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AEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGA VFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIG HAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPS EDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIG VTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3382c | lytB1 | - | 100% (329) | PROBABLE LYTB-RELATED PROTEIN LYTB1 |
| M. tuberculosis H37Rv | Rv1110 | ispH | 5e-81 | 50.97% (310) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3414c | lytB1 | 0.0 | 100.00% (329) | LYTB-like protein LYTB1 |
| M. gilvum PYR-GCK | Mflv_2079 | ispH | 2e-82 | 50.49% (309) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. leprae Br4923 | MLBr_01938 | ispH | 2e-80 | 51.28% (312) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. abscessus ATCC 19977 | MAB_1257 | ispH | 5e-84 | 51.92% (312) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. marinum M | MMAR_0277 | lytB2 | 1e-133 | 75.40% (313) | LytB-related protein LytB2 |
| M. avium 104 | MAV_1230 | ispH | 2e-78 | 51.34% (298) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. smegmatis MC2 155 | MSMEG_5224 | ispH | 1e-85 | 52.43% (309) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. thermoresistible (build 8) | TH_1705 | ispH | 8e-86 | 50.96% (314) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. ulcerans Agy99 | MUL_0168 | ispH | 2e-82 | 52.10% (309) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. vanbaalenii PYR-1 | Mvan_4631 | ispH | 4e-83 | 49.69% (322) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2079|M.gilvum_PYR-GCK ---MPPTVNMG---IPGAAS----SVVERTAGKRVLLAEPRGYCAGVDRA
Mvan_4631|M.vanbaalenii_PYR-1 ---MPPTVNMG---IPGASRTALGSVAGDVTGKRVLLAEPRGYCAGVDRA
MAB_1257|M.abscessus_ATCC_1997 ----MAAVDMG---TPGMVSTAM-RTVGPAISKRVLLAEPRGYCAGVDRA
MSMEG_5224|M.smegmatis_MC2_155 -----------------------------MSGKRVLLAEPRGYCAGVDRA
TH_1705|M.thermoresistible__bu ---MASTINMG---IPGAAS----TVARPAGDRRVLLAEPRGYCAGVDRA
MLBr_01938|M.leprae_Br4923 MKGMPPTVNMG---IPGASR----SIVENLKRKRVLLAEPRGYCAGVDRA
MAV_1230|M.avium_104 ----------------------------------------------MDRA
MUL_0168|M.ulcerans_Agy99 ---MVPTIDMG---IPGASS----SVAHVPTRRRVLLAEPRGYCAGVDRA
Rv3382c|M.tuberculosis_H37Rv ----MAEVFVG----PVAQG-------YASGEVTVLLASPRSFCAGVERA
Mb3414c|M.bovis_AF2122/97 ----MAEVFVG----PVAQG-------YASGEVTVLLASPRSFCAGVERA
MMAR_0277|M.marinum_M ----MTTVNPSSRSRPRPLA-------DESAATTVLLASPRSFCAGVHRA
:.**
Mflv_2079|M.gilvum_PYR-GCK VETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPE---
Mvan_4631|M.vanbaalenii_PYR-1 VETVERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPE---
MAB_1257|M.abscessus_ATCC_1997 VETVERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAIFVDETDEVPE---
MSMEG_5224|M.smegmatis_MC2_155 VETVERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPE---
TH_1705|M.thermoresistible__bu VETVERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPE---
MLBr_01938|M.leprae_Br4923 VETVERSLRKYGPPVYVRHEIVHNRHVVETLERAGAVFVEETDYVPE---
MAV_1230|M.avium_104 VETVERALEKHGPPVYVRHEIVHNRHVVSTLEKAGAVFVEETDEVPE---
MUL_0168|M.ulcerans_Agy99 VETVERALEKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETDQVPE---
Rv3382c|M.tuberculosis_H37Rv IETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPP
Mb3414c|M.bovis_AF2122/97 IETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPP
MMAR_0277|M.marinum_M IEAVERVLDRATGPVYVRKQIVHNRTVVAELQDRGAIFVDELDEIPDPPA
:*:*:* * *:***::**** ** * **:**:: * :*:
Mflv_2079|M.gilvum_PYR-GCK -GAIVVFSAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDY
Mvan_4631|M.vanbaalenii_PYR-1 -GAIVVFSAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDY
MAB_1257|M.abscessus_ATCC_1997 -GAIVVFSAHGVAPTVHEKAAERNLKTIDATCPLVTKVHQEAKRFARDDF
MSMEG_5224|M.smegmatis_MC2_155 -GAIVVFSAHGVAPTVHQSAAERNLKVIDATCPLVTKVHNEAKRFARDDY
TH_1705|M.thermoresistible__bu -GEIVVFSAHGVAPSVHVNAAERNLKVIDATCPLVTKVHNEAKRFARDDY
MLBr_01938|M.leprae_Br4923 -GAIVIFSAHGVAPTVYAAAAERNLRTIDATCPLVTKVHNEVKRFARNDY
MAV_1230|M.avium_104 -GAIVVFSAHGVAPTVHAAAAERNLHTIDATCPLVTKVHNEARRFARNDY
MUL_0168|M.ulcerans_Agy99 -GAIVVFSAHGVAPTVYAAAAERNLQTIDATCPLVTKVHNEARRFARNDY
Rv3382c|M.tuberculosis_H37Rv PGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGD
Mb3414c|M.bovis_AF2122/97 PGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGD
MMAR_0277|M.marinum_M PGAVVVFSAHGVSPAVRAAANGRGLEVVDATCPLVTKVHAEAARFAGRGD
* :*:******:*:* * * *..:*******:*** *. *** .
Mflv_2079|M.gilvum_PYR-GCK DILLVGHEGHEEVVGTAGEAPDHVQVVDNPDAVDNVVVRDPNKVIWLSQT
Mvan_4631|M.vanbaalenii_PYR-1 DILLVGHEGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPNKVIWLSQT
MAB_1257|M.abscessus_ATCC_1997 DILLIGHEGHEEVIGTAGEAPDHVQLVDGPNAVDNVTVRDENKVIWLSQT
MSMEG_5224|M.smegmatis_MC2_155 DILLIGHEGHEEVVGTAGEAPDHVQLVDGPESVDAVTVRDESKVIWLSQT
TH_1705|M.thermoresistible__bu DILLIGHEGHEEVIGTAGEAPDHVQIVDGPEAVDKVTVRDENKVIWLSQT
MLBr_01938|M.leprae_Br4923 DILLIGHEGHEEVIATAGEAPTHVQLVDGLAAVQQVVVRDENKVVWLSQT
MAV_1230|M.avium_104 DILLIGHEGHEEVVGTAGEAPDHVQLVDGVAAVDNVTVRDEDKVVWLSQT
MUL_0168|M.ulcerans_Agy99 DILLIGHEGHEEVVGTAGEAPEHVQLVDGLDGVERVTIRDEDKVVWLSQT
Rv3382c|M.tuberculosis_H37Rv TVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQT
Mb3414c|M.bovis_AF2122/97 TVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQT
MMAR_0277|M.marinum_M TVLLIGHLGHEETDGTLGVAPNSMLLVQNADDVTELDLPEDAQVSYLTQT
::::** ****. .* * ** :*: * : : : :: :*:**
Mflv_2079|M.gilvum_PYR-GCK TLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELV
Mvan_4631|M.vanbaalenii_PYR-1 TLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELV
MAB_1257|M.abscessus_ATCC_1997 TLSVDETMETVQRLRERFPTLQDPPSDDICYATQNRQVAVKAMAPECELV
MSMEG_5224|M.smegmatis_MC2_155 TLSVDETMETVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELV
TH_1705|M.thermoresistible__bu TLSVDETMEIVQKLRERFPKLQDPPSDDICYATQNRQVAVKAMAPECELV
MLBr_01938|M.leprae_Br4923 TLSVDETMRIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECELV
MAV_1230|M.avium_104 TLSVDETMEIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECDLV
MUL_0168|M.ulcerans_Agy99 TLSVDETMEIVARLRQRFAKLQDPPSDDICYATQNRQVAVKAMAPECDLV
Rv3382c|M.tuberculosis_H37Rv TLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVV
Mb3414c|M.bovis_AF2122/97 TLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVV
MMAR_0277|M.marinum_M TLAVDETTDVIDALRKRFPKLAEPPTEDICYATTNRQRAVEAIVRRCDAL
**::*** : ** :*..* :**::****** *** *::::. .*: :
Mflv_2079|M.gilvum_PYR-GCK IVVGSKNSSNSVRLVEVALGAGSRAAHLVDYAEDIDPAWLDGVTTVGVTS
Mvan_4631|M.vanbaalenii_PYR-1 IVVGSKNSSNSVRLVEVALGAGASAAHLVDYADDIDPAWFDGVTTVGVTS
MAB_1257|M.abscessus_ATCC_1997 IVVGSRNSSNSVRLVEVALNAGSRASYLVDYAEDIDPAWLEGVTTVGVTS
MSMEG_5224|M.smegmatis_MC2_155 IVVGSRNSSNSVRLVEVALNAGSDAAHLVDYADDIDPAWLDGVTTIGVTS
TH_1705|M.thermoresistible__bu IVVGSANSSNSVRLVEVALGAGADAAHLVDYADDIDPQWLEGVTTVGVTS
MLBr_01938|M.leprae_Br4923 IVVGSRNSSNSVRLVEVAMGSGAGAAYLVDWAKDIDPAWLAGVTTVGVTS
MAV_1230|M.avium_104 IVVGSRNSSNSVRLVEVALGGGAGAAHLVDWADDIDPAWLEGVTTVGVTS
MUL_0168|M.ulcerans_Agy99 LVVGSRNSSNSVRLVEVALGAGAEAAYLVDWADDIDQSWLQGVTTVGVTS
Rv3382c|M.tuberculosis_H37Rv LVIGSCNSSNSRRLVELAQRSGT-PAYLIDGPDDIEPEWLSSVSTIGVTA
Mb3414c|M.bovis_AF2122/97 LVIGSCNSSNSRRLVELAQRSGT-PAYLIDGPDDIEPEWLSSVSTIGVTA
MMAR_0277|M.marinum_M LVVGSQNSSNSQRLVELARRRGT-PAYLIDGPTDIDPHWLDSTATIGITA
:*:** ***** ****:* *: .::*:* . **: *: ..:*:*:*:
Mflv_2079|M.gilvum_PYR-GCK GASVPEILVRGVLDRLAEHGFDTVQPVTTANETLVFALPREIRPARA--
Mvan_4631|M.vanbaalenii_PYR-1 GASVPEILVRGVLDRLAEHGYDVVQPVTTANETLVFALPREIRPARQ--
MAB_1257|M.abscessus_ATCC_1997 GASVPEVLVRGVLERLAEHGYGEVQPVTTANETLVFALPRELRASRRSG
MSMEG_5224|M.smegmatis_MC2_155 GASVPEILVRGVLERLAEHGYDTVQPVTTANETLVFALPREIRPPRG--
TH_1705|M.thermoresistible__bu GASVPEILVRGVLERLAEYGFDTVQPVTTANETLVFALPREIRPARSQ-
MLBr_01938|M.leprae_Br4923 GASVPDILVQGVLKWLAERGYDVVQSVTTANEALVFALPREIRSAH---
MAV_1230|M.avium_104 GASVPEVLVQGVLERLAECGFDVVQPVTTAQETLVFALPREIRSAR---
MUL_0168|M.ulcerans_Agy99 GASVPEVLVRGVLERLAESGYDMVQPVTTANETLVFALPREIRPAR---
Rv3382c|M.tuberculosis_H37Rv GASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ----
Mb3414c|M.bovis_AF2122/97 GASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ----
MMAR_0277|M.marinum_M GASAPPRLVEQVIDALRLRGPINVVESPVTTESVRFALPPKVRVP----
***.* ** *:. * . * . : *:: *.** ::*