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VMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEV VGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRL RGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLR AIATLTHRGVEGAIVGKALYARRFTLPQALAAVRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1603 | hisA | - | 100% (245) | 1-(5-phosphoribosyl)-5- |
| M. tuberculosis H37Rv | Rv1605 | hisF | 3e-15 | 25.40% (248) | imidazole glycerol phosphate synthase subunit HisF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1629 | hisA | 1e-139 | 100.00% (245) | phosphoribosyl isomerase A |
| M. gilvum PYR-GCK | Mflv_3609 | - | 1e-120 | 87.55% (241) | 1-(5-phosphoribosyl)-5- |
| M. leprae Br4923 | MLBr_01261 | hisA | 1e-120 | 84.43% (244) | phosphoribosyl isomerase A |
| M. abscessus ATCC 19977 | MAB_2666c | - | 1e-108 | 78.10% (242) | phosphoribosyl isomerase A |
| M. marinum M | MMAR_2399 | hisA | 1e-125 | 89.34% (244) | phosphoribosylformimino-5-aminoimidazole carboxamide |
| M. avium 104 | MAV_3183 | - | 1e-126 | 90.91% (242) | 1-(5-phosphoribosyl)-5- |
| M. smegmatis MC2 155 | MSMEG_3209 | - | 1e-114 | 85.48% (241) | 1-(5-phosphoribosyl)-5- |
| M. thermoresistible (build 8) | TH_1159 | hisA | 1e-115 | 83.67% (245) | PROBABLE PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE |
| M. ulcerans Agy99 | MUL_1576 | hisA | 1e-124 | 88.93% (244) | phosphoribosyl isomerase A |
| M. vanbaalenii PYR-1 | Mvan_2808 | - | 1e-121 | 87.92% (240) | 1-(5-phosphoribosyl)-5- |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3609|M.gilvum_PYR-GCK -----MNASS----KLILLPAVDVVEGRAVRLVQGQAGSETEYGSALDAA
Mvan_2808|M.vanbaalenii_PYR-1 --MTSVNPSSSKPSALILLPAVDVVEGRAVRLVQGQAGSETEYGSALDAA
Rv1603|M.tuberculosis_H37Rv ------------MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAA
Mb1629|M.bovis_AF2122/97 ------------MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAA
MLBr_01261|M.leprae_Br4923 ------------MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAA
MAV_3183|M.avium_104 --------------MLILLPAVDVVDGRAVRLVQGKAGSETEYGSALDAA
MMAR_2399|M.marinum_M --------MKEETVPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAA
MUL_1576|M.ulcerans_Agy99 -------------MPLILLPAVDVVEGRAVRLVQGKAGSETEYGSALDAA
TH_1159|M.thermoresistible__bu -------------VSLILLPAVDVVDGKAVRLVQGQAGSETEYGSALDAA
MSMEG_3209|M.smegmatis_MC2_155 MATGATEAAGAGKRGLILLPAVDVVNGQAVRLVQGKAGSETDYGSAIEAA
MAB_2666c|M.abscessus_ATCC_199 -------------MSLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAA
*:*******.:*:*******:***:. ***. :**
Mflv_3609|M.gilvum_PYR-GCK MQWQSDGAEWIHLVDLDAAFGRGSNRELLADVVGRLDVAVELSGGIRDDE
Mvan_2808|M.vanbaalenii_PYR-1 MTWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVAVELSGGIRDDD
Rv1603|M.tuberculosis_H37Rv LGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDE
Mb1629|M.bovis_AF2122/97 LGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDE
MLBr_01261|M.leprae_Br4923 LCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVELSGGIRDDD
MAV_3183|M.avium_104 LGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVQVELSGGIRDDD
MMAR_2399|M.marinum_M LGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVAVELSGGIRDDD
MUL_1576|M.ulcerans_Agy99 LGWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVAVELSGGIRDDD
TH_1159|M.thermoresistible__bu LGWQRDGAEWIHLVDLDAAFGRGSNRELIAEVVGRLDVAVELSGGIRDHE
MSMEG_3209|M.smegmatis_MC2_155 EAWQRDGAEWIHLVDLDAAFGRGSNRELLAEVVGKLDVAVELSGGIRDDE
MAB_2666c|M.abscessus_ATCC_199 LAWQNDGAEWVHLVDLDAAFGRGSNRELLAQVVGELDVKVELSGGIRDDE
** ***:*:**************:**::::**.*** *********.:
Mflv_3609|M.gilvum_PYR-GCK SLAAALATGCARVNLGTAALENPQWCAKVVAEHGEKVAVGLDVKIE----
Mvan_2808|M.vanbaalenii_PYR-1 SLAAALATGCARVNLGTAALENPQWCAKVVAEHGDKVAVGLDVKIV----
Rv1603|M.tuberculosis_H37Rv SLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQII----
Mb1629|M.bovis_AF2122/97 SLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQII----
MLBr_01261|M.leprae_Br4923 SLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIV----
MAV_3183|M.avium_104 SLAAALATGCARVNLGTAALENPQWCARAIGEHGDKVAVGLDVQTI----
MMAR_2399|M.marinum_M SLAAALATGCARVNLGTAALENPQWCARMIAEHGEKVAVGLDVQIV----
MUL_1576|M.ulcerans_Agy99 SLAAALATGCARVNLGTAALENPQWCARMIAEHGEKVAVGLDVQIV----
TH_1159|M.thermoresistible__bu SLQAALATGCARVNLGTAALEDPQWCAEVIAEHGDKVAVGLDVKIDPSHP
MSMEG_3209|M.smegmatis_MC2_155 SLRAALDTGCARVNIGTAALENPQWCARAIAEHGDRVAVGLDAQTDG---
MAB_2666c|M.abscessus_ATCC_199 ALTAALATGCARVNLGTAALEDPEWCASAIARHGERVAVGLDVEIV----
:* *** *******:**** *:*.*** :..**:::*****.:
Mflv_3609|M.gilvum_PYR-GCK DGQYRLRGRGWETDGGDLWTVLERLDGEGCSRFVVTDVTKDGTLNGPNLD
Mvan_2808|M.vanbaalenii_PYR-1 DGQHRLRGRGWETDGGDLWTVLDRLDGEGCSRFVVTDVTKDGTLNGPNLE
Rv1603|M.tuberculosis_H37Rv DGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLD
Mb1629|M.bovis_AF2122/97 DGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGGPNLD
MLBr_01261|M.leprae_Br4923 DGQHRLRGRGWETDGGDLWDVLENLDRQGCSRFIVTDVTKDGTLDGPNLD
MAV_3183|M.avium_104 DGQHRLRGRGWETDGGDLWEVLERLERQGCSRYVVTDVTKDGTLGGPNLD
MMAR_2399|M.marinum_M DGKHRLRGRGWETDGGDLWEVLQRLDSEGCSRYVVTDVTKDGTLAGPNLE
MUL_1576|M.ulcerans_Agy99 GGKHRLRGRGWETDGGDLWEVLQRLDSEGCSRYVVTDVTKDGTLAGPNLE
TH_1159|M.thermoresistible__bu ESRHRLRGRGWESDGGDLWEVLERLNREGCSRYVVTDVTKDGTLKGPNLE
MSMEG_3209|M.smegmatis_MC2_155 AGGFRLRGRGWETDGGDLWEVLDRLDSEGCSRYVVTDVSKDGTLTGPNLD
MAB_2666c|M.abscessus_ATCC_199 EGAHRLRGRGWVSDGGDLWEVLERLRAQGCSRYVVTDVTKDGTLTGPNLE
. .******* :****** **:.* :****::***::***** ****:
Mflv_3609|M.gilvum_PYR-GCK LLAQVCERTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRF
Mvan_2808|M.vanbaalenii_PYR-1 LLTQVCERTDAPVIASGGVSSLDDLRAIATLTDRGVEGAIVGKALYAGRF
Rv1603|M.tuberculosis_H37Rv LLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRF
Mb1629|M.bovis_AF2122/97 LLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRF
MLBr_01261|M.leprae_Br4923 LLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERF
MAV_3183|M.avium_104 LLGAVADRTDAPVIASGGVSSLDDLRAIATLTGRGVEGAIVGKALYAGRF
MMAR_2399|M.marinum_M LLAGVAGRTEAPVIASGGVSSLDDLRAIATLTGQGVEGAIVGKALYAGRF
MUL_1576|M.ulcerans_Agy99 LLAGVAGRTEAPVIASGGVSSLDDLRAIATLTGQGVEGAIVGKALYAGRF
TH_1159|M.thermoresistible__bu LLKAVCDRTDAPVIASGGVSSLDDLRAIAALTDRGVEGAIVGKALYAGRF
MSMEG_3209|M.smegmatis_MC2_155 LLAAVAGRTDAPVIASGGVSSLDDLRAIATLTGVGVEGAIVGKALYAGRF
MAB_2666c|M.abscessus_ATCC_199 LLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRF
** *. ::.****************** :* *:*********** **
Mflv_3609|M.gilvum_PYR-GCK TLPQALDAVRT
Mvan_2808|M.vanbaalenii_PYR-1 TLPQALDAVGP
Rv1603|M.tuberculosis_H37Rv TLPQALAAVRD
Mb1629|M.bovis_AF2122/97 TLPQALAAVRD
MLBr_01261|M.leprae_Br4923 TLPQALAVVRM
MAV_3183|M.avium_104 TLPQALAAVAE
MMAR_2399|M.marinum_M TLPQALTAVRE
MUL_1576|M.ulcerans_Agy99 TLPQALTAVRE
TH_1159|M.thermoresistible__bu TLPEALAAVRQ
MSMEG_3209|M.smegmatis_MC2_155 TLPQALSAVSG
MAB_2666c|M.abscessus_ATCC_199 TLPDAIAAVS-
***:*: .*