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MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSELLVAVHACGVCRTDLHVTEGDLPVHRERVI PGHEVVGEVIEVGSAVGAAAGGEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQSRYTGWDADGGYAEF TTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELPPGGRLGLYGFGGSAHITAQVALAQGAEIHV MTRGARARKLALQLGAASAQDAADRPPVPLDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPDLN YQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADRALGDLSAGRIAGAAVLLI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1862 | adhA | - | 100% (346) | Probable alcohol dehydrogenase adhA |
| M. tuberculosis H37Rv | Rv3045 | adhC | 5e-28 | 27.58% (330) | NADP-dependent alcohol dehydrogenase ADHC |
| M. tuberculosis H37Rv | Rv3086 | adhD | 1e-16 | 29.54% (281) | zinc-type alcohol dehydrogenase AdhD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1893 | adhA | 0.0 | 100.00% (346) | alcohol dehydrogenase AdhA |
| M. gilvum PYR-GCK | Mflv_3343 | - | 1e-152 | 77.45% (337) | alcohol dehydrogenase |
| M. leprae Br4923 | MLBr_02053 | - | 1e-165 | 84.52% (336) | putative alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 2e-25 | 25.97% (308) | NADP-dependent alcohol dehydrogenase C |
| M. marinum M | MMAR_2739 | adhA | 1e-173 | 87.83% (337) | alcohol dehydrogenase AdhA |
| M. avium 104 | MAV_2857 | - | 1e-172 | 86.22% (341) | zinc-binding alcohol dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_3615 | - | 1e-147 | 73.02% (341) | zinc-binding alcohol dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_2673 | - | 1e-157 | 79.47% (341) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_3015 | adhA | 1e-175 | 86.42% (346) | alcohol dehydrogenase AdhA |
| M. vanbaalenii PYR-1 | Mvan_3073 | - | 1e-155 | 78.64% (337) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1862|M.tuberculosis_H37Rv ---------MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSEL
Mb1893|M.bovis_AF2122/97 ---------MVSPATTATMSAWQVRRPGPMDTGPLERVTTRVPRPAPSEL
MMAR_2739|M.marinum_M ------------------MSAWQVRRPGPIDTGPLERVNVEVPRPAPSEL
MUL_3015|M.ulcerans_Agy99 ---------MAAPASTPRMSAWQVRRPGPIDTGPLERVNVEVPRPAPSEL
MAV_2857|M.avium_104 -------------MTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDL
MLBr_02053|M.leprae_Br4923 ------------------MHAWRVRRPGPIQTSPLEWVTTEVPCPEPSEL
Mflv_3343|M.gilvum_PYR-GCK ------------------MRAWRVHRPGPMSTSPLVGVTAQIPEPGRGEL
TH_2673|M.thermoresistible__bu LWTTGAVARDDDRMSASMMSAWRVREPGPMRTRPLEWVRTPVPEPGPGEL
Mvan_3073|M.vanbaalenii_PYR-1 ------------------MRAWQVRRPGPMATKPLVRATVPVPQPGPDEL
MSMEG_3615|M.smegmatis_MC2_155 -------------MSSSAMTAWQVVSPGPVDTRPLHRATVPRPEPGDGEL
MAB_3400|M.abscessus_ATCC_1997 ---------------MVTVSAYAATS----GKDPLVPTTIERREVGPHDV
: *: . . ** . ::
Rv1862|M.tuberculosis_H37Rv LVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAG
Mb1893|M.bovis_AF2122/97 LVAVHACGVCRTDLHVTEGDLPVHRERVIPGHEVVGEVIEVGSAVGAAAG
MMAR_2739|M.marinum_M LVAVRACGVCRTDLHVTEGDLAVHRERVTPGHEVVGEVVEVG----AEAG
MUL_3015|M.ulcerans_Agy99 LVAVRACGVCRTDLHVTEGDLAVHRERVTPGHEVVGEVVEVG----AEAG
MAV_2857|M.avium_104 LVAVRACGVCRTDLHVTEGDLPVHRDRVTPGHEVVGEVIEVG----AEAG
MLBr_02053|M.leprae_Br4923 LVAVRACGVCRTDLHVAEGDLPVHREHVTPGHEVVGEVLGVGSDVDAAAG
Mflv_3343|M.gilvum_PYR-GCK LVAVLACGVCRTDLHVAEGDLPVHRVDVTPGHEVVGEVVGLG-----DGV
TH_2673|M.thermoresistible__bu LVAVRACGVCRTDLHVAEGDLPVHRPGVTPGHEVVGEVVAT------ADG
Mvan_3073|M.vanbaalenii_PYR-1 LVAVRACGVCRTDLHVAEGDLPVHRPRVIPGHEVVGEVVALG----PNTG
MSMEG_3615|M.smegmatis_MC2_155 LVAVRACGVCRTDLHVAEGDLAVHRPNVIPGHEVVGEVVAAG-----PDV
MAB_3400|M.abscessus_ATCC_1997 FIDIKFAGICHSDIHTVRDEWGRANYPIVPGHEIAGVITEVG-----SEV
:: : .*:*::*:*....: . : ****:.* :
Rv1862|M.tuberculosis_H37Rv GEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQ--------SRYTGWDA
Mb1893|M.bovis_AF2122/97 GEFDRGDRVGIAWLRHTCGVCKYCRRGSENLCPQ--------SRYTGWDA
MMAR_2739|M.marinum_M DEFAVGDRVGIAWLRHTCGVCKYCRRGDENLCPK--------SLYTGWDA
MUL_3015|M.ulcerans_Agy99 DEFAVGDRVGIAWLRHTCGVCKYCRRGDENLCPK--------SLYTGWDA
MAV_2857|M.avium_104 DEFGVGDRVGIAWLRHTCGVCKYCRRGDENLCPE--------SRYTGWDA
MLBr_02053|M.leprae_Br4923 --FDVGDRVGIAWLRYTCGVCNYCRSGTENLCVQ--------SRYTGWDV
Mflv_3343|M.gilvum_PYR-GCK ETFAVGDRVGIAWLRHTCGACRYCTRGDENLCPQ--------SRYTGWDA
TH_2673|M.thermoresistible__bu TDFRVGDRVGIAWLRHTCGQCRYCRRGQENLCPE--------SRYTGWDA
Mvan_3073|M.vanbaalenii_PYR-1 SRFAVGDRVGIAWLRHTCGTCRYCLRGQENLCPE--------SRYTGWDA
MSMEG_3615|M.smegmatis_MC2_155 HGFAAGDRVGVAWLRYTCGRCAYCLRGRENLCPE--------SRYTGWDA
MAB_3400|M.abscessus_ATCC_1997 TKFKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQT
* **:.*:. : :* * * * *::* . . * :.
Rv1862|M.tuberculosis_H37Rv DGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELPPGG
Mb1893|M.bovis_AF2122/97 DGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRTELPPGG
MMAR_2739|M.marinum_M DGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRAELPPGG
MUL_3015|M.ulcerans_Agy99 DGGYAEFTTVPAAFAHHLPSGYSDSELAPLLCAGIIGYRSLLRAELPPGG
MAV_2857|M.avium_104 DGGYAEFATVPAAFAHPLPGGYSDSELAPLLCAGIIGYRALLRAQLPPGG
MLBr_02053|M.leprae_Br4923 DGGYAEFTTVPAAFAHHLPSGYSDCELAPLLCAGIIGYRSLLRSELPPGG
Mflv_3343|M.gilvum_PYR-GCK DGGYAEFATVPAAFALPLPSGYTDTELAPLLCAGIIGYRALLRADLPPGG
TH_2673|M.thermoresistible__bu DGGYAEFATVPAAYAHRLPAGYSDAELAPLLCAGIIGYRALRRAELPPGG
Mvan_3073|M.vanbaalenii_PYR-1 DGGYAEFATVPADFALRLPDGYSDTELAPLLCAGIIGYRALLRAELPPGG
MSMEG_3615|M.smegmatis_MC2_155 DGGYAEYTTVPAAYAHRLPGGYSDTELAPLLCAGIIGYRALMRTRLPASG
MAB_3400|M.abscessus_ATCC_1997 QGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGK
:***:: .* :. :* . . ******** : .* : ..
Rv1862|M.tuberculosis_H37Rv RLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAA
Mb1893|M.bovis_AF2122/97 RLGLYGFGGSAHITAQVALAQGAEIHVMTRGARARKLALQLGAASAQDAA
MMAR_2739|M.marinum_M RLGLYGFGGSAHITAQVALAQGAEVHVMTRGAEARELALELGAASAQGAA
MUL_3015|M.ulcerans_Agy99 RLGLYGFGGSAHITAQVALAQGAEVHVMTRGAEARELALELGAASAQGAA
MAV_2857|M.avium_104 RLGLYGFGGSAHITAQVALAQGAEVHVMTRGERARELAIELGAASAQGAA
MLBr_02053|M.leprae_Br4923 RLGIYGFGGSAHIAAQVALVQGAEVHVMTRGARAQELALELGAASAQGVA
Mflv_3343|M.gilvum_PYR-GCK RLGIYGFGGSAHLTAQVALAQGAEVHVMTRGALARELALALGAASAQGAA
TH_2673|M.thermoresistible__bu RLGIYGFGGSAHLTAQVALAQGAEVHVMTRGAQARELALALGAASAQGAA
Mvan_3073|M.vanbaalenii_PYR-1 RLGIYGFGGSAHLTAQVALAGGAEVHVMTRGEQARELALSLGAASAQGAA
MSMEG_3615|M.smegmatis_MC2_155 RLGIYGFGGSAHLTAQVALARGARVHVMTRSEQARELALALGAASAQGAT
MAB_3400|M.abscessus_ATCC_1997 RVAVVGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATA
*:.: *:** .*::.::. . **.: *:::. : .: ***: .:
Rv1862|M.tuberculosis_H37Rv DRPPVP-----LDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPD
Mb1893|M.bovis_AF2122/97 DRPPVP-----LDAAILFAPVGDLVLPALEALDRGGILAIAGIHLTDIPD
MMAR_2739|M.marinum_M DPPPVP-----LDAAILFAPVGELVLPALAGLDRGGTLAVAGIHLSDIPP
MUL_3015|M.ulcerans_Agy99 DPPPVP-----LDAAILFAPVGELVLPALAGLDRGGTLAVAGIHLSDIPP
MAV_2857|M.avium_104 DPPPVP-----LDAAILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPS
MLBr_02053|M.leprae_Br4923 DLPPVP-----LDAAIVFAPVGDLVLPACEALNRGGTLAIAGIHLSDIPQ
Mflv_3343|M.gilvum_PYR-GCK DPSPVP-----LDSAILFAPVGELVLPALEALDRGGTLAIAGIHLSDIPE
TH_2673|M.thermoresistible__bu DPPPVP-----LDAAILFAPVGHLVLPALEALDRGGTLSIAGIHLTDIPT
Mvan_3073|M.vanbaalenii_PYR-1 DPPPVP-----LDAAILFAPVGDLVLPAMEALDRGGTLSIAGIHLSDIPV
MSMEG_3615|M.smegmatis_MC2_155 DMPPEP-----LDAAILFAPVGDLVLPAMAALDRGGVLAIAGIHLSDIPS
MAB_3400|M.abscessus_ATCC_1997 DPDTFKSLRNSFDLILNTVSSNLDMGKYLGLLGVDGTLVELGLPENPIEV
* . :* : .. . : *. .* * *: . *
Rv1862|M.tuberculosis_H37Rv LNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADR
Mb1893|M.bovis_AF2122/97 LNYQQHLFQERQIRSVTSNTRADARAFFDFAAQHHIEVTTPEYPLGQADR
MMAR_2739|M.marinum_M LNYQRHLFQERQIRSVTSNTRGDARAFLNFAGQHHIEVTTPEYPLGQADR
MUL_3015|M.ulcerans_Agy99 LNYQRHLFQERQIRSVTSNTRGDARAFLNFAGQHHIEVTTPEYPLRQADR
MAV_2857|M.avium_104 LNYQRHLFQERQVRSVTSNTRADARAFLDFAGTHHISVTTPEYPLGQADR
MLBr_02053|M.leprae_Br4923 LNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHIAVTTPEYPLEQADQ
Mflv_3343|M.gilvum_PYR-GCK LNYQRHLFQERQLRSVTANTRADSREFLDFAARHRIEVTTEQYPLGRADE
TH_2673|M.thermoresistible__bu LDYQRHLFQERQVRSVTANTRDDARAFLDFAAQHRIEVTTPEYPLDRADD
Mvan_3073|M.vanbaalenii_PYR-1 LNYQRHLFRERQMRSVTANTRADAQAFLDFAAGHRLEVTSPRYPLDRADD
MSMEG_3615|M.smegmatis_MC2_155 LNYQDHLFQEREIRSVTANTRADAREFLSFVAEHRMQVTTPEYPLDRADQ
MAB_3400|M.abscessus_ATCC_1997 PGFP-LLTNRRSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDASYINE
.: * ..*.: . . ::: ::.* . * : :
Rv1862|M.tuberculosis_H37Rv ALGDLSAGRIAGAAVLLI---
Mb1893|M.bovis_AF2122/97 ALGDLSAGRIAGAAVLLI---
MMAR_2739|M.marinum_M ALSDLSAGRIAGAAVLIV---
MUL_3015|M.ulcerans_Agy99 ALSDLSAGRIAGAAVLIV---
MAV_2857|M.avium_104 ALADLSAGRIAGAAVLLV---
MLBr_02053|M.leprae_Br4923 ALTDLSVGRISGAAVLLA---
Mflv_3343|M.gilvum_PYR-GCK ALADLSAGRISGAGVLVV---
TH_2673|M.thermoresistible__bu ALTDLSEGRIAGAAVLRV---
Mvan_3073|M.vanbaalenii_PYR-1 ALGDLCTGRIAGAAVLVV---
MSMEG_3615|M.smegmatis_MC2_155 ALADLGAGRISGAAVLVL---
MAB_3400|M.abscessus_ATCC_1997 AYERVVASDVRYRFVIDTQTL
* : . : *: