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SGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTT GQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKL MAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAG TEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQ LEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIA RK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2258c | - | - | 100% (353) | Possible transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv0839 | - | 4e-09 | 31.43% (105) | hypothetical protein Rv0839 |
| M. tuberculosis H37Rv | Rv0560c | - | 5e-07 | 37.76% (98) | benzoquinone methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2282c | - | 0.0 | 100.00% (353) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2768 | - | 1e-141 | 69.54% (348) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_01783 | - | 7e-96 | 65.20% (273) | putative transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4742c | - | 1e-130 | 65.52% (348) | hypothetical protein MAB_4742c |
| M. marinum M | MMAR_3349 | - | 1e-159 | 77.05% (353) | transcriptional regulatory protein |
| M. avium 104 | MAV_2182 | - | 1e-154 | 76.29% (350) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_4338 | - | 1e-141 | 69.54% (348) | transcriptional regulatory protein |
| M. thermoresistible (build 8) | TH_4552 | - | 3e-37 | 31.23% (333) | PUTATIVE Methyltransferase type 12 |
| M. ulcerans Agy99 | MUL_1293 | - | 1e-159 | 77.05% (353) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3765 | - | 1e-142 | 70.57% (350) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2258c|M.tuberculosis_H37Rv -----------------------MSGALETTEEFGNRFVAAIDSAGLAIL
Mb2282c|M.bovis_AF2122/97 -----------------------MSGALETTEEFGNRFVAAIDSAGLAIL
MMAR_3349|M.marinum_M --------------------MTAIDGGTETTEEFGGRIVAAIDSAGLTIL
MUL_1293|M.ulcerans_Agy99 --------------------MTAIDGGTETTEEFGGRIVAAIDSAGLTIL
MAV_2182|M.avium_104 -----------------------MT-ALETTDEFTDRITAAIDGASLALL
Mflv_2768|M.gilvum_PYR-GCK ----------------MTTLAENSAPSSETTEEFAQRIVGALDAASLALL
Mvan_3765|M.vanbaalenii_PYR-1 MNCPMTVGAGRSSVSGMTTLIGNTAVAPETTEEFAERIVGTIDGASIAIL
MSMEG_4338|M.smegmatis_MC2_155 ------------MNLDEVTVSTTTSPTPDTTEDFAARVVECLDSASTAIL
MAB_4742c|M.abscessus_ATCC_199 ------------------MTAPSANPVPETTEEFSERLTAAIDNAALVLL
MLBr_01783|M.leprae_Br4923 --------------------------------------------------
TH_4552|M.thermoresistible__bu -----------MTAPRTPSGPTTRGVDPENLMAFVLRAVTEVGAALNAAL
Rv2258c|M.tuberculosis_H37Rv VSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEY
Mb2282c|M.bovis_AF2122/97 VSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEY
MMAR_3349|M.marinum_M LSVGHQTGLLDVISQLPPSTSTQIAEAVGLDERYVREWLGGMTAGQVIEY
MUL_1293|M.ulcerans_Agy99 LSVGHQTGLLDVISQLPPSTSAQIAEAVGLDERYVREWLGGMTAGQVIEY
MAV_2182|M.avium_104 LSIGHQTALLDTMAGLPPATSDRIAEAAGLNERYVREWLAGMTTGRVVDY
Mflv_2768|M.gilvum_PYR-GCK VSIGHQTHLFDTMANLPPSTSTQIADAAGLNERYVREWLGGVAAGRIVDY
Mvan_3765|M.vanbaalenii_PYR-1 LSIGHQTGLFDTLAQLPPATSTQIADAAGLDERYVREWLGGMVAGRIVDY
MSMEG_4338|M.smegmatis_MC2_155 LSIGHQTGLFDTMRSLPPATSTQIADAAGLNERYVREWLGGLVAAKVIEY
MAB_4742c|M.abscessus_ATCC_199 MSIGHQTGLLDTLAASAGSTSEQLADAAGLEERYVREWLAGMTVAHVVDY
MLBr_01783|M.leprae_Br4923 ------------MVGLSLVTSTQIAYVAGLNERYVREWLGDMTTGHVVDY
TH_4552|M.thermoresistible__bu VVMGDRLGYYRSLAAHGASTPAELAERTGTDEHYAREWLNAQAAGAFVSY
: *. .:* .* :*:*.**** ... .:.*
Rv2258c|M.tuberculosis_H37Rv DAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREG
Mb2282c|M.bovis_AF2122/97 DAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREG
MMAR_3349|M.marinum_M DAETATYSLPEHRAAMLTRAAGPNNLARVTQFISLLGEVEQKVIACFREG
MUL_1293|M.ulcerans_Agy99 DAETATYSLPEHRAAMLTRAAGPNNLARVTQFISLLGEVEQKVIACFREG
MAV_2182|M.avium_104 HPATAEYSLPAHRAKVLTRAAGPDNLALVALFLPLLAEVEQKIIGCFRTG
Mflv_2768|M.gilvum_PYR-GCK DPAAQTFSLPAHRAAVLTRTAGPDNLARVTQFIPLLSEVEQKVIACFRDG
Mvan_3765|M.vanbaalenii_PYR-1 DAAAQAYSLPPHRAAVLTRAAGPDNFARVAQFIPLLGEVEQKVIGCFHNG
MSMEG_4338|M.smegmatis_MC2_155 APDERTYHLPEHRAAMLTRAAGPDNLARVAQFIPLLAEVEQKIVDRFRHG
MAB_4742c|M.abscessus_ATCC_199 EPVSAIYTLPSHRAATLTREAGLNNLARLAQYLPLLSEVEQKILGCFRRG
MLBr_01783|M.leprae_Br4923 YAETGTYSLSVHRVAVLVWATGTNNLASVAQFIPLFSGFEQQFIGGFCDD
TH_4552|M.thermoresistible__bu DPTTGRYLLPPEHAEALTDETSPAFVGGLFQIAHGTVCDTASILEAARTG
. : *. .:. *. :. .. : ..: .
Rv2258c|M.tuberculosis_H37Rv GGVPYSEY-PRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVA
Mb2282c|M.bovis_AF2122/97 GGVPYSEY-PRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVA
MMAR_3349|M.marinum_M GGVHYTQY-PRFHTLMAEMSGEVFDSALVDVIVPLVEGLPERLQAGAEAA
MUL_1293|M.ulcerans_Agy99 GGVHYTQY-PRFHTLMAEMSGEVFDSALVDVIVPLVESLPERLQAGAEVA
MAV_2182|M.avium_104 GGLPYTEF-PRFHALMAEQSGVVFDTALVDVVLPLVDGLVPWLRRGADVA
Mflv_2768|M.gilvum_PYR-GCK GGLSYAEY-PRFHTLMAEQSGEVFDAALVDGILPMAEGLTDRLRQGVDVA
Mvan_3765|M.vanbaalenii_PYR-1 GGLSYAEY-PRFHTLMAEESGEVFDAALVDVILPMVDGLPARLRSGVDVA
MSMEG_4338|M.smegmatis_MC2_155 GGLPYSEY-PRFHRLMAEQSGEVFDAALIDVILPMASGLVDRLQAGADLA
MAB_4742c|M.abscessus_ATCC_199 GGLQYQDY-PRFHAVMGERSREVFDKALIRTVLPLVEGLPEGLEGGLDVA
MLBr_01783|M.leprae_Br4923 VGGPYSEF-PRFYSLMAEMSGAMFDAAFVDVVLPLANGLPERLRSGAGVA
TH_4552|M.thermoresistible__bu GGVGWGDHNADVHIGCERFFRPTYHAHLLAEWLPALDGVLDKLTAGASVA
* : :. . .: . :. :: :* ..: * * *
Rv2258c|M.tuberculosis_H37Rv DFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFE
Mb2282c|M.bovis_AF2122/97 DFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFE
MMAR_3349|M.marinum_M DFGCGSGHAVNLLAQAFPKSRFTGIDFSEPAIAAASQEAKRRGLSNATFQ
MUL_1293|M.ulcerans_Agy99 DFGCGSGHAVNLLAQAFPKSRFTGIDFSEPAIAAASQEAQRRGLSNATFQ
MAV_2182|M.avium_104 DFGCGSGHAINVMAQAFPASRFTGIDFSEHAIAAGIAEAAERGLANASFE
Mflv_2768|M.gilvum_PYR-GCK DFGCGSGHAVNVMAKAFPASRFTGIDFSEEGLAAGRDEARRLGLTNASFN
Mvan_3765|M.vanbaalenii_PYR-1 DFGCGSGHAVNVMASAFPASRFVGLDFSEEGLAAGVAESRDLGLTNATFA
MSMEG_4338|M.smegmatis_MC2_155 DIGCGSGHAVNVIAQAFPASRCTGIDFSEEGLATGRDEAQRLGLDNATFI
MAB_4742c|M.abscessus_ATCC_199 DFGCGSGYAINLMAQAFPASRFTGVDFSDEAIATAAADAERLGLRNASFL
MLBr_01783|M.leprae_Br4923 DFDCGSGHVVNVLVRAFPASWFIGIDFSNEAVAIHTAEEDRLGLGTVTFE
TH_4552|M.thermoresistible__bu DVGCGHGASTRLMAEAFPRSTFQGSDVHAPSIEVARQRAAGTGPDAVRNI
*..** * .::. ** * * *. .: * .
Rv2258c|M.tuberculosis_H37Rv RHDLAELDKVG--AYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMV
Mb2282c|M.bovis_AF2122/97 RHDLAELDKVG--AYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMV
MMAR_3349|M.marinum_M SRDLTTLDDVG--VYDVITAFDTIHDQAQPARVLENIYRALRPGGVLLMV
MUL_1293|M.ulcerans_Agy99 SRDLTTLDDVG--VYDVITAFDTIHDQAQPARVLENIYRALRPGGVLLMV
MAV_2182|M.avium_104 SHNLADLDRAD--AYDLITVFDAIHDQAQPARVLANIHRALRPGGVLLMA
Mflv_2768|M.gilvum_PYR-GCK ATDVATYDAAE--SFDVITAFDAIHDQAHPARVLANIHAALRPGGTFLMV
Mvan_3765|M.vanbaalenii_PYR-1 ATDVADYDAVD--AFDLITAFDSIHDQAHPGRVLANIQRALRPGGTFLMV
MSMEG_4338|M.smegmatis_MC2_155 ARDVAELDETE--AYDVITAFDAIHDQAHPARVLENIHRALRPGGVFLMV
MAB_4742c|M.abscessus_ATCC_199 SADVATLNAPA--TYDLITAFDTIHDQAHPAAVLANIHRALRPGGVLLMA
MLBr_01783|M.leprae_Br4923 SHNLARLDKAA--AYDVITVFDASHDHAQPVRVLENIYQALRPGDVLLMA
TH_4552|M.thermoresistible__bu AFETAGADAVAGGPYDLITMFDCLHDMGDPVGAARHLREVIADDGTWMIV
: : : :*:** ** ** ..* . :: .: ... ::.
Rv2258c|M.tuberculosis_H37Rv DIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGA------GLGTVW
Mb2282c|M.bovis_AF2122/97 DIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGA------GLGTVW
MMAR_3349|M.marinum_M DVKASSRLEDNVGNPMSTYLYTISMMHCMTVSLALDGV------GLGTVW
MUL_1293|M.ulcerans_Agy99 DVKASSRLEDNVGNPMSTYLYTISMMHCMTVSLALDGV------GLGTVW
MAV_2182|M.avium_104 DIKASSRLEDNVGVPMSTYLYTTSLMHCMTVSLAADGA------GLGTAW
Mflv_2768|M.gilvum_PYR-GCK DIKSSSRLENNIGVPFAPYLYTVSAMHCMSVSLGLDGD------GLGTCW
Mvan_3765|M.vanbaalenii_PYR-1 DIKSSSRVEDNVGAPLAPYLYTVSTMHCMSVSLGLGGD------GLGTCW
MSMEG_4338|M.smegmatis_MC2_155 DIKASTHVENNIGVPFAPYLYTVSTLHCMTVSLALDGD------GLGTVW
MAB_4742c|M.abscessus_ATCC_199 DIKASSRLEDNIGVAMSTYRYTVSLTHCMPVSLGLEGA------GLGTMW
MLBr_01783|M.leprae_Br4923 SIKVSSQLEDNVDVLMSIYLYTASLMHCMTVSLALQGAPDWMRCGEGGWP
TH_4552|M.thermoresistible__bu EPAAGDRVEDNL-TPIGRAYYGFSTLLCTPASLSQPVG-----LALGTQA
. . ::*:*: :. * * * ..**. . *
Rv2258c|M.tuberculosis_H37Rv GRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK-----
Mb2282c|M.bovis_AF2122/97 GRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK-----
MMAR_3349|M.marinum_M GSQLATKMLADAGFEDVTVAEIESDPLNNYYIARK-----
MUL_1293|M.ulcerans_Agy99 GSQLATKMLADAGFEDVTVAEIESDPLNNYYIARK-----
MAV_2182|M.avium_104 GTQLAVAMLGEAGFADVRVAEIESDPINNYYIARKS----
Mflv_2768|M.gilvum_PYR-GCK GREVATTMLADAGFGDVQVREIESDPINYYYIARK-----
Mvan_3765|M.vanbaalenii_PYR-1 GRDLATSMLADAGFRDVQVREIDSDPLNLYYIATK-----
MSMEG_4338|M.smegmatis_MC2_155 GRELATSMLADAGFDDIVVREIDTDPINYYYVARKR----
MAB_4742c|M.abscessus_ATCC_199 GRQLAESMLAEAGFSDVTVREIEQDTSNYFYIARR-----
MLBr_01783|M.leprae_Br4923 PRCSATRDWTTCGWS---ISSPTRSTTTYIYIATKLPRLT
TH_4552|M.thermoresistible__bu GPARIREVVTAAGFTR--FRLVADTPFNNVFEVRP-----
.*: . . : .