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ALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLLVVRAAPTSWEGALRAWTGMGGFVL ATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGG PWALLGASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLL GSVPVGGPTVRVALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELS QRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSPATARPPQRIGS AAPGRWCWR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2262c | - | - | 100% (360) | hypothetical protein Rv2262c |
| M. tuberculosis H37Rv | Rv2051c | ppm1 | 2e-10 | 28.61% (367) | polyprenol-monophosphomannose synthase Ppm1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2285c | - | 0.0 | 100.00% (329) | hypothetical protein Mb2285c |
| M. gilvum PYR-GCK | Mflv_3117 | - | 9e-12 | 26.37% (364) | apolipoprotein N-acyltransferase |
| M. leprae Br4923 | MLBr_01441 | - | 3e-09 | 26.97% (356) | putative apolipoprotein N-acyltransferase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3354 | lnt | 1e-123 | 69.77% (311) | apolipoprotein n-acyltransferase, Lnt |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3860 | - | 9e-11 | 26.46% (359) | polyprenol-monophosphomannose synthase Ppm1 |
| M. thermoresistible (build 8) | TH_0732 | - | 2e-13 | 28.19% (376) | Polyprenol-monophosphomannose synthase Ppm1 |
| M. ulcerans Agy99 | MUL_1289 | - | 1e-124 | 68.32% (322) | hypothetical protein MUL_1289 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3117|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_3860|M.smegmatis_MC2_155 MADD--RARRFDRFR-------------------VRPEEITEVI-PAVTD
TH_0732|M.thermoresistible__bu MADRGRRDRRAPGRRSGPTSGPTSGPTSGPASGPTRSEPPTDPIGFDPIT
MLBr_01441|M.leprae_Br4923 --------------------------------------MVDEIIEIDPVD
Rv2262c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2285c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3354|M.marinum_M --------------------------------------------------
MUL_1289|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3117|M.gilvum_PYR-GCK ---------------------MGETAAD--ADAPERPT------------
MSMEG_3860|M.smegmatis_MC2_155 DDPLEDPLDDDVAPGLDDAEPEPEPRDE--HDEPSRPATG---SRIGGWV
TH_0732|M.thermoresistible__bu DDPAEDPAEDPAEDPAGDDPVEDPATDEPATDEPSRADTAEPGDRPADRL
MLBr_01441|M.leprae_Br4923 DDPVNGAFATLAVP---SRVVKLRATVCHALAQMGVATVA----------
Rv2262c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2285c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3354|M.marinum_M --------------------------------------------------
MUL_1289|M.ulcerans_Agy99 --------------------------------------------------
Mflv_3117|M.gilvum_PYR-GCK --RARRFGQAVVDRLPRLTAAIVAGLALCVSFPPFGWWYIAILAFAVLGW
MSMEG_3860|M.smegmatis_MC2_155 ARRGSRFGKGVLDRCAPLSAAIGGGLALWLSFPPIGWWFTAFPGLALLGW
TH_0732|M.thermoresistible__bu IRFAHRAGRAVLDRLPQLGLTVLAGLLLCVSFPPMGWWYLAPVALALLGG
MLBr_01441|M.leprae_Br4923 --RVPATWAMLVPRLPRLVVAVVAGLLFCASFPSLNWWWAAVVAFALLAW
Rv2262c|M.tuberculosis_H37Rv ---MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLL
Mb2285c|M.bovis_AF2122/97 ---MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLL
MMAR_3354|M.marinum_M ---------------------MALGTLPALAFPAPSWWWLAWFALVPLLL
MUL_1289|M.ulcerans_Agy99 ---MVPHPRALRRRAFGWTAALALGTLPALTFPAPSWWWLAWFALVPLLL
: * :**. .**: * .:. *
Mflv_3117|M.gilvum_PYR-GCK VLTRERTTVAGGAG-----YGLLFGLAFYVPLLPWISGLVGAVPWLALSV
MSMEG_3860|M.smegmatis_MC2_155 VLTRTATTKAGGFG-----YGVLFGLAFYVPLLPWISGLVGAVPWLALAF
TH_0732|M.thermoresistible__bu VLVHRATTLAGGFG-----YGVLFGLAFHIPLLPWISGLVGAVPWLALSV
MLBr_01441|M.leprae_Br4923 VLTHPTTTPVGGLG-----YGFLFGLAFYLPLLSWISSLVGATPWWALAT
Rv2262c|M.tuberculosis_H37Rv VVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWL
Mb2285c|M.bovis_AF2122/97 VVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWL
MMAR_3354|M.marinum_M LVRAAATSGDGAVRAGCGVAGFVLANQYWLAASIGPLLALLALGMGALWL
MUL_1289|M.ulcerans_Agy99 LVRAAATFGDGAVRAGCGVAGFVLANQYWLAASIGPLLVLLALGMGALWL
:: * *. *.::. : : : * .*
Mflv_3117|M.gilvum_PYR-GCK VEALFCALFGMLAVVVRRLPGWPLWFAGLWSAQEWLKSTVPFGGFPWGVV
MSMEG_3860|M.smegmatis_MC2_155 AESLFCGLFGLGAVVVVRLPGWPLWFATLWVAAEWAKSTFPFGGFPWGAS
TH_0732|M.thermoresistible__bu VQAVFPGLFGLAAVAVRRLPGRPVWFALLWVAYEWIKSSVPFGGFPWGVV
MLBr_01441|M.leprae_Br4923 AAAFLPGFFGLLAVVVGPLPGWPIWFAVVWAAQEWLKSVVPFGGFPWGSV
Rv2262c|M.tuberculosis_H37Rv PAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGG-PWALL
Mb2285c|M.bovis_AF2122/97 PAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGG-PWALL
MMAR_3354|M.marinum_M PWGWVAHRLLSAPLSAARAAGALAVVPSAWVVAEAARSWPPLGG-PWAPL
MUL_1289|M.ulcerans_Agy99 PWGWVAHRLLSAPLSAARAAGALAVVPSAWVVAEAARSWPPLGG-PWAPL
. . : .: . . .. * . * :* .:** **.
Mflv_3117|M.gilvum_PYR-GCK GFSQSESP-LLPLAYVGGAPLVSFALVLLAFSLGALVLGVADWWRRDAAT
MSMEG_3860|M.smegmatis_MC2_155 SYGQTNGP-LLALARIGGAPLVSFAVALIGFSLTLLTAQIVWWWR-HGHK
TH_0732|M.thermoresistible__bu AYSQTNGP-LLALAQIGGAPLVSFAVALTGFSLAALTAAIVRWWRSDSHR
MLBr_01441|M.leprae_Br4923 AFGQADGP-LLPLAQLGGAPLLSMAIVLVGCSTTAIALEVVKWWRSSGQS
Rv2262c|M.tuberculosis_H37Rv GASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCR----------
Mb2285c|M.bovis_AF2122/97 GASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCR----------
MMAR_3354|M.marinum_M GASQWNQPYTLASASVGGVWLTSFLVMAVNTAIVAGIVGQ----------
MUL_1289|M.ulcerans_Agy99 GASQWNQPYTLASASVGGVWLTSFLVMAVNTAIVAGIVGR----------
. .* . * *. * :**. * *: : :
Mflv_3117|M.gilvum_PYR-GCK R-AATPPAVVLPGLCIAVVVLASTLAWPHVRKAGLGAGD-EPPVTVAAVQ
MSMEG_3860|M.smegmatis_MC2_155 P-GVPAPAVMLPGVAIAASLLVTALVWPQVRQSGTGAGD-DTAVTVAAVQ
TH_0732|M.thermoresistible__bu ---AAPPAVVLPGLCIAAVLLATAVVWPQVRYSGAGADAADQPIRVAAVQ
MLBr_01441|M.leprae_Br4923 NRSDPPPAVVLPGVCVCLVLLAVVVVWPQVRHAGAGSGG-EPVITVAAVQ
Rv2262c|M.tuberculosis_H37Rv ---ATGGRLVALGCVIGCAGLGPASYLLGSVPVGG------PTVRVALVQ
Mb2285c|M.bovis_AF2122/97 ---ATGGRLVALGCVIGCAGLGPASYLLGSVPVGG------PTVRVALVQ
MMAR_3354|M.marinum_M ---GLP-RLVLLGCAVAGVGLGPLWYLVGPAPAAG------PAIRVALVQ
MUL_1289|M.ulcerans_Agy99 ---GLP-RLVLLGCAVAGVGLGPLWYLVGPAPAAG------PAIRVALVQ
:: * : * . : ** **
Mflv_3117|M.gilvum_PYR-GCK GNVPRLGLEFNAQRRAVLDNHVRETLRLADDVRAGRVPQ-PMLVVWPENS
MSMEG_3860|M.smegmatis_MC2_155 GNVPRLGLEFNAQRRAVLDNHVKETLRLADDVKAGRAAQ-PMFVIWPENS
TH_0732|M.thermoresistible__bu GNVPRLGLDFNAQRRAVLDNHVRETMRLAEDVRAGRAEQ-PLFVVWPENS
MLBr_01441|M.leprae_Br4923 GNVPRLGLDFNAQRRAVLDNHVHETLRLAEDVRAGIVPQ-PQFVIWPENA
Rv2262c|M.tuberculosis_H37Rv A-----GDIADAAARLAAG----------EEFTAAVADQRPDLVVWGESS
Mb2285c|M.bovis_AF2122/97 A-----GDIADAAARLAAG----------EEFTAAVADQRPDLVVWGESS
MMAR_3354|M.marinum_M P-----GPIADSMARQAAG----------EELTAGLVGQRPDLVVWGESS
MUL_1289|M.ulcerans_Agy99 P-----GPIADSTARQAAG----------EELTAGLVGQRPDLVVWGESS
* :: * . . ::. *. . * * :*:* *.:
Mflv_3117|M.gilvum_PYR-GCK SDIDPIANPDAAQEISRAAAAIDAPVLVGGVVAAPGYSRDNPVSNNTVIV
MSMEG_3860|M.smegmatis_MC2_155 SDIDPLLNADASAQITTAAEAIDAPILVGGVVRADGYTPDNPVANNTVIV
TH_0732|M.thermoresistible__bu SDIDPLANPDAHQQISAAAAAIRAPILVGGVVRAPGYRPDNPVATNSVLV
MLBr_01441|M.leprae_Br4923 SDIDPLVNGDAGQEITVAAATIDAPILVGTVLDVQGPVPQAPEYTNTVIV
Rv2262c|M.tuberculosis_H37Rv VGQDLTRHPDVLARLAELSQRVGADLLVN----VDAPAPDGGIYKSAVLV
Mb2285c|M.bovis_AF2122/97 VGQDLTRHPDVLARLAELSQRVGADLLVN----VDAPAPDGGIYKSAVLV
MMAR_3354|M.marinum_M VGHDLADHPGDLARLADLSARVGADLLVN----VDARAPGGGIYKSSVLL
MUL_1289|M.ulcerans_Agy99 VGHDLADHPGDLAWLADLSARVGADLLVN----VDARAPGGGIYKSSVLL
. * : . :: : : * :**. . . ..:*::
Mflv_3117|M.gilvum_PYR-GCK WNPETGPSDRHDKRIVQPFGEYLPWRSFFSKLSSYADRAGYFVP--GDGD
MSMEG_3860|M.smegmatis_MC2_155 WEPTDGPGERHDKQIVQPFGEYLPWRGFFKHLSSYADRAGYFVP--GTGT
TH_0732|M.thermoresistible__bu WDPETGPTDRHDKQIVQPFGEYLPWRDFFRRLSPYADRAGYFIP--VDGD
MLBr_01441|M.leprae_Br4923 WNPGTGPADRHDKEIVQPFGEYLPMPWLFKRLSKYADRVSHIVPRQSQSS
Rv2262c|M.tuberculosis_H37Rv G--AHEAVGSYRKTRLVPFGEYVLRCARF---SAGSP-ATARPPQR----
Mb2285c|M.bovis_AF2122/97 G--AHEAVGSYRKTRLVPFGEYVPLRPLFGWITRYSK-AAAKDRQRGAGP
MMAR_3354|M.marinum_M G--EHGVAGSYRKTRLVPFGEYVPLRRLVGWITQGTK-AAAEDRRRGTGP
MUL_1289|M.ulcerans_Agy99 G--EHGVAGSYRKTRLVPFGEYFPLRWLVGWITQGTK-AAAEDRRRGTGP
: * : *****. . : : .
Mflv_3117|M.gilvum_PYR-GCK GVVEAAGIPVGITTCWEVIFDRAARESVRNGAQLLAVPSNNATFDQAMSE
MSMEG_3860|M.smegmatis_MC2_155 GVVHAAGVPIGITTCWEVIFDRAARESVLNGAQVLAVPSNNATFDEAMSA
TH_0732|M.thermoresistible__bu GVVTAAGVPVGVTTCWEVIFDRAARESVRNGAEVLAVPTNNATFDEAMSE
MLBr_01441|M.leprae_Br4923 GVVRIAGVPIGVTTCWEVIFDRAARKAVLNGAQLLAAPTNNATFNKTMSE
Rv2262c|M.tuberculosis_H37Rv --------------------------------------------IGSAAP
Mb2285c|M.bovis_AF2122/97 VVLAVNSLHIAPLISYEMTFSDLTRHAARLGAALLVYQSSTSTFQGSWAQ
MMAR_3354|M.marinum_M VVLHAGPLAIGPLISYETTFSDLARREALLGAELLAFQSSTSSFQGSWAQ
MUL_1289|M.ulcerans_Agy99 VVVHAGPLAIGPLISYETTFSDLARREALLGAELLAFQSSTSSFQGSWTQ
: :
Mflv_3117|M.gilvum_PYR-GCK QQLAFGR-LRAVEHDRYVVVAGTTGISAVIAPDGHEIVRTGWFEPAYLDQ
MSMEG_3860|M.smegmatis_MC2_155 QQLAFGK-LRAVEHDRYVVVAGTTGISAVIAPDGHEISRTEWFQPAYLDN
TH_0732|M.thermoresistible__bu QHLAFAR-LRAVEHNRYAVVAGTTGISAVITPDGREVARTRFFEPAYLDV
MLBr_01441|M.leprae_Br4923 QQLAFAK-VRAVEHDRYVVVTGTTGISSVIAPDGSELVRTDFFVPAYLDM
Rv2262c|M.tuberculosis_H37Rv ---------------------------------GR---WCWR--------
Mb2285c|M.bovis_AF2122/97 PQLAAQPAVRAVEAGIPAVHASLSGDSSAFDTRGRRLAWCSAEFNGAIVV
MMAR_3354|M.marinum_M PQLASQPAVRAVEVGRPAVHAGLSGDSSAFDARGRRLAWCPSDFAGVTVV
MUL_1289|M.ulcerans_Agy99 PQLASQPAVRAVEVGRPAVHAGLSGDSSAFDARGRRLAWCPSDFAGVTVV
*
Mflv_3117|M.gilvum_PYR-GCK QVRLKTSLTPATRFGPYVEGVLIALGVS----GVVGAILHNGSFLPGRLR
MSMEG_3860|M.smegmatis_MC2_155 QIRLKTDLTPATKWGPIVQAVLVIAGVA----VLLIAILHNGRFAPRMLR
TH_0732|M.thermoresistible__bu QVRLKTQLSPATRYGPVIHGALIAAALAGLGAALAGTVLQNGRLVPHALR
MLBr_01441|M.leprae_Br4923 QVRLKAKLTPATCWGLTLQWILVGTAGA----IVLAAMRHNNGSRSRIVL
Rv2262c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2285c|M.bovis_AF2122/97 NVPLASNVTLYLRLGDWVPVTAFVVMGAG----------FAVFLRRSLAR
MMAR_3354|M.marinum_M SIELGSRDTLYRRLGDWVPVTALVVLAG-----------YAGSAGLRRYR
MUL_1289|M.ulcerans_Agy99 SIELGSRDTLYRRLGDWVPVTALVVLAG-----------YAGSAGLRRYR
Mflv_3117|M.gilvum_PYR-GCK -RRRPTSDDGEGAT------------------------------------
MSMEG_3860|M.smegmatis_MC2_155 -RRSATTVKR----------------------------------------
TH_0732|M.thermoresistible__bu GRRRAKESHDDGPATRPRHHGQSTSESAHSGDHPDLQRTGQSAADRGSGA
MLBr_01441|M.leprae_Br4923 GLGSSASLKTRVRQANVREALTLRLGDRPLIHLSRLVTTLRSIYKGGQKP
Rv2262c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2285c|M.bovis_AF2122/97 VSDCADK-------------------------------------------
MMAR_3354|M.marinum_M MRDTLRA-------------------------------------------
MUL_1289|M.ulcerans_Agy99 MRDTLRA-------------------------------------------
Mflv_3117|M.gilvum_PYR-GCK --------------------
MSMEG_3860|M.smegmatis_MC2_155 --------------------
TH_0732|M.thermoresistible__bu SGLPRGARADRRRRQPRRHR
MLBr_01441|M.leprae_Br4923 RYFGRHKGAK----------
Rv2262c|M.tuberculosis_H37Rv --------------------
Mb2285c|M.bovis_AF2122/97 --------------------
MMAR_3354|M.marinum_M --------------------
MUL_1289|M.ulcerans_Agy99 --------------------