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M. tuberculosis H37Rv Rv2764c (thyA)

annotation: thymidylate synthase
coordinates: 3073680 - 3074471
length: 263

TPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGW
LHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERM
ALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDN
HVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv2764c thyA - 100% (263) thymidylate synthase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2786c thyA 1e-158 100.00% (263) thymidylate synthase
M. gilvum PYR-GCK Mflv_4007 thyA 1e-141 87.40% (262) thymidylate synthase
M. leprae Br4923 MLBr_01519 thyA 1e-138 85.50% (262) thymidylate synthase
M. abscessus ATCC 19977 MAB_3091c - 1e-132 83.21% (262) thymidylate synthase (ThyA)
M. marinum M MMAR_1956 thyA 1e-143 89.69% (262) thymidylate synthase ThyA
M. avium 104 MAV_3652 thyA 1e-147 91.60% (262) thymidylate synthase
M. smegmatis MC2 155 MSMEG_2670 thyA 1e-141 88.17% (262) thymidylate synthase
M. thermoresistible (build 8) TH_0692 thyA 1e-139 86.26% (262) PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)
M. ulcerans Agy99 MUL_2178 thyA 1e-144 90.08% (262) thymidylate synthase
M. vanbaalenii PYR-1 Mvan_2380 thyA 1e-139 87.02% (262) thymidylate synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4007|M.gilvum_PYR-GCK          ----MPTATPYEDLLRLVLDTGTPKSDRTGTGTRSLFGHQMRYDLNAGFP
Mvan_2380|M.vanbaalenii_PYR-1       ----MPIATPYEDLLRLVLDTGTTKSDRTGTGTRSLFGHQMRYDLNAGFP
MSMEG_2670|M.smegmatis_MC2_155      ----MPIDTPYEDLLRLVTERGTPKSDRTGTGTRSLFGHQMRYDLSAGFP
MAB_3091c|M.abscessus_ATCC_199      ----MSLPTPYEDLLRLVLEEGTPKADRTGTGTRSVFGHQLRYRLEDGFP
TH_0692|M.thermoresistible__bu      VPINGSIPTPYEDLLRLVLERGTPKADRTGTGTRSLFGHQMRYDLSAGFP
Rv2764c|M.tuberculosis_H37Rv        -------MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFP
Mb2786c|M.bovis_AF2122/97           -------MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFP
MMAR_1956|M.marinum_M               ----MPIATPYEDLLRRVLETGTAKSDRTGTGTRSLFGQQIRYDLGCGFP
MUL_2178|M.ulcerans_Agy99           ----MPIATPYEDLLRRVLETGTAKSDRTGTGTRSLFGQQIRYDLGCGFP
MLBr_01519|M.leprae_Br4923          ----MLIATPYEDLLRLVLDCGVAKMDRTGTGTRSLFGQQLRYDLSVGFP
MAV_3652|M.avium_104                ----MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFP
                                            ******** * : *..* *********:**:*:** *  ***

Mflv_4007|M.gilvum_PYR-GCK          LITTKKVHTKSIVYELLWFLRGDSNVRWLQERGVTIWDEWASPTGDLGPV
Mvan_2380|M.vanbaalenii_PYR-1       LITTKKVHTKSIVYELLWFLRGDSNVRWLQEHGVTIWDEWASPTGDLGPV
MSMEG_2670|M.smegmatis_MC2_155      LITTKKVHTKSVIYELLWFLRGDSNVRWLQEHGVTIWDEWASETGDLGPI
MAB_3091c|M.abscessus_ATCC_199      LITTKKVHLKSVIYELLWFLRGESNVRWLQERGVTIWDEWASEAGELGPV
TH_0692|M.thermoresistible__bu      LITTKKVHTKSVIYELLWFLRGDSNVRWLQDRGVTIWDEWADDDGELGPV
Rv2764c|M.tuberculosis_H37Rv        LLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPI
Mb2786c|M.bovis_AF2122/97           LLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPI
MMAR_1956|M.marinum_M               LLTTKKVHFKSVVYELLWFLRGDSNVGWLQQHGVTIWDEWASETGDLGPI
MUL_2178|M.ulcerans_Agy99           LLTTKKVHFKSVVYELLWFLRGDSNVGWLQQHGVTIWDEWASETGDLGPI
MLBr_01519|M.leprae_Br4923          LVTTKKVHFKSVVYELLWFLRGDSNVAWLHEHGVNIWDEWASSTGDLGPI
MAV_3652|M.avium_104                LITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPI
                                    *:****** **: *********:**: **: :**.******.  *:***:

Mflv_4007|M.gilvum_PYR-GCK          YGVQWRSWPTPSGEHIDQISAALDLLKRDPDSRRNIVSAWNVGEIPQMAL
Mvan_2380|M.vanbaalenii_PYR-1       YGVQWRSWPTPSGAHIDQISAALDLLRRDPDSRRNIVSAWNVGEIPQMAL
MSMEG_2670|M.smegmatis_MC2_155      YGVQWRSWPTPSGEHIDQISSALELLKSDPDSRRNIVSAWNVGEIPQMAL
MAB_3091c|M.abscessus_ATCC_199      YGVQWRAWPTPSGEHIDQISAALDLLRTNPDSRRNIVSAWNVGEIPQMAL
TH_0692|M.thermoresistible__bu      YGVQWRSWPTPSGEHVDQISAALELLRTDPDSRRIIVSAWNVADLDEMAL
Rv2764c|M.tuberculosis_H37Rv        YGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMAL
Mb2786c|M.bovis_AF2122/97           YGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMAL
MMAR_1956|M.marinum_M               YGVQWRSWPTPSGEHIDQISAALELLRTDPDSRRIIVSAWNVGQIPQMAL
MUL_2178|M.ulcerans_Agy99           YGVQWRSWPTPSGEHIDQISAALELLRTDPDSRRIIVSAWNVGQIPQMAL
MLBr_01519|M.leprae_Br4923          YGVQWRSWPTSSGDYIDQISTALDLLRTEPDSRRIIVSAWNVGEIPQMAL
MAV_3652|M.avium_104                YGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMAL
                                    ******:**:.** ::****:**:**: :***** *******.:: .***

Mflv_4007|M.gilvum_PYR-GCK          PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
Mvan_2380|M.vanbaalenii_PYR-1       PPCHAFFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
MSMEG_2670|M.smegmatis_MC2_155      PPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
MAB_3091c|M.abscessus_ATCC_199      PPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
TH_0692|M.thermoresistible__bu      PPCHTLFQFYVAGGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
Rv2764c|M.tuberculosis_H37Rv        PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
Mb2786c|M.bovis_AF2122/97           PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
MMAR_1956|M.marinum_M               PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
MUL_2178|M.ulcerans_Agy99           PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
MLBr_01519|M.leprae_Br4923          PPCHAFFQFYVAQGRLSCQLYQRSADMFLGVPFNIASYALLTHMMAAQSG
MAV_3652|M.avium_104                PPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG
                                    ****::*****: *:***********:*********************:*

Mflv_4007|M.gilvum_PYR-GCK          LGVGEFIWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAPRDSIFDYTY
Mvan_2380|M.vanbaalenii_PYR-1       LGVGEFIWTGGDCHIYDNHVEQVTEQLSREPRPYPELVLAQRDSLFDYIY
MSMEG_2670|M.smegmatis_MC2_155      LDVGEFIWTGGDCHIYDNHTEQVALQLSREPRPYPELVLAPRDSIFDYTY
MAB_3091c|M.abscessus_ATCC_199      LGVGDFVWTGGDCHIYDNHVEQVTEQLSRDPYPYPTLVLAQRDSIFDYRY
TH_0692|M.thermoresistible__bu      LQVGEFIWTGGDCHIYDNHVEQVRLQLSRDPRPYPELELAPRDSIFDYTF
Rv2764c|M.tuberculosis_H37Rv        LSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTY
Mb2786c|M.bovis_AF2122/97           LSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTY
MMAR_1956|M.marinum_M               LSVGEFIWTGGDCHIYGNHVEQVTEQLRREPRPYPKLSLSQRDSIFDYTY
MUL_2178|M.ulcerans_Agy99           LSVGEFIWTGGDCHIYDNHVEQVTEQLRREPRPYPKLSLSQRDSIFDYTY
MLBr_01519|M.leprae_Br4923          LLVGEFVWTGGDCHIYDNHVEQVQLQLSREPRAYPELFLAQRDSIFDYVY
MAV_3652|M.avium_104                LSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLAHRDSIFDYTY
                                    * **:*:*********.**.***  ** *:* .** * *: ***:*:* :

Mflv_4007|M.gilvum_PYR-GCK          EDVVIKNYEPHPAIKAPVAI
Mvan_2380|M.vanbaalenii_PYR-1       EDVVIKNYDPHPAIKAPVAV
MSMEG_2670|M.smegmatis_MC2_155      EDIAIVNYDPHPAIKAPVAV
MAB_3091c|M.abscessus_ATCC_199      EDITVENYQHHAAIKAPVAV
TH_0692|M.thermoresistible__bu      EDVVIRNYDPHPAIKAPVAV
Rv2764c|M.tuberculosis_H37Rv        EDIVVKNYDPHPAIKAPVAV
Mb2786c|M.bovis_AF2122/97           EDIVVKNYDPHPAIKAPVAV
MMAR_1956|M.marinum_M               EDVVVQDYDPHPAIKAPVAV
MUL_2178|M.ulcerans_Agy99           EDVVVQDYDPHPAIKAPVAV
MLBr_01519|M.leprae_Br4923          EDVVVTNYDPHPAIKAPVAI
MAV_3652|M.avium_104                DDVVVHNYDPHPAIKAPVAV
                                    :*:.: :*: *.*******:

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv2764c	thyA	-	100% (263)	thymidylate synthase