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IASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLF LTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALS TNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2593c | ruvA | - | 100% (196) | Holliday junction DNA helicase motor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2624c | ruvA | 1e-104 | 100.00% (196) | Holliday junction DNA helicase RuvA |
| M. gilvum PYR-GCK | Mflv_3825 | ruvA | 8e-74 | 70.10% (194) | Holliday junction DNA helicase motor protein |
| M. leprae Br4923 | MLBr_00482 | ruvA | 1e-76 | 76.35% (203) | Holliday junction DNA helicase RuvA |
| M. abscessus ATCC 19977 | MAB_2883c | - | 5e-74 | 73.27% (202) | Holliday junction DNA helicase RuvA |
| M. marinum M | MMAR_2110 | ruvA | 2e-86 | 84.77% (197) | Holliday junction DNA helicase RuvA |
| M. avium 104 | MAV_3474 | ruvA | 1e-85 | 83.92% (199) | Holliday junction DNA helicase motor protein |
| M. smegmatis MC2 155 | MSMEG_2944 | ruvA | 3e-82 | 78.87% (194) | Holliday junction DNA helicase motor protein |
| M. thermoresistible (build 8) | TH_1491 | - | 1e-17 | 69.70% (66) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1715 | ruvA | 1e-86 | 84.77% (197) | Holliday junction DNA helicase RuvA |
| M. vanbaalenii PYR-1 | Mvan_2574 | ruvA | 2e-74 | 71.13% (194) | Holliday junction DNA helicase motor protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3825|M.gilvum_PYR-GCK -------------------------MIASVRGEVLDIALDHVVIEAAGVG
Mvan_2574|M.vanbaalenii_PYR-1 -------------------------MIAAVRGEVLDIALDHVVIEAAGVG
MSMEG_2944|M.smegmatis_MC2_155 -------------------------MIASVRGEVIDIALDHAVIEAAGVG
Rv2593c|M.tuberculosis_H37Rv -------------------------MIASVRGEVLEVALDHVVIEAAGVG
Mb2624c|M.bovis_AF2122/97 -------------------------MIASVRGEVLEVALDHVVIEAAGVG
MMAR_2110|M.marinum_M -------------------------MISSLRGEVLEVALDHVVIEAAGVG
MUL_1715|M.ulcerans_Agy99 -------------------------MISSLRGEVLEVALDHVVIEAAGVG
MLBr_00482|M.leprae_Br4923 -------------------------MIFSVRGEVLEVALDHAVIEAAGIG
MAV_3474|M.avium_104 -------------------------MIASVRGEVLEVALDHAVIEAAGVG
MAB_2883c|M.abscessus_ATCC_199 -------------------------MIASVNGEVIDIALDHVVIEAAGVG
TH_1491|M.thermoresistible__bu VANRRALVLAGGGLAGIAWETGVLLGIADESPHTADLLLTSDVLVGTSAG
* .. :: * *: .:. *
Mflv_3825|M.gilvum_PYR-GCK YKVMATP------------------------------------------A
Mvan_2574|M.vanbaalenii_PYR-1 YKVMATP------------------------------------------A
MSMEG_2944|M.smegmatis_MC2_155 YKVMATP------------------------------------------S
Rv2593c|M.tuberculosis_H37Rv YRVNATP------------------------------------------A
Mb2624c|M.bovis_AF2122/97 YRVNATP------------------------------------------A
MMAR_2110|M.marinum_M YRVNATP------------------------------------------S
MUL_1715|M.ulcerans_Agy99 YRVNATP------------------------------------------S
MLBr_00482|M.leprae_Br4923 YRVNATP------------------------------------------S
MAV_3474|M.avium_104 YRVNATP------------------------------------------S
MAB_2883c|M.abscessus_ATCC_199 YRVNATP------------------------------------------A
TH_1491|M.thermoresistible__bu SAVAAQLGSGAPLTRLFERQLDPNTAEIKPRVAIDDLTAEFLEAVRRPGS
* * :
Mflv_3825|M.gilvum_PYR-GCK TLATLRRGSEARLITAMIVREDS-------QTLYGFADSDAR--------
Mvan_2574|M.vanbaalenii_PYR-1 TLATLRRGAEARLITAMIVREDS-------MTLYGFADSDAR--------
MSMEG_2944|M.smegmatis_MC2_155 TLATLRRGTEARLITAMIVREDS-------MTLYGFVDGDAR--------
Rv2593c|M.tuberculosis_H37Rv TLATLRQGTEARLITAMIVREDS-------MTLYGFPDGETR--------
Mb2624c|M.bovis_AF2122/97 TLATLRQGTEARLITAMIVREDS-------MTLYGFPDGETR--------
MMAR_2110|M.marinum_M TLATLRQGTDARLITAMIVREDS-------MTLYGFVDGETR--------
MUL_1715|M.ulcerans_Agy99 TLATLRQGTDARLITAMIVREDS-------MTLYGFVDGETR--------
MLBr_00482|M.leprae_Br4923 ALATLRQGSQARLVTAMVVREDS-------MTLYGFSDAENR--------
MAV_3474|M.avium_104 TLSTLRTGTQARLITAMIVREDS-------MTLYGFTDAETR--------
MAB_2883c|M.abscessus_ATCC_199 TLSTLRRGTQIRLITAMIVREDS-------MTLYGFTDTDAR--------
TH_1491|M.thermoresistible__bu TVEKLRRIGAVALSTGTVGEAERRAVIAARLPAHDWPDRDLRLSAVDVGT
:: .** * *. : . : . :.: * : *
Mflv_3825|M.gilvum_PYR-GCK ---------------DLFLTLLGVSGIGPSIALGALAMYD---GPTLRQA
Mvan_2574|M.vanbaalenii_PYR-1 ---------------NLFLTLLGVSGIGPSIALGALAMYD---GPTLRQA
MSMEG_2944|M.smegmatis_MC2_155 ---------------DLFLTLLGVSGVGPKIALATLAVYD---PQALRQA
Rv2593c|M.tuberculosis_H37Rv ---------------DLFLTLLSVSGVGPRLAMAALAVHD---APALRQV
Mb2624c|M.bovis_AF2122/97 ---------------DLFLTLLSVSGVGPRLAMAALAVHD---APALRQV
MMAR_2110|M.marinum_M ---------------DLFLTLLSVSGVGPRLAMATLSVHD---ANGLRQA
MUL_1715|M.ulcerans_Agy99 ---------------DLFLTLLSVSGVGPRLAMATLSVHD---ANGLRQA
MLBr_00482|M.leprae_Br4923 ---------------DLFLALLSVSGVGPRLAMATLAVHD---AAALRQA
MAV_3474|M.avium_104 ---------------DLFLTLLSVSGVGPRLAMATLAVHD---AGALRQA
MAB_2883c|M.abscessus_ATCC_199 ---------------DLFTTLLGVSGVGPKIAMATLAVYD---APTLRQA
TH_1491|M.thermoresistible__bu GELVCFDRDSGVPLVDAVAASCAVPGVWPPVTIGERRYMDGGVASTVNMA
: . : .*.*: * :::. * :. .
Mflv_3825|M.gilvum_PYR-GCK IGDGDLTALTRIPK-------VGKKTAELLALTLRDKVGSSTSSGVAA--
Mvan_2574|M.vanbaalenii_PYR-1 IGDGDVTALTRIPK-------VGKKTAELLVLTLRDKVGTSTSAGVAS--
MSMEG_2944|M.smegmatis_MC2_155 LADGDVTALTRVPG-------IGKRGAERMVLELRDKIGPVSAGGGAA--
Rv2593c|M.tuberculosis_H37Rv LADGNVAALTRVPG-------IGKRGAERMVLELRDKVGVAATGGALS--
Mb2624c|M.bovis_AF2122/97 LADGNVAALTRVPG-------IGKRGAERMVLELRDKVGVAATGGALS--
MMAR_2110|M.marinum_M LADGDVTALTRVPG-------IGKRGAERMVVELRDKVGPAGSAATAP--
MUL_1715|M.ulcerans_Agy99 LADGDVTALTRVPG-------IGKRGAERMVVELRDKVGPAGSAATAP--
MLBr_00482|M.leprae_Br4923 LADSDVASLTRVPG-------IGKRGAERIVLELRDKVGPVGASGLTVGT
MAV_3474|M.avium_104 LHDGDVAALTRVPG-------IGKRGAERMVLELRDKIGAAGAAGAPAGA
MAB_2883c|M.abscessus_ATCC_199 LADGDVAALTRVPG-------IGKRGAERLVLELREKVAAAPGGTTELG-
TH_1491|M.thermoresistible__bu LAADCDTVVALVPSRRDTPSPFGPGPAREIDEFGGAAVGVFADDASVAAF
: . : :: :* .* *. : :.
Mflv_3825|M.gilvum_PYR-GCK ---AGGHGIRGPVVEALVGLGFAVKQAEEATDKVLANDP----EATTSSA
Mvan_2574|M.vanbaalenii_PYR-1 ---AGGHGIRGPVVEALVGLGFAQKQAEEATDKVLANEP----EATTSSA
MSMEG_2944|M.smegmatis_MC2_155 ---VGGHAIRGPVVEALVGLGFAAKQAEEATDKVLANDP----EATTSSA
Rv2593c|M.tuberculosis_H37Rv ---TNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANH----DATTSSA
Mb2624c|M.bovis_AF2122/97 ---TNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANH----DATTSSA
MMAR_2110|M.marinum_M A--VNGHTVRAPVVEALVGLGFAAKQAEEATDKVLAGDG----EATTSSA
MUL_1715|M.ulcerans_Agy99 A--VNGHTVRAPVVEALVGLGFAAKQAEEATDKVLAGDG----EATTSSA
MLBr_00482|M.leprae_Br4923 A--ADGNAVRGSVVEALVGLGFAAKQAEEATDQVLDGELGKDGAVATSSA
MAV_3474|M.avium_104 A--RNGHAVRGPVVEALVGLGFAAKQAEEATDKVLAAEP----EAGTSGA
MAB_2883c|M.abscessus_ATCC_199 R--GTASLVRSQVVEALIGLGFAAKQAEQATDTVLAQDNPGDTGADVSGV
TH_1491|M.thermoresistible__bu GXXXGGHAVRGPVVEALVGLGFSAKQAEEATDKVLADDP----DASTSTA
. :*. *****:****: ****:*** ** : . .* .
Mflv_3825|M.gilvum_PYR-GCK LRAALSMLGKK-
Mvan_2574|M.vanbaalenii_PYR-1 LRAALSMLGKK-
MSMEG_2944|M.smegmatis_MC2_155 LRAALSMLGKK-
Rv2593c|M.tuberculosis_H37Rv LRSALSLLGKAR
Mb2624c|M.bovis_AF2122/97 LRSALSLLGKAR
MMAR_2110|M.marinum_M LRAALSLLGKAR
MUL_1715|M.ulcerans_Agy99 LRAALSLLGKAR
MLBr_00482|M.leprae_Br4923 LRAALSLLGKTR
MAV_3474|M.avium_104 LRAALSLLGKSR
MAB_2883c|M.abscessus_ATCC_199 LRSALALLGKTR
TH_1491|M.thermoresistible__bu LRSALSMLGRK-
**:**::**: