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VSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLFRAGLLTEEQRDGLLAGLDSL AQDVADGSFGPLVTDEDVHAALERGLIDRVGPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDV VGALAEQAAAHPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPYGSGALAGSSL GLDPDAIAADLGFSAAADNSVDATAARDFAAEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWST GSSIMPQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL VASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAAEQRGVGLQELTDDELAAISP ELTPQVREVLTIEGSVSARDCRGGTAPGRVAEQLNAIGEAAERLRRQLVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1659 | argH | - | 100% (470) | argininosuccinate lyase |
| M. tuberculosis H37Rv | Rv1098c | fumC | 3e-15 | 24.87% (390) | fumarate hydratase |
| M. tuberculosis H37Rv | Rv0777 | purB | 2e-06 | 24.86% (358) | adenylosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1687 | argH | 0.0 | 100.00% (470) | argininosuccinate lyase |
| M. gilvum PYR-GCK | Mflv_3523 | - | 0.0 | 84.89% (470) | argininosuccinate lyase |
| M. leprae Br4923 | MLBr_01413 | argH | 0.0 | 87.87% (470) | argininosuccinate lyase |
| M. abscessus ATCC 19977 | MAB_2343 | - | 0.0 | 78.16% (467) | argininosuccinate lyase ArgH |
| M. marinum M | MMAR_2469 | argH | 0.0 | 90.21% (470) | argininosuccinate lyase ArgH |
| M. avium 104 | MAV_3111 | argH | 0.0 | 89.10% (468) | argininosuccinate lyase |
| M. smegmatis MC2 155 | MSMEG_3769 | argH | 0.0 | 85.04% (468) | argininosuccinate lyase |
| M. thermoresistible (build 8) | TH_1599 | argH | 0.0 | 84.83% (468) | Probable Argininosuccinate lyase argH |
| M. ulcerans Agy99 | MUL_1651 | argH | 0.0 | 90.43% (470) | argininosuccinate lyase |
| M. vanbaalenii PYR-1 | Mvan_3307 | - | 0.0 | 84.47% (470) | argininosuccinate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3523|M.gilvum_PYR-GCK MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDVVASKAHARVLF
Mvan_3307|M.vanbaalenii_PYR-1 MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDVVASKAHARVLF
Rv1659|M.tuberculosis_H37Rv MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLF
Mb1687|M.bovis_AF2122/97 MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLF
MMAR_2469|M.marinum_M MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
MUL_1651|M.ulcerans_Agy99 MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
MLBr_01413|M.leprae_Br4923 MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLF
MAV_3111|M.avium_104 MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILY
MSMEG_3769|M.smegmatis_MC2_155 MSTNEGSLWGGRFADGPSDALAALSKSTHFDWALAPYDIKASKAHARVLH
TH_1599|M.thermoresistible__bu VSTNKGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDITASKAHVRVLH
MAB_2343|M.abscessus_ATCC_1997 MSTNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLR
:**.:********* **: **.**********.*****: ** **. :*
Mflv_3523|M.gilvum_PYR-GCK RAGLLTEEQRDGLLAGLDSLGSDVADGSFGPLVSDEDVHGALERGLIDRV
Mvan_3307|M.vanbaalenii_PYR-1 RAGLLTEEQRDGLLAGLDSLGSDVADGSFGPLVSDEDVHGALERGLIDRV
Rv1659|M.tuberculosis_H37Rv RAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRV
Mb1687|M.bovis_AF2122/97 RAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRV
MMAR_2469|M.marinum_M RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIERV
MUL_1651|M.ulcerans_Agy99 RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIDRV
MLBr_01413|M.leprae_Br4923 RAGLLNEEQRDGLLAGLDNLAEDVADGSFLPLVTDEDVHAALERGLIDRV
MAV_3111|M.avium_104 RAGLLSEEQRDGLLAGLDSLAEDVADGSFTPLVTDEDVHAALERGLIDRV
MSMEG_3769|M.smegmatis_MC2_155 RAGLLTDEQRDGLLAGLDSLGSDVADGSFEPLPTDEDVHGALERGLIDRV
TH_1599|M.thermoresistible__bu RAGLLTDEQRDGLLDGLDRLADDVAAGRFVPDDTDEDVHGALERGLIERV
MAB_2343|M.abscessus_ATCC_1997 KAGLLTDEQLGALVEGLEQLGRDVASGVFVPADTDEDVHGALERGLIERV
:****.:** ..*: **: *. *** * * * :*****.*******:**
Mflv_3523|M.gilvum_PYR-GCK GPELGGRLRAGRSRNDQVATLFRLWLRDAVRRVADGVLEVVGALTTQAAA
Mvan_3307|M.vanbaalenii_PYR-1 GADLGGRLRAGRSRNDQVATLFRLWLRDAIRRVADGVLEVVAALATQAAA
Rv1659|M.tuberculosis_H37Rv GPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAA
Mb1687|M.bovis_AF2122/97 GPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAA
MMAR_2469|M.marinum_M GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
MUL_1651|M.ulcerans_Agy99 GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
MLBr_01413|M.leprae_Br4923 GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAE
MAV_3111|M.avium_104 GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALDVVGALVAQAAA
MSMEG_3769|M.smegmatis_MC2_155 GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVADGCLEVVNALAVQAAA
TH_1599|M.thermoresistible__bu GPELGGRLRAGRSRNDQVATLFRLWLRDAVRSVGAGVLDVVDALADQAAA
MAB_2343|M.abscessus_ATCC_1997 GPDIGGRLRAGRSRNDQVATLFRMWLRDAAGRISEGVLDVVQALADQAGA
*.::***************:***:***** :. * *:** ** **.
Mflv_3523|M.gilvum_PYR-GCK HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPY
Mvan_3307|M.vanbaalenii_PYR-1 HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPY
Rv1659|M.tuberculosis_H37Rv HPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPY
Mb1687|M.bovis_AF2122/97 HPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPY
MMAR_2469|M.marinum_M HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
MUL_1651|M.ulcerans_Agy99 HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
MLBr_01413|M.leprae_Br4923 HSSTIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPY
MAV_3111|M.avium_104 HPEAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRIVDFDKRAAVSPY
MSMEG_3769|M.smegmatis_MC2_155 HPTAIMPGKTHLQAAQPILLAHHLLAHAHPLLRDVDRLADFDDRTAVSPY
TH_1599|M.thermoresistible__bu HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLLDFDRRAAVSPY
MAB_2343|M.abscessus_ATCC_1997 HPDAIMPGKTHLQAAQPVLLAHHLLAHAQPLLRDVDRLVDWDRRTAVSPY
*. :*********:***:**********:*****: *: *:* *:*****
Mflv_3523|M.gilvum_PYR-GCK GSGALAGSSLGLDPDAIAEELGFAAAADNSIDATASRDFAAEAAFVFSMI
Mvan_3307|M.vanbaalenii_PYR-1 GSGALAGSSLGLDPDAIAEELGFAAAADNSIDATASRDFAAEAAFVFSMI
Rv1659|M.tuberculosis_H37Rv GSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFAAEAAFVFAMI
Mb1687|M.bovis_AF2122/97 GSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFAAEAAFVFAMI
MMAR_2469|M.marinum_M GSGALAGSSLGLDPDAIAADLGFTTAADNSVDATASRDFAAEAAFIFAMI
MUL_1651|M.ulcerans_Agy99 GSGALAGSSLGLDPDAIAADLGFTTAADNSVDATASRDFAAEAAFVFAMI
MLBr_01413|M.leprae_Br4923 GSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFAAEAAFVFAMI
MAV_3111|M.avium_104 GSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFAAEAAFVFAMI
MSMEG_3769|M.smegmatis_MC2_155 GSGALAGSSLGLDPDAIAEDLGFASAADNSVDATASRDFAAEAAFVFAQI
TH_1599|M.thermoresistible__bu GSGALAGSSLGLDPDAIAEELGFSAAADNSIDATAARDFAAEAAFVFAMT
MAB_2343|M.abscessus_ATCC_1997 GAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFAAEAGFVFAMI
*:**************:* :***.:*****:***::*******.*:*:
Mflv_3523|M.gilvum_PYR-GCK GVDLSRLAEDVILWSTTEFGYVELHDAWSTGSSIMPQKKNPDIAELARGK
Mvan_3307|M.vanbaalenii_PYR-1 GVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
Rv1659|M.tuberculosis_H37Rv AVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
Mb1687|M.bovis_AF2122/97 AVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MMAR_2469|M.marinum_M AVDLSRLAEDIIIWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MUL_1651|M.ulcerans_Agy99 AVDLSRLAEDIIIWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MLBr_01413|M.leprae_Br4923 AVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGK
MAV_3111|M.avium_104 GVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGK
MSMEG_3769|M.smegmatis_MC2_155 GVDLSRLAEDIILWSSTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
TH_1599|M.thermoresistible__bu GVDLSRLAEDIILWSTTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MAB_2343|M.abscessus_ATCC_1997 GIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGK
.:*****:**:*:*.:*****. *.*:***********************
Mflv_3523|M.gilvum_PYR-GCK SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Mvan_3307|M.vanbaalenii_PYR-1 SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Rv1659|M.tuberculosis_H37Rv SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Mb1687|M.bovis_AF2122/97 SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
MMAR_2469|M.marinum_M SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVVQLELLLPAMAGL
MUL_1651|M.ulcerans_Agy99 SGRLIGNLTGLLATLKSQPLAYNRDLQEDKEPVFDSVVQLELLLPAMAGL
MLBr_01413|M.leprae_Br4923 SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
MAV_3111|M.avium_104 SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDAVAQLELVLPAMAGL
MSMEG_3769|M.smegmatis_MC2_155 SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
TH_1599|M.thermoresistible__bu SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLRLLLPAMTGL
MAB_2343|M.abscessus_ATCC_1997 TGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVSQLELLLPAMAGL
:*******:*******:***************:**:* **.*:****:**
Mflv_3523|M.gilvum_PYR-GCK VATLRFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
Mvan_3307|M.vanbaalenii_PYR-1 VGTLRFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
Rv1659|M.tuberculosis_H37Rv VASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
Mb1687|M.bovis_AF2122/97 VASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
MMAR_2469|M.marinum_M VGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVPFRSAHEAAGAAVRTA
MUL_1651|M.ulcerans_Agy99 VGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVPFRSAHEAAGAAVRTA
MLBr_01413|M.leprae_Br4923 VASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVA
MAV_3111|M.avium_104 VGSLTFDVQRMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAA
MSMEG_3769|M.smegmatis_MC2_155 VGTLTFDEERMAELAPAGYTLATDIAEWLVRQGVPFRIAHEAAGAAVKVA
TH_1599|M.thermoresistible__bu VATLTFDTARMAELAPLGYTLATDMAEWLVRRGVPFRVAHEAAGAAVRAA
MAB_2343|M.abscessus_ATCC_1997 VATLRFHTERMAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVA
*.:* *. *** *** *:*****:***:**:*:*** ****** **:.*
Mflv_3523|M.gilvum_PYR-GCK EARGVGLEELEDAELAGIHPELTAEVRDVLSTEGSVNSRDARGGTAPIQV
Mvan_3307|M.vanbaalenii_PYR-1 EARGIGLEDLADAELTGIHPQLTADVREVLTTEGSVNSRDARGGTAPTQV
Rv1659|M.tuberculosis_H37Rv EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRV
Mb1687|M.bovis_AF2122/97 EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRV
MMAR_2469|M.marinum_M EERSVGLEELTDDELAAISPELTPQVRDVLTIEGSVSARDSRGGTAPKRV
MUL_1651|M.ulcerans_Agy99 EERSVGLEELTDDELAAISPELTPQVRDVLTIEGSVSARDSRGGTAPKRV
MLBr_01413|M.leprae_Br4923 EGRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQA
MAV_3111|M.avium_104 EQRAVGLDELTDDELAAISPALTPQVREVLTIEGSVSSRDARGGTAPARV
MSMEG_3769|M.smegmatis_MC2_155 EGRGVGLDALTDDEFASINPALTPDVREVLTVEGSVNARNARGGTAPTQV
TH_1599|M.thermoresistible__bu EARGIGLEELSDAELAEIHPELTPQVREVLTVEGSVNARDARGGTAPVQV
MAB_2343|M.abscessus_ATCC_1997 EARGVGLEDLTDEEFAAIHPELTGDVRAVLTTAGSVASRDARGGTAPERV
* *.:**: * * *:: * . ** :** **: *** :* .****** :.
Mflv_3523|M.gilvum_PYR-GCK ARQLGAVRDTADELRRRLRR---
Mvan_3307|M.vanbaalenii_PYR-1 ARQLSAVRDTSERFRVRLRR---
Rv1659|M.tuberculosis_H37Rv AEQLNAIGEAAERLRRQLVR---
Mb1687|M.bovis_AF2122/97 AEQLNAIGEAAERLRRQLVR---
MMAR_2469|M.marinum_M AEQLQIVREITARLGHELMR---
MUL_1651|M.ulcerans_Agy99 AEQLQIVREITARLGHELMR---
MLBr_01413|M.leprae_Br4923 AKQLTVVRANANQLRQLLMR---
MAV_3111|M.avium_104 VEQIDTVAATAARLRERLGGPA-
MSMEG_3769|M.smegmatis_MC2_155 AKQLGVVRKAMEELRIRLS----
TH_1599|M.thermoresistible__bu ARQLDLVRDTASRLRLRLEG---
MAB_2343|M.abscessus_ATCC_1997 AEQRELVLARLNVLRGQNGRHPG
..* : :