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M. tuberculosis H37Rv Rv2875 (mpt70)

annotation: MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70
coordinates: 3187030 - 3187611
length: 193

MKVKNTIAATSFAAAGLAALAVAVSPPAAAGDLVGPGCAEYAAANPTGPASVQGMSQDPVAVAASNNPEL
TTLTAALSGQLNPQVNLVDTLNSGQYTVFAPTNAAFSKLPASTIDELKTNSSLLTSILTYHVVAGQTSPA
NVVGTRQTLQGASVTVTGQGNSLKVGNADVVCGGVSTANATVYMIDSVLMPPA
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2875mpt70-100% (193)MAJOR SECRETED IMMUNOGENIC PROTEIN MPT70
M. tuberculosis H37RvRv2873mpt839e-6870.27% (185) cell surface lipoprotein mpt83 (lipoprotein P23)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2900mpb701e-105100.00% (193) major secreted immunogenic protein mpb70 precursor
M. gilvum PYR-GCKMflv_4085-8e-6061.66% (193) beta-Ig-H3/fasciclin
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_1834mpt701e-6867.51% (197) major secreted immunogenic protein Mpt70
M. avium 104-----
M. smegmatis MC2 155MSMEG_5196-2e-3037.25% (204) fasciclin domain-containing protein
M. thermoresistible (build 8)TH_1983-4e-3439.50% (200) fasciclin domain protein
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_2259-6e-6162.11% (190) beta-Ig-H3/fasciclin

CLUSTAL 2.0.9 multiple sequence alignment


Rv2875|M.tuberculosis_H37Rv         -MKVKN-TIAATSFAAAGLAALAVAV------------------------
Mb2900|M.bovis_AF2122/97            -MKVKN-TIAATSFAAAGLAALAVAV------------------------
Mflv_4085|M.gilvum_PYR-GCK          -MTIMMKSFAGAGLAVTAALGLSFAT------------------------
Mvan_2259|M.vanbaalenii_PYR-1       MMTTRRKTAAVAGIAAVAIFGAACSSEGADSTASSATTTSESAMESATTA
MMAR_1834|M.marinum_M               -MKFHNPAIAATGLAAAAAVGLVVAT------------------------
MSMEG_5196|M.smegmatis_MC2_155      -MHTRTKTLGAAAAIAAIATSLPLAVTAYAE------------------P
TH_1983|M.thermoresistible__bu      -VQTRTKVFGAVTGAAAIAFSLPLAGTAHGE------------------P
                                     :       . .   ..   .   :                         

Rv2875|M.tuberculosis_H37Rv         SPPAAAGD----------LVGPGCAEYAAANPTGPASVQGMSQDPVAVAA
Mb2900|M.bovis_AF2122/97            SPPAAAGD----------LVGPGCAEYAAANPTGPASVQGMSQDPVAVAA
Mflv_4085|M.gilvum_PYR-GCK          ATTASAAP-----------AGPGCAAYVQQVPEGPGSVQGMAMDPVATAA
Mvan_2259|M.vanbaalenii_PYR-1       MTTSSAAPSA---DPAANLIGSGCAAYAEQVPDGPGSVAGMAADPVTVAA
MMAR_1834|M.marinum_M               APSAMASPP-------DTLVGPGCSAYAQQVPTGPGSVAGMAAEPVAVAA
MSMEG_5196|M.smegmatis_MC2_155      ETTTEAEP----TVEIPDPQGPGCDDFKKAVP----SWKALNDVPVSQAL
TH_1983|M.thermoresistible__bu      GDPPTPAPDLMVTADIPDPEGPGCDAFKAEVS----DFKNLARVPVGDAL
                                      .. .              *.**  :    .    .   :   **  * 

Rv2875|M.tuberculosis_H37Rv         SNNPELTTLTAALSGQLNPQVNLVDTLNSGQYTVFAPTNAAFSKLPASTI
Mb2900|M.bovis_AF2122/97            SNNPELTTLTAALSGQLNPQVNLVDTLNSGQYTVFAPTNAAFSKLPASTI
Mflv_4085|M.gilvum_PYR-GCK          SNNPLLTTLTKAVSGQLNPNVNLVDTLNGAEFTVFAPTDEAFAKLDPATV
Mvan_2259|M.vanbaalenii_PYR-1       SNNPMLKTLTQALSGQLNPGVNLVDTLNGGEFTVFAPTDDAFAKIDPATI
MMAR_1834|M.marinum_M               SNNPMLTTLTSALSGKLNPQVNLVDTLNGGQFTVFAPTDAAFGKIDAATI
MSMEG_5196|M.smegmatis_MC2_155      AAIPEISTFNAAVSGGLNPAVNIDPVLDNGPYVVFAPTNEAFAKLAPGQL
TH_1983|M.thermoresistible__bu      AAIPQISTFNSAISGQLNPEVNIVPVLNNGPYVVFAPTNEAFEELPAGKL
                                    :  * :.*:. *:** *** **:  .*:.. :.*****: ** :: .. :

Rv2875|M.tuberculosis_H37Rv         DELKTNSSLLTSILTYHVVAGQTSPANVVGTRQTLQGASVTVTGQGNSLK
Mb2900|M.bovis_AF2122/97            DELKTNSSLLTSILTYHVVAGQTSPANVVGTRQTLQGASVTVTGQGNSLK
Mflv_4085|M.gilvum_PYR-GCK          ETLKTDSNLLTNILTYHVVPGQAAPDQVVGEHVTVQGATVNVTGAPDHLM
Mvan_2259|M.vanbaalenii_PYR-1       ETLKTDSDLLTSILTYHVVPGQAAPDQVAGEHATVQGATVTVTGAGNDLK
MMAR_1834|M.marinum_M               DSLKTDAPLLKKILTYHVVPGQLSPSQVVGTHSTVEGASLTVTGSGNDLQ
MSMEG_5196|M.smegmatis_MC2_155      DAIAADPAALTSLDYYHAFLGLLGNDDVKGQRPTQQGAEIKVTGKGGDIE
TH_1983|M.thermoresistible__bu      DALAADPAALTQLGYYHAFLGLLGPDTVKGQRPTQDGAEIKVTGEGGDIT
                                    : : ::.  *..:  **.. *  .   * * : * :** :.***  . : 

Rv2875|M.tuberculosis_H37Rv         VGN-ADVVCGGVSTANATVYMIDSVLMP----------------------
Mb2900|M.bovis_AF2122/97            VGN-ADVVCGGVSTANATVYMIDSVLMP----------------------
Mflv_4085|M.gilvum_PYR-GCK          VND-ASVACGGVQTANATVYLIDTVLMP----------------------
Mvan_2259|M.vanbaalenii_PYR-1       VNE-AGLVCGGVKTANATVYMIDTVLMP----------------------
MMAR_1834|M.marinum_M               VGD-AAVVCGGVQTANAVVYMIDTVLMP----------------------
MSMEG_5196|M.smegmatis_MC2_155      VNDTAKLVCGAIHAQNARIYLIDTVLDPNNPPEALTPTVSGTSTTPTTTT
TH_1983|M.thermoresistible__bu      VNDTAEVVCGGIQAANARIYLIDKVLDPAQAPDPITP---GSSSTNSSSD
                                    *.: * :.**.: : ** :*:**.** *                      

Rv2875|M.tuberculosis_H37Rv         --------------------PA------
Mb2900|M.bovis_AF2122/97            --------------------PA------
Mflv_4085|M.gilvum_PYR-GCK          --------------------PAM-----
Mvan_2259|M.vanbaalenii_PYR-1       --------------------PAN-----
MMAR_1834|M.marinum_M               --------------------PS------
MSMEG_5196|M.smegmatis_MC2_155      ETTEPAPAEAPESAETPEAMPAADAPIG
TH_1983|M.thermoresistible__bu      SSDSSGSSDSSE-----QALPAEDPTA-
                                                        *: