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M. tuberculosis H37Rv Rv2207 (cobT)

annotation: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
coordinates: 2471411 - 2472496
length: 361

MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWVASCQQRCPPRQFERARVVVFAGDHGVAR
SGVSAYPPEVTAQMVANIDAGGAAINALADVAGATVRVADLAVDADPLSERIGAHKVRRGSGNIATEDAL
TNDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAEPVAVVGFGTGIDDAGWARK
TAAVRDALFRVRPVLPDPVGLLRCAGGADLAAIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHR
WWQAGHRSSEPGHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEAGVSTRSVDG
VDRTAPPAVSP

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv2207 cobT - 100% (361) nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb2230 cobT 0.0 100.00% (361) nicotinate-nucleotide--dimethylbenzimidazole
M. gilvum PYR-GCK Mflv_2942 cobT 1e-140 74.78% (341) nicotinate-nucleotide--dimethylbenzimidazole
M. leprae Br4923 MLBr_00868 cobT 1e-163 81.41% (355) nicotinate-nucleotide--dimethylbenzimidazole
M. abscessus ATCC 19977 MAB_1953c cobT 1e-126 69.01% (342) nicotinate-nucleotide--dimethylbenzimidazole
M. marinum M MMAR_3252 cobT 1e-169 85.15% (357) nicotinate-nucleotide-dimethylbenzimidazol
M. avium 104 MAV_2283 cobT 1e-160 83.14% (344) nicotinate-nucleotide--dimethylbenzimidazole
M. smegmatis MC2 155 MSMEG_4275 cobT 1e-143 75.58% (344) nicotinate-nucleotide--dimethylbenzimidazole
M. thermoresistible (build 8) TH_1436 cobT 1e-141 73.91% (345) Probable nicotinate-nucleotide-dimethylbenzimidazol
M. ulcerans Agy99 MUL_3565 cobT 1e-169 84.59% (357) nicotinate-nucleotide--dimethylbenzimidazole
M. vanbaalenii PYR-1 Mvan_3571 cobT 1e-143 75.95% (341) nicotinate-nucleotide--dimethylbenzimidazole

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4275|M.smegmatis_MC2_155      ----MTDTQVTFDSVVTPDADAAAAARDRQKRLTKPPGSLGRLEELSVWV
TH_1436|M.thermoresistible__bu      ------VSTVDIGPVEPPDEAAAAAARARQGELTKPAGSLGRLEDLSVWV
Mflv_2942|M.gilvum_PYR-GCK          --------MAYFPDVPAPDPEAAAAARDRQAILTKPSGALGRLEDLSVWV
Mvan_3571|M.vanbaalenii_PYR-1       --------MAYFPEIPAPDADAAAAARARQALLTKPAGALGRLEDLSVWV
MAB_1953c|M.abscessus_ATCC_199      MTQAEPPEAPRFAPVSAPDPGIADAARARQHRLTKPTGALGRLEELSVWA
Rv2207|M.tuberculosis_H37Rv         --------MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWV
Mb2230|M.bovis_AF2122/97            --------MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWV
MMAR_3252|M.marinum_M               --------MIGFAPISAPDALAEAAARARQDALTKPRGALGRLEDLSAWV
MUL_3565|M.ulcerans_Agy99           --------MIGFAPISAPDALAEAAARARQDALTKPRGALGRLEDLSAWV
MLBr_00868|M.leprae_Br4923          ---------MEFAPVSPPDGHAAAAARARQDTLTKPRGALGRLEDLSIWV
MAV_2283|M.avium_104                ---------MEFATVSPPDPGAAAAARARQDTLTKPRGALGRLEDLSVWI
                                               :  : .**     *** **  **** *:** **:** * 

MSMEG_4275|M.smegmatis_MC2_155      AACQGTCPPQPLTRPRIVVFAGDHGVTKSGVSAFPAEVTAQMVANFDAGG
TH_1436|M.thermoresistible__bu      ASCQSLCPPRQFERARVVVFAGDHGVARAGVSAYPVEVTAQMMANFQTGG
Mflv_2942|M.gilvum_PYR-GCK          ASCQGVCPPKQFERARVVVFAGDHGVARAGVSAYPAEVTAAMVANFAAGG
Mvan_3571|M.vanbaalenii_PYR-1       AACQGGCPPRQFERARVVVFAGDHGVAASGVSAYPADVTAAMVANIAAGG
MAB_1953c|M.abscessus_ATCC_199      AACQNRCPPTTFQRPRVVVFAGDHGVAAAGVSAYPASVTAQMVRNMDAGG
Rv2207|M.tuberculosis_H37Rv         ASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGG
Mb2230|M.bovis_AF2122/97            ASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGG
MMAR_3252|M.marinum_M               ASCQGQCPPRQFQRARVVVFAGDHGVTRSGVSAYPPDVTAQMVANIDGGG
MUL_3565|M.ulcerans_Agy99           ASCQGQCPPRQFQRARVVVFAGDHGITRSGVSAYPPDATAQMVANIDGGG
MLBr_00868|M.leprae_Br4923          ASCQGQCPPRQFQRARIVVFAGDHGVARSGVSAYPPQLTAQMVANIDRGG
MAV_2283|M.avium_104                AACQGQCPPRQFERARVVVFAGDHGVARCGVSAYPPEVTAQMVANFDAGG
                                    *:**  ***  : *.*:********:: .****:* . ** *: *:  **

MSMEG_4275|M.smegmatis_MC2_155      AAINVLADAAGATVRVVDICVDCDQPLSPAVGAHKVRRGSGNIAVEDALS
TH_1436|M.thermoresistible__bu      AAINVLAGVAGAGVRVVDMAVDVDEPLTEAIGRHKIRRGSGNIAVEDALT
Mflv_2942|M.gilvum_PYR-GCK          AAVNVLAEVAGASVRVVDMAVDVAEPLSPAIGAHKIRRSSGDIAVEDALT
Mvan_3571|M.vanbaalenii_PYR-1       AAVNVLAEVAGASVRVADIAVDTAEPLSPAIGADKIRRSSGNIAVEDALT
MAB_1953c|M.abscessus_ATCC_199      AAVNVLAALTGAGVRVADMAVG---------------RPSGNIAVEDALT
Rv2207|M.tuberculosis_H37Rv         AAINALADVAGATVRVADLAVDAD-PLSERIGAHKVRRGSGNIATEDALT
Mb2230|M.bovis_AF2122/97            AAINALADVAGATVRVADLAVDAD-PLSERIGAHKVRRGSGNIATEDALT
MMAR_3252|M.marinum_M               AAINALADVAGATVRVVDLAVDAE-ALSEQIGAHKVRRGSGDIATEDALT
MUL_3565|M.ulcerans_Agy99           AAINALADVAGATVRVVDLAVDAE-ALSEQIGAHKVRRGSGDIATEDALT
MLBr_00868|M.leprae_Br4923          AAINALASIADATIRIADLAVDAD-PLSQQIGIHKVRRGSGDIAIQDALT
MAV_2283|M.avium_104                AAINALAGVAGASVRVADLAVDAD-PPDDRIGANKVRRGSGDITVQDALT
                                    **:*.**  :.* :*:.*:.*.               * **:*: :***:

MSMEG_4275|M.smegmatis_MC2_155      AEEAAAAVDAGRRIADEEVDAGADLLIAGDMGIGNTTAATTLVAALSGAE
TH_1436|M.thermoresistible__bu      AEQTVAAVQAGRRIADEEVDAGADLLIAGDMGIGNTTAATALIGTLTDTE
Mflv_2942|M.gilvum_PYR-GCK          PDEVVRAIDAGRRIADEEVDSGADLLIAGDMGIGNTTPATTLVAALTDSE
Mvan_3571|M.vanbaalenii_PYR-1       PDEVVAAVDAGRRIADEEVDSGADLLIAGDMGIGNTTPATTLIAAMTDSE
MAB_1953c|M.abscessus_ATCC_199      GEQTHAALAAGIALADAEVDGGADLLIAGDMGIGNTTPATVLVAALTGSE
Rv2207|M.tuberculosis_H37Rv         NDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAE
Mb2230|M.bovis_AF2122/97            NDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAE
MMAR_3252|M.marinum_M               DDQTAAAIAAGQQIADAEVDAGADLLIAGDMGIGNTTPAAVLVAALTNTE
MUL_3565|M.ulcerans_Agy99           DDQTAAAIAAGQQIADAEVDAGADLLIAGDMGIGNTTPAAVLVAALTNTE
MLBr_00868|M.leprae_Br4923          EDETARAIIAGQRIADEEVDRGADLLIAGDIGIGNTTAAAVLVAALTNAE
MAV_2283|M.avium_104                AEETERALSAGAAIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTNVE
                                     ::.  *: **  :** *** *********:******.*:.*:.:::. *

MSMEG_4275|M.smegmatis_MC2_155      PVAVVGRGTGIDDQGWMRKTSAVRDALYRARGVVDDPLGLLRVCGGADLA
TH_1436|M.thermoresistible__bu      PVAVIGRGTGIDDTGWMRKTAAVRDAMFRARRAGSDPITLLRVCGGADLA
Mflv_2942|M.gilvum_PYR-GCK          PVVVVGRGTGIDDAGWMRKTAAVRDALYRTRRLSADPVALLRICGGADLA
Mvan_3571|M.vanbaalenii_PYR-1       PVAVVGRGTGIDDAGWARKTAAIRDALYRTRRLSADPIALLRICGGADLA
MAB_1953c|M.abscessus_ATCC_199      PVAVVGRGTGVDDAGWMRKTAAVRDALRRTKDVRTDPVALLGVAGGADLA
Rv2207|M.tuberculosis_H37Rv         PVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLA
Mb2230|M.bovis_AF2122/97            PVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLA
MMAR_3252|M.marinum_M               PVAVVGFGTGVDDATWSRKTAAVRDALFRSARVLPDPVALLRCCGGADLA
MUL_3565|M.ulcerans_Agy99           PVAVVGFGTGVDDATWSRKTAAVRDALFRSARVLPDPVALLRCCGGADLA
MLBr_00868|M.leprae_Br4923          PVAVVGFGTGIDDASWARKTAAVRDALCRIRLVLPDPVGLLRCCGGADLA
MAV_2283|M.avium_104                PVVAVGFGTGIDDAGWARKTAAVRDALFRARRVLPDPVALLRCAGGADLA
                                    **..:* ***:**  * ***:*:***: *      **: **  .******

MSMEG_4275|M.smegmatis_MC2_155      AMAGFCAQAAVRRTPVLLDGLVVTAAALVADRLAPGARAWWQAGHRSTEP
TH_1436|M.thermoresistible__bu      AITGLLAQAAVRRTPVLLDGLVSAAAALLAEQLAPGARQWWQAGHRSTEP
Mflv_2942|M.gilvum_PYR-GCK          AMTGFCAQAAVRRTPVLLDGMVVTAAALAADTLAPGARQWWQAGHRSTEP
Mvan_3571|M.vanbaalenii_PYR-1       AMTGFCAQAAVRRTPLVLDGMVVTAAALAAERLAPGARLWWQAGHRSTEP
MAB_1953c|M.abscessus_ATCC_199      AMTGFLAQAAVRRTPVLLDGLVVTSAALVAEQLAPGARQWWLAGHRSTEP
Rv2207|M.tuberculosis_H37Rv         AIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEP
Mb2230|M.bovis_AF2122/97            AIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEP
MMAR_3252|M.marinum_M               AMAGFCAQAAVRRTPLLLDGMAVTAAALVAERLAPGARQWWQAGHRSTEP
MUL_3565|M.ulcerans_Agy99           AMAGFCAQAAVRRTPLLLDGMAVTAAALVAERLAPGARQWWQAGHRSTEP
MLBr_00868|M.leprae_Br4923          AMAGFCAQAAVRRTPLLLDGMVVTAAALVAERLAPGSWQWWQAGHQSTEP
MAV_2283|M.avium_104                ALAGFCAQAAVRRTPLLLDGMAVTAAALVAEHLAPGARLWWQAGHRSTEP
                                    *::*: *********::***:. ::*** *: ****:  ** ***:*:**

MSMEG_4275|M.smegmatis_MC2_155      AHALALTQLQLEPIVDLQMRLGEGTGAAVALPVVRAAVATLTSMATFDEA
TH_1436|M.thermoresistible__bu      AHALALQRLELEPILDLGMRLGEGTGAAMALPVVRAAVAVLADMATFDEA
Mflv_2942|M.gilvum_PYR-GCK          AHSLALQRLDLTPLLELDMRLGEGSGAVVALPVLRAAVATLASMATFEEA
Mvan_3571|M.vanbaalenii_PYR-1       AHTLALRDLGLEPLVELGMRLGEGSGALVALPVLRAAVATLASMATFEEA
MAB_1953c|M.abscessus_ATCC_199      AHSLALQRLRLDPVLDLQMRLGEGSGALVALPVLQAAVGTLAQMATFDEA
Rv2207|M.tuberculosis_H37Rv         GHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEA
Mb2230|M.bovis_AF2122/97            GHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEA
MMAR_3252|M.marinum_M               GHQLALTALALDPVVDLRMRLGEGTGATVALPVLRAAVAALSSMATFAEA
MUL_3565|M.ulcerans_Agy99           GHQLALTALALDPVVDLRMRLGEGTGATVALPVLRAAVAALSSMATFAEA
MLBr_00868|M.leprae_Br4923          GHALALAALDLDPILDLRMRLGEGTGATAALLVLRAAVAALTSMTTFAEA
MAV_2283|M.avium_104                GHALALTALDLEPILDLRMRLGEGTGAALALPIVRAAVAALSSMATFAQA
                                    .* ***  * * *:::* ******:**  ** :::***..*:.*:** :*

MSMEG_4275|M.smegmatis_MC2_155      GISES---------------
TH_1436|M.thermoresistible__bu      RVSTGP--------------
Mflv_2942|M.gilvum_PYR-GCK          GIGAEQT-------------
Mvan_3571|M.vanbaalenii_PYR-1       GIGGG---------------
MAB_1953c|M.abscessus_ATCC_199      RVDTA---------------
Rv2207|M.tuberculosis_H37Rv         GVSTRSVDGVDRTAPPAVSP
Mb2230|M.bovis_AF2122/97            GVSTRSVDGVDRTAPPAVSP
MMAR_3252|M.marinum_M               GVST-ACDDAGATEPPES--
MUL_3565|M.ulcerans_Agy99           GVST-ACDDAGATEPPES--
MLBr_00868|M.leprae_Br4923          GVAG------TSTSPPS---
MAV_2283|M.avium_104                GVSD------PSAHP-----
                                     :

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv2207	cobT	-	100% (361)	nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase