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VSVWLRAGALVAAVMLSLSGCGGFHAGAPSTAGPCEIVPNGTPAPKTPPATVPSSRNLATNPEIATGYRR DMTVVRTAHYAAATANPLATQVACRVLRDGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSV QAYDGREVAPAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGRTPWRDLFGPAVT LADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDGSPKPAGTRLTNPAYSKTLSAIASAGANAFYSG DIAHDIVAAASDTSNGRTPGLLTIEDLAGYLAKRRQPLCTTYRGREICGMPSSGGVAVAATLGILEHFPM SDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRLPGGSLTTLVDPGYLAARAALISPQ HSMGSARPGDFGAPTAVAPPVPEHGTSHLSVVDSYGNAATLTTTVESSFGSYHLVDGFILNNQLSDFSAE PHATDGSPVANRVEPGKRPRSSMAPTLVFDHSSAGRGALYAVLGSPGGSMIIQFVVKTLVAMLDWGLNPQ QAVSLVDFGAANSPHTNLGGENPEINTSDDGDHDPLVQGLRALGHRVNLAEQSSGLSAITRSEAGWAGGA DPRREGAVMGDDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2394 | ggtB | - | 100% (643) | PROBABLE GAMMA-GLUTAMYLTRANSPEPTIDASE PRECURSOR GGTB (GAMMA-GLUTAMYLTRANSFERASE) (GLUTAMYL TRANSPEPTIDASE) |
| M. tuberculosis H37Rv | Rv0773c | ggtA | 5e-52 | 30.77% (559) | bifunctional cephalosporin |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2415 | ggtB | 0.0 | 99.84% (643) | gamma-glutamyltranspeptidase precursor GgtB |
| M. gilvum PYR-GCK | Mflv_3716 | - | 0.0 | 69.87% (634) | gamma-glutamyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2788 | - | 0.0 | 67.97% (640) | gamma-glutamyltranspeptidase (GgtB) |
| M. marinum M | MMAR_3713 | ggtB | 0.0 | 78.87% (639) | gamma-glutamyltranspeptidase precursor GgtB |
| M. avium 104 | MAV_0717 | ggt | 6e-49 | 30.27% (565) | gamma-glutamyltransferase |
| M. smegmatis MC2 155 | MSMEG_3076 | ggt | 0.0 | 70.71% (635) | gamma-glutamyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0486 | ggtA | 1e-34 | 30.60% (451) | bifunctional acylase, GgtA |
| M. vanbaalenii PYR-1 | Mvan_1330 | - | 2e-25 | 26.15% (585) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0717|M.avium_104 --------------------------------------------------
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Rv2394|M.tuberculosis_H37Rv MSVWLRAGALVAAVMLSLSGCGGFHAGAPS-TAGPCEIVPNGTPAPKT-P
Mb2415|M.bovis_AF2122/97 MSVWLRAGALVAAVMLSLSGCGGFHAGAPS-TAGPCEIVPNGTPAPKT-P
MMAR_3713|M.marinum_M MTFVKRCGAVLAVAALALAGCGTTHVGAPN-SAGPCEIVPNGTPAPKTSV
Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTA-RQDTPAAPPGPCDIVANGT
MSMEG_3076|M.smegmatis_MC2_155 MLIASGCSDGAERPRRPAPGPCEIVSNGTP-VPKTPESPP---------P
MAB_2788|M.abscessus_ATCC_1997 MRALTRALAIASIALLASAGCAGDMTSRPGGAAEPCGITANGVPITKT-A
Mvan_1330|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_0717|M.avium_104 ----------MNQPFGWDFPYAWPRKPVLADNVVCTSQPLAAQAGLRMLA
MUL_0486|M.ulcerans_Agy99 -----------------------------------------------MQR
Rv2394|M.tuberculosis_H37Rv PATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLR
Mb2415|M.bovis_AF2122/97 PATVPSSRNLATNPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLR
MMAR_3713|M.marinum_M AAAAPSSRNVATNPEIATGYRTDMTPVHTAHYSVSAANPLATQAACRVLR
Mflv_3716|M.gilvum_PYR-GCK PVSSDGGRSDDTAPETATGYRSDMTAVHTRSYAVATANPLATRAACEVLR
MSMEG_3076|M.smegmatis_MC2_155 PPGAPAGRDIATQPEVATGYRTDMTAVRTATYAVATANPLATEAACKVLR
MAB_2788|M.abscessus_ATCC_1997 ATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQAACKVLR
Mvan_1330|M.vanbaalenii_PYR-1 ------------------MATAQRPPALSANAMVSSSHPAASLAGARVLA
:
MAV_0717|M.avium_104 EGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGLNASGRSP
MUL_0486|M.ulcerans_Agy99 SGG-----DLICRIRLALRLDLSVRMAAHAHPGRQ--RRVH-LTAAGRP-
Rv2394|M.tuberculosis_H37Rv DGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREV
Mb2415|M.bovis_AF2122/97 DGGTAADAVVAAQAVLGLVEPQSSGIGGGGYLVYFDARTGSVQAYDGREV
MMAR_3713|M.marinum_M DGGTAADAVVAAQAVLGLVEPQSSGIGGGGVLLYYDARTRSVQAYDGREV
Mflv_3716|M.gilvum_PYR-GCK DGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQAFDGRET
MSMEG_3076|M.smegmatis_MC2_155 DGGTAADALITAQAVLGLVEPQASGLGGGGFLLYHDAATGAVRAFDGRET
MAB_2788|M.abscessus_ATCC_1997 DGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQTYDGREV
Mvan_1330|M.vanbaalenii_PYR-1 DGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWTVNGSGYG
.** : : :.. . .
MAV_0717|M.avium_104 AAWTPEY-----------FGGNAVPVLGWNSVTVPGAVSAWTELHARFGK
MUL_0486|M.ulcerans_Agy99 -------------------SGSSDACRRRERRRRR----YRHRHHPHPGG
Rv2394|M.tuberculosis_H37Rv APAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGR
Mb2415|M.bovis_AF2122/97 APAAATENYLRWVSDVDRSAPRPNARASGRSIGVPGILRMLEMVHNEHGR
MMAR_3713|M.marinum_M APAAATENYMRWISDADHSAPRPDPRASGRSIGVPGILRMLEMVHNEHGT
Mflv_3716|M.gilvum_PYR-GCK APAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQVHAEHGR
MSMEG_3076|M.smegmatis_MC2_155 APAAATENYLRWISEADRTEPRPDARASGRSIGVPGIVRLLDVVHREYGK
MAB_2788|M.abscessus_ATCC_1997 APAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYDVHAEHGA
Mvan_1330|M.vanbaalenii_PYR-1 PDGGTPEFY-------AAQGLSSIPLDGPLAVAVPGAVAALRALHLGGAT
. * .
MAV_0717|M.avium_104 LPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAEAFAPEGR
MUL_0486|M.ulcerans_Agy99 TGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAEAFLPGGR
Rv2394|M.tuberculosis_H37Rv TPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDG
Mb2415|M.bovis_AF2122/97 TPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEARKYFLNPDG
MMAR_3713|M.marinum_M TPWRDLFSPAVALADNGFDISPRMAAAISDSAPQLGADPQARGYFLTPDG
Mflv_3716|M.gilvum_PYR-GCK TPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAAYFLNADR
MSMEG_3076|M.smegmatis_MC2_155 KAWRELFDPAVNLADRGFDISPRLAAALLDAAPQLRLDPEASAYFLNQDG
MAB_2788|M.abscessus_ATCC_1997 APWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADLYLLNTDG
Mvan_1330|M.vanbaalenii_PYR-1 RELEQLWEPAARIAGDGLPCSARTAGDVVTALG----------------D
. *: ** . *: *. .
MAV_0717|M.avium_104 APR-PGERFRLPAHADTLEAIAASRGEAFYRGALAARVAEHAAAN-----
MUL_0486|M.ulcerans_Agy99 APK-PGELFTFPDHADTLEKIAASTGAAFYRGELADKLEAHARAN-----
Rv2394|M.tuberculosis_H37Rv SPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRT
Mb2415|M.bovis_AF2122/97 SPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRT
MMAR_3713|M.marinum_M TPKAVGTRLTNPAYAKALSEIASAGASVFYTGDIAHDIVAAAGDTSGGRT
Mflv_3716|M.gilvum_PYR-GCK TPKSAGTTLTNPAYAKTLGAVAAD-PEAFYTGDIARAIVASVTDPSGGRT
MSMEG_3076|M.smegmatis_MC2_155 TPKRVGTRLTNPAYAKTLGAIATDGADAFYTGDIARAIVAAAADTSGGRT
MAB_2788|M.abscessus_ATCC_1997 SAKPAGTKITNPAYAKTLGAVAADGPDAFYRGAIAEAIVAAAADTSSGRT
Mvan_1330|M.vanbaalenii_PYR-1 SAPAVGSRVPQPELAATIRRLARD-PEGFYTGEFAQRAVAALQAGG----
:. * . * : :: :* ** * :*
MAV_0717|M.avium_104 GGAMTADDLAAHRADWVETITGDYRGYTVHEIP-PNGHGIVALIALGILE
MUL_0486|M.ulcerans_Agy99 DAALRASDLAAHRTDWVGTISTNYRDYTIHEIP-PNGQGIVALIALGILD
Rv2394|M.tuberculosis_H37Rv PGLLTIEDLAGYLAKRRQPLCTTYRGREICGMP--SSGGVAVAATLGILE
Mb2415|M.bovis_AF2122/97 PGLLTIEDLAGYLAKRRQPLCTTYRGREICGMP--SSGGVAVAATLGILE
MMAR_3713|M.marinum_M PSLITLEDLSAYPAKKREPLCTTYRGRQICGMPTPSSGGVAVAATLGILE
Mflv_3716|M.gilvum_PYR-GCK PGLMTVEDLADYTVKQRDPLCTPYRGKEICGMPPPSSGGIAVAATLGMLE
MSMEG_3076|M.smegmatis_MC2_155 PSLLTENDLATYTVKTRDPLCTTYRGREICGMPPPSSGGIAVAATLGILE
MAB_2788|M.abscessus_ATCC_1997 PSLMTTADLSGYTAKRRAALCTTYRDHEICGMPAPSSGGIAVAATLGILQ
Mvan_1330|M.vanbaalenii_PYR-1 APFSGDEWTAGAEVNPEPAITGRYAGAVVHQTPLPTPGWMVLQQAALCDG
: .. .: * . : * . :. :
MAV_0717|M.avium_104 RFDMASLPVDSADS---------VHLQIEAVKLAFADAQAYLADIEHMPL
MUL_0486|M.ulcerans_Agy99 QFDMSCYPVDSADS---------VHLQIEALKLAFSDAQHQLADIDHMTV
Rv2394|M.tuberculosis_H37Rv HFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRL
Mb2415|M.bovis_AF2122/97 HFPMSDYAPSKVDLNGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVQL
MMAR_3713|M.marinum_M HFPMSEYRPDNLDPNGGRPSVMGVHLVAEAERLAYADRDKYVADADFVPP
Mflv_3716|M.gilvum_PYR-GCK RFPMADHAPTDVDLNGGRPSVMGVHLISEAERLAYADRDRYVADTDFVAL
MSMEG_3076|M.smegmatis_MC2_155 HFAMKQHRPTDLDRNGGHPTVMGVHLISEAERLAYADRDRYVADTDFVAL
MAB_2788|M.abscessus_ATCC_1997 NFPMASFRPTDIDLDGGKPTVDGVHYIAEAERLAYADRDKYVADTDFVAL
Mvan_1330|M.vanbaalenii_PYR-1 VVGFSGWLS-----------AEAIDRLARAARLTFADRLALCASDN----
. : :. .* :*:::* *. :
MAV_0717|M.avium_104 R---PEHLLDTEYLERRAALIDPARAKPVSAG------------APAGGT
MUL_0486|M.ulcerans_Agy99 G---PDQLLDKEYLRGRAALIDLKQAKPASAG------------TPKGGT
Rv2394|M.tuberculosis_H37Rv PGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGT
Mb2415|M.bovis_AF2122/97 PGGSLTTLVDPGYLAARAALISPQHSMGSARPGDFGAPTAVAPPVPEHGT
MMAR_3713|M.marinum_M PGGSLSTLVDPAYLAGRAALISPQHSMGTAKPGDFGLPTTIAAPVPEHGT
Mflv_3716|M.gilvum_PYR-GCK PGGSPDTLLGNDYLAGRAALISPDRSMGTAEPGNFGPPTAPVPPTPEHGT
MSMEG_3076|M.smegmatis_MC2_155 PGGSPNTLLDSAYLTGRAALISEDRTMGTAQPGSFGPPVTAAP-VREHGT
MAB_2788|M.abscessus_ATCC_1997 PGNSPDTLLNPTYLAGRARLISGDTTMGVAKPGEFNIPASAAVSTPEHGT
Mvan_1330|M.vanbaalenii_PYR-1 --------------DGSRYVLTPDRIEAQRRDLDCGTEARGPVEVRAGDT
:: . .*
MAV_0717|M.avium_104 VYLTAADAAGMMVSMIQSNYMGFGSGVVVPGTGISLQNRGA-NFTAGLGH
MUL_0486|M.ulcerans_Agy99 IYLTAADADGLMVSMIQSNYMGFGSGVVVPGTGISLQNRGS-GFVATPGH
Rv2394|M.tuberculosis_H37Rv SHLSVVDSYGNAATLTTTVESSFGSYHLVDG--FILNNQLS-DFSAEPHA
Mb2415|M.bovis_AF2122/97 SHLSVVDSYGNAATLTTTVESSFGSYHLVDG--FILNNQLS-DFSAEPHA
MMAR_3713|M.marinum_M SHVSVVDSYGNAAALTTTVESAFGSFHMVDG--FLLNNQLS-DFNAQPYD
Mflv_3716|M.gilvum_PYR-GCK SHVSVVDRDGNAASLTTTVESAFGSFHMVDG--FLLNNQLT-DFSAEPAG
MSMEG_3076|M.smegmatis_MC2_155 SQVSIIDSFGNAAALTTTVESAFGSFHMVDG--FLLNNQLT-DFSAEPVS
MAB_2788|M.abscessus_ATCC_1997 SQVTVVDARGNAASLTTTVESAFGSFHMVDG--FFLNNQLT-DFSAEPVG
Mvan_1330|M.vanbaalenii_PYR-1 TSTVVVDAEGRAVSFIHSLAFTFGAKFTVPGTGVILNNRLARGAYLIPGH
* * .:: : **: * * . *:*: : .
MAV_0717|M.avium_104 P------NSVGPNKRPYHTIIPGFVTKGG------APVMSFGVMGGMMQP
MUL_0486|M.ulcerans_Agy99 P------NQVGPRKRPYHTIIPGFVTKDG------APVLSFGVMGAQMQP
Rv2394|M.tuberculosis_H37Rv TDGSPVANRVEPGKRPRSSMAPTLVFDHS-SAGRGALYAVLGSPGGSMII
Mb2415|M.bovis_AF2122/97 TDGSPVANRVEPGKRPRSSMAPTLVFDHS-SAGRGALYAVLGSPGGSMII
MMAR_3713|M.marinum_M SDGAPVANRIQPGKRPRSSMAPTFVFDGA-PAEHSSLYAVVGSPGGSTIV
Mflv_3716|M.gilvum_PYR-GCK PDGAPVANRLEPGKRPRSTMAPTLIFDTS-GPDRR-LYAVAGSPGGSTII
MSMEG_3076|M.smegmatis_MC2_155 PEGTPIPNRVEPGKRPRSTMAPTLIFDHD-GGERGPLYAVLGSPGGSVII
MAB_2788|M.abscessus_ATCC_1997 KDGLPVANRLQPGKRPRSSMAPTLVFERAESGKRGALLLALGSPGGSVII
Mvan_1330|M.vanbaalenii_PYR-1 P------NEVAPRRKPLHTLNAWVVTDDA-----GALLHVGNTPGGDGQV
* : * ::* :: . .: . . *.
MAV_0717|M.avium_104 QGHVQVMVRIADHGQNPQAACDGPRFRWVQGTQVSCENGFP---------
MUL_0486|M.ulcerans_Agy99 QGHVQMMVRIADYGQNPQAACDGPRFRWVQELKVSCEKGFP---------
Rv2394|M.tuberculosis_H37Rv QFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGD
Mb2415|M.bovis_AF2122/97 QFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGD
MMAR_3713|M.marinum_M QFVVKTLVAMLDWGLDPQQAVSAVDFGAANTPRTNVGGEHPDINTADNGA
Mflv_3716|M.gilvum_PYR-GCK QFVVKTVVGMLDWGLDPQQAVSMVDFGADNSPETNVGGEHPVIDTADDGA
MSMEG_3076|M.smegmatis_MC2_155 QFVVKTVVGLLDWGLDPQQAVSMVDFGAANTPKTNVGGEHPNVDTSDNGD
MAB_2788|M.abscessus_ATCC_1997 QFVVKTLVGILDWGLDPQQAVSMVDFGANNSPKTNVGGEHPSIDARDNGA
Mvan_1330|M.vanbaalenii_PYR-1 QWNMQLLSHVLDHGLDPAEAVSAPRFTVFPGSDADVVGSPDELR-VEQSL
* :: : : * * :* * . * ..
MAV_0717|M.avium_104 -AATLDELRRRGHDLVAVDDYNQFGSCQAIWRMDTGYVA-ASDPRRDGQA
MUL_0486|M.ulcerans_Agy99 -PSTLDELRRRGHDLVTVEDYNEFGSCQAIWRLEHGYLA-GSDPRRDGQA
Rv2394|M.tuberculosis_H37Rv HDPLVQGLRALGHRVNLAEQS---SGLSAITRSEAGWAG-GADPRREGAV
Mb2415|M.bovis_AF2122/97 HDPLVQGLRALGHRVNLAEQS---SGLSAITRSEAGWAG-GADPRREGAV
MMAR_3713|M.marinum_M HDPLVEGLRALGHQVNLADQS---SGLSAITRSKSGWTG-GADPRREGVV
Mflv_3716|M.gilvum_PYR-GCK DDPLVRGLRELGHKVDLADQS---SGLSAIVRAGDGWVG-GADPRREGAV
MSMEG_3076|M.smegmatis_MC2_155 HDPLVRGLRRLGHDVNLDDQS---SGLSAIARTESGWIG-GADPRREGLV
MAB_2788|M.abscessus_ATCC_1997 DDPLIQRLRARGHIVDVADQS---SGLSALVRRGPGWIG-GADPRREGLV
Mvan_1330|M.vanbaalenii_PYR-1 PAGVRRQLAAAGHRVVDQPALGGGGSAQLISVDERGVLAGAADPRQEGVA
* ** : .. . : * . .:***::* .
MAV_0717|M.avium_104 AAF------
MUL_0486|M.ulcerans_Agy99 AAF------
Rv2394|M.tuberculosis_H37Rv MGDDA----
Mb2415|M.bovis_AF2122/97 MGDDA----
MMAR_3713|M.marinum_M MGDTS----
Mflv_3716|M.gilvum_PYR-GCK MGDGDAPVS
MSMEG_3076|M.smegmatis_MC2_155 MGDPG----
MAB_2788|M.abscessus_ATCC_1997 MGDTG----
Mvan_1330|M.vanbaalenii_PYR-1 LGVD-----
.