For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. tuberculosis H37Rv Rv3810 (pirG)

annotation: EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53)
coordinates: 4273739 - 4274593
length: 284

VPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTETTERPEHHEFKQAAVLTDLPGELMSALSQGLSQFG
INIPPVPSLTGSGDASTGLTGPGLTSPGLTSPGLTSPGLTDPALTSPGLTPTLPGSLAAPGTTLAPTPGV
GANPALTNPALTSPTGATPGLTSPTGLDPALGGANEIPITTPVGLDPGADGTYPILGDPTLGTIPSSPAT
TSTGGGGLVNDVMQVANELGASQAIDLLKGVLMPSIMQAVQNGGAAAPAASPPVPPIPAAAAVPPTDPIT
VPVA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3810pirG-100% (284)EXPORTED REPETITIVE PROTEIN PRECURSOR PIRG (CELL SURFACE PROTEIN) (EXP53)
M. tuberculosis H37RvRv1753cPPE242e-0929.54% (237) PPE family protein
M. tuberculosis H37RvRv1158c-2e-0931.38% (188) hypothetical protein Rv1158c

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3840pirG1e-162100.00% (284) exported repetitive protein precursor PirG (cell surface
M. gilvum PYR-GCKMflv_1158-7e-7051.25% (320) repeat of unknown function XGLTT
M. leprae Br4923MLBr_00091-2e-6652.14% (280) 28 KDa antigen precursor
M. abscessus ATCC 19977MAB_0169c-4e-4745.21% (292) putative exported repetitive protein precursor
M. marinum MMMAR_5374erp1e-11374.91% (275) exported repetitive protein precursor Erp
M. avium 104MAV_0207-8e-8957.50% (320) Erp protein
M. smegmatis MC2 155MSMEG_6405-9e-8056.09% (312) Erp protein
M. thermoresistible (build 8)TH_2084-5e-7153.16% (316) Erp protein
M. ulcerans Agy99MUL_4994erp1e-11875.17% (286) exported repetitive protein precursor Erp
M. vanbaalenii PYR-1Mvan_5651-3e-6952.68% (317) exported repetitive protein precursor PirG (cell surface

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1158|M.gilvum_PYR-GCK          MPNRRRRRLSTALSTVAALAVASPIAVIAVSELSASTLAGRDGAPQHREF
Mvan_5651|M.vanbaalenii_PYR-1       MPNRRRRRLSTALSTVAALAVASPVAVVAITELSAE--PGRDGAPQHREF
MSMEG_6405|M.smegmatis_MC2_155      MPNRRRRKLSTAMSAVAAVAVASPVALIAATQHS--------PAPQHREF
TH_2084|M.thermoresistible__bu      ------------MSTVAALAVASPFAAIAVTELVSS----TQPAPQQREF
Rv3810|M.tuberculosis_H37Rv         MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTET----TERPE-HHEF
Mb3840|M.bovis_AF2122/97            MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTET----TERPE-HHEF
MMAR_5374|M.marinum_M               ------------MSAVAALAVASPCAYFLVYESTTE----TKPTE-HHEF
MUL_4994|M.ulcerans_Agy99           MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTTE----TKPTE-HHEF
MLBr_00091|M.leprae_Br4923          MPNRRRCKLSTAISTVATLAIASPCAYFLVYEPTAS----AKPAAKHYEF
MAV_0207|M.avium_104                MPNRRRRKLSTAMSAVAALAVASPCAYFLVYESTAG----NKAPE-HHEF
MAB_0169c|M.abscessus_ATCC_199      MPNRRRRRLSTALSSVAALAVASPFAIALATNMTQA----AAPAPSQQEF
                                                :*:**::*:*** *     :           .  : **

Mflv_1158|M.gilvum_PYR-GCK          VQAATITDLPGELMTALSQGLAQFGINLPPLPTGLLTGT-----------
Mvan_5651|M.vanbaalenii_PYR-1       VQAATITDLPGELFNALSQGLSQFGINLPPMPTGLLTGS-----------
MSMEG_6405|M.smegmatis_MC2_155      TQAALVTDLPGELMSALSQGLSQFGINLPPMPS--LTGG--AAT------
TH_2084|M.thermoresistible__bu      VQASLLTDLPTELMGALSEGLAQFGINLPPMPS--LTGSGASMS------
Rv3810|M.tuberculosis_H37Rv         KQAAVLTDLPGELMSALSQGLSQFGINIPPVPS--LTG------------
Mb3840|M.bovis_AF2122/97            KQAAVLTDLPGELMSALSQGLSQFGINIPPVPS--LTG------------
MMAR_5374|M.marinum_M               VRAASVADLPTELMTALSQGLSSFGINLPPVPS--LTGGTGTGM------
MUL_4994|M.ulcerans_Agy99           VRAASVADLPTELMTALSQGLSSFGINLPPVPS--LTGGTGTGM------
MLBr_00091|M.leprae_Br4923          KQAASIADLPGEVLDAISQGLSQFGINLPPVPS--LTG------------
MAV_0207|M.avium_104                KQAAVMSDLPGELMGALSQGLSQFGINLPPVPA--LSGGATSTPGLASPG
MAB_0169c|M.abscessus_ATCC_199      VQAAIVSDLPGEVMGAVQQMTSQFGVQIPGLSGLNIPGLG----------
                                     :*: ::*** *:: *:.:  :.**:::* :.   :.*            

Mflv_1158|M.gilvum_PYR-GCK          ----GAAAPTTLSPGLGTAGLTSPGLMPGL--SAAPSLTDPS--LAN---
Mvan_5651|M.vanbaalenii_PYR-1       ----GATSPTTLSPGLGFPSLASPGLTTPG--LTAPTLTDPG--LANPAL
MSMEG_6405|M.smegmatis_MC2_155      ---PSLASPTLTSPGLASPGLTSPGLT-PG--LT-PGLTTPS--LTDPGL
TH_2084|M.thermoresistible__bu      ---PGLTSPGLTSPGLTSPGLTSPGLTSPG--LTSPGLTSPG--LTNPGL
Rv3810|M.tuberculosis_H37Rv         -------------SGDASTGLTGPGLTSPG--LTSPGLTSPG--LTDPAL
Mb3840|M.bovis_AF2122/97            -------------SGDASTGLTGPGLTSPG--LTSPGLTSPG--LTDPAL
MMAR_5374|M.marinum_M               ------------SPGLTSPGLTSPGLTSPG--LTSPGLTTPG--LTSPGL
MUL_4994|M.ulcerans_Agy99           ------------SPGLTSPGLTSPGLTSPG--LTSPGLTSPG--LTSPGL
MLBr_00091|M.leprae_Br4923          -------------TDDPGNGLRTPGLTSPD--LTNQELGTPV--LTAPG-
MAV_0207|M.avium_104                LGSPGLGSPGLGTPGLGTPGLTNPGLTSPG--ATSPGLTSPG--LTSPGL
MAB_0169c|M.abscessus_ATCC_199      ------------GGGLGSLGGANPALTSPGGLTTPGGLTSPSSSLTNPAL
                                                  .    .   *.*       :   *  *   *:    

Mflv_1158|M.gilvum_PYR-GCK          --PALTSPIGATP-GLTTPGLTTPGLTTPGLTDPALA----SPGLTTPAL
Mvan_5651|M.vanbaalenii_PYR-1       TNPALTSPTGAAP-GLTTPGLTTPGLTTPGLTDPALA----SPGLTTPSL
MSMEG_6405|M.smegmatis_MC2_155      TNPALTNPALTSPDGLTSPGLTTPSLTSPGLTTPDAS-LGATPSLTDPGL
TH_2084|M.thermoresistible__bu      TSPGLTDPALTTP-GLTTPGLTTPGLTTPGLTTPGLDPAQTTPGLTTPGV
Rv3810|M.tuberculosis_H37Rv         TSPGLTPT-------------LPGSLAAPGTTLAPTPGVGANPALTNPAL
Mb3840|M.bovis_AF2122/97            TSPGLTPT-------------LPGSLAAPGTTLAPTPGVGANPALTNPAL
MMAR_5374|M.marinum_M               TTPGLTPG-------------MPGDLALPGTTLPPTPGAAVNPALTNPAL
MUL_4994|M.ulcerans_Agy99           TTPGLTPG-------------MPGDLALPGTTLPPTPGAAVNPALTNPAL
MLBr_00091|M.leprae_Br4923          --TGLTPP-------------VTG-----------------SPICTAPDL
MAV_0207|M.avium_104                TSPGLTSPGAAPT---TPGLTAPGALPTTPGGGVATPGAGLNPALSNPGL
MAB_0169c|M.abscessus_ATCC_199      TNPGLTSPSGSTT-----PSLTDPALTNPGLTNPAAP--ASTPGLTPAAG
                                      ..**                                   .*  : .  

Mflv_1158|M.gilvum_PYR-GCK          TDPGLTTPGLTTPGLTTP--GLTTP--GLTTPAALTDPALGLPATGEIPI
Mvan_5651|M.vanbaalenii_PYR-1       TDPALASPGLTTPGLSTPP-ALTDP--ALG-ALPISTSGLG---TGEVPI
MSMEG_6405|M.smegmatis_MC2_155      TNPALTTPSLTTPGLATPSTGLTTP--GLDPSLTPISNAAGLPAPGEVPI
TH_2084|M.thermoresistible__bu      STPDLTNPALTSP-LGEAPGGLTTPSVGLDPALTPISNTAGLPAPGEVPI
Rv3810|M.tuberculosis_H37Rv         TSPTGATPGLTSPTGLDPA----------------------LGGANEIPI
Mb3840|M.bovis_AF2122/97            TSPTGATPGLTSPTGLDPA----------------------LGGANEIPI
MMAR_5374|M.marinum_M               TSPTGLAPGLTSPTGLDPS----------------------LGGTNEIPI
MUL_4994|M.ulcerans_Agy99           TSPTGLAPGLTSPTGLDPS----------------------LGGTNEIPI
MLBr_00091|M.leprae_Br4923          N------LGGTCPS--------------------------------EVPI
MAV_0207|M.avium_104                TSPAGTAPGLGSPT----------------------------VAPSEVPI
MAB_0169c|M.abscessus_ATCC_199      TGATGVNPALTDPAAGLTS------------------------PGGEVPI
                                    .       .   *                                 *:**

Mflv_1158|M.gilvum_PYR-GCK          SAPIGLDP-ALGSYPILGDP-SLAATQP----------VATSSGG--LLG
Mvan_5651|M.vanbaalenii_PYR-1       SAPIGLDP-ALGSYPVLGDP-SLAATQP----------VASSSGG--LLG
MSMEG_6405|M.smegmatis_MC2_155      SAPVGLDP-SLGTYPILGDP-SLATMP------------AASTGGGGLFG
TH_2084|M.thermoresistible__bu      TAPLGPDP-TLGTYPILGDP-SLAMAPP----------VATSTGGGGLIS
Rv3810|M.tuberculosis_H37Rv         TTPVGLDPGADGTYPILGDP-TLGTIP--SSPAT------TSTGGGGLVN
Mb3840|M.bovis_AF2122/97            TTPVGLDPGADGTYPILGDP-TLGTIP--SSPAT------TSTGGGGLVN
MMAR_5374|M.marinum_M               TTPVGLDPGMDGTYPILGDP-SLGYGP--GTSSLGGSGLGSSTGGGGILN
MUL_4994|M.ulcerans_Agy99           TTPVGLDPGMDGTYPILGDP-SLGYGP--GTSSLGGSGLGSSTGGG-ILN
MLBr_00091|M.leprae_Br4923          TTPISLDPGTDGTYPILGDPSTLG-----GTSPI-------STSSGELVN
MAV_0207|M.avium_104                DSGAGLDPGAGGTYPILGDPSTFGNASPIGGGGTGLGGGSSSGGSGGLVN
MAB_0169c|M.abscessus_ATCC_199      TPNPALGT--GLTNPALADP-SLAGLG----TPTGLGGGSGLGGGSSLIS
                                     .  . ..    : * *.** ::.                   ..  :..

Mflv_1158|M.gilvum_PYR-GCK          DLTSAANSLGAGEAIDLLKGVLMPAIMSAVKPPVPPVPAAPLATAAGEV-
Mvan_5651|M.vanbaalenii_PYR-1       DLSSAANSLGAGEAIDLLKGVLMPAIMSAVKPPAP-LPAAPVAQAAGTVP
MSMEG_6405|M.smegmatis_MC2_155      DLSAAADQLGAGQAIDLLKGMVLPAITQAIQSGAQ-AAPAAAPAP---VP
TH_2084|M.thermoresistible__bu      ELSTAANQLGAGQAIDLLKGVVMPAVTSAIKSAAQPPGPDVAPPPAPEVP
Rv3810|M.tuberculosis_H37Rv         DVMQVANELGASQAIDLLKGVLMPSIMQAVQNGGAAAPAASPPVPPIPAA
Mb3840|M.bovis_AF2122/97            DVMQVANELGASQAIDLLKGVLMPSIMQAVQNGGAAAPAASPPVPPIPAA
MMAR_5374|M.marinum_M               DVMQAANQLGAGQAIDLLKGVLMPSIMQAVQNGGAAAPAAAAAVPELPAA
MUL_4994|M.ulcerans_Agy99           DVMQAANQLGAGQAIDLLKGVLVSSIMQAVQNGGAAAPAAAAAVPELPAA
MLBr_00091|M.leprae_Br4923          DLLKVANQLGASQVMDLIKGVVMPAVMQGVQNGNVAGDLSGSVTP--AAI
MAV_0207|M.avium_104                DVMQAANQLGAGQAIDLLKGLVMPAITQGMHGGAAAGALPGAAGALPGAA
MAB_0169c|M.abscessus_ATCC_199      DAMGAVNQLGITQAVDLIKGAIPAAASAAAPPPAS---------------
                                    :   ..:.**  :.:**:** : .:   .                     

Mflv_1158|M.gilvum_PYR-GCK          APVEAG------------LGAAEASFETGAEPGA------
Mvan_5651|M.vanbaalenii_PYR-1       AEAEAA------------LGAAEAAIEPGA----------
MSMEG_6405|M.smegmatis_MC2_155      PPA-------------------------------------
TH_2084|M.thermoresistible__bu      APDA------------------------------------
Rv3810|M.tuberculosis_H37Rv         AAVP--------------PTDP--ITVPVA----------
Mb3840|M.bovis_AF2122/97            AAVP--------------PTDP--ITVPVA----------
MMAR_5374|M.marinum_M               AAAP--------------AAAAPAAVAPAAAAAAAAVPPI
MUL_4994|M.ulcerans_Agy99           AAAP--------------AAAAPAAVAPAAAAAAAAVPPI
MLBr_00091|M.leprae_Br4923          SLIP--------------VT--------------------
MAV_0207|M.avium_104                GALPGAAGALPGAAGALPAAAGAAGALPAAAGAAPALPPV
MAB_0169c|M.abscessus_ATCC_199      ----------------------------------------