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RYLIATAVLVAVVLVGWPAAGAPPSCAGLGGTVQAGQICHVHASGPKYMLDMTFPVDYPDQQALTDYITQ NRDGFVNVAQGSPLRDQPYQMDATSEQHSSGQPPQATRSVVLKFFQDLGGAHPSTWYKAFNYNLATSQPI TFDTLFVPGTTPLDSIYPIVQRELARQTGFGAAILPSTGLDPAHYQNFAITDDSLIFYFAQGELLPSFVG ACQAQVPRSAIPPLAI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3036c | TB22.2 | - | 100% (227) | PROBABLE CONSERVED SECRETED PROTEIN TB22.2 |
| M. tuberculosis H37Rv | Rv1980c | mpt64 | 1e-52 | 45.91% (220) | immunogenic protein MPT64 (antigen MPT64/MPB64) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3062c | TB22.2 | 1e-132 | 99.56% (227) | hypothetical protein Mb3062c |
| M. gilvum PYR-GCK | Mflv_4267 | - | 9e-59 | 49.35% (231) | immunogenic protein MPB64/MPT64 precursor |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1835c | - | 2e-34 | 32.34% (269) | immunogenic protein MPT64 precursor |
| M. marinum M | MMAR_1665 | - | 1e-105 | 79.02% (224) | hypothetical protein MMAR_1665 |
| M. avium 104 | MAV_3901 | - | 4e-98 | 72.25% (227) | immunogenic protein MPB64/MPT64 |
| M. smegmatis MC2 155 | MSMEG_2331 | - | 2e-64 | 53.68% (231) | immunogenic protein MPB64/MPT64 |
| M. thermoresistible (build 8) | TH_2187 | - | 3e-69 | 56.00% (225) | PROBABLE CONSERVED SECRETED PROTEIN TB22.2 |
| M. ulcerans Agy99 | MUL_1902 | - | 1e-103 | 77.68% (224) | hypothetical protein MUL_1902 |
| M. vanbaalenii PYR-1 | Mvan_2092 | - | 9e-68 | 57.27% (220) | immunogenic protein MPB64/MPT64 precursor |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3036c|M.tuberculosis_H37Rv MRYLIA-------TAVLVAVVLVG---WPAAGAPPSCAGLGGTVQAGQIC
Mb3062c|M.bovis_AF2122/97 MRYLIA-------TAVLVAVVLVG---WPAAGAPPSCAGLGGTVQAGQIC
MMAR_1665|M.marinum_M ---MIA-------AAMLVSAVLLA---WPAAAEPPSCASLGGNVEGAQMC
MUL_1902|M.ulcerans_Agy99 MRLMIA-------AAMLVSAVLLA---WPAAAEPPSCASLGGNVEGAQMC
MAV_3901|M.avium_104 MRYLLA-------AALLAPAVLLG---WPAAAEPPSCAALGGSLEDGQMC
Mflv_4267|M.gilvum_PYR-GCK MRFLAAALTAAAVSASLAAGPAALAQPAPPA-TPSACVALSGTVDTDDMC
Mvan_2092|M.vanbaalenii_PYR-1 MRIFAAALTAAGATAGLLAVPAAGLLAAPAAGAQSACAELGGTVDAEQTC
TH_2187|M.thermoresistible__bu MRILKT-------TAALLAGGLISCSIPGTAGAQTACDALGGTVADDRRC
MSMEG_2331|M.smegmatis_MC2_155 MRISTV-------VGVLAAGVLIGGVAAPSAAAQSTCAELGGTVDADQIC
MAB_1835c|M.abscessus_ATCC_199 MPYLSLR--SISASVLVTAASIFGFSGVAGAAPHDYCGDLKGTN-TGKTC
: . * * * *. *
Rv3036c|M.tuberculosis_H37Rv HVHASGPKYMLDMTFPVDYPDQQALTDYITQNRDGFVNVAQGSPLRDQPY
Mb3062c|M.bovis_AF2122/97 HVHASGPKYMLDMTFPVDYPDQRALTDYITQNRDGFVNVAQGSPLRDQPY
MMAR_1665|M.marinum_M HIHATGSTYTLDITFPQDYPDQQALTDYITQNRDGFVSVATGSGRRDQPY
MUL_1902|M.ulcerans_Agy99 HIHATGSTYTLDITFPQDYPDQQALTDYITLNRDGFVSVATGSGRRDQPY
MAV_3901|M.avium_104 RLRAAGPNYTINMVFPADYPDEQALTDYITQNRDGFVNVAQSSGGRDQPY
Mflv_4267|M.gilvum_PYR-GCK LVQVENPTYRLDYSFPADYPDQQALTAYLTQTRDGFVNVAGMPGSWNLPY
Mvan_2092|M.vanbaalenii_PYR-1 HVHAENSTYRLDYTFPVDYPDQQALAAYLTQTRDGFVNVSEMPGSWNLPY
TH_2187|M.thermoresistible__bu EVHAETPTYLLDMVFPVDYPDQQALTDYLIQTRDGFVNVSEMPGSRNLPY
MSMEG_2331|M.smegmatis_MC2_155 QVHTANATYRLDYTFSTTYPDQEAVVGYLSQTRDGFVNVSDMPGSRDQPY
MAB_1835c|M.abscessus_ATCC_199 EIRLSDTGYSVDVTIPLNYPDQKSIAEYVAKTRDAFVNAAKSGAARSTTA
:: . * :: :. ***:.::. *: .**.**..: . .
Rv3036c|M.tuberculosis_H37Rv QMDATSEQHSSGQPP---QATRSVVLKFFQDLGGAHPSTWYKAFNYNLAT
Mb3062c|M.bovis_AF2122/97 QMDATSEQHSSGQPP---QATRSVVLKFFQDLGGAHPSTWYKAFNYNLAT
MMAR_1665|M.marinum_M QMDATTEQHAAGQPP---HNTRSVVLKFFQDLGGAHPFTWYKAFNYNLGT
MUL_1902|M.ulcerans_Agy99 QMDATTEQHAAGQPP---HNTRSVVLKFFQDLGGAHPFTWHKAFNYNLGT
MAV_3901|M.avium_104 QLEATTEQHSAGQPP---HNTRSVVLKFFQDVGGTRSSIWYKAFNYNLGT
Mflv_4267|M.gilvum_PYR-GCK VLDGRGTGYRTGPDD---GGTRSVVFEMYENVGGAHPQTWFKSFNWDVAK
Mvan_2092|M.vanbaalenii_PYR-1 VLDGRGTGYRTGPDG---AGTRSVVFEVYENVGGAHPQTWFKAFNWDVAK
TH_2187|M.thermoresistible__bu ALDARATEYRSGDAA---TGTRSVVFEVYQNVGGAHPTTWYQAFNYDLRT
MSMEG_2331|M.smegmatis_MC2_155 VLDARGSSYSSAVAPGLPARTQSLVLEVFQDVGGAQPETWYKSFNYDLVK
MAB_1835c|M.abscessus_ATCC_199 QLSMKPTEYNSDLPP---RGTQTVVFKVYQTGGNGQPQTAYKAFNWDQSY
:. : : *:::*::.:: *. :. .::**::
Rv3036c|M.tuberculosis_H37Rv SQPITFDTLFVPGT--------TPLDSIYPIVQRELARQTG---------
Mb3062c|M.bovis_AF2122/97 SQPITFDTLFVPGT--------TPLDSIYPIVQRELARQTG---------
MMAR_1665|M.marinum_M KQPITFDTLFAPGT--------TPLDAIYPIVQRELAHQTG---------
MUL_1902|M.ulcerans_Agy99 KQPITFDTLFAPGT--------TPLDAIYPIVQRELAHQTG---------
MAV_3901|M.avium_104 KQPLTFDNLFAPNT--------APLDAIFPIVQRDLERQTP---------
Mflv_4267|M.gilvum_PYR-GCK KAPITFDTLFKPGS--------EPLAVIFPIVRSDISRQLG---------
Mvan_2092|M.vanbaalenii_PYR-1 KAPITFDTLFRPDT--------KPLDVIFPIVQKDISRQLG---------
TH_2187|M.thermoresistible__bu RAPITFDTLFDPES--------APLEVIYPVVQRELQELTG---------
MSMEG_2331|M.smegmatis_MC2_155 RAPITFDTLFKPGS--------RPLDVIFPIVARELETQAG---------
MAB_1835c|M.abscessus_ATCC_199 RKPVLYTVPKDDKDDAPLWRVDDPLKTVAPIVQAQLQQQLAPPPVATPTP
*: : ** : *:* ::
Rv3036c|M.tuberculosis_H37Rv ------------------------FGAAILPSTGLDPAHYQNFAITDDSL
Mb3062c|M.bovis_AF2122/97 ------------------------FGAAILPSTGLDPAHYQNFAITDDSL
MMAR_1665|M.marinum_M ------------------------LGVAILPSNGLDPTHYQNFAITDTDV
MUL_1902|M.ulcerans_Agy99 ------------------------LGVAILPSNGLDPTHYQNFAITDTDV
MAV_3901|M.avium_104 ------------------------LGAAILPSTGHDPSHYQNFAITDDQL
Mflv_4267|M.gilvum_PYR-GCK ------------------------IEAPITTADGLDPAKYTEFAITDDAV
Mvan_2092|M.vanbaalenii_PYR-1 ------------------------VDAPISAADGLDPAKYQEFALTDDSL
TH_2187|M.thermoresistible__bu ------------------------IDQPILPEDGLDPANYQNFALTDDEV
MSMEG_2331|M.smegmatis_MC2_155 ------------------------IVQSISQSAGMDPTHYQNFAITDDSV
MAB_1835c|M.abscessus_ATCC_199 TTTSGQPTTTTSTTTTSTTPPPPPPPLPFSPATLYDPANYQNFAVLNDGI
.: **::* :**: : :
Rv3036c|M.tuberculosis_H37Rv IFYFAQGELLPSFVGACQAQVPRSAIPP--------------LAI-----
Mb3062c|M.bovis_AF2122/97 IFYFAQGELLPSFVGACQAQVPRSAIPP--------------LAI-----
MMAR_1665|M.marinum_M IFYFAQGELLPSFAGATQAQVPRNAIPP--------------LAI-----
MUL_1902|M.ulcerans_Agy99 IFYFAQGELLPSFAGATQAQVPRNAIPPPWRSEVHTGPASDSIAAAPMPS
MAV_3901|M.avium_104 IFYFAPGEMLPAFGGPVQAQVPRNAIPP--------------LAI-----
Mflv_4267|M.gilvum_PYR-GCK IFYFGQGEIMAGAGGALQATIPRSEIAS-------------MLALEPVPV
Mvan_2092|M.vanbaalenii_PYR-1 IFYFGQGEIMPGAGGALQATVPRSAVAA-------------MLAEPAVTQ
TH_2187|M.thermoresistible__bu IFFFSQGELLPHAAGVSQVSVPRTVLVN-------------LLTV-----
MSMEG_2331|M.smegmatis_MC2_155 IFFFDRGALVADSAGALQASVPRWAVAS-------------LLA------
MAB_1835c|M.abscessus_ATCC_199 RFFFDQGAILPDSYGALQVLVPRSAIDP-------------MIA------
*:* * ::. * *. :** : ::
Rv3036c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3062c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1665|M.marinum_M --------------------------------------------------
MUL_1902|M.ulcerans_Agy99 VSWATHPMIGTTKATLCRASRYTLMMRSARNITMPPQKRSPIALSTQEGS
MAV_3901|M.avium_104 --------------------------------------------------
Mflv_4267|M.gilvum_PYR-GCK TP------------------------------------------------
Mvan_2092|M.vanbaalenii_PYR-1 G-------------------------------------------------
TH_2187|M.thermoresistible__bu --------------------------------------------------
MSMEG_2331|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1835c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3036c|M.tuberculosis_H37Rv ----
Mb3062c|M.bovis_AF2122/97 ----
MMAR_1665|M.marinum_M ----
MUL_1902|M.ulcerans_Agy99 PQVW
MAV_3901|M.avium_104 ----
Mflv_4267|M.gilvum_PYR-GCK ----
Mvan_2092|M.vanbaalenii_PYR-1 ----
TH_2187|M.thermoresistible__bu ----
MSMEG_2331|M.smegmatis_MC2_155 ----
MAB_1835c|M.abscessus_ATCC_199 ----