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SRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRFIHDELMLDGSSRLNLATFVTTWMDPEA EKLMAETFDKNMIDKDEYPATAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKW RWRQRVGSWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERGRYVITPEQVLAAVDENTIGVVAILG TTYTGELEPIAEICAALDKLAAGGGVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLT YPGVGFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGYTKVMQALSHTA RWLGDQLREVDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVV REGLSADLARALHDDAVTALAALDKVKPGGHFDAQHFAH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3432c | gadB | - | 100% (460) | PROBABLE GLUTAMATE DECARBOXYLASE GADB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3462c | gadB | 0.0 | 100.00% (460) | glutamate decarboxylase GadB |
| M. gilvum PYR-GCK | Mflv_4935 | - | 0.0 | 78.80% (467) | glutamate decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3740c | - | 0.0 | 81.52% (460) | glutamate decarboxylase GadB |
| M. marinum M | MMAR_1118 | gadB | 0.0 | 91.54% (461) | glutamate decarboxylase, GadB |
| M. avium 104 | MAV_4373 | - | 0.0 | 88.82% (456) | glutamate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_1574 | - | 0.0 | 83.84% (458) | glutamate decarboxylase |
| M. thermoresistible (build 8) | TH_1695 | gadB | 0.0 | 83.30% (443) | PROBABLE GLUTAMATE DECARBOXYLASE GADB |
| M. ulcerans Agy99 | MUL_0878 | gadB | 0.0 | 91.11% (461) | glutamate decarboxylase, GadB |
| M. vanbaalenii PYR-1 | Mvan_1483 | - | 0.0 | 79.48% (463) | glutamate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3432c|M.tuberculosis_H37Rv MSRSHPSVP---------AHSIAPAYTGRMFTAPVPALRMPDESMDPEAA
Mb3462c|M.bovis_AF2122/97 MSRSHPSVP---------AHSIAPAYTGRMFTAPVPALRMPDESMDPEAA
MMAR_1118|M.marinum_M MSRSHPSVP---------AHSIAPAYTGRLFTAPVPALRLPEESMDPEAA
MUL_0878|M.ulcerans_Agy99 MSRSHSSVP---------AHSIAPAYTGRLFTAPVPALRLPEESMDPEAA
MAV_4373|M.avium_104 MP-QHPSLP---------AHAIAPAYTGRLFTAPVPALRMPDESMDPDAA
MAB_3740c|M.abscessus_ATCC_199 MSKSRDQFRLSAHAGKINASAFSPAYTGRLSTAPVPALRLPDEPMDPQAA
TH_1695|M.thermoresistible__bu -----------------------------LATNPVPSLRLPDDPMAPEAV
MSMEG_1574|M.smegmatis_MC2_155 MSHKQSR-----------GPHVAPAYTGRLAMAPVPSLRLPDEAMDPSAA
Mflv_4935|M.gilvum_PYR-GCK MPNVSRHSS------------LAPAYTGRMSMSPVPALRLPDESMEPEQA
Mvan_1483|M.vanbaalenii_PYR-1 MPNVSRHSS------------LTPAYTGRLSTNPIPALRLPDESMDPEQT
: *:*:**:*::.* *. .
Rv3432c|M.tuberculosis_H37Rv YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
Mb3462c|M.bovis_AF2122/97 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
MMAR_1118|M.marinum_M YRFIHDELMLDGSSRLNLATFVTTWMDPEAGKLMAETFDKNMIDKDEYPA
MUL_0878|M.ulcerans_Agy99 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGKLMAETFDKNMIDKDEYPA
MAV_4373|M.avium_104 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGRLMAETFDKNMIDKDEYPA
MAB_3740c|M.abscessus_ATCC_199 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
TH_1695|M.thermoresistible__bu YRFISDELMLDGSSRLNLATFVTTWMDPEAEKLMAQTFDKNMIDKDEYPA
MSMEG_1574|M.smegmatis_MC2_155 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
Mflv_4935|M.gilvum_PYR-GCK YRFIHDELMLDGSSRLNLATFVTTWMDPEAGQLMSETFDKNMIDKDEYPV
Mvan_1483|M.vanbaalenii_PYR-1 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGQLMSETFDKNMIDKDEYPV
**** ************************* :**::*************.
Rv3432c|M.tuberculosis_H37Rv TAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKW
Mb3462c|M.bovis_AF2122/97 TAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKW
MMAR_1118|M.marinum_M TAAIETRCVSMVADLFHAEGLRDDDPSSATGVSTIGSSEAVMLGGLAMKW
MUL_0878|M.ulcerans_Agy99 TAAIETRCVSMVADLFHAEGLRDDDPSSATGVSTIGSSEAVMLGGLAMKW
MAV_4373|M.avium_104 TAAIEQRCVCMVADLFHAEGLNDADPYSACGVSTIGSSEAVMLGGLAMKW
MAB_3740c|M.abscessus_ATCC_199 TAAIESRCVAMVADLFHADNLSTEDPSSAVGVSTIGSSEAVMLAGLALKW
TH_1695|M.thermoresistible__bu TAAIEQRCVCMVADLFHAEDLRDDDPSSATGVSTIGSSEAVMLAGLALKW
MSMEG_1574|M.smegmatis_MC2_155 TAAIEARCVSMVADLFHAEDLRDDDPASAVGVSTIGSSEAVMLAGLAMKW
Mflv_4935|M.gilvum_PYR-GCK TAAIEQRCVCMVADLFHAENLRDDDPSTAIGVSTVGSSEAVMLAGLAMKW
Mvan_1483|M.vanbaalenii_PYR-1 TAAIEQRCVCMVADLFHAEDLRDDDPATAIGVSTIGSSEAVMLAGLAMKW
***** ***.********:.* ** :* ****:********.***:**
Rv3432c|M.tuberculosis_H37Rv RWRQRVG-----SWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERG
Mb3462c|M.bovis_AF2122/97 RWRQRVG-----SWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERG
MMAR_1118|M.marinum_M RWRQKVGK----DWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEKG
MUL_0878|M.ulcerans_Agy99 RWRQKVGK----DWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEKG
MAV_4373|M.avium_104 RWRAKTK-----DWKKRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEEG
MAB_3740c|M.abscessus_ATCC_199 RWRTKIGGTDGTGWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMAKG
TH_1695|M.thermoresistible__bu RWRRRM-EKAGKDWRSRTPNLIMGANVQVVWEKFARYFDVEPRYLPMEKG
MSMEG_1574|M.smegmatis_MC2_155 RWRAKA-----GDWKGRTPNLVMGANVQVVWEKFCRYFDVEPRYLPMAEG
Mflv_4935|M.gilvum_PYR-GCK RWRDKFAGKDGDGWKGRTPNLVMGSNVQVVWEKFCRYFDVEARYLPMEKG
Mvan_1483|M.vanbaalenii_PYR-1 RWRDRVG----DGWKGRTPNLVMGSNVQVVWEKFCRYFDVEARYLPMEEG
*** : .*: * ***:**:*********.******.***** .*
Rv3432c|M.tuberculosis_H37Rv RYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAG-G
Mb3462c|M.bovis_AF2122/97 RYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAG-G
MMAR_1118|M.marinum_M RYVITPEQVVDAVDEDTIGVVAILGTTYTGELEPVAEICAALDRLAAG-G
MUL_0878|M.ulcerans_Agy99 RYVITPEQVVDAVDEDTFGVVAILGTTYTGELEPVAEICAALDRLAAG-G
MAV_4373|M.avium_104 RYVITPEQVVDAVDEDTIGVVAILGTTYTGELEPVADICGALDKLAAR-G
MAB_3740c|M.abscessus_ATCC_199 RYVITPEQVLEVVDEDTIGVVGILGTTFTGELEPIAAICAALDKLAATPG
TH_1695|M.thermoresistible__bu RYVITPQQVLEHVDEDTIGVVAILGTTFTGELEPVGEICAALDKLAAD-G
MSMEG_1574|M.smegmatis_MC2_155 RYVITPEQVLDAVDEDTIGVVAILGTTYTGELEPVAEICEALDKLAAG-G
Mflv_4935|M.gilvum_PYR-GCK RYVITPEQVLDAVDEDTIGVVAILGTTFTGELEPVAEICAALDALAAG-G
Mvan_1483|M.vanbaalenii_PYR-1 RYVITPEQVLDAVDEDTIGVVAILGTTFTGELEPVAEICAALDKLAAT-G
******:**: ***:*:***.*****:******:. ** *** *** *
Rv3432c|M.tuberculosis_H37Rv GVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
Mb3462c|M.bovis_AF2122/97 GVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
MMAR_1118|M.marinum_M GVDVPVHVDAASGGFVVPFLHPDLKWDFRLPRVVSINVSGHKYGLTYPGV
MUL_0878|M.ulcerans_Agy99 GVDVPVHVDAASGGFVVPFLHPDLKWDFRLPRVVSINVSGHKYGLTYPGV
MAV_4373|M.avium_104 GVDVPVHVDAASGGFVVPFLHPELKWDFRLPRVVSINVSGHKYGLTYPGV
MAB_3740c|M.abscessus_ATCC_199 KPDVPVHVDAASGGFVVPFLHPELHWDFRLPRVVSINVSGHKYGLTYPGI
TH_1695|M.thermoresistible__bu GPDVPVHVDAASGGFVVPFLHPDLEWDFRLPRVVSINVSGHKYGLTYPGI
MSMEG_1574|M.smegmatis_MC2_155 GVDVPVHVDAASGGFVVPFIHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
Mflv_4935|M.gilvum_PYR-GCK GCDVPVHVDAASGGFVVPFLNPLLVWDFRLPRVVSINVSGHKYGLTYPGI
Mvan_1483|M.vanbaalenii_PYR-1 -PDVPVHVDAASGGFVVPFLHPDVVWDFRLPRVVSINVSGHKYGLTYPGI
*****************::* : ************************:
Rv3432c|M.tuberculosis_H37Rv GFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mb3462c|M.bovis_AF2122/97 GFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MMAR_1118|M.marinum_M GFVVWRSPEYLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MUL_0878|M.ulcerans_Agy99 GFVVWRSPEYLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MAV_4373|M.avium_104 GFVVWRSKEYLPDELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MAB_3740c|M.abscessus_ATCC_199 GFVVWRGKEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
TH_1695|M.thermoresistible__bu GFVVWRSAEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MSMEG_1574|M.smegmatis_MC2_155 GFVVWRNKEHLPEELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mflv_4935|M.gilvum_PYR-GCK GFVVWRNAEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mvan_1483|M.vanbaalenii_PYR-1 GFVVWRNAEHLPEELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
******. *:**::************************************
Rv3432c|M.tuberculosis_H37Rv GRDGYTKVMQALSHTARWLGDQLR---EVDH---CEVISDGSAIPVVSFR
Mb3462c|M.bovis_AF2122/97 GRDGYTKVMQALSHTARWLGDQLR---EVDH---CEVISDGSAIPVVSFR
MMAR_1118|M.marinum_M GREGYINVMQALSETARWLSAQLR---EVDH---CELIADGSAIPVVAFR
MUL_0878|M.ulcerans_Agy99 GREGYINVMQALSETARWLSAQLR---EVDH---CELIADGSAIPVVAFR
MAV_4373|M.avium_104 GREGYTKVMQTLSGTARWLGEQLR---VSEH---CELISDGSAIPVVAFR
MAB_3740c|M.abscessus_ATCC_199 GRAGYAQVMRCLSETARWFGDELG---KSEH---FEVITDGSAIPVVSFR
TH_1695|M.thermoresistible__bu GRAGYGQVMKTLSDTARWLGDQLR---ASEH---FEVISDGTAIPVVSFR
MSMEG_1574|M.smegmatis_MC2_155 GRAGYTQVMQCLSQTARWLGDELR---DSEH---FELISDGSAIPVVAFR
Mflv_4935|M.gilvum_PYR-GCK GRDGYTQVMHALADTAQWLARELEGMTGSDHKPVFEVITDGSAIPVVAFR
Mvan_1483|M.vanbaalenii_PYR-1 GREGYTTVMRCLSETAQWLSHELASMTGPDNRPVFQVISDGSAIPVVAFK
** ** **: *: **:*:. :* :: ::*:**:*****:*:
Rv3432c|M.tuberculosis_H37Rv LAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADL
Mb3462c|M.bovis_AF2122/97 LAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADL
MMAR_1118|M.marinum_M LAGDRGYTEFDLSHELRTFGWQVPAYTMPDNATDVSVLRIVVREGLSADM
MUL_0878|M.ulcerans_Agy99 LAGDRGYTEFDLSHELRTFGWQVPAYTMPDNATDVSVLRIVVREGLSADM
MAV_4373|M.avium_104 LAKDRGYTEFDVSHELRTYGWQVPAYTMPDNATDVSVLRIVVREGLSADL
MAB_3740c|M.abscessus_ATCC_199 LKGKRPYTEFDISHSLRAFGWQVPAYTMPDDVTDIAVLRVVVREGFSGDL
TH_1695|M.thermoresistible__bu LTGDRGYTEFDVSHALRAYGWQVPAYTMPENATDVAVLRVVVREGLSADL
MSMEG_1574|M.smegmatis_MC2_155 LKGDPGYTEFDISQALRAHGWQVPAYTMPEGAEDVVVLRVVVREGFSADL
Mflv_4935|M.gilvum_PYR-GCK LTEGAKFTVFDISALLRSYGWQVPAYTMPEDATDIAVLRIVVREGFSANL
Mvan_1483|M.vanbaalenii_PYR-1 LVEGTRYTVFDISSLLRGYGWQVPAYTMPDNATDVAVLRIVVREGFSANL
* :* **:* ** .**********:.. *: ***:*****:*.::
Rv3432c|M.tuberculosis_H37Rv ARALHDDAVTALAALDKVKPGGHFDA-QHFAH
Mb3462c|M.bovis_AF2122/97 ARALHDDAVTALAALDKVKPGGHFDA-QHFAH
MMAR_1118|M.marinum_M ARALHDDAVTSLRTLDKVKPGGNYDG-QHFAH
MUL_0878|M.ulcerans_Agy99 ARALHDDAVTSLRTLDKVKPGGNYDG-QHFAH
MAV_4373|M.avium_104 ARALHDDAVSALTSLDKVKPGGHYDA-QHFAH
MAB_3740c|M.abscessus_ATCC_199 ARALRDDLNTVLKGLDELKPNGHFDEVQPFAH
TH_1695|M.thermoresistible__bu ARVLCDDMMTVIEQLDELKPGGQFDSLQPFAH
MSMEG_1574|M.smegmatis_MC2_155 ARALKDDIITVLGQLDALKPRGQFDQLQPFAH
Mflv_4935|M.gilvum_PYR-GCK ARALRDDLREVLGKLDKVGIGGFSDE-EHFAH
Mvan_1483|M.vanbaalenii_PYR-1 ARALRDDLIEVLGKLEKVGVGGFADE-EHFAH
**.* ** : *: : * * : ***