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FEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFGLDVLLAESVNQMLDGERAKREK RDSSGSFGLADQASMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVTLEKIAAW AITEPDSGSDAFGGMKTHVTRDGEDYILNGHKTFITNGPYADVLVVYAKLADGEPASDWRNRPVLVFVLD AGMPGLTQGKPFKKMGMMSSPTGELFFDNVRLTPDRLLCAEGDGRDSARANFAVERLGVALMSLGIINEC HRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQAIERLKAGKQLTLAEASAIKLYSSEA ATDVAMEAVQLFGGNGYMAEYRVEQLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2789c | fadE21 | - | 100% (410) | PROBABLE ACYL-CoA DEHYDROGENASE FADE21 |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 1e-41 | 32.52% (326) | acyl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0400c | fadE7 | 4e-41 | 31.53% (406) | acyl-CoA dehydrogenase FADE7 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2812c | fadE21 | 0.0 | 100.00% (410) | acyl-CoA dehydrogenase FADE21 |
| M. gilvum PYR-GCK | Mflv_3537 | - | 1e-147 | 66.10% (413) | acyl-CoA dehydrogenase domain-containing protein |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 8e-41 | 29.28% (403) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2947c | - | 1e-178 | 76.43% (420) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1919 | fadE21 | 0.0 | 84.95% (412) | acyl-CoA dehydrogenase FadE21 |
| M. avium 104 | MAV_3680 | - | 0.0 | 80.77% (416) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3783 | - | 1e-150 | 66.83% (410) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4655 | - | 1e-149 | 66.75% (409) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2144 | fadE21 | 0.0 | 83.98% (412) | acyl-CoA dehydrogenase FadE21 |
| M. vanbaalenii PYR-1 | Mvan_2342 | - | 0.0 | 78.66% (417) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3537|M.gilvum_PYR-GCK -MLDWSDVDIAVRDAVREFVDKEIRPHLDELESGDMEPYPIVRKLFATFG
MSMEG_3783|M.smegmatis_MC2_155 MMLDWSDVDVAVRDAVREFVDKEIRPHLDELESGDMEPYPIIRKLFSTFG
TH_4655|M.thermoresistible__bu -MLDWSDVDLAVRDAVREFIDKEIRPHLDELESGDMEPYPIVRKLFATFG
Rv2789c|M.tuberculosis_H37Rv -MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFG
Mb2812c|M.bovis_AF2122/97 -MFEWSDTDLMVRDAVRQFIDKEIRPHQDALETGELSPYPIARKLFSQFG
MMAR_1919|M.marinum_M -MIEWSDTDLMMRDAVRQFIDREIRPNLDELETGALSPYPIMRKLFSQFG
MUL_2144|M.ulcerans_Agy99 -MIEWSDTDLMMRGAVRQFIDREIRPNLDELETGALSPYPIMRKLFSQFG
MAV_3680|M.avium_104 -MIEWSDTDLMVRDAVRQFVDKEIRPHLDELESGAMSPYPIARKLFSQFG
MAB_2947c|M.abscessus_ATCC_199 -MIEWSESDELIRESVREFIDKEVEPHRDGLESGELSPYPIARTLFSEFG
Mvan_2342|M.vanbaalenii_PYR-1 -MYEWSDTDIIMRDTVREFIATEIRPHLDDLESGALSPYPIARKLFSEFG
MLBr_00737|M.leprae_Br4923 -MVGWSGNPLFDLFKLPEEHN-ELRATIRALAEKEIAPHAADVDQRARFP
* ** : : *:.. * : *:. : *
Mflv_3537|M.gilvum_PYR-GCK IDAMAKEALDKRLARMREGGE---------KPSKSGGGGMFG----GGSA
MSMEG_3783|M.smegmatis_MC2_155 IDTMAKEALDKRLARLRAGED---------KPGKSSGGGMFG----GGSP
TH_4655|M.thermoresistible__bu IDKMAKEALDKRLARLREGGE---------AKTAGSRGGMFG----GGSP
Rv2789c|M.tuberculosis_H37Rv LDVLLAESVNQMLDGERAKR----------EKRD-SSGSF----GLADQA
Mb2812c|M.bovis_AF2122/97 LDVLLAESVNQMLDGERAKR----------EKRD-SSGSF----GLADQA
MMAR_1919|M.marinum_M LDVLAAESVKSILDAERADQG---------EKRHRTSGSG----GLGPQA
MUL_2144|M.ulcerans_Agy99 LDVLAAESVKSILDAERANQD---------EKRHRTSGSG----GLGPQA
MAV_3680|M.avium_104 LDTMAAEAVKKMLDRERSGAD---------ENGD-SSGAANEFSGGGAQG
MAB_2947c|M.abscessus_ATCC_199 LDVVAAEAIKTILDKERLKAAAIAAGEPKPEKRGGASGGLG---DLAGQV
Mvan_2342|M.vanbaalenii_PYR-1 LDAVAADAVKSMLDKERARHESGSTGEKHEKKAG---GGLG---DIGAQA
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYG----------------------GQGADS
: : . . .
Mflv_3537|M.gilvum_PYR-GCK GMGFVLISELCRVSMGLVTGMGVSLGLTVPTIQGRGTLAQQERWLPGLVT
MSMEG_3783|M.smegmatis_MC2_155 GMGFVLISELCRVSMGLVTGMGVSLGLTVPTIQSRGTLAQQERWLPGLVT
TH_4655|M.thermoresistible__bu GMGFVLISELCRVSMGLVTGMGVSLGLTVPTIQSRGTLAQQERWLPGLVT
Rv2789c|M.tuberculosis_H37Rv SMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVT
Mb2812c|M.bovis_AF2122/97 SMVAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQQERWVPTLVT
MMAR_1919|M.marinum_M SMAAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQKQRWLPELMT
MUL_2144|M.ulcerans_Agy99 SMAAVLVSELAGVSIGLLSTVAVSLGLGAATIMSRGTLAQKQRWLPELMT
MAV_3680|M.avium_104 SMIAVLVSEIARVSIGLLSTASVSLGLGAATIASRGTLAQKERWLPELMT
MAB_2947c|M.abscessus_ATCC_199 SMAAVLVSELAGVSIGLLSTIGVSIGLGAATIMSRGTLAQKERWLPELVT
Mvan_2342|M.vanbaalenii_PYR-1 SMAAVLVSEIAGVSIGLLSTIGVSLGLGAATIMSRGTLAQKERWLPELMT
MLBr_00737|M.leprae_Br4923 VAACIVIEEVARVDASASLIPAVNK-LGTMGLILRGSEELKKQVLPSLAA
:::.*:. *. . .*. * . : **: ::: :* * :
Mflv_3537|M.gilvum_PYR-GCK YEKIGAWAITEPDSGSDAFGGMKSWVARAADGSGDYILNGQKTFITNGPD
MSMEG_3783|M.smegmatis_MC2_155 YEKIGAWAITEPDSGSDAFGGMKSYVVRDGD---DYILNGQKTFITNGPD
TH_4655|M.thermoresistible__bu YEKIGAWAITEPDSGSDAFGGMKSYVVRDGD---DYILNGQKTFITNGPD
Rv2789c|M.tuberculosis_H37Rv LEKIAAWAITEPDSGSDAFGGMKTHVTRDGED---YILNGHKTFITNGPY
Mb2812c|M.bovis_AF2122/97 LEKIAAWAITEPDSGSDAFGGMKTHVTRDGED---YILNGHKTFITNGPY
MMAR_1919|M.marinum_M LEKIAAWAITEPDSGSDAFGGMKTHVKRDGAD---YILNGQKTFITNGPY
MUL_2144|M.ulcerans_Agy99 LEKIAAWAITEPDSGSDAFGGMKTHVKRDGAD---YILNGQKTFITNGPY
MAV_3680|M.avium_104 LEKIAAWAITEPDSGSDAFGGMKTSVRRSGDGDGAYILNGQKTFITNGPY
MAB_2947c|M.abscessus_ATCC_199 LEKIACWAITEPDAGSDAFGGMKTYVKRDGAD---YILNGQKTFITNGPD
Mvan_2342|M.vanbaalenii_PYR-1 LEKIAAWAITEPDAGSDAFGGMKTYVKRDGAD---YILNGQKTFITNGPD
MLBr_00737|M.leprae_Br4923 EGAMASYALSEREAGSDAAS-MRTRAKADGDD---WILNGFKCWITNGGK
:..:*::* ::**** . *:: . . :**** * :****
Mflv_3537|M.gilvum_PYR-GCK ADVVVVYAKLDE---PGVDKRDRKVLTFVLDKGMEGFVQSKPFRKMGIHS
MSMEG_3783|M.smegmatis_MC2_155 ADVVVVYAKLDE--GDGVDKRDRKVLTFVLDKGMEGFVQSKPFRKMGIHS
TH_4655|M.thermoresistible__bu ADVVVVYAKLDE---PGVAPRDRKVLTFVLDKGMEGFVQSRPFRKMGIHS
Rv2789c|M.tuberculosis_H37Rv ADVLVVYAKLAD-GEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMS
Mb2812c|M.bovis_AF2122/97 ADVLVVYAKLAD-GEPASDWRNRPVLVFVLDAGMPGLTQGKPFKKMGMMS
MMAR_1919|M.marinum_M ADVLLVYAKLDEAGATSSDRRDRPVLIFVLESGMAGLTQGKPFKKMGMMS
MUL_2144|M.ulcerans_Agy99 ADVLLVYAKLDEAGATSSDRRDRPVLIFVLESGMAGLTQGKPFKKMGMMS
MAV_3680|M.avium_104 ADVLVVYAKLDE-GDPSVDKRNRSVLVFVLDAGMPGLTQGKPFKKMGMMS
MAB_2947c|M.abscessus_ATCC_199 ADVLIVYAKLDE-DDPTMDRRNRKVLTFVLDSGMPGLTQGKAFKKMGMMS
Mvan_2342|M.vanbaalenii_PYR-1 ADVLVVYAKL-A-DDPATDPRQRPVLTFVLDSGMAGLTQGRPFKKMGMMS
MLBr_00737|M.leprae_Br4923 STWYTVMAVTDP------DKGANGISAFIVHKDDEGFSIGPKEKKLGIKG
: * * . : *::. . *: . :*:*: .
Mflv_3537|M.gilvum_PYR-GCK SRTGELFFNNVRLGRDRLLGETENNEAGDGRDSARSSFSAERIGVAAMAL
MSMEG_3783|M.smegmatis_MC2_155 SRTGELFFNNVRLGRDRLLGETEDHGAGDGRDSARSSFSAERIGVAAMAL
TH_4655|M.thermoresistible__bu SRTGELFFNNVRLGRDRLLGESEDQ-AGDGRDSARSSFSAERIGVAAMAL
Rv2789c|M.tuberculosis_H37Rv SPTGELFFDNVRLTPDRLLCAE-----GDGRDSARANFAVERLGVALMSL
Mb2812c|M.bovis_AF2122/97 SPTGELFFDNVRLTPDRLLCAE-----GDGRDSARANFAVERLGVALMSL
MMAR_1919|M.marinum_M SPTGELFFDNVRLTPDRLLGESEHHGDGDGRESARANFAVERLGVALMAL
MUL_2144|M.ulcerans_Agy99 SPTGELFFDNVRLTPDRLLGESEHHGDGDGRESARANFAVERLGVALMAL
MAV_3680|M.avium_104 SPTGELFFDNVRLTPDRLLGESEQHTEGDGRDSARANFAAERIGIAMMAL
MAB_2947c|M.abscessus_ATCC_199 SPTGELFFDNVRITADRLLGETEEHGGGDGRESARANFAAERVGVSLMAL
Mvan_2342|M.vanbaalenii_PYR-1 SPTGELFFDNVRLSPDRLLGETEQHGAGDGRDSARANFAAERLGIALMSL
MLBr_00737|M.leprae_Br4923 SPTTELYFDKCRIPGDRIIGEP-----GTGFKTALATLDHTRPTIGAQAV
* * **:*:: *: **:: * * .:* :.: * :. ::
Mflv_3537|M.gilvum_PYR-GCK GVIEECLRLSVDYAKTRKLWGQEIGQFQLIQLKLATMEVARMNVRNMLFR
MSMEG_3783|M.smegmatis_MC2_155 GVIEECLRLSVDYAKSRKLWGQEIGQFQLIQLKLANMEVARMNVRNMLFR
TH_4655|M.thermoresistible__bu GVIEECLRLCVDYAKNRKLWGQEIAQFQLIQLKLAKMEVARMNVRNMLFR
Rv2789c|M.tuberculosis_H37Rv GIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQ
Mb2812c|M.bovis_AF2122/97 GIINECHRLCVDYAKTRTLWGRNIGQFQLIQLKLAKMEVARINVQNMVFQ
MMAR_1919|M.marinum_M GIINECHRLCVDYAKTRTLWGKNIGQFQLIQLKLAKMEVARINVENMVFQ
MUL_2144|M.ulcerans_Agy99 GIINECHRLCVDYAKTRTLWGKNIGQFQLIQLKLAKMEVARINVENMVFQ
MAV_3680|M.avium_104 GIIDECHRLCVDYAKSRTLWGKNIGQFQLIQLKLAKMEIARMNVQNMVFH
MAB_2947c|M.abscessus_ATCC_199 GIINECHRRCLDYAKMRTLWGQNIGQFQLIQLKLAKMEVARINVQNMVFQ
Mvan_2342|M.vanbaalenii_PYR-1 GIINECHRLCLDYAKTRTLWGRNIGQFQLIQLKLARIEVARMNVQNMVFQ
MLBr_00737|M.leprae_Br4923 GIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYA
*: : . .: *:* *. :*..*. ** **: ** : : .. :::
Mflv_3537|M.gilvum_PYR-GCK VIESSQSGAPISLAEASAIKWYCSQAATDVAMDAIQLFGGNGYMTEYRVE
MSMEG_3783|M.smegmatis_MC2_155 VIESSQEGKPISLAEASAIKWYCSQAATDVAMDAVQLFGGNGYMTEYRVE
TH_4655|M.thermoresistible__bu VIEAAEKGVPISLAEASAIKWYCSEAATDVAMDAVQLFGGNGYMTEYRVE
Rv2789c|M.tuberculosis_H37Rv AIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVE
Mb2812c|M.bovis_AF2122/97 AIERLKAGKQLTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVE
MMAR_1919|M.marinum_M TLEKLKAGREPTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVE
MUL_2144|M.ulcerans_Agy99 TLEKLKAGREPTLAEASAIKLYSSEAATDVAMEAVQLFGGNGYMAEYRVE
MAV_3680|M.avium_104 TIERQQAGKPLTLAEASAIKLYSSEAATEVAMEAVQLFGGNGYMAEYRVE
MAB_2947c|M.abscessus_ATCC_199 TLEKLQHGKMPSLAEASAIKLYSSETATDVAMDAVQLFGGNGYMAEYRVE
Mvan_2342|M.vanbaalenii_PYR-1 TLERLGAGRMPSLAEASAIKLYSSEAATEAAMEAVQLFGGNGYMAEYRVE
MLBr_00737|M.leprae_Br4923 AAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVE
. * ::* * :.*: * :.: :*:***** ** ::: **
Mflv_3537|M.gilvum_PYR-GCK QLARDAKSLMIYAGSNEVQITHVARGLLSS-----
MSMEG_3783|M.smegmatis_MC2_155 QLARDAKSLMIYAGSNEVQITHVARGLLS------
TH_4655|M.thermoresistible__bu QLARDAKSLMIYAGSNEVQITHVARGLLNA-----
Rv2789c|M.tuberculosis_H37Rv QLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
Mb2812c|M.bovis_AF2122/97 QLARDAKSLMIYAGSNEVQVTHIAKGLLGEPASRA
MMAR_1919|M.marinum_M QLARDAKSLMIYAGSNEVQVTHIAKGLLG------
MUL_2144|M.ulcerans_Agy99 QLARDAKSLMIYAGSNEVQVTHIAKGLLG------
MAV_3680|M.avium_104 QLARDAKSLMIYAGSNEVQVTHIAKGLLSS-----
MAB_2947c|M.abscessus_ATCC_199 QLARDAKSLMIYAGSNEVQVTHIAKGLLAG-----
Mvan_2342|M.vanbaalenii_PYR-1 QLARDAKSLMIYAGSNEIQVTHIAKGLLSG-----
MLBr_00737|M.leprae_Br4923 RFMRDAKITQIYEGTNQIQRVVMSRALLR------
:: **** ** *:*::* . :::.**