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RAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEHRRIMSLVAIGA AVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGE LGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPG SLEVEAWMRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFER IWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQS VEAYCYAPAERSGSDSESRFA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2337c | - | - | 100% (372) | hypothetical protein Rv2337c |
| M. tuberculosis H37Rv | Rv1355c | moeY | 4e-05 | 24.43% (352) | hypothetical protein Rv1355c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2365c | - | 0.0 | 99.73% (372) | hypothetical protein Mb2365c |
| M. gilvum PYR-GCK | Mflv_4376 | - | 4e-10 | 25.59% (297) | hypothetical protein Mflv_4376 |
| M. leprae Br4923 | MLBr_01751 | - | 1e-05 | 22.65% (287) | hypothetical protein MLBr_01751 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4921 | moeY | 7e-09 | 23.86% (373) | molybdopterin biosynthesis protein, MoeY |
| M. avium 104 | MAV_2505 | - | 8e-08 | 25.66% (339) | hypothetical protein MAV_2505 |
| M. smegmatis MC2 155 | MSMEG_3955 | - | 1e-05 | 29.46% (129) | hypothetical protein MSMEG_3955 |
| M. thermoresistible (build 8) | TH_0558 | - | 3e-06 | 28.57% (133) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0484 | moeY | 4e-09 | 24.24% (363) | hypothetical protein MUL_0484 |
| M. vanbaalenii PYR-1 | Mvan_1968 | - | 6e-10 | 26.01% (373) | hypothetical protein Mvan_1968 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 -----------------------------------MAYGCNPRGAARVSD
Mvan_1968|M.vanbaalenii_PYR-1 -----------------------------------MTFEHSGAQADDSNG
Mflv_4376|M.gilvum_PYR-GCK -----------------------------------MTHADTDRTG-----
MMAR_4921|M.marinum_M ---------------------------------------MNR--------
MUL_0484|M.ulcerans_Agy99 MSSLRSPALQRSNTSGTDDTGNTETLGTGNSRPTTNSNQLDRSPDSPCLH
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 ERDVSPYARVLALD--DPADAAVLQRLRADSKVDFVDHHERQLQELLSLL
Mvan_1968|M.vanbaalenii_PYR-1 RVEDQSAAGALVLDPAEPADQQVLDSLRGDPAIVFIDRAAQQAETLARLL
Mflv_4376|M.gilvum_PYR-GCK -------HRAVVLDESEPAHVQTLARLRADSGIEFLDP-----------L
MMAR_4921|M.marinum_M -------PVILDESD--ASDRRTLAELRADPHIEVIDRWDEQKANAQSVL
MUL_0484|M.ulcerans_Agy99 SGPNSAAPKIINPAHKPANQQRRSPELRADPHIEVIDRWDEQKANAQSVL
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 PTPDPQLIAEPCRWVYYPWRHVVVSMLGPRGFRAVRLDRNRNEITAEEQV
Mvan_1968|M.vanbaalenii_PYR-1 PAPTGELTDEPRRWAYYPWRRTVVSILGPRAFARVRADRNRNLITSQEQE
Mflv_4376|M.gilvum_PYR-GCK PAGGG----TPTRWVYYAWRRAVVRVPEPGLFRRERLDRHRNLVTLDEIA
MMAR_4921|M.marinum_M PPLAPEIMAESKRWAFYPWRKTVVSILGPRSFRALRLDRNRNLITGSEQD
MUL_0484|M.ulcerans_Agy99 PPLAPEIMAESKRWAFYPWRKTVVSILGPRSFRALRLDRNRNLITGSEQD
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 ALGRLHIGVAGLSVGHVIAHTLAAQGLCGQLRLADFDRLELSNLNRVPAT
Mvan_1968|M.vanbaalenii_PYR-1 ALGSLRVGVVGLSVGHAVAHTLAMQGLCGELRLADFDDLELSNLNRVPAT
Mflv_4376|M.gilvum_PYR-GCK TLGTLRIGVVGLSVGHAIAHTLAAEGLCGALRLADFDELELSNLNRVPAT
MMAR_4921|M.marinum_M RLGRLKIGVVGLSVGHAVAHMLATQGLCGTLRLADFDTLEVSNLNRVPAT
MUL_0484|M.ulcerans_Agy99 RLGRLKIGVVGLSVGHAVAHMLATQGLCGTLRLADLDTLEVSNLNRVPAT
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 VFDLGLNKAEVAARRIAELDPYLTVRVFDNGLTFDTVDQFLEGLDVVVEQ
Mvan_1968|M.vanbaalenii_PYR-1 VFDIGVNKAVTAARRIAEVDPYLAVRVIDSGLTDQTVDAFLDGLDIVVEE
Mflv_4376|M.gilvum_PYR-GCK VFDLGVNKAVACARRIAELDPYLPVEVVTGGVTADTVDAFLDGVDIVVEE
MMAR_4921|M.marinum_M VFDLGVNKATVAARRIAELDPYLPVEVNTSGLSAAAMDAFLDGLDILVEE
MUL_0484|M.ulcerans_Agy99 VFDLGVNKATVAARRIAELDPYLPVEVNTSGLSAAAMDAFLDGLDILVEE
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 CDSLDIKALLREGARSHGIPVLMATSDRGLIDVERFDLEPRRSILHGLLG
Mvan_1968|M.vanbaalenii_PYR-1 CDSLDVKALVREAARSRRQPVLMATSDRGLIDVERFDLEPERPIFHGLLG
Mflv_4376|M.gilvum_PYR-GCK CDSLDIKVLVRHAARTQKVPVLMATSSGGLLDVERFDLEPDRPVFHGLLG
MMAR_4921|M.marinum_M CDSLDMKVGVRLAARARHIPVLMATSDRGLVDIERFDMDPSRPILHGLLG
MUL_0484|M.ulcerans_Agy99 CDSLDMKVGVRLAARARHIPVLMATSDRGLVDIERFDMDPSRPILHGLLG
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2365c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01751|M.leprae_Br4923 ELDIRLLPEMSNREKIPYILRFLEAERLSPRTATTLVEIDRSLSTWPQLA
Mvan_1968|M.vanbaalenii_PYR-1 EVDAASLAGLDSREKIPHVLRIIDGGNLSARGAASLVEVGQTLSTWPQLV
Mflv_4376|M.gilvum_PYR-GCK DVDAAVLARLSSKDKVPHVLRVIDATALRPRMQASLIEVGTSLTTWPQLS
MMAR_4921|M.marinum_M DIDLDELSGLSNREKLPYILRLFDIQGLSTRSAASLVEIEQTLATWPQLA
MUL_0484|M.ulcerans_Agy99 DIDLDELSGLSNREKLPYILRLFDIQGLSTRSAASLVEIEQTLATWPQLA
MSMEG_3955|M.smegmatis_MC2_155 --------------------------------------------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 --------------------------------------------------
Rv2337c|M.tuberculosis_H37Rv --------------MRAGR---WGPGMTGLDPAEFLS-------------
Mb2365c|M.bovis_AF2122/97 --------------MRAGR---WGPGMTGLDPAEFLS-------------
MLBr_01751|M.leprae_Br4923 GDVALGATAVAEAVRRIGLGEELRSGRARIDVASALNQLTEPDMA---RH
Mvan_1968|M.vanbaalenii_PYR-1 GDVLVGAAAVAEAVRRIGLGEPLSSGRARLDTATALTGLTDPMRR---AP
Mflv_4376|M.gilvum_PYR-GCK SEVAIGAATVAEAVRRIGLGEDLGSGRVRVDVPALLDDVHDPSPPPGDRG
MMAR_4921|M.marinum_M SEVSLGATAVCEAVRRIGLNEPLASGRVRIDVGQALDRVAEPAPHD-ESS
MUL_0484|M.ulcerans_Agy99 SEVSLGATAVCEAVRRIGLNEPLASGRVRIDVGQALDRVAEPAPHD-ESS
MSMEG_3955|M.smegmatis_MC2_155 -------------------------MNTHFPDTETIH-------------
TH_0558|M.thermoresistible__bu --------------------------------------------------
MAV_2505|M.avium_104 ------------------------MMMQMTADTEVIT-------------
Rv2337c|M.tuberculosis_H37Rv ---------------------------LVEAAALAPSADNRREVQLEHAG
Mb2365c|M.bovis_AF2122/97 ---------------------------LVEAAALAPSADNRREVQLEHAG
MLBr_01751|M.leprae_Br4923 RP-ANPTQCSELA-------LSGIEGVIATAAIRAPSGGNLQPWHIDAGP
Mvan_1968|M.vanbaalenii_PYR-1 QPGWDPVTVEDPAD------VRDAVHAVALAANRAPSGGNVQPWHIESGR
Mflv_4376|M.gilvum_PYR-GCK DATLSATAADDTAARAPGTAGTDAMTAIAAAAVRAPSGGNTQPWQVEVGD
MMAR_4921|M.marinum_M PSGADCAMAAEPPE-------SAAHLIVAAAANRAPSAANNQPWHIETDP
MUL_0484|M.ulcerans_Agy99 PSGADCAMAAEPPE-------SAAHLIVAAAANRAPSAANNQPWHIESDP
MSMEG_3955|M.smegmatis_MC2_155 --------------------------AALALAMRAPSIHNSQPWQWRVGE
TH_0558|M.thermoresistible__bu ----------------------------LALAVRAPSVHNSQPWRWRVGT
MAV_2505|M.avium_104 --------------------------AAIELACHAPSLHNSQPWRWVAGS
* *** * : :
Rv2337c|M.tuberculosis_H37Rv RRVRLWGDQT-WRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVC--
Mb2365c|M.bovis_AF2122/97 RRVRLWGDQT-WRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVC--
MLBr_01751|M.leprae_Br4923 DALVIRIAPE-HTDSLDVGFRGSAVAVGAALFNARVAAAAHGVLGPVS--
Mvan_1968|M.vanbaalenii_PYR-1 DVVTIRVAPE-FQSTIDVGFRGSAVAVGAATFNARVAAAAHQLSGEVT--
Mflv_4376|M.gilvum_PYR-GCK TTLTIRLDTD-LTSTMDVGYRASAVAVGAATFNARVAASAHGLRADVTFE
MMAR_4921|M.marinum_M NSVTIELSTE-HVATLDVDYRASAVAVGAAWFNARVAAAKHGVLGPAD--
MUL_0484|M.ulcerans_Agy99 NSVTIELSTE-HVATLDVDYRASAVAVGAAWFNARVAAAKHGVLGPAD--
MSMEG_3955|M.smegmatis_MC2_155 RSVHLYADLDRHLTSTDPDSRDLLLSCGAALHHCVIAFAALGWYASVHR-
TH_0558|M.thermoresistible__bu ESLHLWADPEHHLPSIDPDRRDLLVSCGAALNHCIIALAALGWQAKVHR-
MAV_2505|M.avium_104 TGVDLFVDPRRTVKSADKSGREAIISCGAALDHFRVAMAAAGWSSNVAQ-
: : : : :: *** : : . .
Rv2337c|M.tuberculosis_H37Rv -WFPDSGNPGLVAEIDVDRLPQTR-VDPIEGAIERRRTNRRVRFRGPPLS
Mb2365c|M.bovis_AF2122/97 -WFPDSGNPGLVAEIDVDRLPQTR-VDPIEVAIERRRTNRRVRFRGPPLS
MLBr_01751|M.leprae_Br4923 -LAENVDGAPLRVTLSLGDGWNPD-LAAVYEPMLVRETN-RNHGKPTMVL
Mvan_1968|M.vanbaalenii_PYR-1 -FVEGDDRSPLTAVVTLAEGRDEH-LASLYPALAARETN-RRHGTPSELP
Mflv_4376|M.gilvum_PYR-GCK TFEQGPQGPPLTATVRTAPGQEPE-LARLYDGMLRRETN-RHTGERAEID
MMAR_4921|M.marinum_M ---IAGHGHRLSAVVKLADGGDPN-LARLYEPMWLRETN-RHRGAAVALE
MUL_0484|M.ulcerans_Agy99 ---IAGHGHRLSAAVKLADGGDPN-LARLYEPMWLRETN-RHRGAAVALE
MSMEG_3955|M.smegmatis_MC2_155 --LPNPAEPEHLASIELRRQTPTD-LDIALAAAIPRRRTDRRHYSAWPVS
TH_0558|M.thermoresistible__bu --FPNPAEPLHLASLELSVHKPTE-AEVSLAAAIPRRRTDRRLYSNWPVP
MAV_2505|M.avium_104 --FPNPNNLDHLASIDVVPTEYVARARRDLADAILRRRTNRLPFRAPKHW
. : *. . *
Rv2337c|M.tuberculosis_H37Rv QGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHE
Mb2365c|M.bovis_AF2122/97 QGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHE
MLBr_01751|M.leprae_Br4923 TETIDVLHAAAV-AEGARLHLLTARDDIVRAATILAAADRSRYLTPRLHE
Mvan_1968|M.vanbaalenii_PYR-1 PATVAALDAAGR-REGARVQLLEDREVIDALGTLLAETDRIRYLTPHLHT
Mflv_4376|M.gilvum_PYR-GCK DETIDALTRVAE-SEGARLHLVTGTEDIRKIASVLGDADRIRYLTPALHA
MMAR_4921|M.marinum_M DGVAASLEAVAA-AEGARLQLLTGADEIADVASIFAASDRVRYLTQHMHA
MUL_0484|M.ulcerans_Agy99 DGVAASLEAVAA-AEGARLQLLTGADEIADVASIFAASDRVRYLTQHMHA
MSMEG_3955|M.smegmatis_MC2_155 HSDIAMMGARAA-RAGVMLRRVESLSRLQDIVAESIARHAADDGYLRELT
TH_0558|M.thermoresistible__bu FGDIALMGARAA-RAGVRLLRVEDLDHVRSAXXX----------------
MAV_2505|M.avium_104 SALEPVLRDVGR--DHSVALDVLGPDARPGLVEAARLTEALRRYDDDYHH
: . . .
Rv2337c|M.tuberculosis_H37Rv ELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTV
Mb2365c|M.bovis_AF2122/97 ELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTV
MLBr_01751|M.leprae_Br4923 EMISELRWPG--DSFPDTGIDVRSLEMDWHQLAAFDVLRRTDVMELLAQW
Mvan_1968|M.vanbaalenii_PYR-1 DMASELRWPG--DGLPDSGIDVRSLELGAAELVTLDILRRPEVMSLLTAW
Mflv_4376|M.gilvum_PYR-GCK EMIRELRWPG--DPDPHTGIDIATLELDPADTVFLDILRSGPVMAHLAAW
MMAR_4921|M.marinum_M EMLSEIRWPT--TDSMESGIDMRSLEMDRWELTGFNIARRPDVIRKLAEW
MUL_0484|M.ulcerans_Agy99 EMLSEIRWPT--TDSMESGIDMRSLEMDRWELTGFNIARRPDVIRKLAEW
MSMEG_3955|M.smegmatis_MC2_155 AWSGKYASTA--------GVPARSAPKPEPGAPLSSRMF-----------
TH_0558|M.thermoresistible__bu ------------------GCTSR---------------------------
MAV_2505|M.avium_104 ELDWWTSPSR-----KFDGIPESALVSEADDRRVDVNRR-----------
*
Rv2337c|M.tuberculosis_H37Rv GMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTL
Mb2365c|M.bovis_AF2122/97 GMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTL
MLBr_01751|M.leprae_Br4923 NVGAALGQDTHDRVVASS-ALAVISVPGHALADYARGGSAVEAIWVAAQR
Mvan_1968|M.vanbaalenii_PYR-1 NAGAVLGADTRARIVNSG-ALALILTDDISLTGYARGGSAAEAVWIAAQQ
Mflv_4376|M.gilvum_PYR-GCK GAGSALGDTTRGAVASAS-AVAAVTVRGDTLADYARGGAAMEAVWVRAQE
MMAR_4921|M.marinum_M EAGAGLGNYTRARICASS-GFGVVSIQGDTLADYARGGSAMEAVWITAQH
MUL_0484|M.ulcerans_Agy99 EAGAGLGNYTRARICASS-GFGVVSIQGDTLADYARGGSAMEAVWITAQH
MSMEG_3955|M.smegmatis_MC2_155 -AGAALKQPDTGAGADEGAVVLALGTADDTRMSRLRAGEATSLILLTATA
TH_0558|M.thermoresistible__bu -----FRRP--------------------TRRRRTRAVSHG---------
MAV_2505|M.avium_104 -FPVDPLDERSSAGSYDDAKILVLSTPEDTRADALRVGQVLSRILLECTA
Rv2337c|M.tuberculosis_H37Rv LGAELQPFAASAVLSLPACEWVAPHVRAALVGG--------WNLLAPGHW
Mb2365c|M.bovis_AF2122/97 LGAELQPFAASAVLSLPACEWVAPHVRAALVGG--------WNLLAPGHW
MLBr_01751|M.leprae_Br4923 YGFAVQPISPVFLYAHSVDELHALSAQFADELGQLGKDFRSLARIPADNS
Mvan_1968|M.vanbaalenii_PYR-1 HGLSVQPISPVFLYAHTADELHELSPRFADRLADLQRRFRQLTAVGPGEA
Mflv_4376|M.gilvum_PYR-GCK HGLAVQPISPAFLYARDRRELDALSPAFTQRLADLQYSLQASIGVDSDES
MMAR_4921|M.marinum_M LGLAVQPLAPVFLYARNDDELRGLSPDFAAHLGSLQERLRALTHTRADES
MUL_0484|M.ulcerans_Agy99 LGLAVQPLAPVFLYARNDDELRGLSPDFAAHLGSLQERLRALTHTRADES
MSMEG_3955|M.smegmatis_MC2_155 MGLATCPVTEPLEISETRDAVQAEVFGAS---------AFPQMMLRVGWA
TH_0558|M.thermoresistible__bu ------------EAGDNREKNHSPWWAS-------------NLAVR-GWL
MAV_2505|M.avium_104 AGLATCPVTHVTELEAGRDLIRHLMADPAAVP---------QVLIRVGVE
.
Rv2337c|M.tuberculosis_H37Rv PMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA
Mb2365c|M.bovis_AF2122/97 PMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA
MLBr_01751|M.leprae_Br4923 LVLVLRLTVAGPASVRSRR-SFERIRLLSG------------
Mvan_1968|M.vanbaalenii_PYR-1 TALILRLTSAPPPSVRSRRRPLHSASTPVS------------
Mflv_4376|M.gilvum_PYR-GCK LILILRVFRGPRPSAPSRRRKIPGRSTPT-------------
MMAR_4921|M.marinum_M HVLLFRFSHAPKTSVRSLRRSLGTVSAAAMTGSG--------
MUL_0484|M.ulcerans_Agy99 HVLLFRFSHAPKTSVRSLRRSLGTVSAAAMTGSG--------
MSMEG_3955|M.smegmatis_MC2_155 PVNADPLPPTPRRHVADAVRWLDGSPFEPESE----------
TH_0558|M.thermoresistible__bu GN----LVFT-RRGVEQLGSSLGS------------------
MAV_2505|M.avium_104 PEGESPPRPTPRRPLGDVLQFRPLSDR---------------