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VAYFPEIPAPDADAAAAARARQALLTKPAGALGRLEDLSVWVAACQGGCPPRQFERARVVVFAGDHGVAA SGVSAYPADVTAAMVANIAAGGAAVNVLAEVAGASVRVADIAVDTAEPLSPAIGADKIRRSSGNIAVEDA LTPDEVVAAVDAGRRIADEEVDSGADLLIAGDMGIGNTTPATTLIAAMTDSEPVAVVGRGTGIDDAGWAR KTAAIRDALYRTRRLSADPIALLRICGGADLAAMTGFCAQAAVRRTPLVLDGMVVTAAALAAERLAPGAR LWWQAGHRSTEPAHTLALRDLGLEPLVELGMRLGEGSGALVALPVLRAAVATLASMATFEEAGIGGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3571 | cobT | - | 100% (347) | nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2230 | cobT | 1e-143 | 75.95% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. gilvum PYR-GCK | Mflv_2942 | cobT | 1e-173 | 88.41% (345) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. tuberculosis H37Rv | Rv2207 | cobT | 1e-143 | 75.95% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. leprae Br4923 | MLBr_00868 | cobT | 1e-139 | 71.72% (343) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. abscessus ATCC 19977 | MAB_1953c | cobT | 1e-130 | 70.67% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. marinum M | MMAR_3252 | cobT | 1e-144 | 75.95% (341) | nicotinate-nucleotide-dimethylbenzimidazol |
| M. avium 104 | MAV_2283 | cobT | 1e-141 | 73.90% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. smegmatis MC2 155 | MSMEG_4275 | cobT | 1e-148 | 76.25% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
| M. thermoresistible (build 8) | TH_1436 | cobT | 1e-145 | 75.07% (341) | Probable nicotinate-nucleotide-dimethylbenzimidazol |
| M. ulcerans Agy99 | MUL_3565 | cobT | 1e-144 | 75.37% (341) | nicotinate-nucleotide--dimethylbenzimidazole |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3571|M.vanbaalenii_PYR-1 --------MAYFPEIPAPDADAAAAARARQALLTKPAGALGRLEDLSVWV
Mflv_2942|M.gilvum_PYR-GCK --------MAYFPDVPAPDPEAAAAARDRQAILTKPSGALGRLEDLSVWV
MSMEG_4275|M.smegmatis_MC2_155 ----MTDTQVTFDSVVTPDADAAAAARDRQKRLTKPPGSLGRLEELSVWV
TH_1436|M.thermoresistible__bu ------VSTVDIGPVEPPDEAAAAAARARQGELTKPAGSLGRLEDLSVWV
MAB_1953c|M.abscessus_ATCC_199 MTQAEPPEAPRFAPVSAPDPGIADAARARQHRLTKPTGALGRLEELSVWA
Mb2230|M.bovis_AF2122/97 --------MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWV
Rv2207|M.tuberculosis_H37Rv --------MIGFAPVSTPDAAAEAAARARQDSLTKPRGALGSLEDLSVWV
MMAR_3252|M.marinum_M --------MIGFAPISAPDALAEAAARARQDALTKPRGALGRLEDLSAWV
MUL_3565|M.ulcerans_Agy99 --------MIGFAPISAPDALAEAAARARQDALTKPRGALGRLEDLSAWV
MLBr_00868|M.leprae_Br4923 ---------MEFAPVSPPDGHAAAAARARQDTLTKPRGALGRLEDLSIWV
MAV_2283|M.avium_104 ---------MEFATVSPPDPGAAAAARARQDTLTKPRGALGRLEDLSVWI
: : .** *** ** **** *:** **:** *
Mvan_3571|M.vanbaalenii_PYR-1 AACQGGCPPRQFERARVVVFAGDHGVAASGVSAYPADVTAAMVANIAAGG
Mflv_2942|M.gilvum_PYR-GCK ASCQGVCPPKQFERARVVVFAGDHGVARAGVSAYPAEVTAAMVANFAAGG
MSMEG_4275|M.smegmatis_MC2_155 AACQGTCPPQPLTRPRIVVFAGDHGVTKSGVSAFPAEVTAQMVANFDAGG
TH_1436|M.thermoresistible__bu ASCQSLCPPRQFERARVVVFAGDHGVARAGVSAYPVEVTAQMMANFQTGG
MAB_1953c|M.abscessus_ATCC_199 AACQNRCPPTTFQRPRVVVFAGDHGVAAAGVSAYPASVTAQMVRNMDAGG
Mb2230|M.bovis_AF2122/97 ASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGG
Rv2207|M.tuberculosis_H37Rv ASCQQRCPPRQFERARVVVFAGDHGVARSGVSAYPPEVTAQMVANIDAGG
MMAR_3252|M.marinum_M ASCQGQCPPRQFQRARVVVFAGDHGVTRSGVSAYPPDVTAQMVANIDGGG
MUL_3565|M.ulcerans_Agy99 ASCQGQCPPRQFQRARVVVFAGDHGITRSGVSAYPPDATAQMVANIDGGG
MLBr_00868|M.leprae_Br4923 ASCQGQCPPRQFQRARIVVFAGDHGVARSGVSAYPPQLTAQMVANIDRGG
MAV_2283|M.avium_104 AACQGQCPPRQFERARVVVFAGDHGVARCGVSAYPPEVTAQMVANFDAGG
*:** *** : *.*:********:: .****:* . ** *: *: **
Mvan_3571|M.vanbaalenii_PYR-1 AAVNVLAEVAGASVRVADIAVDTAEPLSPAIGADKIRRSSGNIAVEDALT
Mflv_2942|M.gilvum_PYR-GCK AAVNVLAEVAGASVRVVDMAVDVAEPLSPAIGAHKIRRSSGDIAVEDALT
MSMEG_4275|M.smegmatis_MC2_155 AAINVLADAAGATVRVVDICVDCDQPLSPAVGAHKVRRGSGNIAVEDALS
TH_1436|M.thermoresistible__bu AAINVLAGVAGAGVRVVDMAVDVDEPLTEAIGRHKIRRGSGNIAVEDALT
MAB_1953c|M.abscessus_ATCC_199 AAVNVLAALTGAGVRVADMAVG---------------RPSGNIAVEDALT
Mb2230|M.bovis_AF2122/97 AAINALADVAGATVRVADLAVDAD-PLSERIGAHKVRRGSGNIATEDALT
Rv2207|M.tuberculosis_H37Rv AAINALADVAGATVRVADLAVDAD-PLSERIGAHKVRRGSGNIATEDALT
MMAR_3252|M.marinum_M AAINALADVAGATVRVVDLAVDAE-ALSEQIGAHKVRRGSGDIATEDALT
MUL_3565|M.ulcerans_Agy99 AAINALADVAGATVRVVDLAVDAE-ALSEQIGAHKVRRGSGDIATEDALT
MLBr_00868|M.leprae_Br4923 AAINALASIADATIRIADLAVDAD-PLSQQIGIHKVRRGSGDIAIQDALT
MAV_2283|M.avium_104 AAINALAGVAGASVRVADLAVDAD-PPDDRIGANKVRRGSGDITVQDALT
**:*.** :.* :*:.*:.*. * **:*: :***:
Mvan_3571|M.vanbaalenii_PYR-1 PDEVVAAVDAGRRIADEEVDSGADLLIAGDMGIGNTTPATTLIAAMTDSE
Mflv_2942|M.gilvum_PYR-GCK PDEVVRAIDAGRRIADEEVDSGADLLIAGDMGIGNTTPATTLVAALTDSE
MSMEG_4275|M.smegmatis_MC2_155 AEEAAAAVDAGRRIADEEVDAGADLLIAGDMGIGNTTAATTLVAALSGAE
TH_1436|M.thermoresistible__bu AEQTVAAVQAGRRIADEEVDAGADLLIAGDMGIGNTTAATALIGTLTDTE
MAB_1953c|M.abscessus_ATCC_199 GEQTHAALAAGIALADAEVDGGADLLIAGDMGIGNTTPATVLVAALTGSE
Mb2230|M.bovis_AF2122/97 NDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAE
Rv2207|M.tuberculosis_H37Rv NDETAAAITAGQQIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTDAE
MMAR_3252|M.marinum_M DDQTAAAIAAGQQIADAEVDAGADLLIAGDMGIGNTTPAAVLVAALTNTE
MUL_3565|M.ulcerans_Agy99 DDQTAAAIAAGQQIADAEVDAGADLLIAGDMGIGNTTPAAVLVAALTNTE
MLBr_00868|M.leprae_Br4923 EDETARAIIAGQRIADEEVDRGADLLIAGDIGIGNTTAAAVLVAALTNAE
MAV_2283|M.avium_104 AEETERALSAGAAIADEEVDAGADLLIAGDMGIGNTTAAAVLVAALTNVE
::. *: ** :** *** *********:******.*:.*:.:::. *
Mvan_3571|M.vanbaalenii_PYR-1 PVAVVGRGTGIDDAGWARKTAAIRDALYRTRRLSADPIALLRICGGADLA
Mflv_2942|M.gilvum_PYR-GCK PVVVVGRGTGIDDAGWMRKTAAVRDALYRTRRLSADPVALLRICGGADLA
MSMEG_4275|M.smegmatis_MC2_155 PVAVVGRGTGIDDQGWMRKTSAVRDALYRARGVVDDPLGLLRVCGGADLA
TH_1436|M.thermoresistible__bu PVAVIGRGTGIDDTGWMRKTAAVRDAMFRARRAGSDPITLLRVCGGADLA
MAB_1953c|M.abscessus_ATCC_199 PVAVVGRGTGVDDAGWMRKTAAVRDALRRTKDVRTDPVALLGVAGGADLA
Mb2230|M.bovis_AF2122/97 PVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLA
Rv2207|M.tuberculosis_H37Rv PVAVVGFGTGIDDAGWARKTAAVRDALFRVRPVLPDPVGLLRCAGGADLA
MMAR_3252|M.marinum_M PVAVVGFGTGVDDATWSRKTAAVRDALFRSARVLPDPVALLRCCGGADLA
MUL_3565|M.ulcerans_Agy99 PVAVVGFGTGVDDATWSRKTAAVRDALFRSARVLPDPVALLRCCGGADLA
MLBr_00868|M.leprae_Br4923 PVAVVGFGTGIDDASWARKTAAVRDALCRIRLVLPDPVGLLRCCGGADLA
MAV_2283|M.avium_104 PVVAVGFGTGIDDAGWARKTAAVRDALFRARRVLPDPVALLRCAGGADLA
**..:* ***:** * ***:*:***: * **: ** .******
Mvan_3571|M.vanbaalenii_PYR-1 AMTGFCAQAAVRRTPLVLDGMVVTAAALAAERLAPGARLWWQAGHRSTEP
Mflv_2942|M.gilvum_PYR-GCK AMTGFCAQAAVRRTPVLLDGMVVTAAALAADTLAPGARQWWQAGHRSTEP
MSMEG_4275|M.smegmatis_MC2_155 AMAGFCAQAAVRRTPVLLDGLVVTAAALVADRLAPGARAWWQAGHRSTEP
TH_1436|M.thermoresistible__bu AITGLLAQAAVRRTPVLLDGLVSAAAALLAEQLAPGARQWWQAGHRSTEP
MAB_1953c|M.abscessus_ATCC_199 AMTGFLAQAAVRRTPVLLDGLVVTSAALVAEQLAPGARQWWLAGHRSTEP
Mb2230|M.bovis_AF2122/97 AIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEP
Rv2207|M.tuberculosis_H37Rv AIAGFCAQAAVRRTPLLLDGVAVTAAALVAERLAPGAHRWWQAGHRSSEP
MMAR_3252|M.marinum_M AMAGFCAQAAVRRTPLLLDGMAVTAAALVAERLAPGARQWWQAGHRSTEP
MUL_3565|M.ulcerans_Agy99 AMAGFCAQAAVRRTPLLLDGMAVTAAALVAERLAPGARQWWQAGHRSTEP
MLBr_00868|M.leprae_Br4923 AMAGFCAQAAVRRTPLLLDGMVVTAAALVAERLAPGSWQWWQAGHQSTEP
MAV_2283|M.avium_104 ALAGFCAQAAVRRTPLLLDGMAVTAAALVAEHLAPGARLWWQAGHRSTEP
*::*: *********::***:. ::*** *: ****: ** ***:*:**
Mvan_3571|M.vanbaalenii_PYR-1 AHTLALRDLGLEPLVELGMRLGEGSGALVALPVLRAAVATLASMATFEEA
Mflv_2942|M.gilvum_PYR-GCK AHSLALQRLDLTPLLELDMRLGEGSGAVVALPVLRAAVATLASMATFEEA
MSMEG_4275|M.smegmatis_MC2_155 AHALALTQLQLEPIVDLQMRLGEGTGAAVALPVVRAAVATLTSMATFDEA
TH_1436|M.thermoresistible__bu AHALALQRLELEPILDLGMRLGEGTGAAMALPVVRAAVAVLADMATFDEA
MAB_1953c|M.abscessus_ATCC_199 AHSLALQRLRLDPVLDLQMRLGEGSGALVALPVLQAAVGTLAQMATFDEA
Mb2230|M.bovis_AF2122/97 GHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEA
Rv2207|M.tuberculosis_H37Rv GHGLALAALGLDPIVDLHMRLGEGTGAAVALMVLRAAVAALSSMATFTEA
MMAR_3252|M.marinum_M GHQLALTALALDPVVDLRMRLGEGTGATVALPVLRAAVAALSSMATFAEA
MUL_3565|M.ulcerans_Agy99 GHQLALTALALDPVVDLRMRLGEGTGATVALPVLRAAVAALSSMATFAEA
MLBr_00868|M.leprae_Br4923 GHALALAALDLDPILDLRMRLGEGTGATAALLVLRAAVAALTSMTTFAEA
MAV_2283|M.avium_104 GHALALTALDLEPILDLRMRLGEGTGAALALPIVRAAVAALSSMATFAQA
.* *** * * *:::* ******:** ** :::***..*:.*:** :*
Mvan_3571|M.vanbaalenii_PYR-1 GIGGG---------------
Mflv_2942|M.gilvum_PYR-GCK GIGAEQT-------------
MSMEG_4275|M.smegmatis_MC2_155 GISES---------------
TH_1436|M.thermoresistible__bu RVSTGP--------------
MAB_1953c|M.abscessus_ATCC_199 RVDTA---------------
Mb2230|M.bovis_AF2122/97 GVSTRSVDGVDRTAPPAVSP
Rv2207|M.tuberculosis_H37Rv GVSTRSVDGVDRTAPPAVSP
MMAR_3252|M.marinum_M GVST-ACDDAGATEPPES--
MUL_3565|M.ulcerans_Agy99 GVST-ACDDAGATEPPES--
MLBr_00868|M.leprae_Br4923 GVAG------TSTSPPS---
MAV_2283|M.avium_104 GVSD------PSAHP-----
: