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MKGHLATFGHPALPTYRGSWLSREPGSPYRLPAGAGRDRGDACRRIPRRTGSGTLLRPGQRCTFAANADP MAKGVDRALCEIVAERRQLDLDLAKAQVRSALANQRYHRDVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2331A | - | - | 100% (112) | hypothetical protein Rv2331A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2359 | - | 2e-63 | 99.11% (112) | hypothetical protein Mb2359 |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3639 | fdhF | 7e-10 | 50.88% (57) | formate dehydrogenase H FdhF |
| M. avium 104 | MAV_2075 | - | 6e-12 | 56.14% (57) | FdhF protein |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1474 | fdhF | 5e-10 | 50.88% (57) | formate dehydrogenase H FdhF |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3639|M.marinum_M MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLG
MUL_1474|M.ulcerans_Agy99 MAPNKDAVKTVCAYCGVGCGIVLQTTTDPQTGKRRVAKSTGDKSHPANLG
MAV_2075|M.avium_104 -------MNTMCAYCGVGCGMVLQITTDPQTGRRHVAKSVGNKEHPANFG
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M RLCTKGTTTADLLAAPGRMESAHLRAHRAGHLESIPIDDAITQCAMRLRA
MUL_1474|M.ulcerans_Agy99 RLCTKGTTTADLLAAPGRMESAHLRAHRAGHLESIPIDDAITQCAMRLRA
MAV_2075|M.avium_104 RLCTKGATTADLLAAPGRMDSAHARAGRGEPLEPIGTDQAITRCAKQLRA
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M IIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTNQIESNSRLCMAGA
MUL_1474|M.ulcerans_Agy99 IIDEHGPDAVGVYVSGQMSIEAQYLANKLTKGFIGTKQIESNSRLCMAGA
MAV_2075|M.avium_104 IIDEHGPDAFAMYVSGQMSLEAQYLANKLTKGFIGTNQIESNSRLCMASA
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M SSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERVKS
MUL_1474|M.ulcerans_Agy99 SSGYKLSLGADGPPGSYQDFDHADVFLVIGANMADCHPILFLRMMERVKS
MAV_2075|M.avium_104 GSGYKLSLGADGPPGSYQDFEHADVFFVIGANMADCHPILFLRMMDRVKA
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M GAKLIVVDPRRTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQF
MUL_1474|M.ulcerans_Agy99 GAKLIVVDPRRTATADKADLFLQIAPGTDLALLNGLLHLIVENEQTDPQF
MAV_2075|M.avium_104 GAKLIVVDPRRTATAEKADLFLQIAPGTDLALLNGLLHLIVENGHTDGEF
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M ISEFTEGWEVMPSFLEQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSC
MUL_1474|M.ulcerans_Agy99 ISEFTEGWEVMPSFLEQFTPDRVSEITGIPSEDIRTAARWIGTAANWMSC
MAV_2075|M.avium_104 IAEFTEGWEVMPSFLEQYTPDRVSEITGIPEQDIRAAAQLIGEADNFMSC
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M WTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREM
MUL_1474|M.ulcerans_Agy99 WTMGLNQSTHGTWNTNALCNLHLATGAICRPGSGPFSLTGQPNAMGGREM
MAV_2075|M.avium_104 WTMGLNQSTHGTWNTNAICNLHLATGAICKPGSGPFSLTGQPNAMGGREM
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M GYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMAD
MUL_1474|M.ulcerans_Agy99 GYMGPGLPGQRSVLSAPDREFVEEQWGLPGGALRTDVSGGVIDMFSRMAD
MAV_2075|M.avium_104 GYMGPGLPGQRSVASAADREFVEDVWGVPRGRLRTEVGTGTIDMFSRMAD
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M GEIKACWIICSNPVATVANRKTVLAGLEKAELVISQDAFFETETNEYANV
MUL_1474|M.ulcerans_Agy99 GEIKACWIICSNPVATVANRKTVLAGLEKAELVISQDAFFETETNEYANV
MAV_2075|M.avium_104 GQIKACWIICTNPVASVANRKTVLAGLERAELVIAQDAYLGTETSEYADV
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M LLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQIIARIACEMGF
MUL_1474|M.ulcerans_Agy99 LLPAALWTESDGVMVNCERNMSLFPKAVDPVGDALPDWQIIARIACEMGF
MAV_2075|M.avium_104 LLPAALWAETEGVMVNSERNITLSQPAVAAPGGAMPDWQIIARIACEMGF
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M SESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRLRETPLQWPCPPDGA
MUL_1474|M.ulcerans_Agy99 SESFSYSSAAEVFEEIKRFSNPATGYDLRGISHDRLRETPLQWPCPPDGA
MAV_2075|M.avium_104 SEAFSYSCAEEVFEEIKRFWNPTTGYDLRGVSYERLRRQPLQWPCPPQST
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M SNRSPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEM
MUL_1474|M.ulcerans_Agy99 SNRSPIRYLNDGVSQLQFVRADGTVPRLAFPTATGRAVFFARPHLVPDEM
MAV_2075|M.avium_104 ADRNPIRYLNDGVSQTQLVREDGTVPRLAFPTPSGRAVFFARPHLQPEEM
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M PDGDYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQ
MUL_1474|M.ulcerans_Agy99 PDGDYPFLLNTGRLAHQWHTLTKTGKIAKLNKLNPGPFVEVHPDDAADMQ
MAV_2075|M.avium_104 PDDDYPFLLNTGRLPHQWHTMTKTGKVAKLNKLNPGPFVEIHPDDAARLG
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M ICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAV
MUL_1474|M.ulcerans_Agy99 ICEGDHIEIASRRGRAVLPVVITDRVRPGNCFAPFHWNDAFGEYLSINAV
MAV_2075|M.avium_104 IGEHDRVEIASRRGRAVLPAVVSDRVRPGNCFAPFHWNDAFGEYLSINAV
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M TNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADTCADATAPKLLA
MUL_1474|M.ulcerans_Agy99 TNDAVDPISRQPEYKACAVTLTKVARPQLQPEPGEPADACADATAPKLLA
MAV_2075|M.avium_104 TNDAVDPISNQPEFKACAVTLTKVAVSHPDSAIG-TGPSAGHDTPESAPT
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M DTAQFSVTQVDALAELLGVANEPTPQFGPFARSYLAGLIAGLRSETGRRM
MUL_1474|M.ulcerans_Agy99 DTAQFSVTQVDALAELLGVGNEPTPQFGPSARSYLAGLIAGLRSETGRRM
MAV_2075|M.avium_104 EVREISVSQVDALGELLGVATSFKPEFNELGRSYLAGMLTGLRSDVGRRA
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M AGVPTLPVSSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSD
MUL_1474|M.ulcerans_Agy99 AGVSTLPISSPFDTGTRLWLDGLLAGMFARAETPPALPFPQTPGAAAQSD
MAV_2075|M.avium_104 GGVPTLPPSAPFDSRTRLWVDGLLAGLFSRADASQQAALPEPPQPAAQQP
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M NAAEA----AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGM
MUL_1474|M.ulcerans_Agy99 NAAEA----AVEQPPIVVLWASQTGTAEELAASVAAQLSAAELPVVLHGM
MAV_2075|M.avium_104 PAAPAGATPAPERAPVVVLWASQTGNAEELAADVAAQLAAAELPVALHSM
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M DEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAATAPSLAGTRY
MUL_1474|M.ulcerans_Agy99 DEFAVADLVSTQRLLLVTSTTGDGEPPDNGAAFWRELCAPTAPSLAGTRY
MAV_2075|M.avium_104 DDFPAAELAATRELLLITSTTGDGDAPDNGSGLWRALTGDAAPRLGNTRY
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M SVLALGDSNYADFCGHGRALDHRLAELGASRVTDRVDCEPDYEESAARWL
MUL_1474|M.ulcerans_Agy99 SVLALGDSNYADFCGHGRALDHRLAELGASRITDRVDCEPDYEESAARWL
MAV_2075|M.avium_104 AVLALGDSNYDDFCGHGRKLDARLAELGATRIAERVDCEPDYEQAAAKWV
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M QEVLDGLRRTAPPV---------ITAAPVRAASIANR--PQGYTKKRPLL
MUL_1474|M.ulcerans_Agy99 QEVLDGLRRTAPPV---------ITAEPVRAASIASR--PQGYTKKRPLL
MAV_2075|M.avium_104 ADVIEALTRTPTAVGGDGGATVSARTSPVAAPSRPNTPAPHTYSKKHPLI
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M TSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVD
MUL_1474|M.ulcerans_Agy99 TSVMRNTTLSRPRSAKDVRQLVFRVPEQTVSYEAGDALGVWPRNAHQLVD
MAV_2075|M.avium_104 TDMVRNTTLNGPKSTKDVRHLVFNLPEDAVSYEAGDALGVWPRNSDELVD
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M EWLGVTQLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTL
MUL_1474|M.ulcerans_Agy99 EWLGVTRLDGHTEVEVAGHGTMSLRAALTDRFEIAHLSPDLLRFVAQRTL
MAV_2075|M.avium_104 EWLAVTGLDGQTPVEVGEHGLMSLRSALTERIEIAHISRDLVRFVQERTG
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M DSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLK
MUL_1474|M.ulcerans_Agy99 DSNTANQLAELMRPENKAALADWTWGRQSVDLLAQSPVRASVDEWMSVLK
MAV_2075|M.avium_104 DA----KLAELLKPENKRALADWTWGRQSIDLLAQLPVSASAHEWLRVLK
Rv2331A|M.tuberculosis_H37Rv --------------------------------------------------
Mb2359|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3639|M.marinum_M PIQPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPS
MUL_1474|M.ulcerans_Agy99 PIQPRLYSISSSPKEHPGEVHLTVSPVRYNFQGVPRRGVCSTYLADRSPS
MAV_2075|M.avium_104 RLQPRLYSISSSPKACPGEVHLTVSPVRYNFQGVPRRGVCSTYLAARSPG
Rv2331A|M.tuberculosis_H37Rv -----------------------------------MKGHLATFGHPALPT
Mb2359|M.bovis_AF2122/97 -----------------------------------MKGHLATFGHPALPT
:* :*: *
MMAR_3639|M.marinum_M DQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGP
MUL_1474|M.ulcerans_Agy99 DQIAIYVRKSSNFRPPSDPRTPMIMIGPGTGIAPFRGFLQERRALGHTGP
MAV_2075|M.avium_104 DRVAVYLQPSSNFRPPSDPDTPMIMIGPGTGIAPFRGFLQERRALGHRGP
Rv2331A|M.tuberculosis_H37Rv YRGSWLSRE------------------PGS---PYR--------------
Mb2359|M.bovis_AF2122/97 YRGSWLSRE------------------PGS---PYR--------------
: : : **: *:*
MMAR_3639|M.marinum_M NWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLM
MUL_1474|M.ulcerans_Agy99 NWLFFGEQHAATDFYYRDEIQAMHRDGLLTNLDLAFSRDQRDKVYVQHLM
MAV_2075|M.avium_104 NWLFFGEQHAATDFYYRDELEQMREDGFLTELDLAFSRDQQHKVYVQHLM
Rv2331A|M.tuberculosis_H37Rv -------------------------------LPAGAGRDRGDACRRIPRR
Mb2359|M.bovis_AF2122/97 -------------------------------LPAGAGRDRGDACRRLPRR
* . .**: .
MMAR_3639|M.marinum_M QQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESAT
MUL_1474|M.ulcerans_Agy99 QQRGAQLWQWLQDGAQVYVCGTADPMAKDVDRMLCQIVAEHGGLDPESAT
MAV_2075|M.avium_104 RNRGKQLWSWLQDGAQLYVCGTADPMAKDVDRALCDIAAEFGNLDPDAAK
Rv2331A|M.tuberculosis_H37Rv TGSG----TLLRPGQRCTFAANADPMAKGVDRALCEIVAERRQLDLDLAK
Mb2359|M.bovis_AF2122/97 TGSG----TLLRPGQRCTFAANADPMAKGVDRALCEIVAERRQLDLDLAK
* *: * : ....******.*** **:*.** ** : *.
MMAR_3639|M.marinum_M AFVHALSADKRYHRDVY
MUL_1474|M.ulcerans_Agy99 AFVHALSADKRYHRDVY
MAV_2075|M.avium_104 AYVQSLSADKRYHRDVY
Rv2331A|M.tuberculosis_H37Rv AQVRSALANQRYHRDVH
Mb2359|M.bovis_AF2122/97 AQVRSALANQRYHRDVH
* *:: *::******: