For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLKRVPWTVVLPSLAFVALVLTWGKQIGPVVGLLAAVLLAGAVLAAVNHAEVVAARVGEPFGSLVLAVAV TTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGIAGLSLLLGSLRYGVTLFNPHGSGAALATVTTL ATLSLVLPTFTTSQSGPELSPGQLIFAGAASLGLYVLFLFTQTVRHRDFFLPVAQKGAVEDDSHADPPST RAALLSLGLLLVALVAVVGLAKVESPVIEEVVSAAGFPQSFVGVVIATLVLLPETLAAARAARQGRLQTS LNLAYGSAMASIGLTIPTIALASLWLSGPLQLGLGAIQLVLLVLTVVVSVLTVVPGRATRLQGEVHLVLL AAYLFLAVVP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1607 | chaA | - | 100% (360) | Probable ionic transporter integral membrane protein chaA |
| M. tuberculosis H37Rv | Rv3273 | - | 4e-06 | 23.12% (385) | transmembrane carbonic anhydrase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1633 | chaA | 0.0 | 100.00% (360) | ionic transporter integral membrane protein chaA |
| M. gilvum PYR-GCK | Mflv_0842 | - | 6e-06 | 23.59% (390) | integral membrane protein MviN |
| M. leprae Br4923 | MLBr_01267 | - | 1e-154 | 77.75% (364) | putative antiporter |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_2409 | chaA | 1e-167 | 86.11% (360) | ionic transporter integral membrane protein ChaA |
| M. avium 104 | MAV_3179 | chaA | 1e-150 | 78.43% (357) | calcium/proton exchanger |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1607|M.tuberculosis_H37Rv ------------------------MLKR--VPWTVVLPSLAFVALVLTWG
Mb1633|M.bovis_AF2122/97 ------------------------MLKR--VPWTVVLPSLAFVALVLTWG
MMAR_2409|M.marinum_M ------------------------MWKR--LSWTVVAPLLALVALVLSWG
MLBr_01267|M.leprae_Br4923 ------------------------MLKR--IAWTALVPLFALAVLALTWG
MAV_3179|M.avium_104 ---------------------MSKWLSRNVLSWTVVVPVLAVVVLALIWG
Mflv_0842|M.gilvum_PYR-GCK MPDARPEMSDRAVVSRSWGMAVATLVSR-LTGFARIVLLAAILGAALSSA
.* :: : *. .* .
Rv1607|M.tuberculosis_H37Rv KQIGPVVGLLAAVLLAGAVLAAVNHAEVVAARVGEPFG------------
Mb1633|M.bovis_AF2122/97 KQIGPVVGLLAAVLLAGAVLAAVNHAEVVAARVGEPFG------------
MMAR_2409|M.marinum_M QHIGPVVGLLEAVLLAGAVLAAVHHAEVVAHRVGEPFG------------
MLBr_01267|M.leprae_Br4923 REIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEPFG------------
MAV_3179|M.avium_104 ERLGPVLVALAALFLIGAVVAAVHHAEVVAHRIGEPFG------------
Mflv_0842|M.gilvum_PYR-GCK FTVANQLPNMIAALVLEATFTAIFVPVLARAERDDPDGGAAFIRRLLTLA
:. : : * :: *..:*: . :. . .:* *
Rv1607|M.tuberculosis_H37Rv -SLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGIAGL
Mb1633|M.bovis_AF2122/97 -SLVLAVAVTTIEVALIVALMVSGGDDAATLARDTVFAAVMITTNGIAGL
MMAR_2409|M.marinum_M -SLVLAVAVTVIEVALIVTLMASGGHQAATLARDTVFAAVMITTNGIAGL
MLBr_01267|M.leprae_Br4923 -SLVLAAAVTVIEVALIVTLMASGENESWTLARDTAFAALMITTNGIAGF
MAV_3179|M.avium_104 -SLVLAAAVTIIEVALIVELMASGGNETATLARDTAFAALMITTNGIAGL
Mflv_0842|M.gilvum_PYR-GCK TALLLAVTIISTVGAPLLVNLMLGSEPLVNQPLTTAFAFLLLPQIIFYGL
:*:**.:: * :: : * . . . *.** :::. : *:
Rv1607|M.tuberculosis_H37Rv SLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPE---
Mb1633|M.bovis_AF2122/97 SLLLGSLRYGVTLFNPHGSGAALATVTTLATLSLVLPTFTTSQSGPE---
MMAR_2409|M.marinum_M SLLLGSQRYGVTLFNAHGSGTALATVTTLATLSLVLPTFTTSQPGPE---
MLBr_01267|M.leprae_Br4923 SLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNE---
MAV_3179|M.avium_104 SLLLGSRRYGVTLFNAEGSGAALATLTTLATLSLVLPAFTTTQVGKE---
Mflv_0842|M.gilvum_PYR-GCK SSVFMAILNTRNIFGPPAWAPVVNNVVAIATLGLYVLVPGELSLDPVRMG
* :: : .:*.. . ...: .:.::***.* : . .
Rv1607|M.tuberculosis_H37Rv ---------------LSPGQLIFAGAASLGLYVLFLFTQTVRHRDF----
Mb1633|M.bovis_AF2122/97 ---------------LSPGQLIFAGAASLGLYVLFLFTQTVRHRDF----
MMAR_2409|M.marinum_M ---------------FSPGQLGFAAVASLALYLLFVFTQTVRHRDF----
MLBr_01267|M.leprae_Br4923 ---------------FSPGQLAFAAVASLGLYLLFVFTQTIRHRDF----
MAV_3179|M.avium_104 ---------------FSPGQLTFAAVASLLVYLLFVFTQTVRHRDF----
Mflv_0842|M.gilvum_PYR-GCK DAKLLVLGIGTTLGVVAQAAVLFVAIRRERISLRPLWGIDARLKKFGMMA
.: . : *.. : : :: * :.*
Rv1607|M.tuberculosis_H37Rv -----FLPVAQKG-----AVEDDSHADPPSTR------------------
Mb1633|M.bovis_AF2122/97 -----FLPVAQKG-----AVEDDSHADPPSTR------------------
MMAR_2409|M.marinum_M -----FLPVAQKG-----AVDDDRHADPPSTR------------------
MLBr_01267|M.leprae_Br4923 -----FLPVAQKGQKG-LFEEDESHADPPSAR------------------
MAV_3179|M.avium_104 -----FLPIAQKGQKS-LFE-DESHADPPSTR------------------
Mflv_0842|M.gilvum_PYR-GCK LAMVLYVLVSQVGFIVGNQVASASAASGPAIYNYTWLILQLPFGIVGVTV
:: ::* * . *. *:
Rv1607|M.tuberculosis_H37Rv ----------------------AALLSLGLLLVALVAVVGLAKVESPVIE
Mb1633|M.bovis_AF2122/97 ----------------------AALLSLGLLLVALVAVVGLAKVESPVIE
MMAR_2409|M.marinum_M ----------------------AAMTSLALLLVALVAVVGLAKMESPIIE
MLBr_01267|M.leprae_Br4923 ----------------------SALISLALLLVALIAVVGLAELQSSAIE
MAV_3179|M.avium_104 ----------------------EALVSLVLLLCALVAVVGLAEEESPAVE
Mflv_0842|M.gilvum_PYR-GCK LTVVMPRLSRNAASGDGGAVLADLSLATRLTMLTLIPIVALMTVGGPAIG
: * : :*:.:*.* .. :
Rv1607|M.tuberculosis_H37Rv EVVSAAGFP---------------------------------------QS
Mb1633|M.bovis_AF2122/97 EVVSAAGFP---------------------------------------QS
MMAR_2409|M.marinum_M RMVVAAGFP---------------------------------------QS
MLBr_01267|M.leprae_Br4923 HLVTAVGFP---------------------------------------QP
MAV_3179|M.avium_104 RAVTAVGFP---------------------------------------QT
Mflv_0842|M.gilvum_PYR-GCK SALFSYGNFGAVDAGYLGMAITLSAFTLIPYTMVLLQLRVFYAREEPWTP
: : * .
Rv1607|M.tuberculosis_H37Rv FVGVVIATLVLLPETLAAARAARQG-------------------------
Mb1633|M.bovis_AF2122/97 FVGVVIATLVLLPETLAAARAARQG-------------------------
MMAR_2409|M.marinum_M FVGVIIATLVLLPETLAAGRAARQG-------------------------
MLBr_01267|M.leprae_Br4923 FVGVVIATLVLLPETLAAVRAARRG-------------------------
MAV_3179|M.avium_104 FVGVIIAALVLLPETLAAVRAARQG-------------------------
Mflv_0842|M.gilvum_PYR-GCK IVLIVVITIVKIAASLASPHLTDDPQLVAGYLGLANGLGFLAGATVGYLL
:* ::: ::* :. :**: : :
Rv1607|M.tuberculosis_H37Rv ---------------------RLQTSLNLAYGSAMASIGLTIPTIALASL
Mb1633|M.bovis_AF2122/97 ---------------------RLQTSLNLAYGSAMASIGLTIPTIALASL
MMAR_2409|M.marinum_M ---------------------RLQISLNLAYGSAMASIGLTIPTIALASI
MLBr_01267|M.leprae_Br4923 ---------------------RIQTSLNLAYGSAMASIGLTIPAIALASI
MAV_3179|M.avium_104 ---------------------RIQISLNLAYGSAMASIGLTIPAIALASI
Mflv_0842|M.gilvum_PYR-GCK LRARLDPPGGHLVSRDVVRTILVTITASLAAGLIAHIADQILGLEQLTEH
: : .** * . : *:.
Rv1607|M.tuberculosis_H37Rv WLSG--------------PLQLGLGAIQLVLLVLTVVVSVLTVVPGRATR
Mb1633|M.bovis_AF2122/97 WLSG--------------PLQLGLGAIQLVLLVLTVVVSVLTVVPGRATR
MMAR_2409|M.marinum_M WLSG--------------PLLLGLGALQLVLLVLTVVVSALTVLPGRATR
MLBr_01267|M.leprae_Br4923 WLTG--------------PLILGLGATQLVLLALTVVISVLTVVPGRATR
MAV_3179|M.avium_104 WLKG--------------PLVLGLGAIQLVLLALTVVISVLTVVPGRATR
Mflv_0842|M.gilvum_PYR-GCK WGGGGSLIRLAVLGLVMGPIILGVLIAAKVPDALAGVAAVRRRLGARGAT
* * *: **: * .*: * :. : .*.:
Rv1607|M.tuberculosis_H37Rv LQGEVHLVLLAAYLFLAVVP------------------------------
Mb1633|M.bovis_AF2122/97 LQGEVHLVLLAAYLFLAVVP------------------------------
MMAR_2409|M.marinum_M LQGELHLVVLAAYIFLAVSP------------------------------
MLBr_01267|M.leprae_Br4923 LQGEVHLVLLAAFVFLAIIP------------------------------
MAV_3179|M.avium_104 LQGEVHLVLLAAYVFLAVSP------------------------------
Mflv_0842|M.gilvum_PYR-GCK TGSPVPQMSPRALTYADRSNRRGPSAETADDGRRKGSAVSDKPTSDSPSG
. : : * :
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK PDSTAPPSGPNSTAPPSGPNSTAPPSGPNSTAPPSADDFQPDVPDSYQPD
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK PAADDSATTALPAQGVPTQSPSKSPTETPTEAVKRPRADYSNDPTREALA
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK FDPPREPAIETATPAEDTHLIPGATIAGGRYRLLVSHGGPEHLQFWQATD
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK TALDRQVALTFVAPDATMPDQQVQGILDRTQRLSQIDMPGVARVLDVLKT
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK ATGGLVVSEWIRGGSLAEVAATNPSPIGGARAIQSLAAAAEVAHRNGVAL
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK SIDHPSRIRVSIDGDVALAFPATLPDATPDDDIRGIGASLYALLINRWPL
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK PETGEPSGLAPAELDAAGQPAEPRSIDRDIPFQISAAAAHAVQEGGGIRS
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK APTLLNLLQQATAIADRTDHISPVDEPSPAAVADTSWSADPEDAEEAAAR
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK RRRNLTIGLSVAGVIVVVAVILLATVLSRIFGDVGSGLGGDELGLNAPSS
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK SQTDSPSTATGSALEPVRATVFSPEGEADAPDAASLAIDGDPSTVWPIDT
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK YTDPVPFPNFKNGVGLMLQLSEPARIGSVTVNLNSTGTAVQIRSSSTATP
Rv1607|M.tuberculosis_H37Rv --------------------------------------------------
Mb1633|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2409|M.marinum_M --------------------------------------------------
MLBr_01267|M.leprae_Br4923 --------------------------------------------------
MAV_3179|M.avium_104 --------------------------------------------------
Mflv_0842|M.gilvum_PYR-GCK SSLEDTTALTEPTTLKPGSNTIEVDDAEPTSYVLVWVSTLGQVGGQSRSD
Rv1607|M.tuberculosis_H37Rv ----------
Mb1633|M.bovis_AF2122/97 ----------
MMAR_2409|M.marinum_M ----------
MLBr_01267|M.leprae_Br4923 ----------
MAV_3179|M.avium_104 ----------
Mflv_0842|M.gilvum_PYR-GCK IAEITLNAAS