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MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTA ARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQT GLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLA HTDSGLLMSTFGPRTALWLLLAKGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNE VVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3056 | dinP | - | 100% (346) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv1537 | dinX | 1e-46 | 36.05% (344) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv3394c | - | 2e-08 | 25.00% (300) | hypothetical protein Rv3394c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3082 | dinP | 0.0 | 100.00% (346) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_4310 | - | 1e-137 | 68.30% (347) | DNA polymerase IV |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2702c | - | 5e-46 | 35.45% (347) | DNA polymerase IV |
| M. marinum M | MMAR_2359 | dinP_1 | 4e-44 | 36.05% (344) | DNA polymerase IV, DinP_1 |
| M. avium 104 | MAV_3925 | - | 1e-149 | 78.59% (341) | DNA polymerase IV |
| M. smegmatis MC2 155 | MSMEG_2294 | dinB | 1e-142 | 73.02% (341) | DNA polymerase IV |
| M. thermoresistible (build 8) | TH_0006 | dinP | 1e-144 | 71.95% (353) | POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN P DINP (DNA POLYMERASE |
| M. ulcerans Agy99 | MUL_1535 | dinP_1 | 6e-45 | 35.53% (349) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_2037 | - | 1e-137 | 70.50% (339) | DNA polymerase IV |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3056|M.tuberculosis_H37Rv ----MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPR
Mb3082|M.bovis_AF2122/97 ----MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPR
MAV_3925|M.avium_104 ------------MLHVDLDQFLASVELRRRPELAGLPVIVGGNGDPNEPR
Mflv_4310|M.gilvum_PYR-GCK MSDPPAAGERDWVLHVDMDQFLASVELQRRPDLVGLPVIVGGNGDPAEPR
Mvan_2037|M.vanbaalenii_PYR-1 MTTPGTGPGKEWILHVDMDQFLASVELQRHPELVGHPVIVGGSGDPTEPR
MSMEG_2294|M.smegmatis_MC2_155 MT--------KWVLHVDLDQFLASVELRRRPDLRGQPVIVGGSGDPSEPR
TH_0006|M.thermoresistible__bu ------VPAMTWVLHVDLDQFLAAVELRRRPELAGTPVIVGGSGDPTEPR
MMAR_2359|M.marinum_M -------MESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----R
MUL_1535|M.ulcerans_Agy99 ----MPVVESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----R
MAB_2702c|M.abscessus_ATCC_199 -----MCAAGRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGTGG----R
:**:*:* *:*:** :* * * **:*** *. *
Rv3056|M.tuberculosis_H37Rv KVVTCASYEARAYGVRAGMPLRTAARRCP---EATFLPSNPAAYNAASEE
Mb3082|M.bovis_AF2122/97 KVVTCASYEARAYGVRAGMPLRTAARRCP---EATFLPSNPAAYNAASEE
MAV_3925|M.avium_104 KVVTCASYEAREFGVRAGMPLRAAARRCPPDSGVTFLPSDPAAYDAASDQ
Mflv_4310|M.gilvum_PYR-GCK KVVTCASYEARTFGVHAGMPLRAAARRCP---DATFLPSDPEAYDAASDR
Mvan_2037|M.vanbaalenii_PYR-1 KVVTCASYEARQFGVHAGMPLRSAARRCP---DATFLPSDPEAYDAASER
MSMEG_2294|M.smegmatis_MC2_155 KVVTCASYEAREFGVHAGMPLRAAARRCP---DATFLPSDPAAYDEASEQ
TH_0006|M.thermoresistible__bu KVVTCASYEARRFGVHAGMPLRTAARKCP---DATFLPSDPQAYDAASEQ
MMAR_2359|M.marinum_M GVVAGASYEARVFGARSAMPMHQARRLIG--VTAVVLPPRGAVYGVASRR
MUL_1535|M.ulcerans_Agy99 GVVAGASYEARVFGARSAMPMHQARRLIG--VTAVVLPPRGAVYGVASRR
MAB_2702c|M.abscessus_ATCC_199 GVVAGASYEARVFGARSAMPMHQARRLVG--INAVVLPPRGSVYGVASRR
**: ****** :*.::.**:: * * ...**. .*. ** .
Rv3056|M.tuberculosis_H37Rv VVALLRDLGYPVEVWGWDEAYLAVAPGT----------PDDPIEVAEEIR
Mb3082|M.bovis_AF2122/97 VVALLRDLGYPVEVWGWDEAYLAVAPGT----------PDDPIEVAEEIR
MAV_3925|M.avium_104 VMGLLRDLGHPVEVWGWDEAYLAVT-------------ATDPIEVAEQIR
Mflv_4310|M.gilvum_PYR-GCK VMGILRDLGHPVEVWGWDEAYVGARV-------------SDPFALARHIQ
Mvan_2037|M.vanbaalenii_PYR-1 VMGLLRDLGHPIEVWGWDEAYVGARV-------------ADPLALAHRIQ
MSMEG_2294|M.smegmatis_MC2_155 VMGLLRDLGHPLEVWGWDEAYLGADLPDE----------SDPVEVAERIR
TH_0006|M.thermoresistible__bu VMDLLRDFGHPVEVLGWDEAFIGIGGGGTGEGVGGSAAATDPVALAEDIR
MMAR_2359|M.marinum_M VFDTVRGLVPVVEQLSFDEAFGEPPQLGG-------AATAEVEQFCEDLR
MUL_1535|M.ulcerans_Agy99 VFDTVRGLVPVVEQLSFDEAFGEPPQLGG-------AATAEVEQFCEDLR
MAB_2702c|M.abscessus_ATCC_199 VFETVRSMIPILEQLSFDEAFGEPSELFG-------ATTSAVADYIHELR
*. :*.: :* .:***: . ::
Rv3056|M.tuberculosis_H37Rv KVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRT
Mb3082|M.bovis_AF2122/97 KVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRT
MAV_3925|M.avium_104 GVISSETGLSCSVGISDNKQRAKIATGFAKPDGVFVLTDANWMALMADRP
Mflv_4310|M.gilvum_PYR-GCK TVVASQTGLTCSVGISDNKQRAKVATGFGKPAGVHMLTDENWMPVMGDRP
Mvan_2037|M.vanbaalenii_PYR-1 HVVAAETGLSCSVGISDNKQRAKVATGFGKPAGVHALTDDNWMLTMGDRP
MSMEG_2294|M.smegmatis_MC2_155 TVVAAETGLSCSVGISDNKQRAKVATGFAKPAGIYVLTEANWMTVMGDRP
TH_0006|M.thermoresistible__bu AAVTAETGLSCSIGISDNKQRAKVATGFAKPAGIYRLTDANWMAVMGDRP
MMAR_2359|M.marinum_M RRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARQEEQLLLGGLP
MUL_1535|M.ulcerans_Agy99 RRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARKEEQLLLGGLP
MAB_2702c|M.abscessus_ATCC_199 SRVLGETGLTASVGAGSGKQIAKIASGLAKPDGVRIIAPEEERTLLDELP
: :*** .*:* ...** **:*:*:.** *: :: : : .
Rv3056|M.tuberculosis_H37Rv VEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLL-A
Mb3082|M.bovis_AF2122/97 VEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLL-A
MAV_3925|M.avium_104 VDALWGVGPKTAKKLADLQITTVWQLAHSDAELLTATFGPRTGLWLLLLA
Mflv_4310|M.gilvum_PYR-GCK VDALWGVGPKTAKKLAAIGITTVADLAGTDSAELTKTFGPTTGLWILLLA
Mvan_2037|M.vanbaalenii_PYR-1 VDALWGVGPKTAKKLAAMGITTVADLAGTDAAVLTTAFGPTTGLWILLLA
MSMEG_2294|M.smegmatis_MC2_155 PDALWGVGPKTTKKLAAMGITTVADLAVTDPSVLTTAFGPSTGLWLLLLA
TH_0006|M.thermoresistible__bu VDALWGVGPKTAKRLATLGITTVADLEATDATVLTTTFGPSTGLWLLLLA
MMAR_2359|M.marinum_M VRRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLA
MUL_1535|M.ulcerans_Agy99 VRRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLA
MAB_2702c|M.abscessus_ATCC_199 VRKLWGIGPVAEERLNRLGINTIGQFAALQTSEAASVLGGTIGPALHQLA
***:** : ::* : * *: :: :* . : *
Rv3056|M.tuberculosis_H37Rv KGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVV
Mb3082|M.bovis_AF2122/97 KGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVV
MAV_3925|M.avium_104 KGGGDDHVSAQPWVPRSRSHVVTFPRDLTDRAEMETAVTDLADQAVAEVL
Mflv_4310|M.gilvum_PYR-GCK KGGGDTTVSAEPWVPRSRSHVITFPQDLTERAAMDEAVTELARRTLDEVI
Mvan_2037|M.vanbaalenii_PYR-1 KGGGDTKVSAEPWVPRSRSHVVTFPQDLTDRSEMARAVADLAQYTLAEVT
MSMEG_2294|M.smegmatis_MC2_155 KGGGDTEVSSEPWVPRSRSHVVTFPQDLTERREMDSAVRDLALQTLAEIV
TH_0006|M.thermoresistible__bu KGGGDTEVSAEPWVPRSRSHVVTFPRDLTERAEMDAAVADLARRTVDEVV
MMAR_2359|M.marinum_M RGIDDRPVAER-AEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLL
MUL_1535|M.ulcerans_Agy99 RGIDDRPVAER-AEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLL
MAB_2702c|M.abscessus_ATCC_199 RGVDDRPVAER-AETKQISAESTFPDDLTTLDQLRQAIEPIGVHAHRRLI
:* .* *: . .:. * **. *** : *: :. : .:
Rv3056|M.tuberculosis_H37Rv ASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFEL
Mb3082|M.bovis_AF2122/97 ASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFEL
MAV_3925|M.avium_104 AAGRVVTRVAVTVRTATFYTRTKIRKLDAPSTDRDVIVAAALRVLDLFEL
Mflv_4310|M.gilvum_PYR-GCK AQQRIVTHVAVTLRTSSFHTRSKIRKLPEPTIDADAVISTATTLLDAFDL
Mvan_2037|M.vanbaalenii_PYR-1 EQQRVVTRVAVTVRTSTFYTRTKIRKLSSPTTDSDPVVGTALDLLGQFDL
MSMEG_2294|M.smegmatis_MC2_155 EQGRIVTRVAVTVRTSTFYTRTKIRKLPAPSTDAGQIVDTALAVLDQFEL
TH_0006|M.thermoresistible__bu AAGRIVTRVAVTVRTDTFSTRTKIRKLPVPSTDPDLITATALAVMDLFDI
MMAR_2359|M.marinum_M RDGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPVQ
MUL_1535|M.ulcerans_Agy99 RDGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPAQ
MAB_2702c|M.abscessus_ATCC_199 KHGRGVRTVTVKLRRSDMSILTRSATLPYATTERAVLMSAARRLLLDPVE
* *:*.:: : :: .* .: : : * ::
Rv3056|M.tuberculosis_H37Rv DRPVRLLGVRLELA------------------------------------
Mb3082|M.bovis_AF2122/97 DRPVRLLGVRLELA------------------------------------
MAV_3925|M.avium_104 DRPVRLLGVRLELVMPD---------------------------------
Mflv_4310|M.gilvum_PYR-GCK QRPVRLLGVRLELAMPSATAARG---------------------------
Mvan_2037|M.vanbaalenii_PYR-1 DRPVRLLGVRLELVMPDSER------------------------------
MSMEG_2294|M.smegmatis_MC2_155 DRPVRLLGVRLELAMDDVPRPAVTAGT-----------------------
TH_0006|M.thermoresistible__bu ERPVRLLGVRLELAMESGAQAGQAGR------------------------
MMAR_2359|M.marinum_M IGPIRLLGVGFSGLSEVRQESLFPDLDLAAETSEEAHQDFHPSHGALSST
MUL_1535|M.ulcerans_Agy99 IGPIRLLGVGFSGLSELRQESLFPDLDLAAETSEEAHKDFHPSHGALSST
MAB_2702c|M.abscessus_ATCC_199 IGPIRLVGVGFSGFSDVQQTSLFPDLDQAEPVAES---DEVPSTAEPTHS
*:**:** :.
Rv3056|M.tuberculosis_H37Rv --------------------------------------------------
Mb3082|M.bovis_AF2122/97 --------------------------------------------------
MAV_3925|M.avium_104 --------------------------------------------------
Mflv_4310|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2037|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2294|M.smegmatis_MC2_155 --------------------------------------------------
TH_0006|M.thermoresistible__bu --------------------------------------------------
MMAR_2359|M.marinum_M PAGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRGSGPGPARTFPIE
MUL_1535|M.ulcerans_Agy99 PAGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRDSGPGPARTFPIE
MAB_2702c|M.abscessus_ATCC_199 TAG--WGVGDDVDHAEFGHGWIQGTGHGVMTVRFETRSSGPGIARTFAVD
Rv3056|M.tuberculosis_H37Rv -----------------------------------------
Mb3082|M.bovis_AF2122/97 -----------------------------------------
MAV_3925|M.avium_104 -----------------------------------------
Mflv_4310|M.gilvum_PYR-GCK -----------------------------------------
Mvan_2037|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_2294|M.smegmatis_MC2_155 -----------------------------------------
TH_0006|M.thermoresistible__bu -----------------------------------------
MMAR_2359|M.marinum_M TSDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MUL_1535|M.ulcerans_Agy99 TSDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MAB_2702c|M.abscessus_ATCC_199 DPGIARADPVASLDWPGESAEP-VDDGDEIGTGG-------