLAALAVHDTGRQAVDDGYTMARAAGAARHG
Mflv_4213|M.gilvum_PYR-GCK VAADWGIDLVPIPTGSMVQGLAALAVHDPGHRLVDDGYTMARAGAAARFG
Mvan_2154|M.vanbaalenii_PYR-1 VASDWGIDMVPVPTGSMVQGLAALAVHDPERRLVDDGYTMARAAAGARHG
MSMEG_2402|M.smegmatis_MC2_155 AAIGWGIDVVPVPAGSMVQGLAALAVHDAARQAVDDGYTMARAAAGARHG
TH_0233|M.thermoresistible__bu AAISWGIDVVPVPAASMVQGLAALAVHDPGRHAVDDGYTMAGAAADTRHG
MAB_3279c|M.abscessus_ATCC_199 AARGWGITVIPLPSASMAQGLAALAVHDPERMAVDDSYTMARAAGATRFG
.* .**: ::*:*: **.**********. ***.* ** *.. :*.*
Rv2974c|M.tuberculosis_H37Rv SVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAS
Mb2999c|M.bovis_AF2122/97 SVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAS
MMAR_1741|M.marinum_M SVRIATETALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLAP
MAV_3819|M.avium_104 SVRIATETALTWAGSCRPGDGLGIAGGEVLIVAADAVGAAIGLLDLLLAS
Mflv_4213|M.gilvum_PYR-GCK SVRIAAEDALTWAGACRPGDGLGITGDEVVVVGDDIVSAATGLIDLLLAA
Mvan_2154|M.vanbaalenii_PYR-1 TVRVAAEEALTWAGACKPGDGLGIAGDEVVIVGADVVAAGAGLIDLMLAA
MSMEG_2402|M.smegmatis_MC2_155 SVRVATEEALTWAGACKPGDGLGIAGDEVLIVGPDVTAAAAGLIDLLLAA
TH_0233|M.thermoresistible__bu SVRVATEQALTWAGPCGPGDGLGIAGGEVLIVGRDIASAAMGLIDLLLGG
MAB_3279c|M.abscessus_ATCC_199 LVRVATERALTWSGTCEPGDAMGIIGDEVLVLNHDIANATKALVSIMLSS
**:*:: ****:*.* ***.:** *.**::: * . * .*:.::*.
Rv2974c|M.tuberculosis_H37Rv GGDLVTVLIGAGVTED--------VAVVLERHVHDHHPGTELVSYRTGHR
Mb2999c|M.bovis_AF2122/97 GGDLVTVLIGAGVTED--------VAVVLERHVHDHHPGTELVSYRTGHR
MMAR_1741|M.marinum_M GGDLVTVLIGAGIDDDE---RIARLVESLERHMHDHHPGTELVIYRTGHR
MAV_3819|M.avium_104 GGDLVTVLLGAGLDADGSDAHAGAVVDILEEHMHDHHPGTELVTYRTGHH
Mflv_4213|M.gilvum_PYR-GCK GGELVTVLTGDGVESE--------VGAALAEHVHHNHLGAELVTFHTGHR
Mvan_2154|M.vanbaalenii_PYR-1 GGELVTVLTGDGVGPE--------IGEALAEHVHHHHPGTDLVTFHTGHR
MSMEG_2402|M.smegmatis_MC2_155 GGELITVLTGHGVDSA--------VGEALQAHVHDKHLGVELVTYHTGHR
TH_0233|M.thermoresistible__bu GGDLATVLVGEGVDPA--------VAERLRDHVHRNHPGTELSVYHTGHR
MAB_3279c|M.abscessus_ATCC_199 GGELVTVLLSDEVDDS--------LAESLIEHTRSHHGGVEVMIYRTGQH
**:* *** . : : * * : :* *.:: ::**::
Rv2974c|M.tuberculosis_H37Rv GDALLIGVE
Mb2999c|M.bovis_AF2122/97 GDALLIGVE
MMAR_1741|M.marinum_M GDALLIGVE
MAV_3819|M.avium_104 GDVLLIGVE
Mflv_4213|M.gilvum_PYR-GCK ADALLIGVE
Mvan_2154|M.vanbaalenii_PYR-1 VDALVIGVE
MSMEG_2402|M.smegmatis_MC2_155 GDALLIGVE
TH_0233|M.thermoresistible__bu GDALLIGVE
MAB_3279c|M.abscessus_ATCC_199 TDVVHIGVE
*.: ****