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M. tuberculosis H37Rv Rv0663 (atsD)

annotation: POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE)
coordinates: 756137 - 758500
length: 787

MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLILLDDVGFGASSAFGGPCRTSTA
ELLAGNGLRYNRFHTTALCSPTRQALLTGRNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGY
NTAQFGKCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTPVEVNRTPEEGYHFM
ADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPHHVPREWADKYRGRFDVGWDALREETFARQKELGV
IPADCQLTARHAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLVDGLQRLGVLDDTLVFYIIDD
NGASAEGTINGTYNEMLNFNGLADIETPRFMTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWG
GTRNGTIVHWPNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMAYSFDDAQAPD
RHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAFDDDVWELYDTTKDWSQAKDLAKEMPEKLHE
LQRLWLIEATRYNVLPLDDDTASRINPDLAGRPVLIRGNTQVLFSNMGRLSENCVLNLKNKSHTVTAEVE
VPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPLPAGAHQVRMEFAYAGGGLGKG
GEVTLYVDGQQVGEGHVEATLAIVFSADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAA
GHLVDPEHAIRIALARQ
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0663atsD-100% (787)POSSIBLE ARYLSULFATASE ATSD (ARYL-SULFATE SULPHOHYDROLASE) (ARYLSULPHATASE)
M. tuberculosis H37RvRv3299catsBe-17743.80% (774) arylsulfatase AtsB
M. tuberculosis H37RvRv0711atsAe-14838.74% (764) arylsulfatase AtsA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0682atsD0.099.87% (787) arylsulfatase AtsD
M. gilvum PYR-GCKMflv_5039-1e-15839.92% (799) sulfatase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4307-1e-15940.38% (790) arylsulfatase AtsA
M. marinum MMMAR_4950atsD0.067.05% (783) arylsulfatase AtsD
M. avium 104MAV_4461-1e-15439.10% (780) arylsulfatase
M. smegmatis MC2 155MSMEG_1451-1e-15540.63% (758) arylsulfatase
M. thermoresistible (build 8)TH_0315-1e-16041.77% (759) arylsulfatase
M. ulcerans Agy99MUL_0454atsD0.065.86% (785) arylsulfatase AtsD
M. vanbaalenii PYR-1Mvan_4467-0.067.18% (783) sulfatase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5039|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_1451|M.smegmatis_MC2_155      --------------------------------------------------
MAV_4461|M.avium_104                --------------------------------------------------
TH_0315|M.thermoresistible__bu      --------------------------------------------------
MAB_4307|M.abscessus_ATCC_1997      MHIPGDDAPEPEQNAERGRLTRRSMLGGIAAAGMGVAAASALVAGCDDDS
Rv0663|M.tuberculosis_H37Rv         --------------------------------------------------
Mb0682|M.bovis_AF2122/97            --------------------------------------------------
MMAR_4950|M.marinum_M               ----------------------------MAKAAK-TPAKKSSTGAASDAH
MUL_0454|M.ulcerans_Agy99           --MGAWQGSEAAAARVSEAVKPIDKEVMMAKAAKKTPAKKSSTGAASDAH
Mvan_4467|M.vanbaalenii_PYR-1       --------------------------------------------------
                                                                                      

Mflv_5039|M.gilvum_PYR-GCK          ------------MTTEFNGKIALDIRDSEPDWGPFAAPTAQPEAPNVLYL
MSMEG_1451|M.smegmatis_MC2_155      ------------MAAEFNGKIELDIRDSEPDWGPFAAPTAAEGAPNVLYV
MAV_4461|M.avium_104                ------MVAGSGQSAEFSGRVELDIRDSEPDWGPYAAPTAPPNAPNILYL
TH_0315|M.thermoresistible__bu      -------------MADFGGKIELDIRDSEPDWGPFAAPTAPEGAPNILYV
MAB_4307|M.abscessus_ATCC_1997      SSRTDRSSAAEEANAGFNGKIELDVRDSKPDWTPYELKHAPDGAPNVLVV
Rv0663|M.tuberculosis_H37Rv         --MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLI
Mb0682|M.bovis_AF2122/97            --MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLI
MMAR_4950|M.marinum_M               REPHLAREYLPIPDPKHVGLTTYDAKDPNTKYPPIKQLRPPQGAPNVLIV
MUL_0454|M.ulcerans_Agy99           REPHLAREHLPIPDPKHVGLTTYDAKDPNTKYPPIKQLCPSQGAPNVLIV
Mvan_4467|M.vanbaalenii_PYR-1       ----MRRDILPIPDPQHVGLTTYDAKDPDTTYPPITPLRPPQGAPNVLIV
                                                  .   *    * :*... : *     .   ***:* :

Mflv_5039|M.gilvum_PYR-GCK          VWDDIGIATWDCFGGLVDMPAMSRIAERGVRLSQFHTTALCSPTRASLLT
MSMEG_1451|M.smegmatis_MC2_155      VWDDIGIATWDCFGGLVEMPAMSRIAEHGVRLSQFHTTALCSPTRAALLT
MAV_4461|M.avium_104                VWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCSPTRAALLT
TH_0315|M.thermoresistible__bu      VWDDVGIGTWDCFGGLVEMPTMSRIAEQGVRLSQFHTTALCSPTRAALLT
MAB_4307|M.abscessus_ATCC_1997      LFDDTGMATWSPYGGRVNMPTLQRLADNGLTYSQWHTTALCSPTRSCLLT
Rv0663|M.tuberculosis_H37Rv         LLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLT
Mb0682|M.bovis_AF2122/97            LLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLT
MMAR_4950|M.marinum_M               LIDDVGFGASSAFGGPCRTPVAERLAAGGLKLNRFHTTALCSPTRQALLT
MUL_0454|M.ulcerans_Agy99           LIDDVGFGASSAFGGPCRTPVAERLAAGGLQLNRFHTTALCSPTRQALLT
Mvan_4467|M.vanbaalenii_PYR-1       LLDDVGFGASSAFGGPCATPTAERLAANGLKLNRFHTTALCSPTRQALLT
                                    : ** *:.: . :**    .. . :*  *:  .::********** .***

Mflv_5039|M.gilvum_PYR-GCK          G--RNATTVGMATIEEFTDGFPNCNGRIPFDTALLSEVLSENGYNTYCIG
MSMEG_1451|M.smegmatis_MC2_155      G--RNPTTVGMATIEEFTDGFPNCSGRIPFETALLPEVLAENGYNTYCIG
MAV_4461|M.avium_104                G--RNATTVGMATIEEFTEGFPNANGRIPFDTALLSEALAEHGYNTYCVG
TH_0315|M.thermoresistible__bu      G--RNPTTVGMATIEEFTDGFPNCSGRIPVDTGLISEVLAEHGWNTYCVG
MAB_4307|M.abscessus_ATCC_1997      G--RNHHVNRFASITEGSDGYPGAAGRLPAQCATIGQVLQDNGYSTFWVG
Rv0663|M.tuberculosis_H37Rv         G--RNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFG
Mb0682|M.bovis_AF2122/97            G--RNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFG
MMAR_4950|M.marinum_M               G--RNHHSVGMGAITEMATSAPGNNSIRPKEKAPLAETLKLNGYSTAQFG
MUL_0454|M.ulcerans_Agy99           GRGRNHHSVGMGAITEMATSAPGNNSIRPKEKAPLAETLKLNGYSTAQFG
Mvan_4467|M.vanbaalenii_PYR-1       G--RNHHSVGMGGVTEIATSAPGYSSIRPKDKAPVAETLRLNGYSTSQFG
                                    *  **     :. : * : . *.  .  *   . : ..*  :*:.*  .*

Mflv_5039|M.gilvum_PYR-GCK          KWHLTPLEESNLAATKRHWPLSRG-FERFYGFMGGETDQWYPDLMYDNHP
MSMEG_1451|M.smegmatis_MC2_155      KWHLTPLEESNLASTKRHWPCSRG-FERFYGFMGGETDQWYPDLTYDNHP
MAV_4461|M.avium_104                KWHLTPLEESNMASTKRHWPTSRG-FERFYGFLGGETDQWYPDLVYDNHP
TH_0315|M.thermoresistible__bu      KWHLTPLEESNMAATKRHWPVSRG-FERFYGFLGGETDQWYPDLVHDNHP
MAB_4307|M.abscessus_ATCC_1997      KNHNVPQEDVSCGGSKSEWPLQKG-FDRYYGFLGGETNNWYPDLVEDNRF
Rv0663|M.tuberculosis_H37Rv         KCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTP
Mb0682|M.bovis_AF2122/97            KCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTP
MMAR_4950|M.marinum_M               KCHEVPGWEVTPMGPFHQWPTGSG-FEYFYGFVGGEANQYYPGLYEGTTA
MUL_0454|M.ulcerans_Agy99           KCHEVSGWEVTPMGPFHQWPTGSG-FEYFYGFVGGEANQYYPGLYEGTTA
Mvan_4467|M.vanbaalenii_PYR-1       KCHEVPVWEVSPVGPFGQWPTGSG-FEHFYGFIGGEANQYYPGLYEGTKP
                                    * * ..  : .  ..   **   * *: :***:***::::**.*  ..  

Mflv_5039|M.gilvum_PYR-GCK          VAPPATPEEGYHLSKDLADKTIEFIRDSKVIAPDKPWFSYVCPGAGHAPH
MSMEG_1451|M.smegmatis_MC2_155      VDPPATPEEGYHLSKDLADKTIEFIRDAKVVASDKPWFTYLCPGAGHAPH
MAV_4461|M.avium_104                VSPPATPEDGYHLSKDLADKTIEFIRDAKVIAPEKPWFSYVCPGAGHAPH
TH_0315|M.thermoresistible__bu      VAPPATPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFTYLCPGAGHAPH
MAB_4307|M.abscessus_ATCC_1997      IEQPTSPEQGYHLSKDLADQALRMLRDQRNTNPSKPWYMWFCPGANHAPH
Rv0663|M.tuberculosis_H37Rv         VEVNRTPEEGYHFMADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPH
Mb0682|M.bovis_AF2122/97            VEVNRTPEEGYHFMADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPH
MMAR_4950|M.marinum_M               VEPPKTPEQGYTLTEDLADRAITWVRQQKALMPDKPFFMYFAPGATHAPH
MUL_0454|M.ulcerans_Agy99           VEPPKTPEQGYTLTEDLADRAITWVRQQKALMPDKPFFMYFAPGATHAPH
Mvan_4467|M.vanbaalenii_PYR-1       VEPEKTPEQGYTLTEDLADRAITWVRQQQALTPDKPFFMYFAPGATHAPH
                                    :    :**:** :  *::*:::  : : :   ..:*:: :..*** ****

Mflv_5039|M.gilvum_PYR-GCK          HVFKEWADRYAGRFDMGYEAYREIVLENQKRLGLVPPDTELSAVNPYLDV
MSMEG_1451|M.smegmatis_MC2_155      HVFKEWADRYKGRFDMGYERYREIVLENQKRMGLVPPDTELSPVNPYSEV
MAV_4461|M.avium_104                HVFKEWADRYAGRFDMGYERYREVVLERQKAMGIVPSDTELSPVNPYLDV
TH_0315|M.thermoresistible__bu      HAPRDWADRYAGRFDMGYERYREVVLENQKKLGIVPPDTELPPINPYQDV
MAB_4307|M.abscessus_ATCC_1997      HSPAEYADKYRGKFDDGYEAYREWVLARMIDKGIMPRETKLTPINPLPND
Rv0663|M.tuberculosis_H37Rv         HVPREWADKYRGRFDVGWDALREETFARQKELGVIPADCQLTAR------
Mb0682|M.bovis_AF2122/97            HVPREWADKYRGRFDVGWDALREETFARQKELGVIPADCQLTAR------
MMAR_4950|M.marinum_M               HVPKVWSDKYRGKFDDGWDALREKTLNRQKELGVVSDDAELTKR------
MUL_0454|M.ulcerans_Agy99           HVPKVWSDKYRGKFDDGWDALREKTLNRQKELGVVSDGAELTKR------
Mvan_4467|M.vanbaalenii_PYR-1       HVPKQWSDKYRGKFDDGWDVLRESMLDNQKALGVVPEDAQLTAR------
                                    *    ::*:* *:** *::  **  : .    *::.   :*.        

Mflv_5039|M.gilvum_PYR-GCK          KGPDGQDWPAQDTVRPWDSLSEDEKRLFARMAEVFAGFLSYTDAQIGRVL
MSMEG_1451|M.smegmatis_MC2_155      TGPDGQPWPAQDTVRPWDSLSDDEKALFCRMAEVFAGFLSYTDAQIGRVL
MAV_4461|M.avium_104                TGPSGEPWPLQDTVRPWDSLNDEEKKLFARMAEVFAGFLSYTDAQIGRIL
TH_0315|M.thermoresistible__bu      KGPHGEPWPLQDTVRPWDSLSDAEKRLFCRMAEVFAGFLSYTDHQIGRVL
MAB_4307|M.abscessus_ATCC_1997      VAVEA------DSVRPWNTLNPDEKRLFSRMAEVFAGFSEYTDAQVGRVI
Rv0663|M.tuberculosis_H37Rv         ----------HAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLV
Mb0682|M.bovis_AF2122/97            ----------HAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLV
MMAR_4950|M.marinum_M               ----------HDEIPAWDDMPDELKPVLARQMEIYAGFLEQTDHEVGRLV
MUL_0454|M.ulcerans_Agy99           ----------HDEIPAWDDMPDEPKPVLARQMEIYAGFLEQTDHEVGRLV
Mvan_4467|M.vanbaalenii_PYR-1       ----------HDEIPAWDDMPDVLKPVLARQMEIYAGFLEQTDHEIGRLV
                                                 : .*: :    * ::.*  *::*** . ** .:**::

Mflv_5039|M.gilvum_PYR-GCK          DYLEESGQLDNTVIVVIS-DNGASGEGGPNGSVNEVKFFNGY--IDSAEE
MSMEG_1451|M.smegmatis_MC2_155      DYLEESGQIDNTIIVVIS-DNGASGEGGPNGSVNETKFFNGY--IDTAEE
MAV_4461|M.avium_104                DYLEESGQLDDTIIVVIS-DNGASGEGGPNGSVNEGKFFNGY--IDTVEE
TH_0315|M.thermoresistible__bu      DYLEESDQLDNTLIVVLS-DNGASGEGGPDGSVNEVKFFNGY--VDTVEE
MAB_4307|M.abscessus_ATCC_1997      DYLEQTGQLDNTVVFYCA-DNGASGEGSPNGSVNENKFFNGY--PDDLAE
Rv0663|M.tuberculosis_H37Rv         DGLQRLGVLDDTLVFYIIDDNGASAEGTINGTYNEMLNFNGLADIETPRF
Mb0682|M.bovis_AF2122/97            DGLQRLGVLDDTLVFYIIGDNGASAEGTINGTYNEMLNFNGLADIETPRF
MMAR_4950|M.marinum_M               DAIDDLGVLDDTLIYYIIGDNGASAEGTINGCFNEMTTLNGLPGIETTEF
MUL_0454|M.ulcerans_Agy99           GAIDDLGVLDDTLIYYIIGDNGASAEGTINGCFNEMTTLNGLPGIETTEF
Mvan_4467|M.vanbaalenii_PYR-1       DAIDDLGALDNTLIYYIIGDNGASAEGTPNGCFNEMCTLNGLAGIETPEF
                                    . ::  . :*:*::     *****.**  :*  **   :**    :    

Mflv_5039|M.gilvum_PYR-GCK          SLKVFDELGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADTAIISW
MSMEG_1451|M.smegmatis_MC2_155      GLKFIDKLGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISW
MAV_4461|M.avium_104                SMKLFDQLGGPQTYNHYPIGWAMAFNTPYKLYKRYASHEGGIADTAIISW
TH_0315|M.thermoresistible__bu      SMRFYDQLGGPQTYNHYPTGWAMAFNTPYKLFKRYASHEGGIADPAIISW
MAB_4307|M.abscessus_ATCC_1997      NMKYIDRLGTPDTYNHYPTGWAVAFSTPFQMFKRYSQFSGGTCDPLVIHW
Rv0663|M.tuberculosis_H37Rv         MTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHW
Mb0682|M.bovis_AF2122/97            MTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHW
MMAR_4950|M.marinum_M               LLSKTDDFGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTVVHW
MUL_0454|M.ulcerans_Agy99           LLSKTDDFGTPDAYNHYAVGWAHALCAPYQWTKQVASHWGGTRNGTVVHW
Mvan_4467|M.vanbaalenii_PYR-1       LLSKIDDFGTPDAYNHYAVGWAHALCGPYQWTKQVASHWGGTRNGTIVHW
                                         * :* *::****. *** *:  *::  *: :.. **  :  :: *

Mflv_5039|M.gilvum_PYR-GCK          PKGIAAHGEIRDNYVNVADITPTVYDLLDITPPATVRGVAQKPLDGVSFK
MSMEG_1451|M.smegmatis_MC2_155      PKGIAARGEVRDNYVNVCDVTPTVYDMLGITPPATVRGVPQKPLDGVSFK
MAV_4461|M.avium_104                PNGIAAHGEIRDNYVNVCDITPTVYDLLGMSPPETVKGIAQKPLDGVSFK
TH_0315|M.thermoresistible__bu      PNGITARDAVCDRYINVVDVTPTVYELIGLTPPDTVRGVRQRPLEGVSFR
MAB_4307|M.abscessus_ATCC_1997      PKGIKAKGEVRHQYHHVTDIVPTILDVAGLTMPETYRGVDQFPVNGVSMR
Rv0663|M.tuberculosis_H37Rv         PNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMA
Mb0682|M.bovis_AF2122/97            PNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMA
MMAR_4950|M.marinum_M               PNGLTEQGGMRDQFHHVIDVAPTILEAAGLPAPHSVNGISQAPLEGVSMM
MUL_0454|M.ulcerans_Agy99           PNGLTEQGGMRDQFHPVIDVAPTILEAAGLPAPHSVNGIAQAPLEGVSMM
Mvan_4467|M.vanbaalenii_PYR-1       PNGIAAKGETRNQFHHVIDVVPTILEAAKLPAPTVVNSIQQAPLEGVSMM
                                    *:*:  :.    .:  * *:.**: :   :. *   ..: * *::***: 

Mflv_5039|M.gilvum_PYR-GCK          VALENPNAPTGKETQFYTMLGTRGIWHRGWFANTVHAASPAGWS----HF
MSMEG_1451|M.smegmatis_MC2_155      AALADPDAPTGKETQFYAMLGTRGIWHKGWFANTVHAATPSGWG----HF
MAV_4461|M.avium_104                AALDDPNADTGKTTQFYTMLGTRGIWHEGWFANTVHAATPAGWS----HF
TH_0315|M.thermoresistible__bu      AALADPDADTGKRTQFYSMLGTRGIWSDGWFANTVHAASPAGWS----NF
MAB_4307|M.abscessus_ATCC_1997      YTFDDKDAATTKKRQYYAMLGTRGIWEDGWKASALHAP-ISGKG----HF
Rv0663|M.tuberculosis_H37Rv         YSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAF
Mb0682|M.bovis_AF2122/97            YSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAF
MMAR_4950|M.marinum_M               STLRDAAAPETHEVQYFEMMGNRGIYFQGWTAVTKHRTPWKAD--APPPF
MUL_0454|M.ulcerans_Agy99           STLRDAAAPETHEVQYFEMMGNRGIYFQGWTAVTKHRTPWKAD--APPPF
Mvan_4467|M.vanbaalenii_PYR-1       STLRDRDADETHTVQYFEMFGNRGIYHKGWTAVTKHRTPWIAD--QPP-L
                                     :: :  *   :  *:: *:*.***:  ** * : * .           :

Mflv_5039|M.gilvum_PYR-GCK          DDDRWELYHVDADRSQVHDLAAEYPEKLDELKALWFSEAQKYNGLPLGD-
MSMEG_1451|M.smegmatis_MC2_155      ADDRWELFHIDADRSQCHDLAAEHPDRLEELKALWFSEADKYNGLPLGD-
MAV_4461|M.avium_104                DADRWELFHIEADRSQCHDLAAENPDKLEELKALWFAEAARYNGLPLSD-
TH_0315|M.thermoresistible__bu      DADRWELYHLESDRSQSRDLAAEHPEKLEELKQLWFDEAAKYNGLPLGD-
MAB_4307|M.abscessus_ATCC_1997      DQDKWELFHVDEDRSESTDLADQHPDKLKALIDAWFEEADNNFVLPLDD-
Rv0663|M.tuberculosis_H37Rv         DDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLPLDDD
Mb0682|M.bovis_AF2122/97            DDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLPLDDD
MMAR_4950|M.marinum_M               DDDVWELYAP-GDWTQAHNLATQNPAKLAELQRLWLIEATKYNVVPLDDR
MUL_0454|M.ulcerans_Agy99           DDDVWELYAP-GDWTQAHNLATQNPAKLAELQRLWLIEATKYNVVPLDDR
Mvan_4467|M.vanbaalenii_PYR-1       DEDVWELYAP-DDWTQAHDLAAEQPERLAALQRLWLIEAVKYNVVPLDDR
                                      * ***:    * ::  :** : * :*  *   *: ** .   :**.* 

Mflv_5039|M.gilvum_PYR-GCK          -LDIFETMSRWRPTLSGERSAYVYYPGTADVGIGAVVELRGRSFAVLAEV
MSMEG_1451|M.smegmatis_MC2_155      -LSILETTTRWRPYLTGERTSYTYYPHTAEVGMGAVVELRGQSFKVLAEV
MAV_4461|M.avium_104                -LNILETMTRSRPYLVGERDSYVYYPDCADVGIGAAAEIRGRSFSVLAEA
TH_0315|M.thermoresistible__bu      -LNLFETLGRWRPHLSRGRTSYTYYPGTAEVGLGAAVDIRGQSFTVLADV
MAB_4307|M.abscessus_ATCC_1997      -RLPTELLTIERPQFEPRRNRYLYYPDASPVPEGVAVNIRGKSYKIVANT
Rv0663|M.tuberculosis_H37Rv         TASRINPDLAGRPVLIRG-NTQVLFSNMGRLSENCVLNLKNKSHTVTAEV
Mb0682|M.bovis_AF2122/97            TASRINPDLAGRPVLIRG-NTQVLFSNMGRLSENCVLNLKNKSHTVTAEV
MMAR_4950|M.marinum_M               GFERINPDIAGRPQLVRG-NSQLLFDGM-RVSEWCVLTIKNKSHSVTAEV
MUL_0454|M.ulcerans_Agy99           GFERINPDIAGRPQLVRG-NSQLLFDGM-RVSEWCVLTIKNKSHSVTAEV
Mvan_4467|M.vanbaalenii_PYR-1       SFERFNPDIAGRPQLIKG-TTQTLFSGM-RLLENCVLNIKNRSHAVSALI
                                         :     ** :         :     :    .  ::.:*. : *  

Mflv_5039|M.gilvum_PYR-GCK          EVDPGGANGVVVKHGGAHGGYVMYLQGGRLHFCYNFLGEYEQTLAAPDPV
MSMEG_1451|M.smegmatis_MC2_155      TVDSAEAQGVIFKHGGAHGGHVLFIADGHLHYVYNFLGEREQVLSAPDPV
MAV_4461|M.avium_104                TVDTTGAEGVLFKQGGAHGGHVLFIQDGRLHYVYNFLGERQQEVSSSVPV
TH_0315|M.thermoresistible__bu      TVDAAGAQGVIVKHGAGHGGYVLFLQDGRLHFVYNFMGEEEQRVSSADPI
MAB_4307|M.abscessus_ATCC_1997      DIS-AQAQGVIFAHGSRFGGHVLFIKDGRLHYVYNFLGIKPEQEFISAPL
Rv0663|M.tuberculosis_H37Rv         EVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPL
Mb0682|M.bovis_AF2122/97            EVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPL
MMAR_4950|M.marinum_M               EVPTGGASGVLITQGGSAGGWTLYAHQGRLKYCYNFLGIDHYMVAATKPI
MUL_0454|M.ulcerans_Agy99           EVPTGGASGLLITQGGSAGGWTLYAHEGRLKYCYNFLGIDHYMVAATKPI
Mvan_4467|M.vanbaalenii_PYR-1       SVPDSGAQGVIVSQGGGVGGWCVYAHENTLKYCYNFFGIEYYFVTAELPL
                                     :    *.*::. :*.  **  ::   . *:: **: *          *:

Mflv_5039|M.gilvum_PYR-GCK          PPGLHTLGFTYTVTGTAEGSHTPIGDAELFLDTERVASLAEMRSQPGTFG
MSMEG_1451|M.smegmatis_MC2_155      PLGHHIFGVRYERTGTVPNSHTPVGVATLFVDGGAVADLADVQTHPAIFA
MAV_4461|M.avium_104                PLGRHLFGASYARTGTVPDSHTPLGDLTLFIDDEVVGTLAGVSTHPGTFG
TH_0315|M.thermoresistible__bu      PAGRHILGVSYHRTGTVDGSHTPLGEVALYVDGTVVATRPDVRAHPANFG
MAB_4307|M.abscessus_ATCC_1997      TPGNRTLGVEFVRRDKGQYGES-LGTTNLYVDGKLAATGP-MRTQVGTFT
Rv0663|M.tuberculosis_H37Rv         PAGAHQVRMEFAYAG---GGLGKGGEVTLYVDGQQVGEGHVEATLAIVFS
Mb0682|M.bovis_AF2122/97            PAGAHQVRMEFAYAG---GGLGKGGEVTLYVDGQQVGEGHVEATLAIVFS
MMAR_4950|M.marinum_M               PTGKHQVRMEFGYDG---GGLGRGGDVTLFYDGKAVGQGRVERTQPMAFS
MUL_0454|M.ulcerans_Agy99           PTGKHQVRMEFGYDG---GGLGRGGDVTLFYDGKAVGQGRVERTQPMAFS
Mvan_4467|M.vanbaalenii_PYR-1       PGGQHLVGFEFAYDG---GGLGKGGTVTLYCDGEPVGTGRVERTEPMAFS
                                    . * : .   :   .    .    *   *: *   ..      :    * 

Mflv_5039|M.gilvum_PYR-GCK          LAGASLSVGRNNGSPVSEAYHPPFAFAGGRIARVNIDTS-----GAPYVD
MSMEG_1451|M.smegmatis_MC2_155      LAGGGIAVGRNTGSGVSRSYRVPFPFTGGEIAQVTVDLS-----GEPYED
MAV_4461|M.avium_104                LAGAGITVGRNGGSGVSSRFKAPFVFTGGTIARVTLDLS-----GRPYRD
TH_0315|M.thermoresistible__bu      LAGGGIAVGRNTGQPVSSAYRAPFAFTGGSIAKVIVDIS-----GTPYRD
MAB_4307|M.abscessus_ATCC_1997      LAGDGLCVGYDSGDNVSPQYTNPGRFTGGTIKVVAVDVS-----DESFID
Rv0663|M.tuberculosis_H37Rv         -ADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVD
Mb0682|M.bovis_AF2122/97            -ADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVD
MMAR_4950|M.marinum_M               -ADEACDVGCDTGSPASPDYGPTANAFSGTIAWVQIDLG--ADSHDHLIT
MUL_0454|M.ulcerans_Agy99           -ADEACDVGCDTGSPASPDYGPTGNAFSGTIAWVQIDLG--ADSHDHLIT
Mvan_4467|M.vanbaalenii_PYR-1       -ADEACDVGSDTGSPTSPDYGPHGNGFNGRIDWVKIDIS--TDDHEHLIT
                                     *. .  ** : *. .*  :       .* *  * :  .           

Mflv_5039|M.gilvum_PYR-GCK          LERDFARAFARD
MSMEG_1451|M.smegmatis_MC2_155      LVTRRATAFARD
MAV_4461|M.avium_104                VETEIALAFSRD
TH_0315|M.thermoresistible__bu      VEREAAMAFARD
MAB_4307|M.abscessus_ATCC_1997      LEKEAQAAFARD
Rv0663|M.tuberculosis_H37Rv         PEHAIRIALARQ
Mb0682|M.bovis_AF2122/97            PEHAIRIALARQ
MMAR_4950|M.marinum_M               AEDRFNIAMAKQ
MUL_0454|M.ulcerans_Agy99           AEDRFNITMAKQ
Mvan_4467|M.vanbaalenii_PYR-1       PQDRFNISMARQ
                                           :::::