For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VSRSHSSVPAHSIAPAYTGRLFTAPVPALRLPEESMDPEAAYRFIHDELMLDGSSRLNLATFVTTWMDPE AGKLMAETFDKNMIDKDEYPATAAIETRCVSMVADLFHAEGLRDDDPSSATGVSTIGSSEAVMLGGLAMK WRWRQKVGKDWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEKGRYVITPEQVVDAVDEDTFGVVAI LGTTYTGELEPVAEICAALDRLAAGGGVDVPVHVDAASGGFVVPFLHPDLKWDFRLPRVVSINVSGHKYG LTYPGVGFVVWRSPEYLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGREGYINVMQALSE TARWLSAQLREVDHCELIADGSAIPVVAFRLAGDRGYTEFDLSHELRTFGWQVPAYTMPDNATDVSVLRI VVREGLSADMARALHDDAVTSLRTLDKVKPGGNYDGQHFAH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0878 | gadB | - | 100% (461) | glutamate decarboxylase, GadB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3462c | gadB | 0.0 | 91.11% (461) | glutamate decarboxylase GadB |
| M. gilvum PYR-GCK | Mflv_4935 | - | 0.0 | 80.22% (460) | glutamate decarboxylase |
| M. tuberculosis H37Rv | Rv3432c | gadB | 0.0 | 91.11% (461) | glutamate decarboxylase GadB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3740c | - | 0.0 | 78.59% (467) | glutamate decarboxylase GadB |
| M. marinum M | MMAR_1118 | gadB | 0.0 | 99.57% (461) | glutamate decarboxylase, GadB |
| M. avium 104 | MAV_4373 | - | 0.0 | 89.72% (457) | glutamate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_1574 | - | 0.0 | 83.22% (459) | glutamate decarboxylase |
| M. thermoresistible (build 8) | TH_1695 | gadB | 0.0 | 82.02% (445) | PROBABLE GLUTAMATE DECARBOXYLASE GADB |
| M. vanbaalenii PYR-1 | Mvan_1483 | - | 0.0 | 80.26% (456) | glutamate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0878|M.ulcerans_Agy99 MSRSHSSVP---------AHSIAPAYTGRLFTAPVPALRLPEESMDPEAA
MMAR_1118|M.marinum_M MSRSHPSVP---------AHSIAPAYTGRLFTAPVPALRLPEESMDPEAA
Mb3462c|M.bovis_AF2122/97 MSRSHPSVP---------AHSIAPAYTGRMFTAPVPALRMPDESMDPEAA
Rv3432c|M.tuberculosis_H37Rv MSRSHPSVP---------AHSIAPAYTGRMFTAPVPALRMPDESMDPEAA
MAV_4373|M.avium_104 MP-QHPSLP---------AHAIAPAYTGRLFTAPVPALRMPDESMDPDAA
MAB_3740c|M.abscessus_ATCC_199 MSKSRDQFRLSAHAGKINASAFSPAYTGRLSTAPVPALRLPDEPMDPQAA
TH_1695|M.thermoresistible__bu -----------------------------LATNPVPSLRLPDDPMAPEAV
MSMEG_1574|M.smegmatis_MC2_155 MSHKQSR-----------GPHVAPAYTGRLAMAPVPSLRLPDEAMDPSAA
Mflv_4935|M.gilvum_PYR-GCK MPNVSRHSS------------LAPAYTGRMSMSPVPALRLPDESMEPEQA
Mvan_1483|M.vanbaalenii_PYR-1 MPNVSRHSS------------LTPAYTGRLSTNPIPALRLPDESMDPEQT
: *:*:**:*::.* *. .
MUL_0878|M.ulcerans_Agy99 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGKLMAETFDKNMIDKDEYPA
MMAR_1118|M.marinum_M YRFIHDELMLDGSSRLNLATFVTTWMDPEAGKLMAETFDKNMIDKDEYPA
Mb3462c|M.bovis_AF2122/97 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
Rv3432c|M.tuberculosis_H37Rv YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
MAV_4373|M.avium_104 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGRLMAETFDKNMIDKDEYPA
MAB_3740c|M.abscessus_ATCC_199 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
TH_1695|M.thermoresistible__bu YRFISDELMLDGSSRLNLATFVTTWMDPEAEKLMAQTFDKNMIDKDEYPA
MSMEG_1574|M.smegmatis_MC2_155 YRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPA
Mflv_4935|M.gilvum_PYR-GCK YRFIHDELMLDGSSRLNLATFVTTWMDPEAGQLMSETFDKNMIDKDEYPV
Mvan_1483|M.vanbaalenii_PYR-1 YRFIHDELMLDGSSRLNLATFVTTWMDPEAGQLMSETFDKNMIDKDEYPV
**** ************************* :**::*************.
MUL_0878|M.ulcerans_Agy99 TAAIETRCVSMVADLFHAEGLRDDDPSSATGVSTIGSSEAVMLGGLAMKW
MMAR_1118|M.marinum_M TAAIETRCVSMVADLFHAEGLRDDDPSSATGVSTIGSSEAVMLGGLAMKW
Mb3462c|M.bovis_AF2122/97 TAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKW
Rv3432c|M.tuberculosis_H37Rv TAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKW
MAV_4373|M.avium_104 TAAIEQRCVCMVADLFHAEGLNDADPYSACGVSTIGSSEAVMLGGLAMKW
MAB_3740c|M.abscessus_ATCC_199 TAAIESRCVAMVADLFHADNLSTEDPSSAVGVSTIGSSEAVMLAGLALKW
TH_1695|M.thermoresistible__bu TAAIEQRCVCMVADLFHAEDLRDDDPSSATGVSTIGSSEAVMLAGLALKW
MSMEG_1574|M.smegmatis_MC2_155 TAAIEARCVSMVADLFHAEDLRDDDPASAVGVSTIGSSEAVMLAGLAMKW
Mflv_4935|M.gilvum_PYR-GCK TAAIEQRCVCMVADLFHAENLRDDDPSTAIGVSTVGSSEAVMLAGLAMKW
Mvan_1483|M.vanbaalenii_PYR-1 TAAIEQRCVCMVADLFHAEDLRDDDPATAIGVSTIGSSEAVMLAGLAMKW
***** ***.********:.* ** :* ****:********.***:**
MUL_0878|M.ulcerans_Agy99 RWRQKVGK----DWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEKG
MMAR_1118|M.marinum_M RWRQKVGK----DWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEKG
Mb3462c|M.bovis_AF2122/97 RWRQRVG-----SWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERG
Rv3432c|M.tuberculosis_H37Rv RWRQRVG-----SWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERG
MAV_4373|M.avium_104 RWRAKTK-----DWKKRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMEEG
MAB_3740c|M.abscessus_ATCC_199 RWRTKIGGTDGTGWKGRTPNLVMGSNVQVVWEKFCRYFDVEPRYLPMAKG
TH_1695|M.thermoresistible__bu RWRRRM-EKAGKDWRSRTPNLIMGANVQVVWEKFARYFDVEPRYLPMEKG
MSMEG_1574|M.smegmatis_MC2_155 RWRAKA-----GDWKGRTPNLVMGANVQVVWEKFCRYFDVEPRYLPMAEG
Mflv_4935|M.gilvum_PYR-GCK RWRDKFAGKDGDGWKGRTPNLVMGSNVQVVWEKFCRYFDVEARYLPMEKG
Mvan_1483|M.vanbaalenii_PYR-1 RWRDRVG----DGWKGRTPNLVMGSNVQVVWEKFCRYFDVEARYLPMEEG
*** : .*: * ***:**:*********.******.***** .*
MUL_0878|M.ulcerans_Agy99 RYVITPEQVVDAVDEDTFGVVAILGTTYTGELEPVAEICAALDRLAAG-G
MMAR_1118|M.marinum_M RYVITPEQVVDAVDEDTIGVVAILGTTYTGELEPVAEICAALDRLAAG-G
Mb3462c|M.bovis_AF2122/97 RYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAG-G
Rv3432c|M.tuberculosis_H37Rv RYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAG-G
MAV_4373|M.avium_104 RYVITPEQVVDAVDEDTIGVVAILGTTYTGELEPVADICGALDKLAAR-G
MAB_3740c|M.abscessus_ATCC_199 RYVITPEQVLEVVDEDTIGVVGILGTTFTGELEPIAAICAALDKLAATPG
TH_1695|M.thermoresistible__bu RYVITPQQVLEHVDEDTIGVVAILGTTFTGELEPVGEICAALDKLAAD-G
MSMEG_1574|M.smegmatis_MC2_155 RYVITPEQVLDAVDEDTIGVVAILGTTYTGELEPVAEICEALDKLAAG-G
Mflv_4935|M.gilvum_PYR-GCK RYVITPEQVLDAVDEDTIGVVAILGTTFTGELEPVAEICAALDALAAG-G
Mvan_1483|M.vanbaalenii_PYR-1 RYVITPEQVLDAVDEDTIGVVAILGTTFTGELEPVAEICAALDKLAAT-G
******:**: ***:*:***.*****:******:. ** *** *** *
MUL_0878|M.ulcerans_Agy99 GVDVPVHVDAASGGFVVPFLHPDLKWDFRLPRVVSINVSGHKYGLTYPGV
MMAR_1118|M.marinum_M GVDVPVHVDAASGGFVVPFLHPDLKWDFRLPRVVSINVSGHKYGLTYPGV
Mb3462c|M.bovis_AF2122/97 GVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
Rv3432c|M.tuberculosis_H37Rv GVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
MAV_4373|M.avium_104 GVDVPVHVDAASGGFVVPFLHPELKWDFRLPRVVSINVSGHKYGLTYPGV
MAB_3740c|M.abscessus_ATCC_199 KPDVPVHVDAASGGFVVPFLHPELHWDFRLPRVVSINVSGHKYGLTYPGI
TH_1695|M.thermoresistible__bu GPDVPVHVDAASGGFVVPFLHPDLEWDFRLPRVVSINVSGHKYGLTYPGI
MSMEG_1574|M.smegmatis_MC2_155 GVDVPVHVDAASGGFVVPFIHPDLVWDFRLPRVVSINVSGHKYGLTYPGV
Mflv_4935|M.gilvum_PYR-GCK GCDVPVHVDAASGGFVVPFLNPLLVWDFRLPRVVSINVSGHKYGLTYPGI
Mvan_1483|M.vanbaalenii_PYR-1 -PDVPVHVDAASGGFVVPFLHPDVVWDFRLPRVVSINVSGHKYGLTYPGI
*****************::* : ************************:
MUL_0878|M.ulcerans_Agy99 GFVVWRSPEYLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MMAR_1118|M.marinum_M GFVVWRSPEYLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mb3462c|M.bovis_AF2122/97 GFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Rv3432c|M.tuberculosis_H37Rv GFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MAV_4373|M.avium_104 GFVVWRSKEYLPDELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MAB_3740c|M.abscessus_ATCC_199 GFVVWRGKEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
TH_1695|M.thermoresistible__bu GFVVWRSAEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
MSMEG_1574|M.smegmatis_MC2_155 GFVVWRNKEHLPEELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mflv_4935|M.gilvum_PYR-GCK GFVVWRNAEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
Mvan_1483|M.vanbaalenii_PYR-1 GFVVWRNAEHLPEELVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRL
******. *:**::************************************
MUL_0878|M.ulcerans_Agy99 GREGYINVMQALSETARWLSAQLR---EVDH---CELIADGSAIPVVAFR
MMAR_1118|M.marinum_M GREGYINVMQALSETARWLSAQLR---EVDH---CELIADGSAIPVVAFR
Mb3462c|M.bovis_AF2122/97 GRDGYTKVMQALSHTARWLGDQLR---EVDH---CEVISDGSAIPVVSFR
Rv3432c|M.tuberculosis_H37Rv GRDGYTKVMQALSHTARWLGDQLR---EVDH---CEVISDGSAIPVVSFR
MAV_4373|M.avium_104 GREGYTKVMQTLSGTARWLGEQLR---VSEH---CELISDGSAIPVVAFR
MAB_3740c|M.abscessus_ATCC_199 GRAGYAQVMRCLSETARWFGDELG---KSEH---FEVITDGSAIPVVSFR
TH_1695|M.thermoresistible__bu GRAGYGQVMKTLSDTARWLGDQLR---ASEH---FEVISDGTAIPVVSFR
MSMEG_1574|M.smegmatis_MC2_155 GRAGYTQVMQCLSQTARWLGDELR---DSEH---FELISDGSAIPVVAFR
Mflv_4935|M.gilvum_PYR-GCK GRDGYTQVMHALADTAQWLARELEGMTGSDHKPVFEVITDGSAIPVVAFR
Mvan_1483|M.vanbaalenii_PYR-1 GREGYTTVMRCLSETAQWLSHELASMTGPDNRPVFQVISDGSAIPVVAFK
** ** **: *: **:*:. :* :: ::*:**:*****:*:
MUL_0878|M.ulcerans_Agy99 LAGDRGYTEFDLSHELRTFGWQVPAYTMPDNATDVSVLRIVVREGLSADM
MMAR_1118|M.marinum_M LAGDRGYTEFDLSHELRTFGWQVPAYTMPDNATDVSVLRIVVREGLSADM
Mb3462c|M.bovis_AF2122/97 LAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADL
Rv3432c|M.tuberculosis_H37Rv LAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADL
MAV_4373|M.avium_104 LAKDRGYTEFDVSHELRTYGWQVPAYTMPDNATDVSVLRIVVREGLSADL
MAB_3740c|M.abscessus_ATCC_199 LKGKRPYTEFDISHSLRAFGWQVPAYTMPDDVTDIAVLRVVVREGFSGDL
TH_1695|M.thermoresistible__bu LTGDRGYTEFDVSHALRAYGWQVPAYTMPENATDVAVLRVVVREGLSADL
MSMEG_1574|M.smegmatis_MC2_155 LKGDPGYTEFDISQALRAHGWQVPAYTMPEGAEDVVVLRVVVREGFSADL
Mflv_4935|M.gilvum_PYR-GCK LTEGAKFTVFDISALLRSYGWQVPAYTMPEDATDIAVLRIVVREGFSANL
Mvan_1483|M.vanbaalenii_PYR-1 LVEGTRYTVFDISSLLRGYGWQVPAYTMPDNATDVAVLRIVVREGFSANL
* :* **:* ** .**********:.. *: ***:*****:*.::
MUL_0878|M.ulcerans_Agy99 ARALHDDAVTSLRTLDKVKPGGNYDG-QHFAH
MMAR_1118|M.marinum_M ARALHDDAVTSLRTLDKVKPGGNYDG-QHFAH
Mb3462c|M.bovis_AF2122/97 ARALHDDAVTALAALDKVKPGGHFDA-QHFAH
Rv3432c|M.tuberculosis_H37Rv ARALHDDAVTALAALDKVKPGGHFDA-QHFAH
MAV_4373|M.avium_104 ARALHDDAVSALTSLDKVKPGGHYDA-QHFAH
MAB_3740c|M.abscessus_ATCC_199 ARALRDDLNTVLKGLDELKPNGHFDEVQPFAH
TH_1695|M.thermoresistible__bu ARVLCDDMMTVIEQLDELKPGGQFDSLQPFAH
MSMEG_1574|M.smegmatis_MC2_155 ARALKDDIITVLGQLDALKPRGQFDQLQPFAH
Mflv_4935|M.gilvum_PYR-GCK ARALRDDLREVLGKLDKVGIGGFSDE-EHFAH
Mvan_1483|M.vanbaalenii_PYR-1 ARALRDDLIEVLGKLEKVGVGGFADE-EHFAH
**.* ** : *: : * * : ***