For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIGKDAEGSPVLVDTGNRLGRRGAAWGAG VGLAIGLFSPALLASAALGAATGALAGTFAHHRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALA SSPMKSVAELSRSTLRSLGAALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWSIVPGPFPPDDA PNVLIVLIDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYNRFHVTAVCSPTRAALLTGRNHHRVGFGSVCE FPGPYPGYSAVRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGAA GQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWLHTVRAQNATKPWMLYYATGATHAPHHVFK EWADKYRGEFDDGWDVYRQKTFERQKRLGIIPPDAELTERPDLFPAWDSMSEAQKRLFARQMEVFAGFSE NADWNVGRLLDAIEDLGESDNTLVFYIWGDNGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIA ALGDEFTAPHFASAWAHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCIDIAPTVLA AIGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYKDGWWACARLDKAPWDLSPE TMRRFAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDKVAELTQLWWQEAERNRVLPLLGGLAVMFGDL PPLPTTARFSFKGDVQNIQRGMVPRICGRSYAIEARLHIPDGGAQGVIVANADFMGGFALWVDEQRHLHH TYSFLGVETYRQVSSEPLPTGDVTVRMLFDSHQPVAASGGRVTLWADDRLIGEGELPQTVPLAFTSYAGM DIGRDNGLVVDRGYEDKAPYAFTGTVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv3299c | atsB | - | 100% (970) | PROBABLE ARYLSULFATASE ATSB (ARYL-SULFATE SULPHOHYDROLASE) (SULFATASE) |
M. tuberculosis H37Rv | Rv0663 | atsD | e-177 | 43.80% (774) | arylsulfatase AtsD |
M. tuberculosis H37Rv | Rv0711 | atsA | e-142 | 37.56% (796) | arylsulfatase AtsA |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3327c | atsB | 0.0 | 99.90% (970) | arylsulfatase AtsB |
M. gilvum PYR-GCK | Mflv_5039 | - | 1e-136 | 36.17% (788) | sulfatase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_4307 | - | 1e-140 | 38.24% (774) | arylsulfatase AtsA |
M. marinum M | MMAR_1232 | atsB | 0.0 | 85.86% (969) | arylsulfatase AtsB (aryl-sulfate sulphohydrolase) |
M. avium 104 | MAV_4461 | - | 1e-139 | 37.66% (794) | arylsulfatase |
M. smegmatis MC2 155 | MSMEG_1451 | - | 1e-140 | 36.89% (797) | arylsulfatase |
M. thermoresistible (build 8) | TH_0315 | - | 1e-141 | 36.65% (813) | arylsulfatase |
M. ulcerans Agy99 | MUL_2658 | atsB | 0.0 | 85.14% (969) | arylsulfatase AtsB (aryl-sulfate sulphohydrolase) |
M. vanbaalenii PYR-1 | Mvan_4467 | - | 1e-177 | 44.10% (780) | sulfatase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5039|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_1451|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4461|M.avium_104 -------------------------------------------------- TH_0315|M.thermoresistible__bu -------------------------------------------------- MAB_4307|M.abscessus_ATCC_1997 -------------------------------------------------- Rv3299c|M.tuberculosis_H37Rv MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIGKDAEG Mb3327c|M.bovis_AF2122/97 MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIGKDAEG MMAR_1232|M.marinum_M -MSEENTLVIVAGYQDLDAAQHDFENLTGRANAKTLPLQGAVLVGKDNEG MUL_2658|M.ulcerans_Agy99 -MSEENTLVIVAGYQDLDAAQHDFENLTGRANAKTLPLQGAVLVGKDNEG Mvan_4467|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5039|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_1451|M.smegmatis_MC2_155 -------------------------------------------------- MAV_4461|M.avium_104 -------------------------------------------------- TH_0315|M.thermoresistible__bu -------------------------------------------------- MAB_4307|M.abscessus_ATCC_1997 -------------MHIPGDDAPEPEQNAERGRLTRRSMLGGIAAAGMGVA Rv3299c|M.tuberculosis_H37Rv SPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTF Mb3327c|M.bovis_AF2122/97 SPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTF MMAR_1232|M.marinum_M NPVLIDTGNRLGRRGAAWGAGAGLAVGLFSPALLASTAVGAAAGALAGTF MUL_2658|M.ulcerans_Agy99 NPVLIDTGNRLGRRGAAWGAGAGLAVGLVSPALLASTAVGAAAGALAGTF Mvan_4467|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_5039|M.gilvum_PYR-GCK -------------------------MTTEFNG------------------ MSMEG_1451|M.smegmatis_MC2_155 -------------------------MAAEFNG------------------ MAV_4461|M.avium_104 -------------------MVAGSGQSAEFSG------------------ TH_0315|M.thermoresistible__bu --------------------------MADFGG------------------ MAB_4307|M.abscessus_ATCC_1997 AASALVAGCDDDSSSRTDRSSAAEEANAGFNG------------------ Rv3299c|M.tuberculosis_H37Rv AHHRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAE Mb3327c|M.bovis_AF2122/97 AHHRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAE MMAR_1232|M.marinum_M IQHRVKSGLADKIGQALSAGSAVVIAVTPAQGRLPVEQTLSGSPMKSVAE MUL_2658|M.ulcerans_Agy99 IQHRVKSGLADKIGQALSAGSAVVIAVTPAQGRLPVEQTLSGSPMKSVAE Mvan_4467|M.vanbaalenii_PYR-1 -------------------MRRDILPIPDPQ------------------- . Mflv_5039|M.gilvum_PYR-GCK -------KIALDIRDSEPDWGPFAAPT----------------------- MSMEG_1451|M.smegmatis_MC2_155 -------KIELDIRDSEPDWGPFAAPT----------------------- MAV_4461|M.avium_104 -------RVELDIRDSEPDWGPYAAPT----------------------- TH_0315|M.thermoresistible__bu -------KIELDIRDSEPDWGPFAAPT----------------------- MAB_4307|M.abscessus_ATCC_1997 -------KIELDVRDSKPDWTPYELKH----------------------- Rv3299c|M.tuberculosis_H37Rv LSRSTLRSLGAALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWS Mb3327c|M.bovis_AF2122/97 LSRSTLRSLGAALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWS MMAR_1232|M.marinum_M LSRSTMRSLGAALQEAMGKFNPDRTKLPIPQRSFGGTIGRTMAESVGDWT MUL_2658|M.ulcerans_Agy99 LSRSTMRSLGAALQEAMGKFNPDRTKLPIPQR----TIGRTMAESVGDWT Mvan_4467|M.vanbaalenii_PYR-1 -------HVGLTTYDAK---DPDTTYPPITPLR----------------- : :: * Mflv_5039|M.gilvum_PYR-GCK ------AQPEAPNVLYLVWDDIGIATWDCFGGLVDMPAMSRIAERGVRLS MSMEG_1451|M.smegmatis_MC2_155 ------AAEGAPNVLYVVWDDIGIATWDCFGGLVEMPAMSRIAEHGVRLS MAV_4461|M.avium_104 ------APPNAPNILYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLS TH_0315|M.thermoresistible__bu ------APEGAPNILYVVWDDVGIGTWDCFGGLVEMPTMSRIAEQGVRLS MAB_4307|M.abscessus_ATCC_1997 ------APDGAPNVLVVLFDDTGMATWSPYGGRVNMPTLQRLADNGLTYS Rv3299c|M.tuberculosis_H37Rv IVPGPFPPDDAPNVLIVLIDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYN Mb3327c|M.bovis_AF2122/97 IVPSPFPPDDAPNVLIVLIDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYN MMAR_1232|M.marinum_M IVAGANAPDDAPNLLIVLIDDAGFGGPDTFGGGIRTPTLSRVANNGLAYN MUL_2658|M.ulcerans_Agy99 IVAGANAPDDAPNVLIVLIDDAGFGGPDTFGGGIRTPTLSRVANNGLAYN Mvan_4467|M.vanbaalenii_PYR-1 ------PPQGAPNVLIVLLDDVGFGASSAFGGPCATPTAERLAANGLKLN . ***:* :: ** *:. . :** *: .*:* .*: . Mflv_5039|M.gilvum_PYR-GCK QFHTTALCSPTRASLLTGRNATTVGMATIEEFTDGFPNCNGRIPFDTALL MSMEG_1451|M.smegmatis_MC2_155 QFHTTALCSPTRAALLTGRNPTTVGMATIEEFTDGFPNCSGRIPFETALL MAV_4461|M.avium_104 QFHTTALCSPTRAALLTGRNATTVGMATIEEFTEGFPNANGRIPFDTALL TH_0315|M.thermoresistible__bu QFHTTALCSPTRAALLTGRNPTTVGMATIEEFTDGFPNCSGRIPVDTGLI MAB_4307|M.abscessus_ATCC_1997 QWHTTALCSPTRSCLLTGRNHHVNRFASITEGSDGYPGAAGRLPAQCATI Rv3299c|M.tuberculosis_H37Rv RFHVTAVCSPTRAALLTGRNHHRVGFGSVCEFPGPYPGYSAVRPRSCAAL Mb3327c|M.bovis_AF2122/97 RFHVTAVCSPTRAALLTGRNHHRVGFGSVCEFPGPYPGYSAVRPRSCAAL MMAR_1232|M.marinum_M RFHLTAICSPTRAALLTGRNHHRVGFGSVCELPGPYPGYSTVKPRSCAAL MUL_2658|M.ulcerans_Agy99 RFHLTAICSPTRAALLTGRNHHRVGFGSVCELPGPYPGYSTVKPRSCAAL Mvan_4467|M.vanbaalenii_PYR-1 RFHTTALCSPTRQALLTGRNHHSVGMGGVTEIATSAPGYSSIRPKDKAPV ::* **:***** .****** :. : * . *. * . . : Mflv_5039|M.gilvum_PYR-GCK SEVLSENGYNTYCIGKWHLTPLEESNLAATKRHWPLSRGFERFYGFMGGE MSMEG_1451|M.smegmatis_MC2_155 PEVLAENGYNTYCIGKWHLTPLEESNLASTKRHWPCSRGFERFYGFMGGE MAV_4461|M.avium_104 SEALAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFERFYGFLGGE TH_0315|M.thermoresistible__bu SEVLAEHGWNTYCVGKWHLTPLEESNMAATKRHWPVSRGFERFYGFLGGE MAB_4307|M.abscessus_ATCC_1997 GQVLQDNGYSTFWVGKNHNVPQEDVSCGGSKSEWPLQKGFDRYYGFLGGE Rv3299c|M.tuberculosis_H37Rv PRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGA Mb3327c|M.bovis_AF2122/97 PRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGA MMAR_1232|M.marinum_M PRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGA MUL_2658|M.ulcerans_Agy99 PRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGA Mvan_4467|M.vanbaalenii_PYR-1 AETLRLNGYSTSQFGKCHEVPVWEVSPVGPFGQWPTGSGFEHFYGFIGGE . * :*: * .** * .* . .. .** **::::** .* Mflv_5039|M.gilvum_PYR-GCK TDQWYPDLMYDNHPVAPPAT---PEEGYHLSKDLADKTIEFIRDSKVIAP MSMEG_1451|M.smegmatis_MC2_155 TDQWYPDLTYDNHPVDPPAT---PEEGYHLSKDLADKTIEFIRDAKVVAS MAV_4461|M.avium_104 TDQWYPDLVYDNHPVSPPAT---PEDGYHLSKDLADKTIEFIRDAKVIAP TH_0315|M.thermoresistible__bu TDQWYPDLVHDNHPVAPPAT---PEDGYHLSKDLADKTIEFIRDAKVIAP MAB_4307|M.abscessus_ATCC_1997 TNNWYPDLVEDNRFIEQPTS---PEQGYHLSKDLADQALRMLRDQRNTNP Rv3299c|M.tuberculosis_H37Rv AGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWLHTVRAQNA Mb3327c|M.bovis_AF2122/97 AGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWLHTVRAQNA MMAR_1232|M.marinum_M AGQYDPIITQDNSVLGIPQG--DDGKPYFFPDDLTDKAIEWLHTVRAQNA MUL_2658|M.ulcerans_Agy99 AGQYDPIITQDNSVLGIPQG--DDGKPYFFPDDLTDKAIEWLHTVRAQNA Mvan_4467|M.vanbaalenii_PYR-1 ANQYYPGLYEGTKPVEPEKT---PEQGYTLTEDLADRAITWVRQQQALTP :.:: * : .. : * :..**:*::: :: : . Mflv_5039|M.gilvum_PYR-GCK DKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYEAYREIVLENQKRLG MSMEG_1451|M.smegmatis_MC2_155 DKPWFTYLCPGAGHAPHHVFKEWADRYKGRFDMGYERYREIVLENQKRMG MAV_4461|M.avium_104 EKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYERYREVVLERQKAMG TH_0315|M.thermoresistible__bu DKPWFTYLCPGAGHAPHHAPRDWADRYAGRFDMGYERYREVVLENQKKLG MAB_4307|M.abscessus_ATCC_1997 SKPWYMWFCPGANHAPHHSPAEYADKYRGKFDDGYEAYREWVLARMIDKG Rv3299c|M.tuberculosis_H37Rv TKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLG Mb3327c|M.bovis_AF2122/97 TKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLG MMAR_1232|M.marinum_M TKPWLLYYSTGATHAPHHVFKEWADKYQGQFDEGWDVYRQKTFERQKELG MUL_2658|M.ulcerans_Agy99 TKPWLLYYSTGATHAPHHVFKEWADKYQGQFDEGWDVYRQKTFERQKELG Mvan_4467|M.vanbaalenii_PYR-1 DKPFFMYFAPGATHAPHHVPKQWSDKYRGKFDDGWDVLRESMLDNQKALG **: : ..** ***** :::*:* *.** *:: *: : . * Mflv_5039|M.gilvum_PYR-GCK LVPPDTELSAVNPYLDVKGPDGQDWPAQDTVRPWDSLSEDEKRLFARMAE MSMEG_1451|M.smegmatis_MC2_155 LVPPDTELSPVNPYSEVTGPDGQPWPAQDTVRPWDSLSDDEKALFCRMAE MAV_4461|M.avium_104 IVPSDTELSPVNPYLDVTGPSGEPWPLQDTVRPWDSLNDEEKKLFARMAE TH_0315|M.thermoresistible__bu IVPPDTELPPINPYQDVKGPHGEPWPLQDTVRPWDSLSDAEKRLFCRMAE MAB_4307|M.abscessus_ATCC_1997 IMPRETKLTPINPLPNDVAVEA------DSVRPWNTLNPDEKRLFSRMAE Rv3299c|M.tuberculosis_H37Rv IIPPDAELTERP----------------DLFPAWDSMSEAQKRLFARQME Mb3327c|M.bovis_AF2122/97 IIPPDAELTERP----------------DLFPAWDSMSEAQKRLFARQME MMAR_1232|M.marinum_M IIPPDAELTERP----------------DLFPAWDSLSEAQQKLFARQME MUL_2658|M.ulcerans_Agy99 IIPPDAELTERP----------------DLFPAWDSLSEAQQKLFARQME Mvan_4467|M.vanbaalenii_PYR-1 VVPEDAQLTARH----------------DEIPAWDDMPDVLKPVLARQME ::* :::*. * . .*: : : ::.* * Mflv_5039|M.gilvum_PYR-GCK VFAGFLSYTDAQIGRVLDYLEESGQLDNTVIVVIS-DNGASGEGGPNGSV MSMEG_1451|M.smegmatis_MC2_155 VFAGFLSYTDAQIGRVLDYLEESGQIDNTIIVVIS-DNGASGEGGPNGSV MAV_4461|M.avium_104 VFAGFLSYTDAQIGRILDYLEESGQLDDTIIVVIS-DNGASGEGGPNGSV TH_0315|M.thermoresistible__bu VFAGFLSYTDHQIGRVLDYLEESDQLDNTLIVVLS-DNGASGEGGPDGSV MAB_4307|M.abscessus_ATCC_1997 VFAGFSEYTDAQVGRVIDYLEQTGQLDNTVVFYCA-DNGASGEGSPNGSV Rv3299c|M.tuberculosis_H37Rv VFAGFSENADWNVGRLLDAIEDLGESDNTLVFYIWGDNGASMEGTNTGSF Mb3327c|M.bovis_AF2122/97 VFAGFSENADWNVGRLLDAIEDLGESDNTLVFYIWGDNGASMEGTNTGSF MMAR_1232|M.marinum_M VFAGFSENADWNVGRLLDAIDGLGESDNTLVFYIWGDNGASMEGTNTGSF MUL_2658|M.ulcerans_Agy99 VFAGFSENADWNVGRLLDAIDGLGESDNTLVFYIWGDNGASMEGTNTGSF Mvan_4467|M.vanbaalenii_PYR-1 IYAGFLEQTDHEIGRLVDAIDDLGALDNTLIYYIIGDNGASAEGTPNGCF ::*** . :* ::**::* :: . *:*:: ***** ** *.. Mflv_5039|M.gilvum_PYR-GCK NEVKFFNGYID--SAEESLKVFDELGGPQTYN------HYPIGWAMAFNT MSMEG_1451|M.smegmatis_MC2_155 NETKFFNGYID--TAEEGLKFIDKLGGPQTYN------HYPIGWAMAFNT MAV_4461|M.avium_104 NEGKFFNGYID--TVEESMKLFDQLGGPQTYN------HYPIGWAMAFNT TH_0315|M.thermoresistible__bu NEVKFFNGYVD--TVEESMRFYDQLGGPQTYN------HYPTGWAMAFNT MAB_4307|M.abscessus_ATCC_1997 NENKFFNGYPD--DLAENMKYIDRLGTPDTYN------HYPTGWAVAFST Rv3299c|M.tuberculosis_H37Rv NEMTFLNGLD--LDAERQLELIEQYGGIAALGDEFTAPHFASAWAHASNT Mb3327c|M.bovis_AF2122/97 NEMTFLNGLD--LDAERQLELIEQYGGIAALGDEFTAPHFASAWAHASNT MMAR_1232|M.marinum_M NEMTFLNGLD--LDAERQLELIEQYGGIEALGDEFTAPHFASAWAHANNT MUL_2658|M.ulcerans_Agy99 NEMTFLNGLD--LDAERQLELIEQYGGIEALGDEFTAPHFASAWAHANNT Mvan_4467|M.vanbaalenii_PYR-1 NEMCTLNGLAGIETPEFLLSKIDDFGTPDAYN------HYAVGWAHALCG ** :** : : * : . *:. .** * Mflv_5039|M.gilvum_PYR-GCK PYKLFKRYASHEGGIADTAIISWPKGIAAHGEIRDNYVNVADITPTVYDL MSMEG_1451|M.smegmatis_MC2_155 PYKLFKRYASHEGGIADPAIISWPKGIAARGEVRDNYVNVCDVTPTVYDM MAV_4461|M.avium_104 PYKLYKRYASHEGGIADTAIISWPNGIAAHGEIRDNYVNVCDITPTVYDL TH_0315|M.thermoresistible__bu PYKLFKRYASHEGGIADPAIISWPNGITARDAVCDRYINVVDVTPTVYEL MAB_4307|M.abscessus_ATCC_1997 PFQMFKRYSQFSGGTCDPLVIHWPKGIKAKGEVRHQYHHVTDIVPTILDV Rv3299c|M.tuberculosis_H37Rv PLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCIDIAPTVLAA Mb3327c|M.bovis_AF2122/97 PLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCIDIAPTVLAA MMAR_1232|M.marinum_M PFQWGKQMASHLGGTRDPMVVCWPSRIPREGGIRSQFTHCIDIAPTVLQA MUL_2658|M.ulcerans_Agy99 PFQWGKQMASHLGGTRDPMVACWPSRIPREGGIRSQFTHCIDIAPTVLQA Mvan_4467|M.vanbaalenii_PYR-1 PYQWTKQVASHWGGTRNGTIVHWPNGIAAKGETRNQFHHVIDVVPTILEA * : *: :.. ** : : ** * . .: : *:.**: Mflv_5039|M.gilvum_PYR-GCK LDITPPATVRGVAQKPLDGVSFKVALENPNAPTGKETQFYTMLGTRGIWH MSMEG_1451|M.smegmatis_MC2_155 LGITPPATVRGVPQKPLDGVSFKAALADPDAPTGKETQFYAMLGTRGIWH MAV_4461|M.avium_104 LGMSPPETVKGIAQKPLDGVSFKAALDDPNADTGKTTQFYTMLGTRGIWH TH_0315|M.thermoresistible__bu IGLTPPDTVRGVRQRPLEGVSFRAALADPDADTGKRTQFYSMLGTRGIWS MAB_4307|M.abscessus_ATCC_1997 AGLTMPETYRGVDQFPVNGVSMRYTFDDKDAATTKKRQYYAMLGTRGIWE Rv3299c|M.tuberculosis_H37Rv IGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYK Mb3327c|M.bovis_AF2122/97 IGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYK MMAR_1232|M.marinum_M IGLPEPTSVDGFEQEPMDGTSFVHTFDDAQAEERHTVQYFENFGSRSIYQ MUL_2658|M.ulcerans_Agy99 IGLPEPTSVDGFEQEPMDGTSFVHTFDDAQAEERHTVQYFENFGSRSIYQ Mvan_4467|M.vanbaalenii_PYR-1 AKLPAPTVVNSIQQAPLEGVSMMSTLRDRDADETHTVQYFEMFGNRGIYH :. * .. * *::*.*: :: : :* : *:: :*.*.*: Mflv_5039|M.gilvum_PYR-GCK RGWFANTVHAASPAGWS------------HFDDDRWELYHVDADRSQVHD MSMEG_1451|M.smegmatis_MC2_155 KGWFANTVHAATPSGWG------------HFADDRWELFHIDADRSQCHD MAV_4461|M.avium_104 EGWFANTVHAATPAGWS------------HFDADRWELFHIEADRSQCHD TH_0315|M.thermoresistible__bu DGWFANTVHAASPAGWS------------NFDADRWELYHLESDRSQSRD MAB_4307|M.abscessus_ATCC_1997 DGWKASALHAP-ISGKG------------HFDQDKWELFHVDEDRSESTD Rv3299c|M.tuberculosis_H37Rv DGWWACARLDKAPWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKN Mb3327c|M.bovis_AF2122/97 DGWWACARLDKAPWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKN MMAR_1232|M.marinum_M DGWWACARLDKAPWDLSPQTMARFSPGNYDPEKDVWELYYLPDDFSQARN MUL_2658|M.ulcerans_Agy99 DGWWACARLDKAPWDLSPQTMARFSPGNYDPEKDVWELYYLPDDFSQARN Mvan_4467|M.vanbaalenii_PYR-1 KGWTAVT-KHRTPWIADQPPL----------DEDVWELY-APDDWTQAHD ** * : . * ***: * :: : Mflv_5039|M.gilvum_PYR-GCK LAAEYPEKLDELKALWFSEAQKYNGLPLGDLDIFETMSR--WRPTLSGER MSMEG_1451|M.smegmatis_MC2_155 LAAEHPDRLEELKALWFSEADKYNGLPLGDLSILETTTR--WRPYLTGER MAV_4461|M.avium_104 LAAENPDKLEELKALWFAEAARYNGLPLSDLNILETMTR--SRPYLVGER TH_0315|M.thermoresistible__bu LAAEHPEKLEELKQLWFDEAAKYNGLPLGDLNLFETLGR--WRPHLSRGR MAB_4307|M.abscessus_ATCC_1997 LADQHPDKLKALIDAWFEEADNNFVLPLDDRLPTELLTI--ERPQFEPRR Rv3299c|M.tuberculosis_H37Rv LAAEHPDKVAELTQLWWQEAERNRVLPLLGGLAVMFG----DLPPLP-TT Mb3327c|M.bovis_AF2122/97 LAAEHPDKVAELTQLWWQEAERNRVLPLLGGLAVMFG----DLPPLP-TT MMAR_1232|M.marinum_M VAAEHPDKLAELRELWWQEAERNRVLPLLGGLAVMYG----ELPPLP-TT MUL_2658|M.ulcerans_Agy99 VAAEHPDKLAELRELWWQEAERNRVLPLLGGLAVMYG----ELPPLP-TI Mvan_4467|M.vanbaalenii_PYR-1 LAAEQPERLAALQRLWLIEAVKYNVVPLDDRSFERFNPDIAGRPQLI-KG :* : *::: * * ** . :** . * : Mflv_5039|M.gilvum_PYR-GCK SAYVYYPGTADVGIGAVVELRGRSFAVLAEVEVDPGGANGVVVKHGGAHG MSMEG_1451|M.smegmatis_MC2_155 TSYTYYPHTAEVGMGAVVELRGQSFKVLAEVTVDSAEAQGVIFKHGGAHG MAV_4461|M.avium_104 DSYVYYPDCADVGIGAAAEIRGRSFSVLAEATVDTTGAEGVLFKQGGAHG TH_0315|M.thermoresistible__bu TSYTYYPGTAEVGLGAAVDIRGQSFTVLADVTVDAAGAQGVIVKHGAGHG MAB_4307|M.abscessus_ATCC_1997 NRYLYYPDASPVPEGVAVNIRGKSYKIVANTDIS-AQAQGVIFAHGSRFG Rv3299c|M.tuberculosis_H37Rv ARFSFKGDVQNIQRGMVPRICGRSYAIEARLHIPDGGAQGVIVANADFMG Mb3327c|M.bovis_AF2122/97 ARFSFKGDVQNIQRGMVPRICGRSYAIEARLHIPDGGAQGVIVANADFMG MMAR_1232|M.marinum_M TRFAFQGGVQNIQRGMVPRVFGRSYAIEARLHIPDGGAEGVIVANADFMG MUL_2658|M.ulcerans_Agy99 TRFAFQGGVQNIQRGMVPRVFGRSYAIEARPHIPDGGAEGVIVANADFMG Mvan_4467|M.vanbaalenii_PYR-1 TTQTLFSGMRLLEN-CVLNIKNRSHAVSALISVPDSGAQGVIVSQGGGVG : . : .:*. : * : *:**:. :. * Mflv_5039|M.gilvum_PYR-GCK GYVMYLQGG-RLHFCYNFLGEYEQTLAAPDPVPPGLHTLGFTYTVTGTAE MSMEG_1451|M.smegmatis_MC2_155 GHVLFIADG-HLHYVYNFLGEREQVLSAPDPVPLGHHIFGVRYERTGTVP MAV_4461|M.avium_104 GHVLFIQDG-RLHYVYNFLGERQQEVSSSVPVPLGRHLFGASYARTGTVP TH_0315|M.thermoresistible__bu GYVLFLQDG-RLHFVYNFMGEEEQRVSSADPIPAGRHILGVSYHRTGTVD MAB_4307|M.abscessus_ATCC_1997 GHVLFIKDG-RLHYVYNFLGIKPEQEFISAPLTPGNRTLGVEFVRRDKGQ Rv3299c|M.tuberculosis_H37Rv GFALWVDEQRHLHHTYSFLGVETYRQVSSEPLPTGDVTVRMLFDSHQPV- Mb3327c|M.bovis_AF2122/97 GFALWVDEQRHLHHTYSFLGVETYRQVSSEPLPTGDVTVRMLFDSHQPV- MMAR_1232|M.marinum_M GFALWVDEQRRLHHTYSFLGIETYRQVSTEPVPTGDVTVRMLFESEAPV- MUL_2658|M.ulcerans_Agy99 GFALWVDEQRRLHHTYSFLGIETYRQVSTEPVPTGDVTVRMLFESEAPV- Mvan_4467|M.vanbaalenii_PYR-1 GWCVYAHEN-TLKYCYNFFGIEYYFVTAELPLPGGQHLVGFEFAYDGGG- * :: *:. *.*:* *:. * . : Mflv_5039|M.gilvum_PYR-GCK GSHTPIGDAELFLDTERVASLAEMRSQPGTFGLAGASLSVGRNNGSPVSE MSMEG_1451|M.smegmatis_MC2_155 NSHTPVGVATLFVDGGAVADLADVQTHPAIFALAGGGIAVGRNTGSGVSR MAV_4461|M.avium_104 DSHTPLGDLTLFIDDEVVGTLAGVSTHPGTFGLAGAGITVGRNGGSGVSS TH_0315|M.thermoresistible__bu GSHTPLGEVALYVDGTVVATRPDVRAHPANFGLAGGGIAVGRNTGQPVSS MAB_4307|M.abscessus_ATCC_1997 YGES-LGTTNLYVDGKLAATGP-MRTQVGTFTLAGDGLCVGYDSGDNVSP Rv3299c|M.tuberculosis_H37Rv --AASGGRVTLWADDRLIGEGELPQTVPLAFTSYAG-MDIGRDNGLVVDR Mb3327c|M.bovis_AF2122/97 --AASGGRVTLWADDRLIGEGELPQTVPLAFTSYAG-MDIGRDNGLVVDR MMAR_1232|M.marinum_M --IGSGGRVTLWANDRLIGEGELPQTVTLAFTSYAG-LDVGRDNGLVVDR MUL_2658|M.ulcerans_Agy99 --VGSGGRVTLWANDRLIGEGELPQTVTLAFTSYAG-LDVGRDNGLVVDR Mvan_4467|M.vanbaalenii_PYR-1 --LGKGGTVTLYCDGEPVGTGRVERTEPMAFSADEA-CDVGSDTGSPTSP * *: : . : * :* : * .. Mflv_5039|M.gilvum_PYR-GCK AY--HPPFAFAGGRIARVNIDTS---GAPYVDLERDFARAFARD---- MSMEG_1451|M.smegmatis_MC2_155 SY--RVPFPFTGGEIAQVTVDLS---GEPYEDLVTRRATAFARD---- MAV_4461|M.avium_104 RF--KAPFVFTGGTIARVTLDLS---GRPYRDVETEIALAFSRD---- TH_0315|M.thermoresistible__bu AY--RAPFAFTGGSIAKVIVDIS---GTPYRDVEREAAMAFARD---- MAB_4307|M.abscessus_ATCC_1997 QY--TNPGRFTGGTIKVVAVDVS---DESFIDLEKEAQAAFARD---- Rv3299c|M.tuberculosis_H37Rv GYEDKAPYAFTG-TVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG Mb3327c|M.bovis_AF2122/97 GYEDKAPYAFTG-TVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG MMAR_1232|M.marinum_M DYEDKAPYTFSG-TVKEVVFDLKPVHPDAEKALHEHASIQAVGQGAAG MUL_2658|M.ulcerans_Agy99 DYEDKALYMFSG-TVKEVVFDLKPVHPDAEKALHEHASIQAVGQGAAG Mvan_4467|M.vanbaalenii_PYR-1 DYGPHG-NGFNG-RIDWVKIDISTDDHEHLITPQDRFNISMARQ---- : * * : * .* . :