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SARRLDASTLRRWAHDAVAALISHTDEINRLNVFPVADADTGTNMLFTMRAAWAQADSDAADDVTAITAA LAAGALRGARGNSGVILSQILRALAEVTAEAAEERGGVLSEVTGEMLAAALRHAVTLVVASMGEAVPGTI VSVLHDAAAAAEDAVCGQADLAAVVVACTQAAAAALDRTPTQLDVLADAGVVDAGGRGLLVLLDALSAIL TGELTRRQVYLPDPKHAAGAAAPPSPTPGFEVMYLLSDCDAENVEQLRARLDALGDSVAIAASGFGEAGA GHYSVHVHADDAGAAVEAGLAVGTLSRIQITSLHGGADRSSAGSWGRERAVLAVVDGEGAEELFVGEGAA VLRTEPGVEISAQQLLHALVKTGAAQVMVLPNGYVAAEEIVAGCAVAADWGIDLVPIPTGSMVQGLAALA VHDPGHRLVDDGYTMARAGAAARFGSVRIAAEDALTWAGACRPGDGLGITGDEVVVVGDDIVSAATGLID LLLAAGGELVTVLTGDGVESEVGAALAEHVHHNHLGAELVTFHTGHRADALLIGVE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_4213 | - | - | 100% (547) | Dak phosphatase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2999c | - | 0.0 | 63.42% (555) | hypothetical protein Mb2999c |
M. tuberculosis H37Rv | Rv2974c | - | 1e-156 | 62.89% (477) | hypothetical protein Rv2974c |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3279c | - | 1e-143 | 51.78% (562) | putative phosphatase/kinase |
M. marinum M | MMAR_1741 | - | 1e-179 | 61.13% (566) | hypothetical protein MMAR_1741 |
M. avium 104 | MAV_3819 | - | 1e-177 | 61.79% (560) | DAK2 domain-containing protein |
M. smegmatis MC2 155 | MSMEG_2402 | - | 0.0 | 67.44% (559) | dihydroxyacetone kinase |
M. thermoresistible (build 8) | TH_0233 | - | 1e-135 | 65.89% (384) | CONSERVED HYPOTHETICAL ALANINE RICH PROTEIN |
M. ulcerans Agy99 | MUL_3169 | - | 8e-05 | 22.90% (393) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_2154 | - | 0.0 | 78.22% (551) | Dak phosphatase |
CLUSTAL 2.0.9 multiple sequence alignment Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 MNFSVLPPEINSLRLFSDAGSTSMLEAAAAWGSLADELQVAASSFSSVTA Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 GLASGAWQGPASAAMSAVAAPYASWLSAAAAQAAGTAGRASAAAAVFEAA Mb2999c|M.bovis_AF2122/97 ---------------------------------MG----TADRPLDASAL Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M ---------------------------------MG----TTERPLDALAL MAV_3819|M.avium_104 ------------------------MAAQRRWVTLGSSWTSHDRPLDAAAL Mflv_4213|M.gilvum_PYR-GCK ---------------------------------------MSARRLDASTL Mvan_2154|M.vanbaalenii_PYR-1 ---------------------------------------MSARRLDASAL MSMEG_2402|M.smegmatis_MC2_155 ---------------------------------------MSARRLDASAL TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 ---------------------------------------MRLSVLDSAAL MUL_3169|M.ulcerans_Agy99 QAAIVHPAMVAANRNELVALVISNLFGQNAPAIAATEAVYEQLWAQDVAV Mb2999c|M.bovis_AF2122/97 RDWAHAVVSDLILHIDEINRLNVFPVADSDTGVNML----FTMRAAVVEA Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M RDWAHTGVSDLITHLDEINRLNVFPVADSDTGANML----FTMRSALAQV MAV_3819|M.avium_104 RDWAHTAVSDLITHIDEINRLNVFPVADSDTGANML----FTMRSALAEL Mflv_4213|M.gilvum_PYR-GCK RRWAHDAVAALISHTDEINRLNVFPVADADTGTNML----FTMRAAWAQA Mvan_2154|M.vanbaalenii_PYR-1 RHWAHAAVADLISHTDEINQLNVFPVADADTGTNML----FTMRAAWAEA MSMEG_2402|M.smegmatis_MC2_155 RDWAHTAVGDLITHTDEINRLNVFPVADADTGTNML----FTMRSAWAHA TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 LDWARASVEGLISRSDEINRLNVFPVADADTGTNML----FTMRSAVNAA MUL_3169|M.ulcerans_Agy99 MAGYHAGVSAIAQQLAPWQQALALPAADADFSLSIFGLQLVKTGTANATT Mb2999c|M.bovis_AF2122/97 DLHANS------QADAEDVARVAAALAAGALNGARG-------------- Rv2974c|M.tuberculosis_H37Rv ------------------------------MNGARG-------------- MMAR_1741|M.marinum_M DSTGGAGPEHPEDPEHRDVAQVAAALAAGALNGARG-------------- MAV_3819|M.avium_104 QAAGGPG----------CVARAAAALSTGALNGARG-------------- Mflv_4213|M.gilvum_PYR-GCK DS-DAADD----------VTAITAALAAGALRGARG-------------- Mvan_2154|M.vanbaalenii_PYR-1 DSCDAGDD----------VTAVAAALAGGALHGARG-------------- MSMEG_2402|M.smegmatis_MC2_155 DA-QSGGD----------VAQVASALAAGALQGARG-------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 EALGEGAT----------VAQVAAALARGAVHGARG-------------- MUL_3169|M.ulcerans_Agy99 TFGGLAIASGANSSADAGVADIAFAFGSGSSASATGGVLNIAGVGGANSS Mb2999c|M.bovis_AF2122/97 ----------------NSGVILSQILRGIAEVTATAAAASGAVLRAVDA- Rv2974c|M.tuberculosis_H37Rv ----------------NSGVILSQILRGIAEVTATAAAASGAVLRAVDA- MMAR_1741|M.marinum_M ----------------NSGVILSQILRGVSDVTDSAAAG--QPLAAIDA- MAV_3819|M.avium_104 ----------------NSGVILSQILRGVADVTATAAARAGGQLAHIEA- Mflv_4213|M.gilvum_PYR-GCK ----------------NSGVILSQILRALAEVTAEAAEERGGVLSEVTG- Mvan_2154|M.vanbaalenii_PYR-1 ----------------NSGVILSQILRAVAEVTASAAEDRDGVLADITG- MSMEG_2402|M.smegmatis_MC2_155 ----------------NSGVILSQILLGLAEVITSAAADRGGDLLDVDG- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 ----------------NSGVILSQIVRGIADAAD--------DQDAIGA- MUL_3169|M.ulcerans_Agy99 ASATGGINIGTGALAVGDGNTVNASSIGVANIGTVAAAFGNNSVTAIANG Mb2999c|M.bovis_AF2122/97 ----NALGAALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--E Rv2974c|M.tuberculosis_H37Rv ----NALGAALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAH--E MMAR_1741|M.marinum_M ----ALLAAALWRGVELVITSMGGEEVPGTIVSVLRAAAVAVRQCADAGE MAV_3819|M.avium_104 ----AVLGAALQRGVELVIASMGGEEIPGTIVSVLRAAATAVAQCARAGE Mflv_4213|M.gilvum_PYR-GCK ----EMLAAALRHAVTLVVASMG-EAVPGTIVSVLHDAAAAAEDAVCGQA Mvan_2154|M.vanbaalenii_PYR-1 ----PLLSSALRHAVTLVVTSMG-EAVPGTIVSVLHDAAEAAEEAVSAEA MSMEG_2402|M.smegmatis_MC2_155 ----PLFGAALRHGVALVAVSMG-DPVPGTIVTVLQAAADAAEKCVVGGA TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 ----EVVRRALRQASQFVIASMS-TPVEGTIVSVLAAAADAADDAQS--D MUL_3169|M.ulcerans_Agy99 VENNATVAAAFGNNNTDVSAIVNGVENTGVVSAVFGSDNSGVSANAFGVE Mb2999c|M.bovis_AF2122/97 GLAGAVTAAGDAAVIALEKT------------------PEQLDVLADAGA Rv2974c|M.tuberculosis_H37Rv GLAGAVTAAGDAAVIALEKT------------------PEQLDVLADAGA MMAR_1741|M.marinum_M GLAAAVAAAGDAAVVALEKT------------------PEQLDVLADAGV MAV_3819|M.avium_104 GVTAAVIAAGDAAVIALEKT------------------PEQLDVLADAGA Mflv_4213|M.gilvum_PYR-GCK DLAAVVVACTQAAAAALDRT------------------PTQLDVLADAGV Mvan_2154|M.vanbaalenii_PYR-1 ELADVVAACAHAAGAALDRT------------------PTQLDVLADAGV MSMEG_2402|M.smegmatis_MC2_155 DLAEVAASAADAAATALERT------------------PQQLDVLAEAGV TH_0233|M.thermoresistible__bu ----VVSTAAEAAVVALEKT------------------PEQLDVLARAGV MAB_3279c|M.abscessus_ATCC_199 DLPVLVTTAADAAVSALEKT------------------PKQLDVLADNGV MUL_3169|M.ulcerans_Agy99 NNAIVATAAGSGNSNVMANAGGVGANEILVAAALGNNNSAIANATGVGGT . :. . .: .: . :. . *. Mb2999c|M.bovis_AF2122/97 VDAGGRGLLVLLDALRSTICGQAPA---------------RAVYEPSPRA Rv2974c|M.tuberculosis_H37Rv VDAGGRGLLVLLDALRSTICGQAPA---------------RAVYEPSPRA MMAR_1741|M.marinum_M VDAGGRGLLVLLDALRSTITGAAPA---------------RSVYEPAPRS MAV_3819|M.avium_104 VDAGGRGLLVLLDALRTTITGQAPA---------------RTVYRLAPRT Mflv_4213|M.gilvum_PYR-GCK VDAGGRGLLVLLDALSAILTGELTR---------------RQVYLPDPKH Mvan_2154|M.vanbaalenii_PYR-1 VDAGGRGLVVLLDALCATLTGHAPR---------------RGVYQPSPNK MSMEG_2402|M.smegmatis_MC2_155 VDSGGRGLLVLLDAMTATITGHAPR---------------RPAYTPAPPR TH_0233|M.thermoresistible__bu VDAGGRGFVALLDALTLTLTGQLPY---------------RPEYRPAPPE MAB_3279c|M.abscessus_ATCC_199 VDAGARGLVVILDALVSVVAGELPS---------------RREYSPSPPK MUL_3169|M.ulcerans_Agy99 LGTGAISLIGNNNTLYADATGAGHIGTVASALFGDNNGVKATSFGLNNIA :.:*. .:: ::: * : Mb2999c|M.bovis_AF2122/97 LPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQLRDR Rv2974c|M.tuberculosis_H37Rv LPTDTAT----------------QRPAPQFEVMYLLAVCDAAAADQLRDR MMAR_1741|M.marinum_M PALGVGV----------------PAPIPQFEVMYLLAGCDAAAADTLRDR MAV_3819|M.avium_104 AAPEAAA----------------PRPAPQFEVMYRLDDCAPAAADALRDR Mflv_4213|M.gilvum_PYR-GCK AAGAAAP----------------PSPTPGFEVMYLLSDCDAENVEQLRAR Mvan_2154|M.vanbaalenii_PYR-1 SSAPSSA----------------AHATPSFEVMYLLADCHAEDIEKLRAA MSMEG_2402|M.smegmatis_MC2_155 ATASSSVSARAGVPADDV----APTQVPQFEVMYLLSGCAPEAVEHLRAG TH_0233|M.thermoresistible__bu PAVTTPA----------------APAPPQFEVMYLLSGCDARGVERLRRR MAB_3279c|M.abscessus_ATCC_199 NAPSQVWVAGPGRGGGGLNLDPPRELPPEFEVMYLLCGCDELQIADLRAQ MUL_3169|M.ulcerans_Agy99 TVATAGGSGNTTVAAEASGAENVAVLATAFGNNNPTVTANVLGAGNLATA . * . * Mb2999c|M.bovis_AF2122/97 LKELGESVAIAA----------------------------APP------- Rv2974c|M.tuberculosis_H37Rv LKELGESVAIAA----------------------------APP------- MMAR_1741|M.marinum_M LSELGDSVAIAA----------------------------APS------- MAV_3819|M.avium_104 LTELGDSVGIAS----------------------------APSSAQ---- Mflv_4213|M.gilvum_PYR-GCK LDALGDSVAIAA----------------------------SGFGEAG--- Mvan_2154|M.vanbaalenii_PYR-1 LEELGDSIAIAA----------------------------SGFGEAGGAG MSMEG_2402|M.smegmatis_MC2_155 LEQIGESVAIAT----------------------------SGG------- TH_0233|M.thermoresistible__bu LSEIGESVAVAA----------------------------SGS------- MAB_3279c|M.abscessus_ATCC_199 LDAMGDSIAIAG----------------------------DGE------- MUL_3169|M.ulcerans_Agy99 ATALGNNNTINANVVGLENIATVATAGGNDNGVGASGVGVGGNIGNIATA :*:. : Mb2999c|M.bovis_AF2122/97 -DSYSVHVHTDDAGA----------------------------------- Rv2974c|M.tuberculosis_H37Rv -DSYSVHVHTDDAGA----------------------------------- MMAR_1741|M.marinum_M -ESYSVHVHTDDAGA----------------------------------- MAV_3819|M.avium_104 -HTYSVHVHTDDAGA----------------------------------- Mflv_4213|M.gilvum_PYR-GCK AGHYSVHVHADDAGA----------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 PGHYSVHVHADDAGA----------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -DRYSVHVHVDDAGA----------------------------------- TH_0233|M.thermoresistible__bu -GGYSVHVHCDDAGG----------------------------------- MAB_3279c|M.abscessus_ATCC_199 -MGHSVHAHVNDAGA----------------------------------- MUL_3169|M.ulcerans_Agy99 FGNSNSQVSADASGAGGNLGTVATAFGNENNVTASAFGAGNIGNVSSALF . :. : :*. Mb2999c|M.bovis_AF2122/97 -----------------------------AVEAGLAVGRVSRIVISALGS Rv2974c|M.tuberculosis_H37Rv -----------------------------AVEAGLAVGRVSRIVISALGS MMAR_1741|M.marinum_M -----------------------------AVEAGLAAGRLSKIVISALSS MAV_3819|M.avium_104 -----------------------------AVEAGLAAGRLSRIVISALSS Mflv_4213|M.gilvum_PYR-GCK -----------------------------AVEAGLAVGTLSRIQITSLHG Mvan_2154|M.vanbaalenii_PYR-1 -----------------------------AVEAGLAVGSLSRIQITSLSG MSMEG_2402|M.smegmatis_MC2_155 -----------------------------AVEAGLAVGTLNRIQITALTG TH_0233|M.thermoresistible__bu -----------------------------AVEAGLACGVPSRIQITALSG MAB_3279c|M.abscessus_ATCC_199 -----------------------------AIEAGMKFGTPQSIQISSLRG MUL_3169|M.ulcerans_Agy99 SNNNTISASSIGVENIGTVATSIGDNNTVSATNGLGLGGNIATVATALGG : *: * ::* . Mb2999c|M.bovis_AF2122/97 GTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGE--------------- Rv2974c|M.tuberculosis_H37Rv GTSGLPAG---GWTRGRAVLAVVDGDGAAELFAGE--------------- MMAR_1741|M.marinum_M GTTALAAG---GWTRQRAVLAVVDGDGAAELFAAE--------------- MAV_3819|M.avium_104 GGPGLPAG---GWTRERAVLAVVDGDGAAGLFSGE--------------- Mflv_4213|M.gilvum_PYR-GCK GADRSSAG---SWGRERAVLAVVDGEGAEELFVGE--------------- Mvan_2154|M.vanbaalenii_PYR-1 GGDRHPAG---GWSRQRAVLAVVDGDGAESLFTGE--------------- MSMEG_2402|M.smegmatis_MC2_155 SGGSRPSG---GWERERAVLAVVDGDGGAELFAGE--------------- TH_0233|M.thermoresistible__bu -GAAHPAA---GWSRERAALAVVDGDGAAELFATE--------------- MAB_3279c|M.abscessus_ATCC_199 GLDVPGGGHHDGRHRHRRVLALAEGDGAATLFSSE--------------- MUL_3169|M.ulcerans_Agy99 QNNTVSAETGTGGANIASVSTVLFGENNTASASAVGAGNIANVATVSFCD . . . . :: *:. Mb2999c|M.bovis_AF2122/97 -----------------------------------GACVLRPGPDAVTPA Rv2974c|M.tuberculosis_H37Rv -----------------------------------GACVLRPGPDAVTPA MMAR_1741|M.marinum_M -----------------------------------GACVLRPGAGAAAPA MAV_3819|M.avium_104 -----------------------------------GACVLQRDPAAADPV Mflv_4213|M.gilvum_PYR-GCK -----------------------------------GAAVLRT-----EPG Mvan_2154|M.vanbaalenii_PYR-1 -----------------------------------GAEILRP-----QSD MSMEG_2402|M.smegmatis_MC2_155 -----------------------------------GAHVLRP-----EAD TH_0233|M.thermoresistible__bu -----------------------------------GAHVLRR-----DPD MAB_3279c|M.abscessus_ATCC_199 -----------------------------------GAQVLRVD------E MUL_3169|M.ulcerans_Agy99 NNTSNASSFGVENIAAVATSYGDGNTVTATNSLGLGGNIATVATALGGQD *. : Mb2999c|M.bovis_AF2122/97 ADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAG-------------- Rv2974c|M.tuberculosis_H37Rv ADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAG-------------- MMAR_1741|M.marinum_M SDLSAHQLVRAVVDTGAAQVMVLPNGYVAVEELVAG-------------- MAV_3819|M.avium_104 TTISAHQLMRAVVDTGAAQVMVLPNGYVAAEELVAG-------------- Mflv_4213|M.gilvum_PYR-GCK VEISAQQLLHALVKTGAAQVMVLPNGYVAAEEIVAG-------------- Mvan_2154|M.vanbaalenii_PYR-1 VPVSAQQLLHALVNTGAAQVMVLPNGYVAAEEIVAG-------------- MSMEG_2402|M.smegmatis_MC2_155 EPVSAKQLLRALVDVGAAQVMVLPNGYVAAEELVAG-------------- TH_0233|M.thermoresistible__bu TPVTAQQLLRALVDTGAGQVMVLPNGYVAAEELVAG-------------- MAB_3279c|M.abscessus_ATCC_199 PPASAKRLLDAVVDSGAHQIMVLPNGLMAAEELVAV-------------- MUL_3169|M.ulcerans_Agy99 NTVSAQAGAGGANIAQVATVLFGDNNTASASGLGAGNIADVATVLFSNNN :*: . . ::. *. :.. : * Mb2999c|M.bovis_AF2122/97 -------------------------CTAAIGWGVDVVPVPTGSMVQG--- Rv2974c|M.tuberculosis_H37Rv -------------------------CTAAIGWGVDVVPVPTGSMVQG--- MMAR_1741|M.marinum_M -------------------------CTAAIGWGVDVVPVPTGSMVQG--- MAV_3819|M.avium_104 -------------------------CTAAIGWGIDVVPIPTESMVQG--- Mflv_4213|M.gilvum_PYR-GCK -------------------------CAVAADWGIDLVPIPTGSMVQG--- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------CAVASDWGIDMVPVPTGSMVQG--- MSMEG_2402|M.smegmatis_MC2_155 -------------------------CTAAIGWGIDVVPVPAGSMVQG--- TH_0233|M.thermoresistible__bu -------------------------CTAAISWGIDVVPVPAASMVQG--- MAB_3279c|M.abscessus_ATCC_199 -------------------------CAAARGWGITVIPLPSASMAQG--- MUL_3169|M.ulcerans_Agy99 TSTASALGVENIATIVTSYGDNNNVSATAPGIGANIATVATALGGQGNTV .:.* . * : .:.: ** Mb2999c|M.bovis_AF2122/97 -------------------------------------LAALAVHDAARQA Rv2974c|M.tuberculosis_H37Rv -------------------------------------LAALAVHDAARQA MMAR_1741|M.marinum_M -------------------------------------LAALAVHDPASQA MAV_3819|M.avium_104 -------------------------------------LAALAVHDTGRQA Mflv_4213|M.gilvum_PYR-GCK -------------------------------------LAALAVHDPGHRL Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------LAALAVHDPERRL MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------LAALAVHDAARQA TH_0233|M.thermoresistible__bu -------------------------------------LAALAVHDPGRHA MAB_3279c|M.abscessus_ATCC_199 -------------------------------------LAALAVHDPERMA MUL_3169|M.ulcerans_Agy99 SAESGGAGANIASVSTVLFGENNTASASAVGAGNIANVATVLFSDSNTST :*:: . *. Mb2999c|M.bovis_AF2122/97 VDDGYSMARAAGASRHGSVRIATQKALTWAG------------------T Rv2974c|M.tuberculosis_H37Rv VDDGYSMARAAGASRHGSVRIATQKALTWAG------------------T MMAR_1741|M.marinum_M VDDGYIMARAAGAARHGSVRIATETALTWAG------------------T MAV_3819|M.avium_104 VDDGYTMARAAGAARHGSVRIATETALTWAG------------------S Mflv_4213|M.gilvum_PYR-GCK VDDGYTMARAGAAARFGSVRIAAEDALTWAG------------------A Mvan_2154|M.vanbaalenii_PYR-1 VDDGYTMARAAAGARHGTVRVAAEEALTWAG------------------A MSMEG_2402|M.smegmatis_MC2_155 VDDGYTMARAAAGARHGSVRVATEEALTWAG------------------A TH_0233|M.thermoresistible__bu VDDGYTMAGAAADTRHGSVRVATEQALTWAG------------------P MAB_3279c|M.abscessus_ATCC_199 VDDSYTMARAAGATRFGLVRVATERALTWSG------------------T MUL_3169|M.ulcerans_Agy99 VSSFGVENIATVATSYGDFNNVSARTPGIGGNIATFATAFGEGNTNVHAE *.. * : .* .. .: : .* Mb2999c|M.bovis_AF2122/97 CKPGDG---------------------------------------LGIAG Rv2974c|M.tuberculosis_H37Rv CKPGDG---------------------------------------LGIAG MMAR_1741|M.marinum_M CKPGDG---------------------------------------LGIAG MAV_3819|M.avium_104 CRPGDG---------------------------------------LGIAG Mflv_4213|M.gilvum_PYR-GCK CRPGDG---------------------------------------LGITG Mvan_2154|M.vanbaalenii_PYR-1 CKPGDG---------------------------------------LGIAG MSMEG_2402|M.smegmatis_MC2_155 CKPGDG---------------------------------------LGIAG TH_0233|M.thermoresistible__bu CGPGDG---------------------------------------LGIAG MAB_3279c|M.abscessus_ATCC_199 CEPGDA---------------------------------------MGIIG MUL_3169|M.ulcerans_Agy99 AGPGGANIATLATVFGDGNAVSVKSIGAGNTASIATMIGNNNTADINVFG . **.. :.: * Mb2999c|M.bovis_AF2122/97 DEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTED---------- Rv2974c|M.tuberculosis_H37Rv DEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTED---------- MMAR_1741|M.marinum_M DEVLIVADDVAAAAIGLVDLLLAPGGDLVTVLIGAGIDDDE---RIA--- MAV_3819|M.avium_104 GEVLIVAADAVGAAIGLLDLLLASGGDLVTVLLGAGLDADGSDAHAG--- Mflv_4213|M.gilvum_PYR-GCK DEVVVVGDDIVSAATGLIDLLLAAGGELVTVLTGDGVESE---------- Mvan_2154|M.vanbaalenii_PYR-1 DEVVIVGADVVAAGAGLIDLMLAAGGELVTVLTGDGVGPE---------- MSMEG_2402|M.smegmatis_MC2_155 DEVLIVGPDVTAAAAGLIDLLLAAGGELITVLTGHGVDSA---------- TH_0233|M.thermoresistible__bu GEVLIVGRDIASAAMGLIDLLLGGGGDLATVLVGEGVDPA---------- MAB_3279c|M.abscessus_ATCC_199 DEVLVLNHDIANATKALVSIMLSSGGELVTVLLSDEVDDS---------- MUL_3169|M.ulcerans_Agy99 LENVATVATAIGDNNGLTANAPGLGANIATVATAIGSGNSQVSAEAGGAG * : .* . *.:: ** . Mb2999c|M.bovis_AF2122/97 ------------VAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE--- Rv2974c|M.tuberculosis_H37Rv ------------VAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE--- MMAR_1741|M.marinum_M -----------RLVESLERHMHDHHPGTELVIYRTGHRGDALLIGVE--- MAV_3819|M.avium_104 -----------AVVDILEEHMHDHHPGTELVTYRTGHHGDVLLIGVE--- Mflv_4213|M.gilvum_PYR-GCK ------------VGAALAEHVHHNHLGAELVTFHTGHRADALLIGVE--- Mvan_2154|M.vanbaalenii_PYR-1 ------------IGEALAEHVHHHHPGTDLVTFHTGHRVDALVIGVE--- MSMEG_2402|M.smegmatis_MC2_155 ------------VGEALQAHVHDKHLGVELVTYHTGHRGDALLIGVE--- TH_0233|M.thermoresistible__bu ------------VAERLRDHVHRNHPGTELSVYHTGHRGDALLIGVE--- MAB_3279c|M.abscessus_ATCC_199 ------------LAESLIEHTRSHHGGVEVMIYRTGQHTDVVHIGVE--- MUL_3169|M.ulcerans_Agy99 GNIATLSSVFGDNNTAVVTAFGASNVPTAATVFGSGNGVKVSTFGLENIA : : . : :*: .. :*:* Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 TLGTVIGDNNTGVVADAGGVGGNIATLANVFGNDNTAAEATASGVGGNIA Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 TLANVFGDGNAVKANVVGFGNVPSAATVIGSNNTVTTDVFGVENIATLAS Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 VYGDGNSGVLAQSGGVGGNIATLATVIGSNNTATEASAVGIGGNTATLGT Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 ALSDGNAVSATANGFGNTATVATAFIGGGNTATASASGVGNIASLATAVG Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 ADNAVSATASGAGGNIAIAATAIGDGNTEVTADAGGLGGNIGVAATAIGG Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 GNTVAASSTGLTIGSVATAVGDGNTGIAARGHQAGNLGIVSTAIGFGNTD Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 VAAAGFGVANIGNVATVIGSNNQNVFAGGTGLSNIATVGGDNNTALAGDQ Mb2999c|M.bovis_AF2122/97 -------------------------------------------------- Rv2974c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1741|M.marinum_M -------------------------------------------------- MAV_3819|M.avium_104 -------------------------------------------------- Mflv_4213|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_2154|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_2402|M.smegmatis_MC2_155 -------------------------------------------------- TH_0233|M.thermoresistible__bu -------------------------------------------------- MAB_3279c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_3169|M.ulcerans_Agy99 SGGLASVNVATVFGSGSGASAFNGFLNLAIGLTDGVMASAGPGNFNVSIH Mb2999c|M.bovis_AF2122/97 ---------- Rv2974c|M.tuberculosis_H37Rv ---------- MMAR_1741|M.marinum_M ---------- MAV_3819|M.avium_104 ---------- Mflv_4213|M.gilvum_PYR-GCK ---------- Mvan_2154|M.vanbaalenii_PYR-1 ---------- MSMEG_2402|M.smegmatis_MC2_155 ---------- TH_0233|M.thermoresistible__bu ---------- MAB_3279c|M.abscessus_ATCC_199 ---------- MUL_3169|M.ulcerans_Agy99 PFFDVQPLFG