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MAAVDMGTPGMVSTAMRTVGPAISKRVLLAEPRGYCAGVDRAVETVERALEKHGAPVYVRHEIVHNRYVV DTLAKAGAIFVDETDEVPEGAIVVFSAHGVAPTVHEKAAERNLKTIDATCPLVTKVHQEAKRFARDDFDI LLIGHEGHEEVIGTAGEAPDHVQLVDGPNAVDNVTVRDENKVIWLSQTTLSVDETMETVQRLRERFPTLQ DPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALNAGSRASYLVDYAEDIDPAWLEG VTTVGVTSGASVPEVLVRGVLERLAEHGYGEVQPVTTANETLVFALPRELRASRRSG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1257 | ispH | - | 100% (337) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1140 | ispH | 1e-158 | 83.99% (331) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. gilvum PYR-GCK | Mflv_2079 | ispH | 1e-165 | 87.05% (332) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. tuberculosis H37Rv | Rv1110 | ispH | 1e-158 | 83.99% (331) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. leprae Br4923 | MLBr_01938 | ispH | 1e-147 | 78.48% (330) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. marinum M | MMAR_4355 | ispH | 1e-155 | 81.57% (331) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH |
| M. avium 104 | MAV_1230 | ispH | 1e-146 | 86.49% (296) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. smegmatis MC2 155 | MSMEG_5224 | ispH | 1e-164 | 91.61% (310) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. thermoresistible (build 8) | TH_1705 | ispH | 1e-163 | 86.19% (333) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. ulcerans Agy99 | MUL_0168 | ispH | 1e-155 | 81.57% (331) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
| M. vanbaalenii PYR-1 | Mvan_4631 | ispH | 1e-165 | 85.59% (333) | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4355|M.marinum_M ---MVPTIDMGIPGASSS----VAHVPTRRRVLLAEPRGYCAGVDRAVET
MUL_0168|M.ulcerans_Agy99 ---MVPTIDMGIPGASSS----VAHVPTRRRVLLAEPRGYCAGVDRAVET
Mb1140|M.bovis_AF2122/97 ---MVPTVDMGIPGASVSSR-SVADRPNRKRVLLAEPRGYCAGVDRAVET
Rv1110|M.tuberculosis_H37Rv ---MVPTVDMGIPGASVSSR-SVADRPNRKRVLLAEPRGYCAGVDRAVET
MLBr_01938|M.leprae_Br4923 MKGMPPTVNMGIPGASRS----IVENLKRKRVLLAEPRGYCAGVDRAVET
MAV_1230|M.avium_104 -------------------------------------------MDRAVET
MAB_1257|M.abscessus_ATCC_1997 ----MAAVDMGTPGMVSTAM-RTVGPAISKRVLLAEPRGYCAGVDRAVET
MSMEG_5224|M.smegmatis_MC2_155 --------------------------MSGKRVLLAEPRGYCAGVDRAVET
Mflv_2079|M.gilvum_PYR-GCK ---MPPTVNMGIPGAAS----SVVERTAGKRVLLAEPRGYCAGVDRAVET
Mvan_4631|M.vanbaalenii_PYR-1 ---MPPTVNMGIPGASRTALGSVAGDVTGKRVLLAEPRGYCAGVDRAVET
TH_1705|M.thermoresistible__bu ---MASTINMGIPGAAS----TVARPAGDRRVLLAEPRGYCAGVDRAVET
:******
MMAR_4355|M.marinum_M VERALEKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETDQVPEGAIVVF
MUL_0168|M.ulcerans_Agy99 VERALEKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETDQVPEGAIVVF
Mb1140|M.bovis_AF2122/97 VERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVF
Rv1110|M.tuberculosis_H37Rv VERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVF
MLBr_01938|M.leprae_Br4923 VERSLRKYGPPVYVRHEIVHNRHVVETLERAGAVFVEETDYVPEGAIVIF
MAV_1230|M.avium_104 VERALEKHGPPVYVRHEIVHNRHVVSTLEKAGAVFVEETDEVPEGAIVVF
MAB_1257|M.abscessus_ATCC_1997 VERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAIFVDETDEVPEGAIVVF
MSMEG_5224|M.smegmatis_MC2_155 VERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPEGAIVVF
Mflv_2079|M.gilvum_PYR-GCK VERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPEGAIVVF
Mvan_4631|M.vanbaalenii_PYR-1 VERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPEGAIVVF
TH_1705|M.thermoresistible__bu VERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPEGEIVVF
***:*.*:*.*:**********:**.** :***:**::*: **** **:*
MMAR_4355|M.marinum_M SAHGVAPTVYAAAAERNLQTIDATCPLVTKVHNEARRFARNDYDILLIGH
MUL_0168|M.ulcerans_Agy99 SAHGVAPTVYAAAAERNLQTIDATCPLVTKVHNEARRFARNDYDILLIGH
Mb1140|M.bovis_AF2122/97 SAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGH
Rv1110|M.tuberculosis_H37Rv SAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGH
MLBr_01938|M.leprae_Br4923 SAHGVAPTVYAAAAERNLRTIDATCPLVTKVHNEVKRFARNDYDILLIGH
MAV_1230|M.avium_104 SAHGVAPTVHAAAAERNLHTIDATCPLVTKVHNEARRFARNDYDILLIGH
MAB_1257|M.abscessus_ATCC_1997 SAHGVAPTVHEKAAERNLKTIDATCPLVTKVHQEAKRFARDDFDILLIGH
MSMEG_5224|M.smegmatis_MC2_155 SAHGVAPTVHQSAAERNLKVIDATCPLVTKVHNEAKRFARDDYDILLIGH
Mflv_2079|M.gilvum_PYR-GCK SAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDYDILLVGH
Mvan_4631|M.vanbaalenii_PYR-1 SAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGH
TH_1705|M.thermoresistible__bu SAHGVAPSVHVNAAERNLKVIDATCPLVTKVHNEAKRFARDDYDILLIGH
*******:*: *: *:*:.************:*.:****:*:****:**
MMAR_4355|M.marinum_M EGHEEVVGTAGEAPEHVQLVDGLDGAERVTIRDEEKVVWLSQTTLSVDET
MUL_0168|M.ulcerans_Agy99 EGHEEVVGTAGEAPEHVQLVDGLDGVERVTIRDEDKVVWLSQTTLSVDET
Mb1140|M.bovis_AF2122/97 EGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDET
Rv1110|M.tuberculosis_H37Rv EGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDET
MLBr_01938|M.leprae_Br4923 EGHEEVIATAGEAPTHVQLVDGLAAVQQVVVRDENKVVWLSQTTLSVDET
MAV_1230|M.avium_104 EGHEEVVGTAGEAPDHVQLVDGVAAVDNVTVRDEDKVVWLSQTTLSVDET
MAB_1257|M.abscessus_ATCC_1997 EGHEEVIGTAGEAPDHVQLVDGPNAVDNVTVRDENKVIWLSQTTLSVDET
MSMEG_5224|M.smegmatis_MC2_155 EGHEEVVGTAGEAPDHVQLVDGPESVDAVTVRDESKVIWLSQTTLSVDET
Mflv_2079|M.gilvum_PYR-GCK EGHEEVVGTAGEAPDHVQVVDNPDAVDNVVVRDPNKVIWLSQTTLSVDET
Mvan_4631|M.vanbaalenii_PYR-1 EGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDET
TH_1705|M.thermoresistible__bu EGHEEVIGTAGEAPDHVQIVDGPEAVDKVTVRDENKVIWLSQTTLSVDET
******:.****** ***:**. ..: *.:** .**:************
MMAR_4355|M.marinum_M MEIVARLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECDLVLVVGSRN
MUL_0168|M.ulcerans_Agy99 MEIVARLRQRFAKLQDPPSDDICYATQNRQVAVKAMAPECDLVLVVGSRN
Mb1140|M.bovis_AF2122/97 MEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
Rv1110|M.tuberculosis_H37Rv MEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MLBr_01938|M.leprae_Br4923 MRIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MAV_1230|M.avium_104 MEIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECDLVIVVGSRN
MAB_1257|M.abscessus_ATCC_1997 METVQRLRERFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MSMEG_5224|M.smegmatis_MC2_155 METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
Mflv_2079|M.gilvum_PYR-GCK METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKN
Mvan_4631|M.vanbaalenii_PYR-1 METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKN
TH_1705|M.thermoresistible__bu MEIVQKLRERFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSAN
*. * :**.:*..***************************:**:**** *
MMAR_4355|M.marinum_M SSNSVRLVEVALGAGAQAAYLVDWADDIDQSWLQGVTTVGVTSGASVPEV
MUL_0168|M.ulcerans_Agy99 SSNSVRLVEVALGAGAEAAYLVDWADDIDQSWLQGVTTVGVTSGASVPEV
Mb1140|M.bovis_AF2122/97 SSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEV
Rv1110|M.tuberculosis_H37Rv SSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEV
MLBr_01938|M.leprae_Br4923 SSNSVRLVEVAMGSGAGAAYLVDWAKDIDPAWLAGVTTVGVTSGASVPDI
MAV_1230|M.avium_104 SSNSVRLVEVALGGGAGAAHLVDWADDIDPAWLEGVTTVGVTSGASVPEV
MAB_1257|M.abscessus_ATCC_1997 SSNSVRLVEVALNAGSRASYLVDYAEDIDPAWLEGVTTVGVTSGASVPEV
MSMEG_5224|M.smegmatis_MC2_155 SSNSVRLVEVALNAGSDAAHLVDYADDIDPAWLDGVTTIGVTSGASVPEI
Mflv_2079|M.gilvum_PYR-GCK SSNSVRLVEVALGAGSRAAHLVDYAEDIDPAWLDGVTTVGVTSGASVPEI
Mvan_4631|M.vanbaalenii_PYR-1 SSNSVRLVEVALGAGASAAHLVDYADDIDPAWFDGVTTVGVTSGASVPEI
TH_1705|M.thermoresistible__bu SSNSVRLVEVALGAGADAAHLVDYADDIDPQWLEGVTTVGVTSGASVPEI
***********:..*: *::***:*.*** *: ****:*********::
MMAR_4355|M.marinum_M LVRGVLERLAESGYDMVQPVTTANETLVFALPREIRPAR---
MUL_0168|M.ulcerans_Agy99 LVRGVLERLAESGYDMVQPVTTANETLVFALPREIRPAR---
Mb1140|M.bovis_AF2122/97 LVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR---
Rv1110|M.tuberculosis_H37Rv LVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR---
MLBr_01938|M.leprae_Br4923 LVQGVLKWLAERGYDVVQSVTTANEALVFALPREIRSAH---
MAV_1230|M.avium_104 LVQGVLERLAECGFDVVQPVTTAQETLVFALPREIRSAR---
MAB_1257|M.abscessus_ATCC_1997 LVRGVLERLAEHGYGEVQPVTTANETLVFALPRELRASRRSG
MSMEG_5224|M.smegmatis_MC2_155 LVRGVLERLAEHGYDTVQPVTTANETLVFALPREIRPPRG--
Mflv_2079|M.gilvum_PYR-GCK LVRGVLDRLAEHGFDTVQPVTTANETLVFALPREIRPARA--
Mvan_4631|M.vanbaalenii_PYR-1 LVRGVLDRLAEHGYDVVQPVTTANETLVFALPREIRPARQ--
TH_1705|M.thermoresistible__bu LVRGVLERLAEYGFDTVQPVTTANETLVFALPREIRPARSQ-
**:***. *** *:. **.****:*:********:*..: