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M. gilvum PYR-GCK Mflv_3523 (-)

annotation: argininosuccinate lyase
coordinates: 3755513 - 3756925
length: 470

STNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDVVASKAHARVLFRAGLLTEEQRDGLLAGLDSLG
SDVADGSFGPLVSDEDVHGALERGLIDRVGPELGGRLRAGRSRNDQVATLFRLWLRDAVRRVADGVLEVV
GALTTQAAAHPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPYGSGALAGSSLG
LDPDAIAEELGFAAAADNSIDATASRDFAAEAAFVFSMIGVDLSRLAEDVILWSTTEFGYVELHDAWSTG
SSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLV
ATLRFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAAEARGVGLEELEDAELAGIHPE
LTAEVRDVLSTEGSVNSRDARGGTAPIQVARQLGAVRDTADELRRRLRR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_3523--100% (470)argininosuccinate lyase
M. gilvum PYR-GCKMflv_2065fumC2e-1229.44% (214) fumarate hydratase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1687argH0.084.89% (470) argininosuccinate lyase
M. tuberculosis H37RvRv1659argH0.084.89% (470) argininosuccinate lyase
M. leprae Br4923MLBr_01413argH0.082.13% (470) argininosuccinate lyase
M. abscessus ATCC 19977MAB_2343-0.079.14% (465) argininosuccinate lyase ArgH
M. marinum MMMAR_2469argH0.084.89% (470) argininosuccinate lyase ArgH
M. avium 104MAV_3111argH0.085.47% (468) argininosuccinate lyase
M. smegmatis MC2 155MSMEG_3769argH0.086.97% (468) argininosuccinate lyase
M. thermoresistible (build 8)TH_1599argH0.087.39% (468) Probable Argininosuccinate lyase argH
M. ulcerans Agy99MUL_1651argH0.085.11% (470) argininosuccinate lyase
M. vanbaalenii PYR-1Mvan_3307-0.094.89% (470) argininosuccinate lyase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3523|M.gilvum_PYR-GCK          MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDVVASKAHARVLF
Mvan_3307|M.vanbaalenii_PYR-1       MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDVVASKAHARVLF
Mb1687|M.bovis_AF2122/97            MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLF
Rv1659|M.tuberculosis_H37Rv         MSTNEGSLWGGRFAGGPSDALAALSKSTHFDWVLAPYDLTASRAHTMVLF
MMAR_2469|M.marinum_M               MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
MUL_1651|M.ulcerans_Agy99           MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
MLBr_01413|M.leprae_Br4923          MSTNQGSLWGGRFAAGPSEALVALSKSTHFDWVLAPYDITASRAHTKMLF
MAV_3111|M.avium_104                MSTREGSLWGGRFADGPSDALAALSKSTHFDWVLAPYDIVASRAHTVILY
MSMEG_3769|M.smegmatis_MC2_155      MSTNEGSLWGGRFADGPSDALAALSKSTHFDWALAPYDIKASKAHARVLH
TH_1599|M.thermoresistible__bu      VSTNKGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDITASKAHVRVLH
MAB_2343|M.abscessus_ATCC_1997      MSTNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLR
                                    :**.:********* **: **.**********.*****: ** **. :* 

Mflv_3523|M.gilvum_PYR-GCK          RAGLLTEEQRDGLLAGLDSLGSDVADGSFGPLVSDEDVHGALERGLIDRV
Mvan_3307|M.vanbaalenii_PYR-1       RAGLLTEEQRDGLLAGLDSLGSDVADGSFGPLVSDEDVHGALERGLIDRV
Mb1687|M.bovis_AF2122/97            RAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRV
Rv1659|M.tuberculosis_H37Rv         RAGLLTEEQRDGLLAGLDSLAQDVADGSFGPLVTDEDVHAALERGLIDRV
MMAR_2469|M.marinum_M               RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIERV
MUL_1651|M.ulcerans_Agy99           RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIDRV
MLBr_01413|M.leprae_Br4923          RAGLLNEEQRDGLLAGLDNLAEDVADGSFLPLVTDEDVHAALERGLIDRV
MAV_3111|M.avium_104                RAGLLSEEQRDGLLAGLDSLAEDVADGSFTPLVTDEDVHAALERGLIDRV
MSMEG_3769|M.smegmatis_MC2_155      RAGLLTDEQRDGLLAGLDSLGSDVADGSFEPLPTDEDVHGALERGLIDRV
TH_1599|M.thermoresistible__bu      RAGLLTDEQRDGLLDGLDRLADDVAAGRFVPDDTDEDVHGALERGLIERV
MAB_2343|M.abscessus_ATCC_1997      KAGLLTDEQLGALVEGLEQLGRDVASGVFVPADTDEDVHGALERGLIERV
                                    :****.:** ..*: **: *. *** * * *  :*****.*******:**

Mflv_3523|M.gilvum_PYR-GCK          GPELGGRLRAGRSRNDQVATLFRLWLRDAVRRVADGVLEVVGALTTQAAA
Mvan_3307|M.vanbaalenii_PYR-1       GADLGGRLRAGRSRNDQVATLFRLWLRDAIRRVADGVLEVVAALATQAAA
Mb1687|M.bovis_AF2122/97            GPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAA
Rv1659|M.tuberculosis_H37Rv         GPDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVATGVLDVVGALAEQAAA
MMAR_2469|M.marinum_M               GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
MUL_1651|M.ulcerans_Agy99           GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
MLBr_01413|M.leprae_Br4923          GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALEVVDALANQAAE
MAV_3111|M.avium_104                GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVAAGALDVVGALVAQAAA
MSMEG_3769|M.smegmatis_MC2_155      GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVADGCLEVVNALAVQAAA
TH_1599|M.thermoresistible__bu      GPELGGRLRAGRSRNDQVATLFRLWLRDAVRSVGAGVLDVVDALADQAAA
MAB_2343|M.abscessus_ATCC_1997      GPDIGGRLRAGRSRNDQVATLFRMWLRDAAGRISEGVLDVVQALADQAGA
                                    *.::***************:***:*****   :. * *:** **  **. 

Mflv_3523|M.gilvum_PYR-GCK          HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPY
Mvan_3307|M.vanbaalenii_PYR-1       HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPY
Mb1687|M.bovis_AF2122/97            HPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPY
Rv1659|M.tuberculosis_H37Rv         HPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFDKRAAVSPY
MMAR_2469|M.marinum_M               HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
MUL_1651|M.ulcerans_Agy99           HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
MLBr_01413|M.leprae_Br4923          HSSTIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVGRIVDFDKRAAVSPY
MAV_3111|M.avium_104                HPEAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRIVDFDKRAAVSPY
MSMEG_3769|M.smegmatis_MC2_155      HPTAIMPGKTHLQAAQPILLAHHLLAHAHPLLRDVDRLADFDDRTAVSPY
TH_1599|M.thermoresistible__bu      HPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLLDFDRRAAVSPY
MAB_2343|M.abscessus_ATCC_1997      HPDAIMPGKTHLQAAQPVLLAHHLLAHAQPLLRDVDRLVDWDRRTAVSPY
                                    *. :*********:***:**********:*****: *: *:* *:*****

Mflv_3523|M.gilvum_PYR-GCK          GSGALAGSSLGLDPDAIAEELGFAAAADNSIDATASRDFAAEAAFVFSMI
Mvan_3307|M.vanbaalenii_PYR-1       GSGALAGSSLGLDPDAIAEELGFAAAADNSIDATASRDFAAEAAFVFSMI
Mb1687|M.bovis_AF2122/97            GSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFAAEAAFVFAMI
Rv1659|M.tuberculosis_H37Rv         GSGALAGSSLGLDPDAIAADLGFSAAADNSVDATAARDFAAEAAFVFAMI
MMAR_2469|M.marinum_M               GSGALAGSSLGLDPDAIAADLGFTTAADNSVDATASRDFAAEAAFIFAMI
MUL_1651|M.ulcerans_Agy99           GSGALAGSSLGLDPDAIAADLGFTTAADNSVDATASRDFAAEAAFVFAMI
MLBr_01413|M.leprae_Br4923          GSGALAGSSLGLDPDAMAQDLGFPAAADNSVDATAARDFAAEAAFVFAMI
MAV_3111|M.avium_104                GSGALAGSSLGLDPDAIAAELGFASAADNSIDATASRDFAAEAAFVFAMI
MSMEG_3769|M.smegmatis_MC2_155      GSGALAGSSLGLDPDAIAEDLGFASAADNSVDATASRDFAAEAAFVFAQI
TH_1599|M.thermoresistible__bu      GSGALAGSSLGLDPDAIAEELGFSAAADNSIDATAARDFAAEAAFVFAMT
MAB_2343|M.abscessus_ATCC_1997      GAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFAAEAGFVFAMI
                                    *:**************:* :***.:*****:***::*******.*:*:  

Mflv_3523|M.gilvum_PYR-GCK          GVDLSRLAEDVILWSTTEFGYVELHDAWSTGSSIMPQKKNPDIAELARGK
Mvan_3307|M.vanbaalenii_PYR-1       GVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
Mb1687|M.bovis_AF2122/97            AVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
Rv1659|M.tuberculosis_H37Rv         AVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MMAR_2469|M.marinum_M               AVDLSRLAEDIIIWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MUL_1651|M.ulcerans_Agy99           AVDLSRLAEDIIIWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MLBr_01413|M.leprae_Br4923          AVDLSRLAEDIILWSSTEFGYARLHDSWSTGSSIMPQKKNPDIAELARGK
MAV_3111|M.avium_104                GVDLSRLAEDVILWSSTEFGYVKLHDAWSTGSSIMPQKKNPDIAELARGK
MSMEG_3769|M.smegmatis_MC2_155      GVDLSRLAEDIILWSSTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGK
TH_1599|M.thermoresistible__bu      GVDLSRLAEDIILWSTTEFGYVTLHDSWSTGSSIMPQKKNPDIAELARGK
MAB_2343|M.abscessus_ATCC_1997      GIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGK
                                    .:*****:**:*:*.:*****. *.*:***********************

Mflv_3523|M.gilvum_PYR-GCK          SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Mvan_3307|M.vanbaalenii_PYR-1       SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Mb1687|M.bovis_AF2122/97            SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
Rv1659|M.tuberculosis_H37Rv         SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
MMAR_2469|M.marinum_M               SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVVQLELLLPAMAGL
MUL_1651|M.ulcerans_Agy99           SGRLIGNLTGLLATLKSQPLAYNRDLQEDKEPVFDSVVQLELLLPAMAGL
MLBr_01413|M.leprae_Br4923          SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
MAV_3111|M.avium_104                SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDAVAQLELVLPAMAGL
MSMEG_3769|M.smegmatis_MC2_155      SGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGL
TH_1599|M.thermoresistible__bu      SGRLIGNLAGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLRLLLPAMTGL
MAB_2343|M.abscessus_ATCC_1997      TGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVSQLELLLPAMAGL
                                    :*******:*******:***************:**:* **.*:****:**

Mflv_3523|M.gilvum_PYR-GCK          VATLRFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
Mvan_3307|M.vanbaalenii_PYR-1       VGTLRFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAA
Mb1687|M.bovis_AF2122/97            VASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
Rv1659|M.tuberculosis_H37Rv         VASLTFNVQRMAELAPAGYTLATDLAEWLVRQGVPFRSAHEAAGAAVRAA
MMAR_2469|M.marinum_M               VGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVPFRSAHEAAGAAVRTA
MUL_1651|M.ulcerans_Agy99           VGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVPFRSAHEAAGAAVRTA
MLBr_01413|M.leprae_Br4923          VASLTFNVERMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGTAVRVA
MAV_3111|M.avium_104                VGSLTFDVQRMAALAPAGYTLATDIAEWLVRQGVPFRSAHEAAGAAVRAA
MSMEG_3769|M.smegmatis_MC2_155      VGTLTFDEERMAELAPAGYTLATDIAEWLVRQGVPFRIAHEAAGAAVKVA
TH_1599|M.thermoresistible__bu      VATLTFDTARMAELAPLGYTLATDMAEWLVRRGVPFRVAHEAAGAAVRAA
MAB_2343|M.abscessus_ATCC_1997      VATLRFHTERMAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVA
                                    *.:* *.  *** *** *:*****:***:**:*:*** ****** **:.*

Mflv_3523|M.gilvum_PYR-GCK          EARGVGLEELEDAELAGIHPELTAEVRDVLSTEGSVNSRDARGGTAPIQV
Mvan_3307|M.vanbaalenii_PYR-1       EARGIGLEDLADAELTGIHPQLTADVREVLTTEGSVNSRDARGGTAPTQV
Mb1687|M.bovis_AF2122/97            EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRV
Rv1659|M.tuberculosis_H37Rv         EQRGVGLQELTDDELAAISPELTPQVREVLTIEGSVSARDCRGGTAPGRV
MMAR_2469|M.marinum_M               EERSVGLEELTDDELAAISPELTPQVRDVLTIEGSVSARDSRGGTAPKRV
MUL_1651|M.ulcerans_Agy99           EERSVGLEELTDDELAAISPELTPQVRDVLTIEGSVSARDSRGGTAPKRV
MLBr_01413|M.leprae_Br4923          EGRGVGLEELTDDELAAISANLTPQVREVLTVEGSVSSRAARGGTAPSQA
MAV_3111|M.avium_104                EQRAVGLDELTDDELAAISPALTPQVREVLTIEGSVSSRDARGGTAPARV
MSMEG_3769|M.smegmatis_MC2_155      EGRGVGLDALTDDEFASINPALTPDVREVLTVEGSVNARNARGGTAPTQV
TH_1599|M.thermoresistible__bu      EARGIGLEELSDAELAEIHPELTPQVREVLTVEGSVNARDARGGTAPVQV
MAB_2343|M.abscessus_ATCC_1997      EARGVGLEDLTDEEFAAIHPELTGDVRAVLTTAGSVASRDARGGTAPERV
                                    * *.:**: * * *:: * . ** :** **:  *** :* .****** :.

Mflv_3523|M.gilvum_PYR-GCK          ARQLGAVRDTADELRRRLRR---
Mvan_3307|M.vanbaalenii_PYR-1       ARQLSAVRDTSERFRVRLRR---
Mb1687|M.bovis_AF2122/97            AEQLNAIGEAAERLRRQLVR---
Rv1659|M.tuberculosis_H37Rv         AEQLNAIGEAAERLRRQLVR---
MMAR_2469|M.marinum_M               AEQLQIVREITARLGHELMR---
MUL_1651|M.ulcerans_Agy99           AEQLQIVREITARLGHELMR---
MLBr_01413|M.leprae_Br4923          AKQLTVVRANANQLRQLLMR---
MAV_3111|M.avium_104                VEQIDTVAATAARLRERLGGPA-
MSMEG_3769|M.smegmatis_MC2_155      AKQLGVVRKAMEELRIRLS----
TH_1599|M.thermoresistible__bu      ARQLDLVRDTASRLRLRLEG---
MAB_2343|M.abscessus_ATCC_1997      AEQRELVLARLNVLRGQNGRHPG
                                    ..*   :      :