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M. tuberculosis H37Rv Rv1110 (ispH)

annotation: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
coordinates: 1236185 - 1237192
length: 335

MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHV
VDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYD
ILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKL
QDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLD
GVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1110 ispH - 100% (335) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. tuberculosis H37Rv Rv3382c lytB1 5e-81 50.97% (310) LYTB-like protein LYTB1

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1140 ispH 0.0 100.00% (335) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. gilvum PYR-GCK Mflv_2079 ispH 1e-162 84.18% (335) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. leprae Br4923 MLBr_01938 ispH 1e-158 82.88% (333) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. abscessus ATCC 19977 MAB_1257 ispH 1e-158 83.99% (331) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. marinum M MMAR_4355 ispH 1e-170 88.36% (335) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH
M. avium 104 MAV_1230 ispH 1e-155 91.22% (296) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. smegmatis MC2 155 MSMEG_5224 ispH 1e-160 89.35% (310) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. thermoresistible (build 8) TH_1705 ispH 1e-162 84.82% (336) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. ulcerans Agy99 MUL_0168 ispH 1e-170 88.66% (335) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. vanbaalenii PYR-1 Mvan_4631 ispH 1e-161 84.23% (336) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

CLUSTAL 2.0.9 multiple sequence alignment


Rv1110|M.tuberculosis_H37Rv         ---MVPTVDMGIPGASVSSR-SVADRPNRKRVLLAEPRGYCAGVDRAVET
Mb1140|M.bovis_AF2122/97            ---MVPTVDMGIPGASVSSR-SVADRPNRKRVLLAEPRGYCAGVDRAVET
MMAR_4355|M.marinum_M               ---MVPTIDMGIPGASSS----VAHVPTRRRVLLAEPRGYCAGVDRAVET
MUL_0168|M.ulcerans_Agy99           ---MVPTIDMGIPGASSS----VAHVPTRRRVLLAEPRGYCAGVDRAVET
MLBr_01938|M.leprae_Br4923          MKGMPPTVNMGIPGASRS----IVENLKRKRVLLAEPRGYCAGVDRAVET
MAV_1230|M.avium_104                -------------------------------------------MDRAVET
Mflv_2079|M.gilvum_PYR-GCK          ---MPPTVNMGIPGAAS----SVVERTAGKRVLLAEPRGYCAGVDRAVET
Mvan_4631|M.vanbaalenii_PYR-1       ---MPPTVNMGIPGASRTALGSVAGDVTGKRVLLAEPRGYCAGVDRAVET
MAB_1257|M.abscessus_ATCC_1997      ----MAAVDMGTPGMVSTAM-RTVGPAISKRVLLAEPRGYCAGVDRAVET
MSMEG_5224|M.smegmatis_MC2_155      --------------------------MSGKRVLLAEPRGYCAGVDRAVET
TH_1705|M.thermoresistible__bu      ---MASTINMGIPGAAS----TVARPAGDRRVLLAEPRGYCAGVDRAVET
                                                                               :******

Rv1110|M.tuberculosis_H37Rv         VERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVF
Mb1140|M.bovis_AF2122/97            VERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVF
MMAR_4355|M.marinum_M               VERALEKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETDQVPEGAIVVF
MUL_0168|M.ulcerans_Agy99           VERALEKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETDQVPEGAIVVF
MLBr_01938|M.leprae_Br4923          VERSLRKYGPPVYVRHEIVHNRHVVETLERAGAVFVEETDYVPEGAIVIF
MAV_1230|M.avium_104                VERALEKHGPPVYVRHEIVHNRHVVSTLEKAGAVFVEETDEVPEGAIVVF
Mflv_2079|M.gilvum_PYR-GCK          VERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPEGAIVVF
Mvan_4631|M.vanbaalenii_PYR-1       VERALEKHGAPIYVRHEIVHNRYVVDTLAKAGAIFVEQTDEVPEGAIVVF
MAB_1257|M.abscessus_ATCC_1997      VERALEKHGAPVYVRHEIVHNRYVVDTLAKAGAIFVDETDEVPEGAIVVF
MSMEG_5224|M.smegmatis_MC2_155      VERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPEGAIVVF
TH_1705|M.thermoresistible__bu      VERALEKHGAPVYVRHEIVHNRHVVETLAKAGAIFVDETDEVPEGEIVVF
                                    ***:*.*:*.*:**********:**.** :***:**::*: **** **:*

Rv1110|M.tuberculosis_H37Rv         SAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGH
Mb1140|M.bovis_AF2122/97            SAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGH
MMAR_4355|M.marinum_M               SAHGVAPTVYAAAAERNLQTIDATCPLVTKVHNEARRFARNDYDILLIGH
MUL_0168|M.ulcerans_Agy99           SAHGVAPTVYAAAAERNLQTIDATCPLVTKVHNEARRFARNDYDILLIGH
MLBr_01938|M.leprae_Br4923          SAHGVAPTVYAAAAERNLRTIDATCPLVTKVHNEVKRFARNDYDILLIGH
MAV_1230|M.avium_104                SAHGVAPTVHAAAAERNLHTIDATCPLVTKVHNEARRFARNDYDILLIGH
Mflv_2079|M.gilvum_PYR-GCK          SAHGVAPTVHVEAAARNLKTIDATCPLVTKVHNEAKRFARDDYDILLVGH
Mvan_4631|M.vanbaalenii_PYR-1       SAHGVAPTVHEEAAARHLRTIDATCPLVTKVHNEAKRFARDDYDILLVGH
MAB_1257|M.abscessus_ATCC_1997      SAHGVAPTVHEKAAERNLKTIDATCPLVTKVHQEAKRFARDDFDILLIGH
MSMEG_5224|M.smegmatis_MC2_155      SAHGVAPTVHQSAAERNLKVIDATCPLVTKVHNEAKRFARDDYDILLIGH
TH_1705|M.thermoresistible__bu      SAHGVAPSVHVNAAERNLKVIDATCPLVTKVHNEAKRFARDDYDILLIGH
                                    *******:*:  *: *:*:.************:*.:****:*:****:**

Rv1110|M.tuberculosis_H37Rv         EGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDET
Mb1140|M.bovis_AF2122/97            EGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDET
MMAR_4355|M.marinum_M               EGHEEVVGTAGEAPEHVQLVDGLDGAERVTIRDEEKVVWLSQTTLSVDET
MUL_0168|M.ulcerans_Agy99           EGHEEVVGTAGEAPEHVQLVDGLDGVERVTIRDEDKVVWLSQTTLSVDET
MLBr_01938|M.leprae_Br4923          EGHEEVIATAGEAPTHVQLVDGLAAVQQVVVRDENKVVWLSQTTLSVDET
MAV_1230|M.avium_104                EGHEEVVGTAGEAPDHVQLVDGVAAVDNVTVRDEDKVVWLSQTTLSVDET
Mflv_2079|M.gilvum_PYR-GCK          EGHEEVVGTAGEAPDHVQVVDNPDAVDNVVVRDPNKVIWLSQTTLSVDET
Mvan_4631|M.vanbaalenii_PYR-1       EGHEEVVGTAGEAPDHVQVVDNPDAVDKVTVRDPNKVIWLSQTTLSVDET
MAB_1257|M.abscessus_ATCC_1997      EGHEEVIGTAGEAPDHVQLVDGPNAVDNVTVRDENKVIWLSQTTLSVDET
MSMEG_5224|M.smegmatis_MC2_155      EGHEEVVGTAGEAPDHVQLVDGPESVDAVTVRDESKVIWLSQTTLSVDET
TH_1705|M.thermoresistible__bu      EGHEEVIGTAGEAPDHVQIVDGPEAVDKVTVRDENKVIWLSQTTLSVDET
                                    ******:.****** ***:**.  ..: *.:** .**:************

Rv1110|M.tuberculosis_H37Rv         MEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
Mb1140|M.bovis_AF2122/97            MEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MMAR_4355|M.marinum_M               MEIVARLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECDLVLVVGSRN
MUL_0168|M.ulcerans_Agy99           MEIVARLRQRFAKLQDPPSDDICYATQNRQVAVKAMAPECDLVLVVGSRN
MLBr_01938|M.leprae_Br4923          MRIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MAV_1230|M.avium_104                MEIVERLRQRFPKLQDPPSDDICYATQNRQVAVKAMAPECDLVIVVGSRN
Mflv_2079|M.gilvum_PYR-GCK          METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKN
Mvan_4631|M.vanbaalenii_PYR-1       METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSKN
MAB_1257|M.abscessus_ATCC_1997      METVQRLRERFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
MSMEG_5224|M.smegmatis_MC2_155      METVRRLREKFPTLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRN
TH_1705|M.thermoresistible__bu      MEIVQKLRERFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSAN
                                    *. * :**.:*..***************************:**:**** *

Rv1110|M.tuberculosis_H37Rv         SSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEV
Mb1140|M.bovis_AF2122/97            SSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEV
MMAR_4355|M.marinum_M               SSNSVRLVEVALGAGAQAAYLVDWADDIDQSWLQGVTTVGVTSGASVPEV
MUL_0168|M.ulcerans_Agy99           SSNSVRLVEVALGAGAEAAYLVDWADDIDQSWLQGVTTVGVTSGASVPEV
MLBr_01938|M.leprae_Br4923          SSNSVRLVEVAMGSGAGAAYLVDWAKDIDPAWLAGVTTVGVTSGASVPDI
MAV_1230|M.avium_104                SSNSVRLVEVALGGGAGAAHLVDWADDIDPAWLEGVTTVGVTSGASVPEV
Mflv_2079|M.gilvum_PYR-GCK          SSNSVRLVEVALGAGSRAAHLVDYAEDIDPAWLDGVTTVGVTSGASVPEI
Mvan_4631|M.vanbaalenii_PYR-1       SSNSVRLVEVALGAGASAAHLVDYADDIDPAWFDGVTTVGVTSGASVPEI
MAB_1257|M.abscessus_ATCC_1997      SSNSVRLVEVALNAGSRASYLVDYAEDIDPAWLEGVTTVGVTSGASVPEV
MSMEG_5224|M.smegmatis_MC2_155      SSNSVRLVEVALNAGSDAAHLVDYADDIDPAWLDGVTTIGVTSGASVPEI
TH_1705|M.thermoresistible__bu      SSNSVRLVEVALGAGADAAHLVDYADDIDPQWLEGVTTVGVTSGASVPEI
                                    ***********:..*: *::***:*.***  *: ****:*********::

Rv1110|M.tuberculosis_H37Rv         LVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR---
Mb1140|M.bovis_AF2122/97            LVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR---
MMAR_4355|M.marinum_M               LVRGVLERLAESGYDMVQPVTTANETLVFALPREIRPAR---
MUL_0168|M.ulcerans_Agy99           LVRGVLERLAESGYDMVQPVTTANETLVFALPREIRPAR---
MLBr_01938|M.leprae_Br4923          LVQGVLKWLAERGYDVVQSVTTANEALVFALPREIRSAH---
MAV_1230|M.avium_104                LVQGVLERLAECGFDVVQPVTTAQETLVFALPREIRSAR---
Mflv_2079|M.gilvum_PYR-GCK          LVRGVLDRLAEHGFDTVQPVTTANETLVFALPREIRPARA--
Mvan_4631|M.vanbaalenii_PYR-1       LVRGVLDRLAEHGYDVVQPVTTANETLVFALPREIRPARQ--
MAB_1257|M.abscessus_ATCC_1997      LVRGVLERLAEHGYGEVQPVTTANETLVFALPRELRASRRSG
MSMEG_5224|M.smegmatis_MC2_155      LVRGVLERLAEHGYDTVQPVTTANETLVFALPREIRPPRG--
TH_1705|M.thermoresistible__bu      LVRGVLERLAEYGFDTVQPVTTANETLVFALPREIRPARSQ-
                                    **:***. *** *:. **.****:*:********:*..:

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1110	ispH	-	100% (335)	4-hydroxy-3-methylbut-2-enyl diphosphate reductase
M. tuberculosis H37Rv	Rv3382c	lytB1	5e-81	50.97% (310)	LYTB-like protein LYTB1