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M. tuberculosis H37Rv Rv3585 (radA)

annotation: DNA repair protein RadA
coordinates: 4026444 - 4027886
length: 480

VANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGGTRRRSVAPASGAVPISAVDAHRTRPC
PTGIDELDRVLGGGIVPGSVTLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGC
GTEVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQTMSTSEADGVTGGVTQVRAVTAALTAAAKANEVA
LILVGHVTKDGAIAGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGIVDPS
NLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPRRAVSGIHQARAAMIAAVLEKHARLAIA
VNDIYLSTVGGMRLTEPSADLAVAIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGF
TIALVPPSDDPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHSGTGHVPLGRGT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv3585radA-100% (480)DNA repair protein RadA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3616radA0.0100.00% (480) DNA repair protein RadA
M. gilvum PYR-GCKMflv_1442-0.072.59% (456) DNA repair protein RadA
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0564c-1e-17366.45% (453) DNA repair protein RadA
M. marinum MMMAR_5085radA0.079.05% (482) DNA repair protein RadA
M. avium 104MAV_0568radA0.081.66% (447) DNA repair protein RadA
M. smegmatis MC2 155MSMEG_6079radA1e-17870.74% (458) DNA repair protein RadA
M. thermoresistible (build 8)TH_0587radA1e-16375.32% (389) DNA REPAIR PROTEIN RADA (DNA REPAIR PROTEIN SMS)
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_5342-0.071.49% (456) DNA repair protein RadA

CLUSTAL 2.0.9 multiple sequence alignment


Rv3585|M.tuberculosis_H37Rv         ----MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGG--
Mb3616|M.bovis_AF2122/97            ----MANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGG--
MMAR_5085|M.marinum_M               ----MANARLQYRCADCRYLTAKWVGRCPECSSWGTVEEVSVLSAVGGGS
MAV_0568|M.avium_104                -------------------MTAKWVGRCLECGTWGTVDEVPALSAVAG--
Mflv_1442|M.gilvum_PYR-GCK          MARTNSKVRSQYRCSECHHTTAKWVGRCSDCGTWGTVDEVALT-AVG---
Mvan_5342|M.vanbaalenii_PYR-1       MARTNSKTRSQFRCSECHHVTPKWVGRCPDCGTWGTVNEVALT-AVG---
TH_0587|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6079|M.smegmatis_MC2_155      MAG--SKIRSQYRCSECQHVAPKWVGRCANCGTWGTVDEVAVL-AGNNKL
MAB_0564c|M.abscessus_ATCC_199      ----MAKPRAQYRCSECQHTTAKWVGRCPDCGTWGSVSETAVLSSIGG--
                                                                                      

Rv3585|M.tuberculosis_H37Rv         --TRRRS--VAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSV
Mb3616|M.bovis_AF2122/97            --TRRRS--VAPASGAVPISAVDAHRTRPCPTGIDELDRVLGGGIVPGSV
MMAR_5085|M.marinum_M               RLGRRAHGPAVPTSQAVPISSVQPNLSRHRPTGIDELDRVLGGGVVPGSV
MAV_0568|M.avium_104                ---RRPR--LTAASQAVPITSIKPDASRHRSTGVDELDRVLGGGVVPGSV
Mflv_1442|M.gilvum_PYR-GCK          G-ATRRA--VAPASPAVPISSIDPGTTRHFHTGISELDRVLGGGLVPGSV
Mvan_5342|M.vanbaalenii_PYR-1       GSATRRA--VAPASPAVPISSIDPGSTRHFHTGISELDRVLGGGLVPGSV
TH_0587|M.thermoresistible__bu      ---------------------------------VTELDRVLGGGLVPGSV
MSMEG_6079|M.smegmatis_MC2_155      NGAARRS--VAPTSPAVPITSIDPGVTRHYPTGVSELDRVLGGGLVAGSV
MAB_0564c|M.abscessus_ATCC_199      -LGAVRA--VAPASAAVPITSIATDTTRHQPTGVSELDRVLGGGLIPGSV
                                                                     : *********::.***

Rv3585|M.tuberculosis_H37Rv         TLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGC
Mb3616|M.bovis_AF2122/97            TLLAGDPGVGKSTLLLEVAHRWAQSGRRALYVSGEESAGQIRLRADRIGC
MMAR_5085|M.marinum_M               TLLAGEPGVGKSTLLLEVAHRWAQSGQRVLYISGEESAGQIRLRADRIGC
MAV_0568|M.avium_104                TLLAGDPGVGKSTLLLEVAHRWAQSGRRALYISGEESAGQIRLRADRIGC
Mflv_1442|M.gilvum_PYR-GCK          TLLAGDPGVGKSTLLLEVAHRWASTGRRALYLSGEESAGQIRLRAERTGC
Mvan_5342|M.vanbaalenii_PYR-1       TLLAGDPGVGKSTLLLEVAHRWASTGRRALYLSGEESAGQIRLRAERTGC
TH_0587|M.thermoresistible__bu      TLLAGDPGVGKSTLLLEVAHRWARAGRRALYLSGEESAGQIRLRAERTGC
MSMEG_6079|M.smegmatis_MC2_155      TLLAGDPGVGKSTLLLEVANRWAHSGKRALYLSGEESAGQIRLRAERTGC
MAB_0564c|M.abscessus_ATCC_199      NLLAGEPGVGKSTLLLKVVHQWAASGGRALYISGEESAAQVRLRAERTGC
                                    .****:**********:*.::** :* *.**:******.*:****:* **

Rv3585|M.tuberculosis_H37Rv         GT-------------EVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQT
Mb3616|M.bovis_AF2122/97            GT-------------EVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQT
MMAR_5085|M.marinum_M               GGPAAPDISEVSAIDNSAEIYLAAESDLHAVLDHIDTVGSALVIVDSVQT
MAV_0568|M.avium_104                GG---------------DQVYLAAESDLHTVLEHVATVKPALVIVDSVQT
Mflv_1442|M.gilvum_PYR-GCK          SH---------------DEVYLAAESDLQTALGHIDAVRPSLVVVDSVQT
Mvan_5342|M.vanbaalenii_PYR-1       SH---------------DEVYLAAESDLQTALGHIDAVQPTLVVVDSVQT
TH_0587|M.thermoresistible__bu      TH---------------DEVFLAAESDLQTALGHIDAVQPSLVVVDSVQT
MSMEG_6079|M.smegmatis_MC2_155      TH---------------DQVYLAAESDLQIALGHIDEVKPSLVVVDSVQT
MAB_0564c|M.abscessus_ATCC_199      VH---------------DEVYLASESDLHSVLGHIEAVKPTLAIIDSVQT
                                                      :::**::**:: .* ::  * .:*.::*****

Rv3585|M.tuberculosis_H37Rv         MSTSEADGVTGGVTQVRAVTAALTAAAKA----NEVALILVGHVTKDGAI
Mb3616|M.bovis_AF2122/97            MSTSEADGVTGGVTQVRAVTAALTAAAKA----NEVALILVGHVTKDGAI
MMAR_5085|M.marinum_M               MSTSEVDGVTGGVTQVRAVTAALTAAAKS----NGFALILVGHVTKDGAI
MAV_0568|M.avium_104                MSTTEADGVAGGVTQVRAVTAALTAAAKA----NGVALILVGHVTKDGAI
Mflv_1442|M.gilvum_PYR-GCK          MSTTEADGVTGGVTQVRAVTTALTMTAKT----TGVAMLLVGHVTKDGAI
Mvan_5342|M.vanbaalenii_PYR-1       MSTTEADGVTGGVTQVRAVTTALTMTAKT----TGVAMLLVGHVTKDGAI
TH_0587|M.thermoresistible__bu      MSTTEADGVTGGVTQVRAVTTALTSYAKASA-APGVAMLLVGHVTKDGAI
MSMEG_6079|M.smegmatis_MC2_155      MSTTEADGVTGGVTQVRAVTTSLTAYAKAAVGDPAVAMILVGHVTKDGAI
MAB_0564c|M.abscessus_ATCC_199      MSTTDADGVTGGVTQVRAVTTALTMAAKS----SGVAMVLVGHVTKDGAI
                                    ***::.***:**********::**  **:      .*::***********

Rv3585|M.tuberculosis_H37Rv         AGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGI
Mb3616|M.bovis_AF2122/97            AGPRSLEHLVDVVLHFEGDRNGALRMVRGVKNRFGAADEVGCFLLHDNGI
MMAR_5085|M.marinum_M               AGPRSLEHLVDVVLHFEGDRNGGLRMVRGVKNRFGAADEVGCFLLHDNGI
MAV_0568|M.avium_104                AGPRSLEHLVDVVLHFEGDRNGSLRMVRGIKNRFGAADEVGCFLLHDNGI
Mflv_1442|M.gilvum_PYR-GCK          AGPRSLEHLVDVVLHFEGDRASALRMVRGVKNRFGAADEVGCFLLHDNGI
Mvan_5342|M.vanbaalenii_PYR-1       AGPRSLEHLVDVVLHFEGDRASALRMVRGIKNRFGAADEVGCFLLHDNGI
TH_0587|M.thermoresistible__bu      AGPRSLEHLVDVVLHFEGDRTTALRMVRGVKNRFGAADEVGCFLLHDSGI
MSMEG_6079|M.smegmatis_MC2_155      AGPRSLEHLVDVVLHFEGDRASSLRMVRGVKNRFGAADEVGCFQLHDNGI
MAB_0564c|M.abscessus_ATCC_199      AGPRSLEHLVDVVLHFEGDKHSALRMVRGIKNRFGAADEVGCFQLRDKGI
                                    *******************:  .******:************* *:*.**

Rv3585|M.tuberculosis_H37Rv         DGIVDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPR
Mb3616|M.bovis_AF2122/97            DGIVDPSNLFLDQRPTPVAGTAITVTLDGKRPLVGEVQALLATPCGGSPR
MMAR_5085|M.marinum_M               EGVADPSNLFLDQRPTPVPGTAITVTLDGKRPLIGEVQALLATPNGGAPR
MAV_0568|M.avium_104                AGVTDPSNLFLDQRSAPVPGTAITVTLDGKRPLIGEVQALLASPSGGSPR
Mflv_1442|M.gilvum_PYR-GCK          ECVSDPSGLFLDQRPKAVSGTAVTVTLDGKRPMIGEVQALIGASASGSPR
Mvan_5342|M.vanbaalenii_PYR-1       ECVSDPSGLFLDQRPKPVSGTAVTVTLDGKRPMIGEVQALIGSPASGSPR
TH_0587|M.thermoresistible__bu      ECVVDPSGLFLDQRPAPVSGTAVTVTLDGKRPLIGEVQALIGAPATGTPR
MSMEG_6079|M.smegmatis_MC2_155      ECVSDPSGLFLDQRPLAVPGTAVTVTLDGKRPMIGEVQALVSPPA-GPPR
MAB_0564c|M.abscessus_ATCC_199      ECVSDPSGLFLEHREKAAAGTAVTVTLDGKRPLLGEVQSLVTTSTNPSPR
                                      : ***.***::*  ...***:*********::****:*: ..   .**

Rv3585|M.tuberculosis_H37Rv         RAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAV
Mb3616|M.bovis_AF2122/97            RAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVGGMRLTEPSADLAV
MMAR_5085|M.marinum_M               RAVSGIDHARAAMISAVLEKHARLSLAVNDMYLSTVGGMRLTDPSSDLAV
MAV_0568|M.avium_104                RAVSGIDHSRAAMITAVLEKHGKLPVAVNDIYLSTVGGMRLTDPSSDLAV
Mflv_1442|M.gilvum_PYR-GCK          RAVSGIDSSRAAMITAVLEKRARLPVGTNDIYLSTVGGMRLTDSSSDLAV
Mvan_5342|M.vanbaalenii_PYR-1       RAVSGIDSSRAAMITAVLEKRAKLPVGMNDIYLSTVGGMRLTDSSSDLAV
TH_0587|M.thermoresistible__bu      RAVSGIDSARAAMITAVLEKRARLPVGSNDIYLSTVGGMRLTDSSSDLAV
MSMEG_6079|M.smegmatis_MC2_155      RAVSGIDSARAAMIGAVLQTRCRMPINSNDLYLSTVGGMRLTDPSADLAV
MAB_0564c|M.abscessus_ATCC_199      RAVSGLDHARSAMVTAVLERHGRLPLGNNDIYMATVGGMRMTDPSADLAI
                                    *****:. :*:**: ***: : ::.:  **:*::******:*:.*:***:

Rv3585|M.tuberculosis_H37Rv         AIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGFTIA
Mb3616|M.bovis_AF2122/97            AIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGFTIA
MMAR_5085|M.marinum_M               AIALASAYANLPLPTTAVMIGEVGLAGDLRRVNGMDRRLAEAARQGFNIA
MAV_0568|M.avium_104                AIALASALSELPLPTTAVMIGEVGLAGDLRRVSGMARRLSEAARQGFSIA
Mflv_1442|M.gilvum_PYR-GCK          ALAIASAYTDLALPTTAIAIGEVGLAGDLRRVTGMDKRLAEAARLGFTVA
Mvan_5342|M.vanbaalenii_PYR-1       ALSIASAFTDLALPTTAIAIGEVGLAGDLRRVTGMDRRLAEAARLGFTYA
TH_0587|M.thermoresistible__bu      ALAIASAYTDLPLPTTAVAIGEVGLAGDLRRVTGMDRRLAEAARLGFGTA
MSMEG_6079|M.smegmatis_MC2_155      ALAIASAYFDIAMPMKAIAIGEVGLAGDLRRVTGMDRRLSEAARLGFTTA
MAB_0564c|M.abscessus_ATCC_199      LMAVASAYTDIALPANMVFIGEVGLAGDIRRTAAVGKRISEAARLGYTHA
                                     :::***  ::.:* . : *********:**. .: :*::**** *:  *

Rv3585|M.tuberculosis_H37Rv         LVPPSD----DPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHS
Mb3616|M.bovis_AF2122/97            LVPPSD----DPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHS
MMAR_5085|M.marinum_M               LVPPG----CEAVPAGLRTLCAPTIVAALEHMIDIADHR-SVPSAKVHRL
MAV_0568|M.avium_104                LIPDGDDPRREIVPSGMRALRAPTIGAALQHMVDIAEPR-KGWTHRALGP
Mflv_1442|M.gilvum_PYR-GCK          VVPSG----AVGAHAGLKVLQADNIGSALQVLRRISQNDASQGRADD---
Mvan_5342|M.vanbaalenii_PYR-1       VVPSG----VTSAPAGLQVLPADNITSALQVLRRISQNGAN---------
TH_0587|M.thermoresistible__bu      VIPPG----VTSVPRGLRAITADNITAALRVLRDIADNGGRQ--------
MSMEG_6079|M.smegmatis_MC2_155      VVPPG----VTSAPAGLKVVAADNIRAAVQTMREIAIAGAQ---------
MAB_0564c|M.abscessus_ATCC_199      VIPPEG---DDLHPAGMHLLRCPTVGRALEVLSEARKIEPEKRPNLRLAQ
                                    ::*            *:: : . .:  *:. :                  

Rv3585|M.tuberculosis_H37Rv         GTGHVPLGRGT
Mb3616|M.bovis_AF2122/97            GTGHVPLGRGT
MMAR_5085|M.marinum_M               DTSH-------
MAV_0568|M.avium_104                QNDTL------
Mflv_1442|M.gilvum_PYR-GCK          -----------
Mvan_5342|M.vanbaalenii_PYR-1       -----------
TH_0587|M.thermoresistible__bu      -----------
MSMEG_6079|M.smegmatis_MC2_155      -----------
MAB_0564c|M.abscessus_ATCC_199      QFTD-------