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TTPGTGPGKEWILHVDMDQFLASVELQRHPELVGHPVIVGGSGDPTEPRKVVTCASYEARQFGVHAGMPL RSAARRCPDATFLPSDPEAYDAASERVMGLLRDLGHPIEVWGWDEAYVGARVADPLALAHRIQHVVAAET GLSCSVGISDNKQRAKVATGFGKPAGVHALTDDNWMLTMGDRPVDALWGVGPKTAKKLAAMGITTVADLA GTDAAVLTTAFGPTTGLWILLLAKGGGDTKVSAEPWVPRSRSHVVTFPQDLTDRSEMARAVADLAQYTLA EVTEQQRVVTRVAVTVRTSTFYTRTKIRKLSSPTTDSDPVVGTALDLLGQFDLDRPVRLLGVRLELVMPD SER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2037 | - | - | 100% (354) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_2771 | - | 2e-44 | 35.99% (339) | DNA polymerase IV |
| M. vanbaalenii PYR-1 | Mvan_5685 | - | 3e-33 | 33.43% (329) | DNA polymerase IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3082 | dinP | 1e-137 | 70.50% (339) | DNA polymerase IV |
| M. gilvum PYR-GCK | Mflv_4310 | - | 1e-165 | 79.55% (352) | DNA polymerase IV |
| M. tuberculosis H37Rv | Rv3056 | dinP | 1e-137 | 70.50% (339) | DNA polymerase IV |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2702c | - | 1e-43 | 34.51% (339) | DNA polymerase IV |
| M. marinum M | MMAR_2359 | dinP_1 | 8e-44 | 35.77% (355) | DNA polymerase IV, DinP_1 |
| M. avium 104 | MAV_3925 | - | 1e-146 | 74.27% (342) | DNA polymerase IV |
| M. smegmatis MC2 155 | MSMEG_2294 | dinB | 1e-160 | 79.25% (347) | DNA polymerase IV |
| M. thermoresistible (build 8) | TH_0006 | dinP | 1e-151 | 73.52% (355) | POSSIBLE DNA-DAMAGE-INDUCIBLE PROTEIN P DINP (DNA POLYMERASE |
| M. ulcerans Agy99 | MUL_1535 | dinP_1 | 5e-44 | 35.77% (355) | DNA polymerase IV |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3082|M.bovis_AF2122/97 ----MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPR
Rv3056|M.tuberculosis_H37Rv ----MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPR
MAV_3925|M.avium_104 ------------MLHVDLDQFLASVELRRRPELAGLPVIVGGNGDPNEPR
Mvan_2037|M.vanbaalenii_PYR-1 MTTPGTGPGKEWILHVDMDQFLASVELQRHPELVGHPVIVGGSGDPTEPR
Mflv_4310|M.gilvum_PYR-GCK MSDPPAAGERDWVLHVDMDQFLASVELQRRPDLVGLPVIVGGNGDPAEPR
MSMEG_2294|M.smegmatis_MC2_155 MT--------KWVLHVDLDQFLASVELRRRPDLRGQPVIVGGSGDPSEPR
TH_0006|M.thermoresistible__bu ------VPAMTWVLHVDLDQFLAAVELRRRPELAGTPVIVGGSGDPTEPR
MMAR_2359|M.marinum_M -------MESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----R
MUL_1535|M.ulcerans_Agy99 ----MPVVESRWVLHLDMDAFFASVEQLTRPTLMGRPVLVGGMGG----R
MAB_2702c|M.abscessus_ATCC_199 -----MCAAGRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGTGG----R
:**:*:* *:*:** :* * * **:*** *. *
Mb3082|M.bovis_AF2122/97 KVVTCASYEARAYGVRAGMPLRTAARRCP---EATFLPSNPAAYNAASEE
Rv3056|M.tuberculosis_H37Rv KVVTCASYEARAYGVRAGMPLRTAARRCP---EATFLPSNPAAYNAASEE
MAV_3925|M.avium_104 KVVTCASYEAREFGVRAGMPLRAAARRCPPDSGVTFLPSDPAAYDAASDQ
Mvan_2037|M.vanbaalenii_PYR-1 KVVTCASYEARQFGVHAGMPLRSAARRCP---DATFLPSDPEAYDAASER
Mflv_4310|M.gilvum_PYR-GCK KVVTCASYEARTFGVHAGMPLRAAARRCP---DATFLPSDPEAYDAASDR
MSMEG_2294|M.smegmatis_MC2_155 KVVTCASYEAREFGVHAGMPLRAAARRCP---DATFLPSDPAAYDEASEQ
TH_0006|M.thermoresistible__bu KVVTCASYEARRFGVHAGMPLRTAARKCP---DATFLPSDPQAYDAASEQ
MMAR_2359|M.marinum_M GVVAGASYEARVFGARSAMPMHQARRLIG--VTAVVLPPRGAVYGVASRR
MUL_1535|M.ulcerans_Agy99 GVVAGASYEARVFGARSAMPMHQARRLIG--VTAVVLPPRGAVYGVASRR
MAB_2702c|M.abscessus_ATCC_199 GVVAGASYEARVFGARSAMPMHQARRLVG--INAVVLPPRGSVYGVASRR
**: ****** :*.::.**:: * * ...**. .*. ** .
Mb3082|M.bovis_AF2122/97 VVALLRDLGYPVEVWGWDEAYLAVAPGT----------PDDPIEVAEEIR
Rv3056|M.tuberculosis_H37Rv VVALLRDLGYPVEVWGWDEAYLAVAPGT----------PDDPIEVAEEIR
MAV_3925|M.avium_104 VMGLLRDLGHPVEVWGWDEAYLAVT-------------ATDPIEVAEQIR
Mvan_2037|M.vanbaalenii_PYR-1 VMGLLRDLGHPIEVWGWDEAYVGARV-------------ADPLALAHRIQ
Mflv_4310|M.gilvum_PYR-GCK VMGILRDLGHPVEVWGWDEAYVGARV-------------SDPFALARHIQ
MSMEG_2294|M.smegmatis_MC2_155 VMGLLRDLGHPLEVWGWDEAYLGADLPDE----------SDPVEVAERIR
TH_0006|M.thermoresistible__bu VMDLLRDFGHPVEVLGWDEAFIGIGGGGTGEGVGGSAAATDPVALAEDIR
MMAR_2359|M.marinum_M VFDTVRGLVPVVEQLSFDEAFGEPPQLGG-------AATAEVEQFCEDLR
MUL_1535|M.ulcerans_Agy99 VFDTVRGLVPVVEQLSFDEAFGEPPQLGG-------AATAEVEQFCEDLR
MAB_2702c|M.abscessus_ATCC_199 VFETVRSMIPILEQLSFDEAFGEPSELFG-------ATTSAVADYIHELR
*. :*.: :* .:***: . ::
Mb3082|M.bovis_AF2122/97 KVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRT
Rv3056|M.tuberculosis_H37Rv KVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRT
MAV_3925|M.avium_104 GVISSETGLSCSVGISDNKQRAKIATGFAKPDGVFVLTDANWMALMADRP
Mvan_2037|M.vanbaalenii_PYR-1 HVVAAETGLSCSVGISDNKQRAKVATGFGKPAGVHALTDDNWMLTMGDRP
Mflv_4310|M.gilvum_PYR-GCK TVVASQTGLTCSVGISDNKQRAKVATGFGKPAGVHMLTDENWMPVMGDRP
MSMEG_2294|M.smegmatis_MC2_155 TVVAAETGLSCSVGISDNKQRAKVATGFAKPAGIYVLTEANWMTVMGDRP
TH_0006|M.thermoresistible__bu AAVTAETGLSCSIGISDNKQRAKVATGFAKPAGIYRLTDANWMAVMGDRP
MMAR_2359|M.marinum_M RRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARQEEQLLLGGLP
MUL_1535|M.ulcerans_Agy99 RRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVARKEEQLLLGGLP
MAB_2702c|M.abscessus_ATCC_199 SRVLGETGLTASVGAGSGKQIAKIASGLAKPDGVRIIAPEEERTLLDELP
: :*** .*:* ...** **:*:*:.** *: :: : : .
Mb3082|M.bovis_AF2122/97 VEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLL-A
Rv3056|M.tuberculosis_H37Rv VEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLL-A
MAV_3925|M.avium_104 VDALWGVGPKTAKKLADLQITTVWQLAHSDAELLTATFGPRTGLWLLLLA
Mvan_2037|M.vanbaalenii_PYR-1 VDALWGVGPKTAKKLAAMGITTVADLAGTDAAVLTTAFGPTTGLWILLLA
Mflv_4310|M.gilvum_PYR-GCK VDALWGVGPKTAKKLAAIGITTVADLAGTDSAELTKTFGPTTGLWILLLA
MSMEG_2294|M.smegmatis_MC2_155 PDALWGVGPKTTKKLAAMGITTVADLAVTDPSVLTTAFGPSTGLWLLLLA
TH_0006|M.thermoresistible__bu VDALWGVGPKTAKRLATLGITTVADLEATDATVLTTTFGPSTGLWLLLLA
MMAR_2359|M.marinum_M VRRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLA
MUL_1535|M.ulcerans_Agy99 VRRLWGIGPVAEEKLHRLGIETVGQLAALADAEVANILGATVGPALHRLA
MAB_2702c|M.abscessus_ATCC_199 VRKLWGIGPVAEERLNRLGINTIGQFAALQTSEAASVLGGTIGPALHQLA
***:** : ::* : * *: :: :* . : *
Mb3082|M.bovis_AF2122/97 KGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVV
Rv3056|M.tuberculosis_H37Rv KGGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVV
MAV_3925|M.avium_104 KGGGDDHVSAQPWVPRSRSHVVTFPRDLTDRAEMETAVTDLADQAVAEVL
Mvan_2037|M.vanbaalenii_PYR-1 KGGGDTKVSAEPWVPRSRSHVVTFPQDLTDRSEMARAVADLAQYTLAEVT
Mflv_4310|M.gilvum_PYR-GCK KGGGDTTVSAEPWVPRSRSHVITFPQDLTERAAMDEAVTELARRTLDEVI
MSMEG_2294|M.smegmatis_MC2_155 KGGGDTEVSSEPWVPRSRSHVVTFPQDLTERREMDSAVRDLALQTLAEIV
TH_0006|M.thermoresistible__bu KGGGDTEVSAEPWVPRSRSHVVTFPRDLTERAEMDAAVADLARRTVDEVV
MMAR_2359|M.marinum_M RGIDDRPVAER-AEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLL
MUL_1535|M.ulcerans_Agy99 RGIDDRPVAER-AEAKQISAESTFAIDLTTLDQLRDALDPIAEHAHQRLL
MAB_2702c|M.abscessus_ATCC_199 RGVDDRPVAER-AETKQISAESTFPDDLTTLDQLRQAIEPIGVHAHRRLI
:* .* *: . .:. * **. *** : *: :. : .:
Mb3082|M.bovis_AF2122/97 ASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFEL
Rv3056|M.tuberculosis_H37Rv ASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFEL
MAV_3925|M.avium_104 AAGRVVTRVAVTVRTATFYTRTKIRKLDAPSTDRDVIVAAALRVLDLFEL
Mvan_2037|M.vanbaalenii_PYR-1 EQQRVVTRVAVTVRTSTFYTRTKIRKLSSPTTDSDPVVGTALDLLGQFDL
Mflv_4310|M.gilvum_PYR-GCK AQQRIVTHVAVTLRTSSFHTRSKIRKLPEPTIDADAVISTATTLLDAFDL
MSMEG_2294|M.smegmatis_MC2_155 EQGRIVTRVAVTVRTSTFYTRTKIRKLPAPSTDAGQIVDTALAVLDQFEL
TH_0006|M.thermoresistible__bu AAGRIVTRVAVTVRTDTFSTRTKIRKLPVPSTDPDLITATALAVMDLFDI
MMAR_2359|M.marinum_M RDGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPVQ
MUL_1535|M.ulcerans_Agy99 RDGRGSRTVTVKLKKADMSTLTRSATLPYATTDVGALLALARRLLLDPAQ
MAB_2702c|M.abscessus_ATCC_199 KHGRGVRTVTVKLRRSDMSILTRSATLPYATTERAVLMSAARRLLLDPVE
* *:*.:: : :: .* .: : : * ::
Mb3082|M.bovis_AF2122/97 DRPVRLLGVRLELA------------------------------------
Rv3056|M.tuberculosis_H37Rv DRPVRLLGVRLELA------------------------------------
MAV_3925|M.avium_104 DRPVRLLGVRLELVMPD---------------------------------
Mvan_2037|M.vanbaalenii_PYR-1 DRPVRLLGVRLELVMPDSER------------------------------
Mflv_4310|M.gilvum_PYR-GCK QRPVRLLGVRLELAMPSATAARG---------------------------
MSMEG_2294|M.smegmatis_MC2_155 DRPVRLLGVRLELAMDDVPRPAVTAGT-----------------------
TH_0006|M.thermoresistible__bu ERPVRLLGVRLELAMESGAQAGQAGR------------------------
MMAR_2359|M.marinum_M IGPIRLLGVGFSGLSEVRQESLFPDLDLAAETSEEAHQDFHPSHGALSST
MUL_1535|M.ulcerans_Agy99 IGPIRLLGVGFSGLSELRQESLFPDLDLAAETSEEAHKDFHPSHGALSST
MAB_2702c|M.abscessus_ATCC_199 IGPIRLVGVGFSGFSDVQQTSLFPDLDQAEPVAES---DEVPSTAEPTHS
*:**:** :.
Mb3082|M.bovis_AF2122/97 --------------------------------------------------
Rv3056|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3925|M.avium_104 --------------------------------------------------
Mvan_2037|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4310|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2294|M.smegmatis_MC2_155 --------------------------------------------------
TH_0006|M.thermoresistible__bu --------------------------------------------------
MMAR_2359|M.marinum_M PAGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRGSGPGPARTFPIE
MUL_1535|M.ulcerans_Agy99 PAGAVWRIGDDVTHRELGHGWVQGAGHGVVTVRFETRDSGPGPARTFPIE
MAB_2702c|M.abscessus_ATCC_199 TAG--WGVGDDVDHAEFGHGWIQGTGHGVMTVRFETRSSGPGIARTFAVD
Mb3082|M.bovis_AF2122/97 -----------------------------------------
Rv3056|M.tuberculosis_H37Rv -----------------------------------------
MAV_3925|M.avium_104 -----------------------------------------
Mvan_2037|M.vanbaalenii_PYR-1 -----------------------------------------
Mflv_4310|M.gilvum_PYR-GCK -----------------------------------------
MSMEG_2294|M.smegmatis_MC2_155 -----------------------------------------
TH_0006|M.thermoresistible__bu -----------------------------------------
MMAR_2359|M.marinum_M TSDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MUL_1535|M.ulcerans_Agy99 TSDITAANPVDSLDWPDFVGQLRVENAADTSTPAVDDLDDG
MAB_2702c|M.abscessus_ATCC_199 DPGIARADPVASLDWPGESAEP-VDDGDEIGTGG-------