For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGCRFPGNVTGPESFWQLLADGVDTIEQ VPPDRWDADAFYDPDPSASGRMTTKWGGFVSDVDAFDADFFGITPREAVAMDPQHRMLLEVAWEALEHAG IPPDSLSGTRTGVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPAVAVDTACSSS LVAIHLACQSLRLRETDVALAGGVQLTLSPFTAIALSKWSALSPTGRCNSFDANADGFVRGEGCGVVVLK RLADAVRDQDRVLAVVRGSATNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVETHGTGTVLGD PIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLAVQRGHIPRNLHFTRWNPAIDA SATRLFVPTESAPWPAAAGPRRAAVSSFGLSGTNAHVVVEQAPDTAVAAAGGMPYVSALNVSGKTAARVA SAAAVLADWMSGPGAAAPLADVAHTLNRHRARHAKFATVIARDRAEAIAGLRALAAGQPRVGVVDCDQHA GGPGRVFVYSGQGSQWASMGQQLLANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDRIQPVLV GMQLALTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRLMARLSGQGAMALLELDAD AAEALIAGYPQVTLAVHASPRQTVIAGPPEQVDTVIAAVATQNRLARRVEVDVASHHPIIDPILPELRSA LADLTPQPPSIPIISTTYESAQPVADADYWSANLRNPVRFHQAVTAAGVDHNTFIEISPHPVLTHALTDT LDPDGSHTVMSTMNRELDQTLYFHAQLAAVGVAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSELAATH PLLGAHIEMPRNGDHVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIALAAASEALGTAADAVAPNIVI NQFEVEQMLPLDGHTPLTTQLIRGGDSQIRVEIYSRTRGGEFCRHATAKVEQSPRECAHAHPEAQGPATG TTVSPADFYALLRQTGQHHGPAFAALSRIVRLADGSAETEISIPDEAPRHPGYRLHPVVLDAALQSVGAA IPDGEIAGSAEASYLPVSFETIRVYRDIGRHVRCRAHLTNLDGGTGKMGRIVLINDAGHIAAEVDGIYLR RVERRAVPLPLEQKIFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQAKSMADDFVQQWR SPMRRVHTADIHDESAVLAAFAETAGDPEHPPVGVVVFVGGASSRLDDELAAARDTVWSITTVVRAVVGT WHGRSPRLWLVTGGGLSVADDEPGTPAAASLKGLVRVLAFEHPDMRTTLVDLDITQDPLTALSAELRNAG SGSRHDDVIAWRGERRFVERLSRATIDVSKGHPVVRQGASYVVTGGLGGLGLVVARWLVDRGAGRVVLGG RSDPTDEQCNVLAELQTRAEIVVVRGDVASPGVAEKLIETARQSGGQLRGVVHAAAVIEDSLVFSMSRDN LERVWAPKATGALRMHEATADCELDWWLGFSSAASLLGSPGQAAYACASAWLDALVGWRRASGLPAAVIN WGPWSEVGVAQALVGSVLDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQVVEE LDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQSTVEPAVPLDKPLTELGLDSLMAVR IRNGARADFGVEPPVALILQGASLHDLTADLMRQLGLNDPDPALNNADTIRDRARQRAAARHGAAMRRRP KPEVQGG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2934 | ppsD | - | 100% (1827) | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD |
M. tuberculosis H37Rv | Rv2933 | ppsC | 0.0 | 45.57% (1545) | phenolpthiocerol synthesis type-I polyketide synthase PPSC |
M. tuberculosis H37Rv | Rv2932 | ppsB | 0.0 | 63.41% (932) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2959 | ppsD | 0.0 | 99.89% (1827) | phenolpthiocerol synthesis type-I polyketide synthase PPSD |
M. gilvum PYR-GCK | Mflv_3391 | - | 0.0 | 57.06% (1842) | beta-ketoacyl synthase |
M. leprae Br4923 | MLBr_02354 | - | 0.0 | 80.28% (1836) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_3148c | - | 0.0 | 38.38% (1428) | polyketide synthase Pks5 |
M. marinum M | MMAR_1773 | ppsD | 0.0 | 71.45% (1832) | phenolpthiocerol synthesis type-I polyketide synthase PpsD |
M. avium 104 | MAV_2370 | - | 0.0 | 40.24% (1444) | mycocerosic acid synthase |
M. smegmatis MC2 155 | MSMEG_4727 | - | 0.0 | 40.13% (1535) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 40.63% (1435) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2016 | ppsD | 0.0 | 71.40% (1832) | phenolpthiocerol synthesis type-I polyketide synthase PpsD |
M. vanbaalenii PYR-1 | Mvan_3124 | - | 0.0 | 58.93% (1843) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAV_2370|M.avium_104 ----------------------------------MVPVAVIGMACRLPGA TH_4621|M.thermoresistible__bu --------------------------VNIVGDTPVNAVAVIGMACRLPGG MSMEG_4727|M.smegmatis_MC2_155 -----------------------------MTQNCVAPVAIIGMACRLPGA MAB_3148c|M.abscessus_ATCC_199 ------------------------------------------MGCRLPGG Rv2934|M.tuberculosis_H37Rv MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGCRFPGN Mb2959|M.bovis_AF2122/97 MTSLAERAAQLSPNARAALARELVRAGTTFPTDICEPVAVVGIGCRFPGN MLBr_02354|M.leprae_Br4923 MTSLAERAAQLSPNARAALARELVRTGTAFPTDISEPVAVVGIGCRFPGN MMAR_1773|M.marinum_M MTSLAERAAQMSPKAREVLARELVRAGTAFPTDIAEPVAVVGIGCRLPGN MUL_2016|M.ulcerans_Agy99 MTSLAERAAQMSPKAREVLAHELVRAGTAFPTDIAEPVAVVGIGCRLPGN Mflv_3391|M.gilvum_PYR-GCK MKTTFDRISAMSAEQRDKLAEQFEKASRVAG---AEPIAVVGMGCRFPGG Mvan_3124|M.vanbaalenii_PYR-1 MKTTFDRISAMSAEQRGKLAEQFEKASRVAG---AEPIAVVGIGCRLPGG :.**:** MAV_2370|M.avium_104 VDSPERLWEALLRGDDFVTEIPPDRWDADEYYDPEPGVPGRSVSRWGAFI TH_4621|M.thermoresistible__bu IDSPQRLWEALLRGDDMVTEIPVDRWDADDYFDPEPGVPGRTVSRWGAFL MSMEG_4727|M.smegmatis_MC2_155 INSPQQLWEALLRGDDFVTEIPTGRWDAEEYYDPEPGVPGRSVSKWGAFL MAB_3148c|M.abscessus_ATCC_199 IESPEQFWQALLRGEDFITEVPPARWDLTEYYDPESGVPGKSPSKWGAFL Rv2934|M.tuberculosis_H37Rv VTGPESFWQLLADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFV Mb2959|M.bovis_AF2122/97 VTGPESFWQLLADGVDTIEQVPPDRWDADAFYDPDPSASGRMTTKWGGFV MLBr_02354|M.leprae_Br4923 VTGPDSFWQLLVDGGDAISEVPPDRWDADAFYDPDPSASGRMTTKWGGFV MMAR_1773|M.marinum_M VSGPDSFWQLLVDGRDAVDEVPADRWDADAFYDPDPRAPGRMTTKWGGFI MUL_2016|M.ulcerans_Agy99 VSGPDSFWQLLVDGRDAVDEVPADRWDADAFYDPDPRAPGRMTTKWGGFI Mflv_3391|M.gilvum_PYR-GCK ATDPDSYWKVLESGTNAVTEVPADRWDGDAYYDPDPMAPGRMPSKWGAYI Mvan_3124|M.vanbaalenii_PYR-1 VTGPDSYWELLENGTDAITEVPADRWDGDAFYDPDPMAPGRMPTKWGAYL .*: *: * * : : ::* *** ::**:. ..*: ::**.:: MAV_2370|M.avium_104 DDVAGFDPEFFGINEREATAMDPQHRLLLETSWEAMEHAGLTEERVADSR TH_4621|M.thermoresistible__bu DDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSS MSMEG_4727|M.smegmatis_MC2_155 DDPAAFDPEFFGITEREAAAIDPQHRLLLETAWEAVEHSGLNPAGLAGSA MAB_3148c|M.abscessus_ATCC_199 EDVGGFDADFFSINEREAVSIDPQHRVLLETSWQAVEHAGIDPRALAGSQ Rv2934|M.tuberculosis_H37Rv SDVDAFDADFFGITPREAVAMDPQHRMLLEVAWEALEHAGIPPDSLSGTR Mb2959|M.bovis_AF2122/97 SDVDAFDADFFGITPREAVAMDPQHRILLEVAWEALEHAGIPPDSLSGTR MLBr_02354|M.leprae_Br4923 PDVDAFDAEFFGITPREAVAMDPQHRMLLEVAWESLEHAGIAPDSLSGTR MMAR_1773|M.marinum_M DDVAGFDADFFGITPREAVAMDPQQRVLLEVAWEALEHAGLPPDSLSGTR MUL_2016|M.ulcerans_Agy99 DDVAGFDADFFGITPREAVAMDPQQRVLLEVAWEALEHAGLPPDSLSGTR Mflv_3391|M.gilvum_PYR-GCK DDMAGFDAEFFGITPREAAAMDPQQRIVLEVAYEALENAGLAPDTVGDIR Mvan_3124|M.vanbaalenii_PYR-1 DDVSGFDADFFGITPREAAAMDPQQRVLLEVAWEALENAGLAPDTLSETR * .**.:**.*. *** ::***:*::**.:::::*::*: : MAV_2370|M.avium_104 TGVFIGLTHGDYQLLAADTRSVEGAYGFSGSNFSLASGRIAYALGVHGPA TH_4621|M.thermoresistible__bu TGVFVGLSHDDYALLTSDAGALEEAYGFTGSAFSMASGRIAYRLGVHGPA MSMEG_4727|M.smegmatis_MC2_155 TGVFMGLTHNDYAHLAADAKALEGPYGFTGTSFSLASGRIAYALGVHGPA MAB_3148c|M.abscessus_ATCC_199 TGVFVGVTHNDYQLVAADAADLGGPYGFAGTNFCMASGRISYALGVHGPS Rv2934|M.tuberculosis_H37Rv TGVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPA Mb2959|M.bovis_AF2122/97 TGVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRIAYLLGLRGPA MLBr_02354|M.leprae_Br4923 TAVMMGLSSWDYTIVNIERRADIDAYLSTGTPHCAAVGRISYLLGLRGPA MMAR_1773|M.marinum_M TAAVMGLSAWDYTIVNLERRAEIDAYISTGNPHSAAVGRISYLLGLRGPA MUL_2016|M.ulcerans_Agy99 TAAVMGLSAWDYTIVNLERRAEIDAYISTGNPHSAAVGRISYLLGLRGPA Mflv_3391|M.gilvum_PYR-GCK GAVMLGVYYNEYQSASAGNPDTIDAYSATGNAHSVTVGRIAYLLGLKGPA Mvan_3124|M.vanbaalenii_PYR-1 TAVMMGVYYTEYQNSSAGNPDTIDAYSATGNAHSVTVGRIAYLLGLKGPA ...:*: :* .* :*. .. : ***:* **::**: MAV_2370|M.avium_104 LTVDTACSSGLTAIHLACRSLHEGESDLALAGGATLALDPRKFSAGSAEG TH_4621|M.thermoresistible__bu VTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLG MSMEG_4727|M.smegmatis_MC2_155 ITVDTACSSSLSAIHMACRSLHDGESDVALAGGVSVLLEPRKAAGGSAAG MAB_3148c|M.abscessus_ATCC_199 LTVDAGCAAGLATVHMGCQSLAAGESDLVLAGGVNLVLEPRRYVGASQQR Rv2934|M.tuberculosis_H37Rv VAVDTACSSSLVAIHLACQSLRLRETDVALAGGVQLTLSPFTAIALSKWS Mb2959|M.bovis_AF2122/97 VAVDTACSSSLVAIHLACQSLRLRETDVALAGGVQLTLSPFTAIALSKWS MLBr_02354|M.leprae_Br4923 MAVDTACSSSLVAIHLACQSLRLRESDVALAGGVQLILSPFTAIALSKWS MMAR_1773|M.marinum_M VAVDTACSSSLVALHLACQSLRLRESDVALAGGVQLMLSPFTSIALSKWS MUL_2016|M.ulcerans_Agy99 VAVDTACSSSLVALHLACQSLRLRESDVALAGGVQLMLSPFTSIALSKWS Mflv_3391|M.gilvum_PYR-GCK VAVDTACSSSLVSIHLACQSLRMRESDLALAGGVSLSLRPETQLALGKWG Mvan_3124|M.vanbaalenii_PYR-1 VAVDTACSSSLVSIHLACHSLRMRESDLALAGGVSLNLRPETQLALAKWG ::**:.*::.* ::*:.*:** *:*:.****. : * * . . MAV_2370|M.avium_104 MLSPTGRCHAFDVAADGFVGGEGSVMLLLKRLNDALRDGDRILAVVRGTA TH_4621|M.thermoresistible__bu MLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTA MSMEG_4727|M.smegmatis_MC2_155 MLSPTGHCHAFDTAADGFVSAEGCVVLTLKRLDDAVADGDRILAVIRGTA MAB_3148c|M.abscessus_ATCC_199 MLSPTGRCHTFTGEADGFVMSEGCVMVLLKRLDDAVRDGDRILAVVRGTA Rv2934|M.tuberculosis_H37Rv ALSPTGRCNSFDANADGFVRGEGCGVVVLKRLADAVRDQDRVLAVVRGSA Mb2959|M.bovis_AF2122/97 ALSPTGRCNSFDANADGFVRGEGCGVVVLKRLADAVRDQDRVLAVVRGSA MLBr_02354|M.leprae_Br4923 ALSPTGRCNSFDANADGFVRGEGCGVVVLKRLVDALRDQDRVLAVVRGSA MMAR_1773|M.marinum_M ALSPTGRCKTFDALADGFVRSEGCGVVVLKRLVDAVRDGDRVLAVVRGSA MUL_2016|M.ulcerans_Agy99 ALSPTGRCKTFDALADGFVRSEGCGVVVLKRLVDAVRDGDRVLAVVRGSA Mflv_3391|M.gilvum_PYR-GCK MLSPHGKCYAFDSRADGFVRGEGAGVVVLKRLTDAVRDGDRVLGVVRGSA Mvan_3124|M.vanbaalenii_PYR-1 MLSPHGKCFAFDSRADGFVRGEGAGVVVLKRLTDAVRDGDRVLGVVRGSA *** *:* :* ***** .**. :: **** **: * **:*.*:**:* MAV_2370|M.avium_104 ANQDGHTVNIATPSKTAQTAVYRAALAAAGVDAGTVGMVEAHGPGTPVGD TH_4621|M.thermoresistible__bu ANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGD MSMEG_4727|M.smegmatis_MC2_155 TNQDGRTVNIATPSADAQAKVYRMALKAAGVEPGTVGLVEAHGTGTPVGD MAB_3148c|M.abscessus_ATCC_199 SNQDGRTVNQSTPSSEAQAAACRTALAVAGVEADTVGLIEAHGTGTPVGD Rv2934|M.tuberculosis_H37Rv TNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVETHGTGTVLGD Mb2959|M.bovis_AF2122/97 TNSDGRSNGMTAPNALAQRDVITSALKLADVTPDSVNYVETHGTGTVLGD MLBr_02354|M.leprae_Br4923 TNQDGRSNGMTAPNALAQRDVITTALRLADITPDSVNYVETHGTGTVLGD MMAR_1773|M.marinum_M INQDGRSNGMTAPNAAAQRDVIGTALKLADATADSVNYVETHGTGTVLGD MUL_2016|M.ulcerans_Agy99 INQDGRSNGMTAPNAAAQRDVIGTALKLADATADSVNYVETHGTGTVLGD Mflv_3391|M.gilvum_PYR-GCK VNQDGRSNGLTAPNAPSQRDVITRALRSADVAAGTVNFVETHGTGTSLGD Mvan_3124|M.vanbaalenii_PYR-1 VNQDGRSNGLTAPNAPSQRDVITRALRSADVAAGTVDYIETHGTGTGLGD *.**:: . ::*. :* . ** *. . :*. :*:**.** :** MAV_2370|M.avium_104 PIEYASLAEVYG-----IDGPCALASVKTNFGHAQAASGALGMMKAILAL TH_4621|M.thermoresistible__bu PIEYNSLTQVYG-----KTGPCALTSVKTNFGHAESAAGALGMMKAILAL MSMEG_4727|M.smegmatis_MC2_155 PLEFSSLAEVYG-----TDGPCALGSIKTNFGHTQSAAGALGVMKAVLAL MAB_3148c|M.abscessus_ATCC_199 PIEYTGLAQVYG-----VDGPCAVGSVKTNFGHTMSAAGALGLMKIVLAV Rv2934|M.tuberculosis_H37Rv PIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLAV Mb2959|M.bovis_AF2122/97 PIEFESLAATYGLGKGQGESPCALGSVKTNIGHLEAAAGVAGFIKAVLAV MLBr_02354|M.leprae_Br4923 PIEFESLAATY----GRGESSCALGSVKTNIGHLEAAAGVAGFIKTVLAL MMAR_1773|M.marinum_M PIEFEALAATYGLGKDKGADSCALGSVKTNLGHLEAAAGITSFIKATLAV MUL_2016|M.ulcerans_Agy99 PIEFEALAATYGLGKDKGADSCALGSVKTNLGHLEAAAGITSFIKATLAV Mflv_3391|M.gilvum_PYR-GCK PIEFDALSAVYG----KGDTPCALGAVKTNMGHMEAAAGIGGFIKAVLTL Mvan_3124|M.vanbaalenii_PYR-1 PIEFDALAAVYG----KGEVPCALGAVKTNMGHLEAAAGVAGFIKTVLSL *:*: .*: .* .**: ::***:** :*:* ..:* *:: MAV_2370|M.avium_104 QHGVVPRNLHFTQLPDDLARIDTKLFVPQQTTPWVSNGGHPRRAAVSSYG TH_4621|M.thermoresistible__bu QHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREGCPRRAAVSSYG MSMEG_4727|M.smegmatis_MC2_155 QHNVIPQNLHFTRLPDQMAEIETGLFVPETITPWPVREGQPRRAAVSAYG MAB_3148c|M.abscessus_ATCC_199 EHGVVPPNLHFTGIPDKLAPVKTNLFVPQTVIPWPGKAQGPRRAGVSAYG Rv2934|M.tuberculosis_H37Rv QRGHIPRNLHFTRWNPAIDASATRLFVPTESAPWPAAAG-PRRAAVSSFG Mb2959|M.bovis_AF2122/97 QRGHIPRNLHFTRWNPAIDASATRLFVPTESAPWPAAAG-PRRAAVSSFG MLBr_02354|M.leprae_Br4923 QHAYIPRNVHFTQWNPAIDASTTRLFVPTESAPWPAIPG-PRRGAVSSFG MMAR_1773|M.marinum_M AHGYIPPNLHFSRWNPAIDASSTRLFVPTQGAQWPAG---LRRAAVSSFG MUL_2016|M.ulcerans_Agy99 AHGYIPPNLHFSRWNPAIDASSTRLFVPTQGAQWPAG---LRRAAVSSFG Mflv_3391|M.gilvum_PYR-GCK QHGAIAPNLHFQKWNPSINATGTRLFVPTEKTDWPETDH-PRRAAVSSFG Mvan_3124|M.vanbaalenii_PYR-1 QHGKIAPNLNFEKWNPQIDPKPTRLFVPTEAQDWPKSEH-PRRAAVSSFG : :. *::* : * **** * **..**::* MAV_2370|M.avium_104 LSGTNVHAILEQAP-EPAPETVAPEGISAESPLLFPLSSTSADELRRTAG TH_4621|M.thermoresistible__bu MSGTNVHAVLEQAP-EPVQRPEESADTDAAGPLVFALSSTSAEELRRTAG MSMEG_4727|M.smegmatis_MC2_155 LSGTNVHAVLEQAPESPAETAAEAISPKAGNALVFPVSASSADALRSTAQ MAB_3148c|M.abscessus_ATCC_199 MSGSNVHAVVEQAP-PVESSTPPAVESPLGSQLIFPVSSTSAEELRRTAA Rv2934|M.tuberculosis_H37Rv LSGTNAHVVVEQAP---DTAV--AAAGGMPYVSALNVSGKTAARVASAAA Mb2959|M.bovis_AF2122/97 LSGTNAHVVVEQAP---DTAV--AAAGGMPYVSALNVSGKTAARVASAAA MLBr_02354|M.leprae_Br4923 LSGTNAHVVIEQAP---DTTVPISAAVGRQYVSALVVSGKTVTRVASAAA MMAR_1773|M.marinum_M LSGTNAHVVLEQPP---APAP---ADQPRSGLSALVVSGKTPQRVAAMAS MUL_2016|M.ulcerans_Agy99 LSGTNAHVVLEQPP---APAP---ADQPRSGLSALVVSGKTPQRVAAMAS Mflv_3391|M.gilvum_PYR-GCK MGGTNAHIVLEQGP---DVAA--APVDPAPKVATLVVSGKTPQRLAAAAA Mvan_3124|M.vanbaalenii_PYR-1 MGGTNAHIVLEQGP---EPAP--AGAADTG-VVTLVVSGKTSERLAASAR :.*:*.* ::** * : :*..: : * MAV_2370|M.avium_104 RLADWVHAHGD------LALP-DLAYTLARRRVHRPVRTAVLAGDRAQLI TH_4621|M.thermoresistible__bu RLAEWVEAHTD------EVVPADLAYTLARRRAHRPVRTTVIADGVEALT MSMEG_4727|M.smegmatis_MC2_155 HLADWLLRSGDGNGRGPAIDLGDLAYTLARRRGFRAARSAVLAGDRGTLV MAB_3148c|M.abscessus_ATCC_199 RLADWVAERPE-------VAPGDVGYTLARRRAHRSVRTAVVADGADELI Rv2934|M.tuberculosis_H37Rv VLADWMSGPGA------AAPLADVAHTLNRHRARHAKFATVIARDRAEAI Mb2959|M.bovis_AF2122/97 VLADWMSGPGA------AAPLADVAHTLNRHRARHAKFATVIARDRAEAI MLBr_02354|M.leprae_Br4923 VLADWMSGPGA------AAPLADVAYTLNQHRVRHPKLATVIARDHADAV MMAR_1773|M.marinum_M ALADWVDGPGG------QTPLADVAHTLNHHRARHGKFGAVVARDRAGAV MUL_2016|M.ulcerans_Agy99 ALADWVDGPGA------QTPLADVAHTLNHHRARHGKFGAVVARDRAGAV Mflv_3391|M.gilvum_PYR-GCK SLADWLDGDGA------QVPLTDVAHTVNHHRSRFPTIATVCARTHAEAV Mvan_3124|M.vanbaalenii_PYR-1 SLADWLDGDGA------DVPLVDVAYTVNHHRSRYQTIATVCARTHAEAV **:*: *:.:*: ::* :* * MAV_2370|M.avium_104 EALREVADGDTPYPAAVGRGDRG-------PVWVFSGQGSQWAAMGADLL TH_4621|M.thermoresistible__bu AGLREVADGDAPYQPAVGMDDKA-------PVWVFSGQGSQWAGMGAELL MSMEG_4727|M.smegmatis_MC2_155 EGLRQIADGEAMPQQAVTNDDRG-------PVWVFSGQGSQWASMGAELL MAB_3148c|M.abscessus_ATCC_199 DALRGVAEGDAPYPAAVAQDDRG-------PVWLFSGQGSQWAGMGAELL Rv2934|M.tuberculosis_H37Rv AGLRALAAGQPRVGVVDCDQHAG----GPGRVFVYSGQGSQWASMGQQLL Mb2959|M.bovis_AF2122/97 AGLRALAAGQPRVGVVDCDQHAG----GPGRVFVYSGQGSQWASMGQQLL MLBr_02354|M.leprae_Br4923 AGLRALAAGQPRVGVVGCDQHAA----GPGRVFVYSGQGSQWAGMGRQLL MMAR_1773|M.marinum_M EGLRALAAGQPGPGVLGCQDVQN----QPGTVFVYSGQGSQWVGMGRQLL MUL_2016|M.ulcerans_Agy99 EGLRALAAGQPGPGVLGCQDVQN----QPGTVFVYSGQGSQWVGMGRQLL Mflv_3391|M.gilvum_PYR-GCK AGLRALAAGQTAPGVVGARAAKS----GTGTVFLYSGQGAQWAGMGRTLL Mvan_3124|M.vanbaalenii_PYR-1 TGLRALADGRPAPGVIAPHDAKGGVAAGKGVVFLYSGQGAQWAGMGKTLL .** :* * . *:::****:**..** ** MAV_2370|M.avium_104 ATEPVFAATVAQAEPLIARESGFSVAEAMSAPQTVTGQDRVQPTLFTMQV TH_4621|M.thermoresistible__bu ATEQVFAAKIAEIEPLVARESGFSVTEAMTASETVTGIDRVQPTLFAIQV MSMEG_4727|M.smegmatis_MC2_155 DREPAFAAAIAELEPLIAAESDFSVTEALTASETVTGIDRVQPTIFAVQV MAB_3148c|M.abscessus_ATCC_199 GKEPVFAETIARLEPLIHAESGFSVTDAISAPETVTGIDRVQPTLFAMQV Rv2934|M.tuberculosis_H37Rv ANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDRIQPVLVGMQL Mb2959|M.bovis_AF2122/97 ANEPAFAKAVAELDPIFVDQVGFSLQQTLIDGDEVVGIDRIQPVLVGMQL MLBr_02354|M.leprae_Br4923 VDEPAFAKAVAELEPTFVAQVGFSLEHTLAYGDEVVGIERIQPVLVGIQL MMAR_1773|M.marinum_M ADEPSFAAAIAELEPDFVAQAGFSLQQTLTEGREVVGIDRIQPVLVGIQL MUL_2016|M.ulcerans_Agy99 ADEPSFAAAIAELEPDFVAQAGFSLQQTLTEGREVVGIDRIQPVLVGIQL Mflv_3391|M.gilvum_PYR-GCK ADEPAFAAAVDELEPAFVDKVGFSLRQTLEAGEPVTGIDRIQPVLVGMQL Mvan_3124|M.vanbaalenii_PYR-1 TSEPAFAAAVDELEPAFVEKVGFSLRQTLEAGEPVVGIDRIQPVLVGMQL * ** : . :* . : .**: .:: *.* :*:**.:. :*: MAV_2370|M.avium_104 ALAATMKAHGVRPGAVIGHSLGEAAAAVVAGALSLEDGARVICRRSRLMS TH_4621|M.thermoresistible__bu ALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGVKVICRRSRLCL MSMEG_4727|M.smegmatis_MC2_155 ALAAAMRSHGVVPGAVIGHSMGEVAASVVSGALSLEDGVKVICRRTRLMT MAB_3148c|M.abscessus_ATCC_199 SLAATLASYGVRPGAVIGHSMGEVAAAVVSEALSLEDGVKVICRRSQLML Rv2934|M.tuberculosis_H37Rv ALTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRLMA Mb2959|M.bovis_AF2122/97 ALTELWRSYGVIPDAVIGHSMGEVSAAVVAGALTPEQGLRVITTRSRLMA MLBr_02354|M.leprae_Br4923 ALTELWRSYGVTPDAVIGHSMGEVSAAVVAGALTPEQGLRVIATRSRLMA MMAR_1773|M.marinum_M ALTALWRSHGVTPDAVVGHSMGEVSAAVVAGALTPADGFKVIATRSRLMA MUL_2016|M.ulcerans_Agy99 ALTALWRSHGVTPDAVVGHSMGEVSAAVVAGALTPADGFKVIATRSRLMA Mflv_3391|M.gilvum_PYR-GCK ALTQLWRSYGVEPDAVIGHSMGEATAAVVAGVLTPAEGFDIIATRTRLMK Mvan_3124|M.vanbaalenii_PYR-1 ALTALWRSYGVEPDAVIGHSMGEATAAVVAGVLTPAEGFDVIATRTRLMK :*: ::** *.**:***:**.:*:**: .*: :* :* *::* MAV_2370|M.avium_104 RVAGTGATASVELPAQQVLSELTARGISDVVVAVVASPQSTVIAGAAPTV TH_4621|M.thermoresistible__bu RLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPESTVIGGATDTV MSMEG_4727|M.smegmatis_MC2_155 RIAGSGAMAMVELPAQQVLSELASRGVDDVVLSVVASPQSTVVGGATASV MAB_3148c|M.abscessus_ATCC_199 RISGAGAMASVDLPAQQVVSELADRDIHDVVLAVVASPQSTVVGGATETV Rv2934|M.tuberculosis_H37Rv RLSGQGAMALLELDADAAEALIAGY--PQVTLAVHASPRQTVIAGPPEQV Mb2959|M.bovis_AF2122/97 RLSGQGAMALLELDADAAEALIAGY--PQVTLAVHASPRQTVIAGPPEQV MLBr_02354|M.leprae_Br4923 RLSGQGAMALLELDADAAEALIADY--PEVTLAVYASPRQSVIAGLPESV MMAR_1773|M.marinum_M RLAGQGAMALLELDSDAAEALIADY--PQVTLAVHASPHQSVVAGPPESV MUL_2016|M.ulcerans_Agy99 RLAGQGAMALLELDSDAAEALIADY--PQVTLAVHASPHQSVVAGPPESV Mflv_3391|M.gilvum_PYR-GCK RLSGQGAMALLELDAQATEKLIADR--PDITIAVYASPKQCVIAGPPEQV Mvan_3124|M.vanbaalenii_PYR-1 RLSGQGAMALLELDAQATEKLIADR--SDVTIAVYASPKQTVIAGPPEQV *::* ** * ::* :: . :: ::.::* ***.. *:.* . * MAV_2370|M.avium_104 RDLVTAWQERGVMAREVPTDVAFHSPQVDPIMDDLTDALAEISPRPPEVP TH_4621|M.thermoresistible__bu RELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILADLQPMTPTVP MSMEG_4727|M.smegmatis_MC2_155 RELIEMWESRGVMAREIAVDVASHSPQVDPILDDLIEALADLDPAEPEIP MAB_3148c|M.abscessus_ATCC_199 RQLIAEWSDRGLMAREVAVDVASHSPQVDPILDDLADALEDLTPRTPVVP Rv2934|M.tuberculosis_H37Rv DTVIAAVATQNRLARRVEVDVASHHPIIDPILPELRSALADLTPQPPSIP Mb2959|M.bovis_AF2122/97 DTVIAAVATQNRLARRVEVDVASHHPIIDPILPELRSALADLTPQPPSIP MLBr_02354|M.leprae_Br4923 DAVISVVAEQNRLARRVDVEVASHHSIIDPILPELRNALADLVPQTPIIP MMAR_1773|M.marinum_M DAVIAAVAGQNRLARRIEVDVASHHPIIDPILPDLRSALADLTPQPPAIP MUL_2016|M.ulcerans_Agy99 DAVIAAVAGQNRLARRIEVDVASHHPIIDPILPDLRSALADLTPQPPAIP Mflv_3391|M.gilvum_PYR-GCK DELVALVDAQGKLARRVEVDVASHHPTIDPVLGELRDALSYLSPAAPKIP Mvan_3124|M.vanbaalenii_PYR-1 DELVAAVDAQGKLARRIEVDVASHHPTIDPVLPELREALAYLTPAAPKIP :: :. :**.: .:** * . :**:: :* . * : * * :* MAV_2370|M.avium_104 YYSATLFDPREQPVCDARYWANNMRRMVRFATAVQAAL------EDGYRV TH_4621|M.thermoresistible__bu YYSATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAAL------EDGFRV MSMEG_4727|M.smegmatis_MC2_155 YYSATLYDPRDYADYDAYYWADNLRHTVRFSAAVQAAL------EDGHRV MAB_3148c|M.abscessus_ATCC_199 LYSSVSFDPRERPIMDADYWVDNLRHTVRFAAAVQAAL------DDGYRV Rv2934|M.tuberculosis_H37Rv IISTT-YESAQ-PVADADYWSANLRNPVRFHQAVTAAG-------VDHNT Mb2959|M.bovis_AF2122/97 IISTT-YESAQ-PVADADYWSANLRNPVRFHQAVTAAG-------VDHNT MLBr_02354|M.leprae_Br4923 IITTT-HEHTQ-AVMDADYWAANLRNPVRFHQAIAQAVSGVGGFNRTCHS MMAR_1773|M.marinum_M MITTT-CEQPQ-PVLDADYWAANLRNPVRFHQAITTAG-------AQHHT MUL_2016|M.ulcerans_Agy99 MITTT-CEQPQ-PVLDADYWAANLRNPVRFHQAITTAG-------AQHHT Mflv_3391|M.gilvum_PYR-GCK LVSTVAYAGSA-PLYSADYWAANLRNPVRFSQAVHEAA-------ADHSN Mvan_3124|M.vanbaalenii_PYR-1 LVSTVGYAGDA-PMYSADYWAANLRNPVRFSQAVHDAS-------AENSN ::. . .* ** *:*. *** *: * MAV_2370|M.avium_104 FAELAPHPLLVRALEQTARSREIPMAALAGMRRGQALPHGLRGFVADLHN TH_4621|M.thermoresistible__bu FGELSPHPLLTRAVEQTARGLDMPVAALPAMRREQEMPHGVRTMVGDLFA MSMEG_4727|M.smegmatis_MC2_155 FAELSPHPLLTHPVEQTARSLDMPLAVFAAMRRQQEMPHGLLGFVADLHS MAB_3148c|M.abscessus_ATCC_199 FGELAPHPLLVYPAEQTARSLDIPMVALAGMRREQELPHGLRDFVGDLYT Rv2934|M.tuberculosis_H37Rv FIEISPHPVLTHALTDTLDPD-GSHT--VMSTMNRELDQ-TLYFHAQLAA Mb2959|M.bovis_AF2122/97 FIEISPHPVLTHALTDTLDPD-GSHT--VMSTMNRELDQ-TLYFHAQLAA MLBr_02354|M.leprae_Br4923 FIEISPHPVLTHAITDTVGGS-GGHV--VTSAMNRDLDQ-TLFFHAQLAT MMAR_1773|M.marinum_M FVEISPHPLLTHAITDTLAAA-ESRTRLITATLQRDGDD-AITFHTNLAA MUL_2016|M.ulcerans_Agy99 FVEISPHPLLTHAITDTLAAA-DSRTRLITATLQRDGDD-AITFHTNLAA Mflv_3391|M.gilvum_PYR-GCK FVEISPHPLLTHAISDTLAAQSTSRKFHVGATLNRDHPE-PLAFHAQLSA Mvan_3124|M.vanbaalenii_PYR-1 FIEISPHPLLTHAISDTLAAQSTSRRYHVGATVNRDNPE-PLAFHAQLAA * *::***:*. . :* : . : :* MAV_2370|M.avium_104 AGAAVDFSVLYPTGRLVDAPLPTWTHRRLWLTDGGLESPTHGGCTVAVHP TH_4621|M.thermoresistible__bu AGAAVDFAALYPSGRLVDAPLPTWTRRKLVLSRENGEQQTRGGCTITVHP MSMEG_4727|M.smegmatis_MC2_155 AGAAVDFSVLYPTGRLLDAPLPAWTHSTLLLDR-ELESSAPGVPSVSVHP MAB_3148c|M.abscessus_ATCC_199 AGGAVDFSVLYPTGQLVDVPLPSWTRRSYLLDLSAQAQQGHGTHTVAVHP Rv2934|M.tuberculosis_H37Rv VG---VAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSE-----LAATHP Mb2959|M.bovis_AF2122/97 VG---VAASEHTTGRLVDLPPTPWHHQRFWVTDRSAMSE-----LAATHP MLBr_02354|M.leprae_Br4923 VG---VTESDSAKGRLVDLPPTPWQHSRFWVADRSAMSE-----LAVAHP MMAR_1773|M.marinum_M VG---KKPADAVTGQLADIPVTPWQHTQFWVEDRSGISE-----LVAAHP MUL_2016|M.ulcerans_Agy99 VG---KKPADAVTGQLADIPVTPWQHTQFWVEDRSGISE-----LVAAHP Mflv_3391|M.gilvum_PYR-GCK LRPPAVTAPDGATGRVVDVPATAWQHTPYWMADRSGGPQ-----FAGAHP Mvan_3124|M.vanbaalenii_PYR-1 VRPPAVQAPEGTPGRLADIPPTAWQHSPYWMVDRSAGQG-----FSGAHP *:: * * ..* : : .** MAV_2370|M.avium_104 LLGPHVHLQEEPERHLWQADVGTAAQPWLADHQIRNVVVLPGAAYCEMAL TH_4621|M.thermoresistible__bu LLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAYCEMAL MSMEG_4727|M.smegmatis_MC2_155 LLGSHVVLPQEPEEHLWQGDVGTEAHPWLSDHRVHQVAVLPGAAYCEMAL MAB_3148c|M.abscessus_ATCC_199 LLGAHVRLAEEPERHIWQADVGTVGQPWIADHQVRHVAVYPGAAYCEMAL Rv2934|M.tuberculosis_H37Rv LLGAHIEMPRNGD-HVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIAL Mb2959|M.bovis_AF2122/97 LLGAHIEMPRNGD-HVWQTDVGTEVCPWLADHKVFGQPIMPAAGFAEIAL MLBr_02354|M.leprae_Br4923 LLGVHVEMPGSGD-HGWQADVGTDVCPWLADHKVFGQPIMPAAAFAEIAV MMAR_1773|M.marinum_M LLGVHIEVPSGHD-HVWQADVGTKACPWLGDHKVFGQAIMPAAGFAEIAL MUL_2016|M.ulcerans_Agy99 LLGVHIEVPSGHD-HVWQADVGTKACPWLGDHKVFGQAIMPAAGFAEIAL Mflv_3391|M.gilvum_PYR-GCK LLGLHVELPAGAG-HVWQSDVGLEAHPWLADHIVHGLPVMPGAGFAEIAL Mvan_3124|M.vanbaalenii_PYR-1 LLGLHVELPSGTG-HVWQSDVGVQAHPWLADHIVHGLAVMPGAGFAEIAL *** *: : * ** *:* **:.** : *.*.:.*:*: MAV_2370|M.avium_104 AAARSVLGAT-AEVRD------IRFEQALLLDEQTTVDASASVSSPGVLH TH_4621|M.thermoresistible__bu AAAREVIDSDGVEVRD------VRFEQMLLLDEQTEVSAVASAVEPGTLE MSMEG_4727|M.smegmatis_MC2_155 AAVTPVLGDT-GEVHD------LKFHDMLLLDDATPVWVSAAVTAPGTAE MAB_3148c|M.abscessus_ATCC_199 SAAAAVFGEG-SAVQS------ISFEQLLTLGESTPISATATAKSADILE Rv2934|M.tuberculosis_H37Rv AAASEALGTAADAVAPNIVINQFEVEQMLPLDGHTPLTTQLIRGGDSQIR Mb2959|M.bovis_AF2122/97 AAASEALGTAADAVAPNIVINQFEVEQMLPLDGHTPLTTQLIRGGDSQIR MLBr_02354|M.leprae_Br4923 AAASEALGVPAGTSGANIVIHQFEVEQMLSLDNHTPLTTQLTYHGNSKIR MMAR_1773|M.marinum_M AAASEAFDLPVDALS----INQLEIEQMLDLDEHTQVTTQLTRRADDKTR MUL_2016|M.ulcerans_Agy99 AAASEAFDLPVDALS----INQLEIEQMLDLDEHTQVTTQLTRRADDKTR Mflv_3391|M.gilvum_PYR-GCK AAAQEALGLPATGVE-----VALEVQEMLLLDAHTTLTTQVSTAEDGTLR Mvan_3124|M.vanbaalenii_PYR-1 AAGREALGLPATGVE-----VQLEVEQMLPLDDHTKLTTQLTRDDEENLR :* .:. . ..: * *. * : . . MAV_2370|M.avium_104 FTVQS-HQGGEQARHASAVLGAATD-EQPAAHDLSALLTAHPHDDDGDEV TH_4621|M.thermoresistible__bu FAVET-AKDGEHERRATAVLGAADDTEPPQAHDIDALLAEHPTRIEGDEL MSMEG_4727|M.smegmatis_MC2_155 FGVET-HQSGDRTQRATAVLRGDVDAERPAAHSIDALLAAHPNRVDGDEL MAB_3148c|M.abscessus_ATCC_199 FVVET-HDEGDVVKRATAVLGNGGDVDMPIAYDLSALRAEHPHRESGDDL Rv2934|M.tuberculosis_H37Rv VEIYSRTRGGEFCRHATAKVEQSPRECAHAHPEAQGPATGTTVS--PADF Mb2959|M.bovis_AF2122/97 VEIYSRTRGGEFCRHATAKVEQSPRECAHAHPEAQGPATGTTVS--PADF MLBr_02354|M.leprae_Br4923 VEIYSRSPRGDFSRHATANVEHVSHNAVQPFQQAPGSSNGVTVS--PADF MMAR_1773|M.marinum_M IEIYSRSASG-WRRHAVAKAETSTPSAAPGLEERTSRQDETDIK--PADL MUL_2016|M.ulcerans_Agy99 IEIYSRSASG-WRRHAVAKAETSTPSAAPVLEERTSRQDETDIK--PADL Mflv_3391|M.gilvum_PYR-GCK VEIHSRSEAGTWTRHAAGSVRAAAG---ATPPRPAPLSEGTPVS--PADF Mvan_3124|M.vanbaalenii_PYR-1 VEIHSRSDAGSWTRHAVGTVKAAAG---PAPAKVVPASDGTPVS--PSDF . : : * ::* . :. MAV_2370|M.avium_104 RRRMDRRGVQYGPAFAGLGAVHSGDETGT-VLAEVALPRQIRSQQAAYGA TH_4621|M.thermoresistible__bu RQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVGLPGQIRSQQAPYGI MSMEG_4727|M.smegmatis_MC2_155 RAGFGTVGIGHGAAFAGLSEAYVATAAEPTVVAAVALPGPLRSGQRGYTV MAB_3148c|M.abscessus_ATCC_199 RASFDERGVQYGPAFQGLAAAYRGDETVRSVLAEVTLPRDVRAQQGSYIV Rv2934|M.tuberculosis_H37Rv YALLRQTGQHHGPAFAALSRIVRL--ADGSAETEISIPDEAPRHPG-YRL Mb2959|M.bovis_AF2122/97 YALLRQTGQHHGPAFAALSRIVRL--ADGSAETEISIPDEAPRHPG-YRL MLBr_02354|M.leprae_Br4923 YAVLRQTGQHHGPVFAVLTRITRL--LDGSAETEITLPDEVPRHPG-YRL MMAR_1773|M.marinum_M YALLRQAGQNHGPAFAALTRILRR--PDGSVETEITLSDEAPRHQG-YRI MUL_2016|M.ulcerans_Agy99 YALLRQAGQNHGPAFAALTRILRR--PDGSVETEITLSDEAPRHQG-YRI Mflv_3391|M.gilvum_PYR-GCK YTALRRTGAHHAHAFAALTRIVR---AAGTADTEIVLPDEATPHRG-VAL Mvan_3124|M.vanbaalenii_PYR-1 YTALRRTGAHHAHAFAALTRIVR---AGGRADTEIVLPDEATPHRG-IAL : * .. .* * . : : :. MAV_2370|M.avium_104 HPALLDACFQSVEAHP--AVRALGDGALGLVLGIRRLRAYGAARNAHYCY TH_4621|M.thermoresistible__bu HPALLDACFQSVAAHP--DVQGAGSGLL-LPLGVRRLQAFGPTRGARYCY MSMEG_4727|M.smegmatis_MC2_155 HPALLDACFQSVIAHP--EVQNIASGML-LPLGVRRLRAYGSTRNVRYCL MAB_3148c|M.abscessus_ATCC_199 HPALLDACFQSVIALP--DVQEASKDALPLPKGVRSLHAYESARATQYCY Rv2934|M.tuberculosis_H37Rv HPVVLDAALQSVGAAIPDGEIAGSAEASYLPVSFETIRVYRDIGRHVRCR Mb2959|M.bovis_AF2122/97 HPVVLDAALQSVGAAIPDGEIAGSAEASYLPVSFETIRVYRDIGRHVRCR MLBr_02354|M.leprae_Br4923 HPVVLDAALQSVGAAIPDGEVAESAEVSYLPVSFEAIRVYRDIGRHALCR MMAR_1773|M.marinum_M HPAMLDAALQSLAAAVPNDEFAGSAEASYLPVSFETLRVYSNPGRHARCR MUL_2016|M.ulcerans_Agy99 HPAMLDAALQSLAAAVPNDEFAGSAEASYLPVSFETLRVYSNPGRHARCR Mflv_3391|M.gilvum_PYR-GCK HPVMLDAALQGLAAALGDDSLTDSNDVTYLPVGFGSVRVFAEVGRRAKCR Mvan_3124|M.vanbaalenii_PYR-1 HPVMLDAALQGLAAAMSDETLSDSTDVTYLPVGFGSIRVFGDIGRRAKCR **.:***.:*.: * . * .. ::.: * MAV_2370|M.avium_104 TRVTKADTSG-------VEADIDVLDEHGAVLLAVQGLRVGTSASESGTR TH_4621|M.thermoresistible__bu ARVTDADGSK-------AEADLDVLDEHGNVLLRVQGLLMGGAAADGDDR MSMEG_4727|M.smegmatis_MC2_155 SRIVKADSFG-------VEADLELLDADGTVLLSAMGLQLGTGNSDKAEE MAB_3148c|M.abscessus_ATCC_199 TRVTKVVGNE-------VEADIDLLDETGSVLIAVRGFRFGTGSSDDEQR Rv2934|M.tuberculosis_H37Rv AHLTNL-DGGTG-----KMGRIVLINDAGHIAAEVDGIYLRR--VERRAV Mb2959|M.bovis_AF2122/97 AHLTNL-DGGTG-----KMGRIVLINDAGHIAAEVDGIYLRR--VERRAV MLBr_02354|M.leprae_Br4923 ARLTNL-DGGTG-----KLGKIVLIDDAGYVAAEVDGIYLRR--IERRVV MMAR_1773|M.marinum_M AQLTNLNDGGAG-----KLGRITLTDDAGNVTVEINDIYLRR--VERRSV MUL_2016|M.ulcerans_Agy99 AQLTNLNDGGAG-----KLGRITLTDDAGNVTVEITDIYLRR--VERRSV Mflv_3391|M.gilvum_PYR-GCK AELLSVASGVDGQGSGDAVGRVTLTDDTGTVLAQVDDVALKR--IQRRTV Mvan_3124|M.vanbaalenii_PYR-1 AELVSVVE-----DSGDAMGRVTLTDDTGTVLAQVDDVHLKR--VQRRTV :.: . . : : : * : .. . : MAV_2370|M.avium_104 DRVLTERLLNIEWRQRELPEP------EHADAASWLLIGTT-------AT TH_4621|M.thermoresistible__bu DRVLGERLLTIEWQRRDLPEA------DSA-AGKWLLVSTS-------AT MSMEG_4727|M.smegmatis_MC2_155 ERLLDERLLTIEWQQRELPRPEGS---ETVDAGSWLVILAGD------DD MAB_3148c|M.abscessus_ATCC_199 DQLLNNRLLAIEWQQQRLPES------VSGAPRRWLLVSTG-------ES Rv2934|M.tuberculosis_H37Rv PLPLEQKIFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQ Mb2959|M.bovis_AF2122/97 PLPLEQKIFDAEWTESPIAAVPAPEPAAETTRGSWLVLADATVDAPGKAQ MLBr_02354|M.leprae_Br4923 PLPLAQKIFDAEWIESPIPASRALEQITETARASWLVLTDWDP------S MMAR_1773|M.marinum_M PLPLAQKIFDTEWVEKSIAGADQPD-----APGSWLVLT----------D MUL_2016|M.ulcerans_Agy99 PLPLAQKIFDTEWVEKSIAGADQPD-----APGSWLVLT----------D Mflv_3391|M.gilvum_PYR-GCK PLPLSQKIFDSRWVPAQATAG-------AAQAGSWLVLADG-------DH Mvan_3124|M.vanbaalenii_PYR-1 PLPLSQKIFDSRWVESAAAAG-------TTATGSWLALADG-------AA * :::: .* . ** : MAV_2370|M.avium_104 ADVLASTLADTLKNHGAQCTTMAWPQQADHTAHAEQLRNQWRGDGFTGVV TH_4621|M.thermoresistible__bu ADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFR-AGIADGVTGVV MSMEG_4727|M.smegmatis_MC2_155 ENPRAAGVVSALIGAGMPTTTMAWSHDADHDAQAAALTARLDEQPLAGVA MAB_3148c|M.abscessus_ATCC_199 VDPWAAELIDSLKVRESEVSLIQWRPNTDRVAALKLLYDQLESGTFDGVL Rv2934|M.tuberculosis_H37Rv AKSMADDFVQQWRSPMRRVHTADIHDESAVLAAFAETAGDPEH-PPVGVV Mb2959|M.bovis_AF2122/97 AKSMADDFVQQWRSPMRRVHTADIHDESAVLAAFAETAGDPEH-PPVGVV MLBr_02354|M.leprae_Br4923 IKSLTDEFIARWRSPMRRVYTANLHDESAMLAAFAETAGDPEH-PPIGVV MMAR_1773|M.marinum_M AKSNADEFVARWSSPQRRVITADLGDEAAMLAAFAETAGDPER-LPVGVV MUL_2016|M.ulcerans_Agy99 AKSNADEFVARWSSPQRRVITADLGDEAAMLAAFAETAGDPER-LPVGVV Mflv_3391|M.gilvum_PYR-GCK TLASAERFAQSFGDAQHRVVTARLGDEAAVRDAFASATTDAAL-PPAGVV Mvan_3124|M.vanbaalenii_PYR-1 GQAAAQDFASRFGADTRRVITADLGDESAVREAFATATADPDL-PPVGVV : . :: ** MAV_2370|M.avium_104 VLTGP-KNGDNDQ-------ESALLSRDHVQHLVRIARELT-DLPGEPPR TH_4621|M.thermoresistible__bu VLTGP-KNGNPDD-------AAARRGSDYVRHLVRITRELA-EIDGDAPR MSMEG_4727|M.smegmatis_MC2_155 VIVGD-SETGTDAHD---VGADARRGADHVRHLVRIARTLA-DAVGEPPR MAB_3148c|M.abscessus_ATCC_199 VVTAPGSEGGADR--------VVLQGADQVRHLVRITRELV-DLPGEPPR Rv2934|M.tuberculosis_H37Rv VFVGGASSR---------LDDELAAARDTVWSITTVVRAVVGTWHGRSPR Mb2959|M.bovis_AF2122/97 VFVGGASSR---------LDDELAAARDTVWSITTVVRAVVGTWHGRSPR MLBr_02354|M.leprae_Br4923 IFVGGAATG---------LDDGLVQARDSVWSISTVVRAIVSTWHGRSPR MMAR_1773|M.marinum_M VFVGGAGNNSGAADDGRISYDGLIQSRDTVWQISTVVRAIVGTWHGRAPR MUL_2016|M.ulcerans_Agy99 VFVGGAGNNSGTADDGRISYDGLIQSRDTVWQISTVVRAIVGTWHGRAPR Mflv_3391|M.gilvum_PYR-GCK VLVDVP------AFDGADAAGGLAAAQNAVWEIAETVRTIVGSWHGTPPR Mvan_3124|M.vanbaalenii_PYR-1 VFCDFGGNP--ATLDGTDVAGGLEHARDVIWGVAGTVRAIVGSWHGKAPR :. . : : : .* :. * .** MAV_2370|M.avium_104 LYVVTRNAQTVLPN-DVPNLGQAGLRGLVRVIGMEHPQLGAGQIDVDEST TH_4621|M.thermoresistible__bu LFVVTRGAQAVLPQ-DRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDA MSMEG_4727|M.smegmatis_MC2_155 LYVVTHRSQHVLDT-DEPYLEHSGLRGLIRVVGMEHPRLRATQIDVDDST MAB_3148c|M.abscessus_ATCC_199 LFVVTRNAQTVVDG-DITNLEQAGLRGLVRVIGAEYPHLRVTHIDVDRHT Rv2934|M.tuberculosis_H37Rv LWLVTGGGLSVADD-EPGTPAAASLKGLVRVLAFEHPDMRTTLVDLDITQ Mb2959|M.bovis_AF2122/97 LWLVTGGGLSVADD-EPGTPAAASLKGLVRVLAFEHPDMRTTLVDLDITQ MLBr_02354|M.leprae_Br4923 LWLIAGGGLSVQDD-ELGAPATAALKGLVRVLALENPDLRATLLDLDATQ MMAR_1773|M.marinum_M LWLVTEGGLVVHD--EPGRPAIGALQGLVRVLAYEHPELRATLVDLDTGA MUL_2016|M.ulcerans_Agy99 LWLVTEGGLVVHD--KPGRPAIGALQGLVRVLAYEHPELRATLVDLDTGA Mflv_3391|M.gilvum_PYR-GCK LWVVSRGGLAVTDGDNGGNPGVGTLKALIRVLAYEHPDLRATLLDVGADG Mvan_3124|M.vanbaalenii_PYR-1 LWLVTQGGLVVSPEDGQGNPGANSLKGLARVLAYEHPDLKTTLLDTGSDG *:::: . * *:.* **:. * * : . :* MAV_2370|M.avium_104 DAQALARQLLAGSE-----EDETAWRDGAWYTARLCPAPLLPEERHTAVA TH_4621|M.thermoresistible__bu DLDRVAVQLLGGGA-----EDETAWRDGQWYTARLSLSPLRPEERKQAVV MSMEG_4727|M.smegmatis_MC2_155 AHEALVRQLLSGSP-----EDETAWRDGQWYAARLCPSPLRAAERRTAVA MAB_3148c|M.abscessus_ATCC_199 AAQNVAGELVSGSE-----EDETAWREDHWYRARLNLGPLGPDDWRSTVA Rv2934|M.tuberculosis_H37Rv DPLTALSAELRNAGSGSRHDDVIAWRGERRFVERLSRATIDVS------- Mb2959|M.bovis_AF2122/97 DPLTALSAELRNAGSGSRHDDVIAWRGERRFVERLSRATIDVS------- MLBr_02354|M.leprae_Br4923 DQIAALTAELHNSASEFGGDDVIAWRGQHRFVERLCKATLDAG------- MMAR_1773|M.marinum_M DSVTRLAGELSSPRDDPNYDDVVAWRDGHRYVTQLCRAILDPEP------ MUL_2016|M.ulcerans_Agy99 DAVTRLAGELSSPRDDPNYDDVVAWRDGHRYVTQLCRAILDPEP------ Mflv_3391|M.gilvum_PYR-GCK DTAAILATEIGSANDSTTTEDTIAWRDGSRLVERLSRAELPAV------- Mvan_3124|M.vanbaalenii_PYR-1 ---AALATEIEAASASAVTEDVIAWRGGTRYVERLSRATLPAT------- : :* *** :* . : MAV_2370|M.avium_104 NHECDGMRLQIRTPGDLESLELVACDRIPPGPGQIEVAVSASSINFADVL TH_4621|M.thermoresistible__bu DCERDGMRLEIRTPGDLETMELAAFDRVPPGPGQIEVAVTASSINFADVL MSMEG_4727|M.smegmatis_MC2_155 DNASEGMRLVVRNPGDLESMELVTFERGTPGPGQIEVAVKASSINFADVL MAB_3148c|M.abscessus_ATCC_199 TPNNEGVRFEVRTPGDLQSLGFVAFDRVAPGPGQIEVSVTATSINFADVL Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 VAFGRYPAFEGRLPELGTDFAGVVTAVGPDVTDHKVGDHVGGLSANGCWG TH_4621|M.thermoresistible__bu IAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWS MSMEG_4727|M.smegmatis_MC2_155 VAFGRCPSFDGRLPELGSEFGGVVTAVGPGVTTHRVGDRVGGVSANGCWS MAB_3148c|M.abscessus_ATCC_199 NVYGRYSSFEGRQ-ELGVDFAGVVTAVGEGVTQHQVGDRVGGMTPTGAWR Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 TFLTCDARLAVTLPPGLADDQAAAVTTAHATAYYGLHELARIGAGDRVLI TH_4621|M.thermoresistible__bu TFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLI MSMEG_4727|M.smegmatis_MC2_155 NFVTCEADLATKLPEGISEHEAAAVGLAYGTVWLGLTELARMSAGDKILI MAB_3148c|M.abscessus_ATCC_199 SFVVVDANLAATLPAEVPDREAAAVPGAHVTAWYGLHELARISAGDKVLI Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 HSATGGVGQAAIAIARAAGAEIFATAGSEQRRQLLRDMGIEHVYDSRTVE TH_4621|M.thermoresistible__bu HSATGGVGLAAIAIARSVGAQIYATAGSPARRDLLRDMGIEHVYDSRSTA MSMEG_4727|M.smegmatis_MC2_155 HSATGGVGQAAIAVARAAGAEIYATAGSEKRRQLLRDWGIEHVYDSRTTA MAB_3148c|M.abscessus_ATCC_199 HSGTGGVGQAAIAIARAAGAEIYATAGSPERRDLLRSWGIKHVYDSRSTD Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 FADLIRHDTDGYGVDIVLNSVTGAAQRAGIELLAFGGRFVEIGKRDIYGD TH_4621|M.thermoresistible__bu FADEIRRDTDGYGVDVVLNSLPGAAQRAGLELLSFGGRFIEIGKRDIYGD MSMEG_4727|M.smegmatis_MC2_155 FADQIRTDTDGYGVDIVLNSVTGPAQRAGLELLAFGGRFVEIGKRDIYAD MAB_3148c|M.abscessus_ATCC_199 FAELIRRDTDGYGVDIVLNSLTGAAQRAGVELLTFGGRFIEIGKRDIYGD Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 TRLGLLPFRRNLTFYALDLALMSFSHPDRLRGLLRTVYRLTADGALPMPE TH_4621|M.thermoresistible__bu TRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADGVLPMPQ MSMEG_4727|M.smegmatis_MC2_155 TRLGLFPFRRNLSFYAVDLALMTVTHPQKIRDLLATVYRLIADGTLPLPE MAB_3148c|M.abscessus_ATCC_199 TRLGLFPFRRNLSFHAVDLVLVAKTRPEAIYRTLTALYGQMAEGVLPLPE Rv2934|M.tuberculosis_H37Rv -------------------------------------------------- Mb2959|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02354|M.leprae_Br4923 -------------------------------------------------- MMAR_1773|M.marinum_M -------------------------------------------------- MUL_2016|M.ulcerans_Agy99 -------------------------------------------------- Mflv_3391|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3124|M.vanbaalenii_PYR-1 -------------------------------------------------- MAV_2370|M.avium_104 STHYPLADAASAIRVMSAAQHTGKLVLDVPHAGRSRVVVPPAQVRAFRSD TH_4621|M.thermoresistible__bu STHYPLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVVVPPEQASPFRSD MSMEG_4727|M.smegmatis_MC2_155 ITHYPLEEAATAIRIMGGAQHTGKLVIDIPDTGQSQVVVPPEQVPVFRGD MAB_3148c|M.abscessus_ATCC_199 ISPSPLQEAAESIRVMGAAGHTGKLVLDLPKAGEVSAVIPPSHAPAFRRD Rv2934|M.tuberculosis_H37Rv -----------------------------------------KGHPVVRQG Mb2959|M.bovis_AF2122/97 -----------------------------------------KGHPVVRQG MLBr_02354|M.leprae_Br4923 -----------------------------------------KDNPVVRPG MMAR_1773|M.marinum_M -----------------------------------------QRDPVIRPG MUL_2016|M.ulcerans_Agy99 -----------------------------------------QRDPVIRPG Mflv_3391|M.gilvum_PYR-GCK -----------------------------------------PGRLQVRGD Mvan_3124|M.vanbaalenii_PYR-1 -----------------------------------------PGQLVVRRD .* . MAV_2370|M.avium_104 GAYIVTGGLGGLGLFLAEKMASPGSRAGCGRIVLCSRALPNPKALATLER TH_4621|M.thermoresistible__bu GAYIVTGGMGGLGLYLAGEMAAAG--AGC--IVLNGRSAPSGEALRTIEQ MSMEG_4727|M.smegmatis_MC2_155 GAYVITGGLGGLGLFLAERMAAAG----CGRIVVNSRSAPSTRSSEIIEL MAB_3148c|M.abscessus_ATCC_199 GAYVVTGGLGGLGLFLARKLAAAG----VGRIILNGRSAPKPEALAAIEQ Rv2934|M.tuberculosis_H37Rv ASYVVTGGLGGLGLVVARWLVDRG----AGRVVLGGRSDPTDEQCNVLAE Mb2959|M.bovis_AF2122/97 ASYVVTGGLGGLGLVVARWLVDRG----AGRVVLGGRSDPTDEQCNVLAE MLBr_02354|M.leprae_Br4923 AAYIVTGGLGGLGLVVARWLVDRG----AGRVVLGSRSDPTEEQRKTLVE MMAR_1773|M.marinum_M ASYIVTGGLGGLGLVVARWLVDSG----AGRVVLNGRSEPSDEQRKVLAE MUL_2016|M.ulcerans_Agy99 ASYIVTGGLGGLGLVVARWLVDSG----AGRVVLNGRSEPSDEQRKVLAE Mflv_3391|M.gilvum_PYR-GCK GSYVVTGALGGVGLAVVRWLVDHG----AGRLVLNGRSGPSPEAQAVIDE Mvan_3124|M.vanbaalenii_PYR-1 GAYVVTGALGGVGMAVVRWLVDHG----AGRLVLNGRSGPSDEVAAELDT .:*::**.:**:*: :. :. * ::: .*: *. . : MAV_2370|M.avium_104 IRQMGADIVVERGDIAEAGTAQRLLDVATATGLPVRGVLHLAAVIEDATL TH_4621|M.thermoresistible__bu LRAAGTEVIVECGXXXRG----QPVEVAVPT------ELRHADEHPDRRG MSMEG_4727|M.smegmatis_MC2_155 IRATGADIVVECGDIAEPDTALRLVAAATQTGLPLRGVLHAAAVVEDATL MAB_3148c|M.abscessus_ATCC_199 IRQGGTEIDVALGDIAEPDTAQRLVAAATETGKPVRGVLHAAALVHDATL Rv2934|M.tuberculosis_H37Rv LQTR-AEIVVVRGDVASPGVAEKLIETARQSGGQLRGVVHAAAVIEDSLV Mb2959|M.bovis_AF2122/97 LQTR-AEIVVVRGDVASPGVAEKLIETARQSGGQLRGVVHAAAVIEDSLV MLBr_02354|M.leprae_Br4923 LEAR-AEIVFLRGDVTSPGVAESLVAAAGRAGGQLRGIVHGAAVIEDSLV MMAR_1773|M.marinum_M LESR-AEVVVVCGDSATEGVAESLVAAAEDQQRQLRGIVHGAAVIDDSLL MUL_2016|M.ulcerans_Agy99 LESR-AEVVVVCGDSATEGVAESLVAAAEDQQRQLRGIVHGAAVIDDSLL Mflv_3391|M.gilvum_PYR-GCK LSAR-AEIAVVTGDIAVPGTAVRLIAAAEETGRPLRGVLHSAAVLDDELV Mvan_3124|M.vanbaalenii_PYR-1 LSHR-AEIAVVTGDVAEPGVAERLVAAAEETGKPLRGLIHSAAVLEDEIF : ::: . * : .* :: * * MAV_2370|M.avium_104 ANITDELIER-DWAAKVYGAWNLHCALQESG-AEQSLDWFCSFSSAAALV TH_4621|M.thermoresistible__bu AQLCDEFARG-EQGAQR----NQHRTDAGEG-QRD--------AHPPGAV MSMEG_4727|M.smegmatis_MC2_155 ANITDELVEH-DWAPKVYGAWNLHQAVQSGGPATSELDWFCAFSSAAALV MAB_3148c|M.abscessus_ATCC_199 ANITDELIDRGDWRPKVHGAWNLHEATADQP-----LDWFCSFSSIAALV Rv2934|M.tuberculosis_H37Rv FSMSRDNLER-VWAPKATGALRMHEATADCE-----LDWWLGFSSAASLL Mb2959|M.bovis_AF2122/97 FSMSRDNLER-VWAPKATGALRMHEATADCE-----LDWWLGFSSAASLL MLBr_02354|M.leprae_Br4923 FTMTRENLER-VWAPKATGALRMHQASVSCE-----LDWWLGFSSVASLL MMAR_1773|M.marinum_M FSMTKDSLER-VWAPKAAGALRLHDATATRE-----LDWWLGFSSTASLL MUL_2016|M.ulcerans_Agy99 FSMTKDSLER-VWAPKAAGALRLHDATATRE-----LDWWLGFSSTASLL Mflv_3391|M.gilvum_PYR-GCK VGLTRESMEK-IWAPKAAGAWRLHEATAGKE-----LDWWVAFSSVASLL Mvan_3124|M.vanbaalenii_PYR-1 VGMTRESLDK-IWAPKAAGALRLHEVTAGSD-----LDWWVGFSSIVSLL : : .: . * . : . : MAV_2370|M.avium_104 GSPGQGAYAAANSWLDAFTRWRRARGLKATAIAWGAWAQIGRGAALADSA TH_4621|M.thermoresistible__bu GHDQPDPGALSDTGLDERGGQFPGVGVQIPVADPGVGIDH-RGAVRVDSG MSMEG_4727|M.smegmatis_MC2_155 GSPGQGAYAAANSWLDAFMQWRRAQGLPATSIAWGAWGEIGRGTAMAE-G MAB_3148c|M.abscessus_ATCC_199 GSPGQGAYAAANSWLDGFTHWRRAQGLPATVIAWGAWSEIGQGTHLAQNA Rv2934|M.tuberculosis_H37Rv GSPGQAAYACASAWLDALVGWRRASGLPAAVINWGPWSEVGVAQALVGSV Mb2959|M.bovis_AF2122/97 GSPGQAAYACASAWLDALVGWRRASGLPAAVINWGPWSEVGVAQALVGSV MLBr_02354|M.leprae_Br4923 GSPGQAAYACASAWLDALVMWRKASGLPSAVINWGPWSDVGVAQALVGSV MMAR_1773|M.marinum_M GSPGQTAYACASAWLDGLVAWRRAAGLPAATINWGPWSEVGVAQALVGTP MUL_2016|M.ulcerans_Agy99 GSPGQTAYACASAWLDGLVAWRRAAGLPAATINWGPWSEVGVAQALVGTP Mflv_3391|M.gilvum_PYR-GCK GSPGQSAYACANAWLDALVTWRAAAGLPATTVNWGQWADVGLASSLRFSV Mvan_3124|M.vanbaalenii_PYR-1 GSPGQAAYACANAWLDGLVAWRTAAGLPALAVNWGQWADVGLASTLRFSV * . * :.: ** . *: * : . MAV_2370|M.avium_104 DVAITPDEGAYAFEALLRHDRACTGYAPITGTPWLTAFAQRSPFAEAFRA TH_4621|M.thermoresistible__bu VPAQQGVDGEVVRHRTLSSVRSGR-------SSRWTAPGSR--CGSGRRY MSMEG_4727|M.smegmatis_MC2_155 DNAIAPDEGAYAFEAILRHDRVYNGYAPVLGASWLTAFAQRSPFAELFLA MAB_3148c|M.abscessus_ATCC_199 EAAILPDEGAYAFDTVLRHNRAYTAYAPMAGISWLADFVERSPFAQAFRD Rv2934|M.tuberculosis_H37Rv LDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQV Mb2959|M.bovis_AF2122/97 LDTISVAEGIEALDSLLAADRIRTGVARLRADRALVAFPEIRSISYFTQV MLBr_02354|M.leprae_Br4923 LDTITPAEGIEAIDSLLAAGRTRTGVARLRADKALVAFPEMRSISYFTWV MMAR_1773|M.marinum_M LDPITPAEGVVALDALLAADRGRTGVARLRSDRALIAFPEIRNLGYFTLV MUL_2016|M.ulcerans_Agy99 LDPITPAEGLVALDALLAADRGRTGVARLRSDRALIAFPEIRNLGYFTLV Mflv_3391|M.gilvum_PYR-GCK LDPITPDEGVEALGGVMAAGLTRVGIARLRLDRAAAAFPEIQQIGFFADL Mvan_3124|M.vanbaalenii_PYR-1 LDPITPAEGVEALGGVMAAGFSRVGIARLRLDRAAAAFPEIQQIGFFADL . :* . : . . MAV_2370|M.avium_104 NGQSATGTS--------KLRAELEELPPEEWSTRLRRLISDQVSLILRRN TH_4621|M.thermoresistible__bu GGESCRRTT--------GPAAGAAARRGR-----------------TRRR MSMEG_4727|M.smegmatis_MC2_155 DTQGASETR--------KLRSELAALPREEWPTHLRRLIAEQVGLLLRRT MAB_3148c|M.abscessus_ATCC_199 AGQNQTETN--------KFLDELRALPREEWPTRLRKLVAEQVGLVLRRS Rv2934|M.tuberculosis_H37Rv VEELDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQST Mb2959|M.bovis_AF2122/97 VEELDSAGDLGDWGGPDALADLDPGEARRAVTERMCARIAAVMGYTDQST MLBr_02354|M.leprae_Br4923 VEQLAAAGDLGDWVGSDTLADLDPAEAQRVVTERMCALIAAVMGYADRST MMAR_1773|M.marinum_M VQELDAAGDGGDWAGPEALKEMDPAEARQVVTERLHTRIAAVMGYADRSA MUL_2016|M.ulcerans_Agy99 VQELDAAGDGGDWAGPEALKEMDPAEARQVVTERLHTRIAAVMGYADRSA Mflv_3391|M.gilvum_PYR-GCK VSELDTDDADDDWEGAEALKTMSAAEINRVVVARLRRRIAGVMGYSNDSA Mvan_3124|M.vanbaalenii_PYR-1 VGELETDDVDEDWGGVEALKSMDAAEVNRVVVARLRRRISAIMGYSDDNA : . MAV_2370|M.avium_104 VDPDRP----LPEYGLDSLGGLELLTRIQTETGIRVSPADIAAIGTIRGL TH_4621|M.thermoresistible__bu RRPRRP----PPPP-----------DRVRHRAGP--------AHGPVRR- MSMEG_4727|M.smegmatis_MC2_155 VDPDRP----LSEYGLDSLGHLELRTRIETETGVRVS---AMDMTTIRGL MAB_3148c|M.abscessus_ATCC_199 IDPDRS----LPDYGLDSLGNLEIRTRIQADTGVRIG---PADVSTVRSL Rv2934|M.tuberculosis_H37Rv VEPAVPLDKPLTELGLDSLMAVRIRNGARADFGVEPPVALILQGASLHDL Mb2959|M.bovis_AF2122/97 VEPAVPLDKPLTELGLDSLMAVRIRNGARADFGVEPPVALILQGASLHDL MLBr_02354|M.leprae_Br4923 VNPAVP----LTELGLDSLMAVRIRNGARADFGVEPPVTLILQGASLQDL MMAR_1773|M.marinum_M VDASMP----LTELGLDSLMAVRIRNTARADFGVEPPVTLILQGASLHDL MUL_2016|M.ulcerans_Agy99 VDASMP----LTELGLDSLMAVRIRNTARADFGVEPPVTLILQGASLHDL Mflv_3391|M.gilvum_PYR-GCK VDTAKP----LTEMGLDSLMAVRMRNTIRGDFGVEPPVALLLQGATLNDV Mvan_3124|M.vanbaalenii_PYR-1 VDTAQP----LTELGLDSLMAVRMRNTIRGDFGVEPPVALLLQGATLADL . . . . * .: MAV_2370|M.avium_104 ADLLRDKLTPAGAAQAERV------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 AQRLCEMLDTDDAVSAPS-------------------------------- MAB_3148c|M.abscessus_ATCC_199 AAHIYDRLAEQESEVASS-------------------------------- Rv2934|M.tuberculosis_H37Rv TADLMRQLGLNDPDPALNNADTIRDRARQRAAARHGAAMRRRPKPEVQGG Mb2959|M.bovis_AF2122/97 TADLMRQLGLNDPDPALNNADTIRDRARQRAAARHGAAMRRRPKPAVQGG MLBr_02354|M.leprae_Br4923 TADVVRQLGLAGPKQALENADTVRDRVQQRAAVRRGAVMRRRPKPDVQGG MMAR_1773|M.marinum_M TVDVIRQLDLAGDEQTHEHVDVVRDRAQQRAAARHGAAMRRKRG------ MUL_2016|M.ulcerans_Agy99 TVDVIRQLDLAGDEQTHEHVDVVRDRAQQRAAARHGAAMRRKRG------ Mflv_3391|M.gilvum_PYR-GCK ALDLIRQLGLA-EEDGSDRPNALRDRAQQRAAARQRAASRRKVGPRS--- Mvan_3124|M.vanbaalenii_PYR-1 ALDLIRQLGLE-EQESAERPNALRERAQQRAAARQRAASRRKVGPRS---