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VVAAPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMCEAFQRTAVMDPDAVALRTPGGNQTMTW RDYAAQVRRVAAGLAGLGVRRGDTVSLMMANRIEFYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGT KVVICEQQYVDRVRASGVPIEHIVCVDGAPPARSR
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1549 | fadD11.1 | - | 100% (175) | POSSIBLE FATTY-ACID-CoA LIGASE FADD11.1 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
M. tuberculosis H37Rv | Rv3089 | fadD13 | 5e-11 | 31.03% (116) | chain-fatty-acid-CoA ligase |
M. tuberculosis H37Rv | Rv0166 | fadD5 | 2e-10 | 35.00% (100) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1576 | fadD11 | 6e-97 | 100.00% (167) | fatty-acid-CoA ligase |
M. gilvum PYR-GCK | Mflv_2962 | - | 2e-11 | 32.54% (126) | AMP-dependent synthetase and ligase |
M. leprae Br4923 | MLBr_00887 | - | 2e-08 | 32.91% (79) | putative long-chain-fatty-acid-CoA ligase |
M. abscessus ATCC 19977 | MAB_1865 | - | 2e-41 | 59.26% (135) | fatty-acid-CoA ligase FadD |
M. marinum M | MMAR_2370 | fadD11 | 4e-69 | 86.96% (138) | fatty-acid-CoA ligase, FadD11 |
M. avium 104 | MAV_3221 | - | 9e-67 | 83.21% (137) | putative acyl-CoA dehydrogenase |
M. smegmatis MC2 155 | MSMEG_3131 | - | 4e-17 | 37.40% (123) | AMP-binding protein |
M. thermoresistible (build 8) | TH_4043 | - | 9e-12 | 30.49% (164) | PUTATIVE AMP-dependent synthetase and ligase |
M. ulcerans Agy99 | MUL_1546 | fadD11 | 3e-69 | 86.96% (138) | fatty-acid-CoA ligase, FadD11 |
M. vanbaalenii PYR-1 | Mvan_1594 | - | 9e-14 | 31.25% (144) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment Rv1549|M.tuberculosis_H37Rv -------MVAAPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMC Mb1576|M.bovis_AF2122/97 MGRHGSRWSRPPCFRVLRLWTYAHRCDLGHTDPLSRRTEMTTTERPTTMC MMAR_2370|M.marinum_M ---------------------------------------MTPTERPTTMC MUL_1546|M.ulcerans_Agy99 ---------------------------------------MTPTERPTTMC MAV_3221|M.avium_104 ----------------------------------------MTAERPATLC MAB_1865|M.abscessus_ATCC_1997 ------------------------------------------MTGPATLC MSMEG_3131|M.smegmatis_MC2_155 ------------------------------------MSGGSATRDDATIV Mflv_2962|M.gilvum_PYR-GCK -----------------------------MTAREFTVPAPFTVEERDNIV MLBr_00887|M.leprae_Br4923 -------------------------------MREFSVPTRFSVGEHDNIA TH_4043|M.thermoresistible__bu ----------------MSIDSNQRSTSSPTTSRADTARAGLAENAPANLA Mvan_1594|M.vanbaalenii_PYR-1 ---------------------MKPGVPTLDRVVSPTATDSTVHDQAPSVA .: Rv1549|M.tuberculosis_H37Rv EAFQRTAVMDPDAVALRTPGGN--QTMTWRDYAAQVRRVAAGLAGLGVRR Mb1576|M.bovis_AF2122/97 EAFQRTAVMDPDAVALRTPGGN--QTMTWRDYAAQVRRVAAGLAGLGVRR MMAR_2370|M.marinum_M EAFQRSAAIDPDAIALRTPGGA--QTLTWREYADQVRQVAGGLAGLGVGR MUL_1546|M.ulcerans_Agy99 EAFQRSAAIDPDAIALRTPGGA--QTLTWREYADQVRQVAGGLAGLGVGR MAV_3221|M.avium_104 EAFQRNAAIDPDAVVLRTPGAT--QTLTWRELAEQVRKVAAGLAGLGVRR MAB_1865|M.abscessus_ATCC_1997 AAFQRTAAQHPDRVALRTVGGG--VVITWRQYRERVREIASGLAGLGVGP MSMEG_3131|M.smegmatis_MC2_155 EIFASRVRQLGDAVAIRDERLE--TAFTWREYGTAALRAAAKLRATGLQR Mflv_2962|M.gilvum_PYR-GCK GAVFTHERDDPDHVIFQRLVDGKWIDVTARQAAGQIRSAARGLIAEGVQA MLBr_00887|M.leprae_Br4923 AVVFEHERDDPNLVIYQRQIDGVWTDVTCAEAASQIRSAALGLIALGMQA TH_4043|M.thermoresistible__bu AMFFDRVRRSGDKEAFRKLDGDRWVSLTWNDTAAQVEAVAAGLLALGIAP Mvan_1594|M.vanbaalenii_PYR-1 RLFRDRVAATPAAEAFRFPDDGSWRSVTWQQVGDRVRLIAAGLIALGVAP . : .* : * * . *: Rv1549|M.tuberculosis_H37Rv GDTVSLMMANRIEFYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTK Mb1576|M.bovis_AF2122/97 GDTVSLMMANRIEFYPLDVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTK MMAR_2370|M.marinum_M GDTVSLMMANRVEFYPLEVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTK MUL_1546|M.ulcerans_Agy99 GDTVSLMMANRVEFYPLEVGAQHVGATSFSVYNTLPAEQLTYVFDNAGTK MAV_3221|M.avium_104 GDTVSLMMANRIEFYPLEIGAQHLGATSFSVYNTLPAEQLTYLFDNAGTK MAB_1865|M.abscessus_ATCC_1997 GDTVALMLTNRPEFHLCDTAVLHCGATPFSVYNTNPPELLGYQFDNADNR MSMEG_3131|M.smegmatis_MC2_155 GETVGLMLTNRPEFHIADMATLLAGATPFSLYPTSAPEQLAEILRNARCR Mflv_2962|M.gilvum_PYR-GCK GDRVALLSATRYEWPILDFAILSIGAVTVPIYETSSAEQVQFVLADSGAV MLBr_00887|M.leprae_Br4923 GDRVSIFSATCFEWAILDLAILSVGAVTVPIYETSSAKQVRWILQDSDAV TH_4043|M.thermoresistible__bu EDRVAIASSTRYEWVLADLAIMCAGAATTTVYPTSNAADTAYIIGDSGSR Mvan_1594|M.vanbaalenii_PYR-1 EDRVALASSTRYEWVLADFSVLCAGAATTTLYPTTNARDVAFIVANSGSR : *.: :. *: : . **.. .:* * . . :: Rv1549|M.tuberculosis_H37Rv VVICEQQYVDRVRAS----GVPIEHIVCVDGAPP---------------- Mb1576|M.bovis_AF2122/97 VVICEQQYVDRVRAS----GVPIEHIVCVDGAPPG---------TLSLTD MMAR_2370|M.marinum_M VVICEEQYVDRIRAS----GAPIEHIVCIDGAPEG---------TMSVQE MUL_1546|M.ulcerans_Agy99 VVICEEQYVDRIRAS----GAPIEHIVCIDGAPEG---------TMSVQE MAV_3221|M.avium_104 VAICEQQYVDRIRAS----GAPVEHIVCIDGAPPG---------TISVEQ MAB_1865|M.abscessus_ATCC_1997 VVICEQQFLPQVRSAV-GLGGKVEHIICVDGAPEG---------TLDLRS MSMEG_3131|M.smegmatis_MC2_155 ILITEPRFVRVLRAA-----VNLSDLTASTVITVG---------TPSWTD Mflv_2962|M.gilvum_PYR-GCK AAIAETDAHAAHIEAQRDTLPALRRIYVIDGS-----------VPALDEL MLBr_00887|M.leprae_Br4923 LVFAETDAHATMVNQLAGELPALRQVLQINSAG----------ATALDQL TH_4043|M.thermoresistible__bu VVFAEDATQLAKLTERRSELPNVDKVVLFDAAPDTPGDDWVTTLADLTAL Mvan_1594|M.vanbaalenii_PYR-1 IVIAEDQTQVDKLLEHRSELPDLEKIVIIDGDGDG---EFVITLDQLEEL : * : : Rv1549|M.tuberculosis_H37Rv ---ARSR------------------------------------------- Mb1576|M.bovis_AF2122/97 LYAAASGDFFDFESTWRAVQPEDIVTLIYTSGTTGNPKGVEMTHANLLFE MMAR_2370|M.marinum_M LYAAAPDD-FDFEATWAAVQPDDVVTLIYTSGTTGNPKGVEMTHANLLFE MUL_1546|M.ulcerans_Agy99 LYAAAPDD-FDFEATWAAVQPDDVVTLIYTSGTTGNPKGVEMTHANLLFE MAV_3221|M.avium_104 LYAAAPRD-FDFESTWRSVRPDDVVTLIYTSGTTGNPKGVEMTHANLLFE MAB_1865|M.abscessus_ATCC_1997 LPPAADFD---FESAWRSVRPDDVLTIVYTSGTTGPPKGVELTHTNFIEN MSMEG_3131|M.smegmatis_MC2_155 LVAEGESIDVDEALDACRAEPSDIATVIYTSGTTGAPKGVELTHHNIMSA Mflv_2962|M.gilvum_PYR-GCK AEAGASVDAAAVDERVASIRSTDAATLIYTSGTTGRPKGCQLTHSNLLYE MLBr_00887|M.leprae_Br4923 AEAGASVDVAQLANRLKTLRAQDPATLIYTSGTTGRPKGCQLTHSNLLYE TH_4043|M.thermoresistible__bu GEEHLRKHPTSVRDAVAGVRPDQLATLIYTSGTTGKPKGVRLPHRAWVYE Mvan_1594|M.vanbaalenii_PYR-1 GAQLLATSPDIVEQRIEGIRPDHLASIIYTSGTTGRPKGVRLPHRAWTYT Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 GYAIDEVLG--IRFGDRVTSFLPSAHIADRMTGLYLQEMFGTQVTAVADA MMAR_2370|M.marinum_M GFAIEEVFG--IQFGDRVTSFLPTAHIADRMTGLYLQEMFGTQVTAVADG MUL_1546|M.ulcerans_Agy99 GFAIEEVFG--IQFGDRVTSFLPTAHIADRMTGLYLQEMFGTQVTAVADG MAV_3221|M.avium_104 CHALNAVLP--SKFGDRVTSYLPSAHIADRAMGLYGLEVFGAQVTVVDDP MAB_1865|M.abscessus_ATCC_1997 ARITEEMGP--LGFDDRAVSYLPDAHAANRWLTHYQNLLYGLQITTVADP MSMEG_3131|M.smegmatis_MC2_155 TREIVDHIG--ARCDMWSVSYLPMAHIAERVSTHYAHILAGSTVVCCPDA Mflv_2962|M.gilvum_PYR-GCK IRGAKACFPEHLAKGEKLLVFLPLAHVLARALTIGAFSNG-VTLGFTSDI MLBr_00887|M.leprae_Br4923 VRGAKECLPTLLQPGQRLLVFLPLAHVLARALTLSAFTYK-MTVGFTSDI TH_4043|M.thermoresistible__bu GITVAEFG--TLGEDDLQLLWLPLAHAFGKVLISGQLACG-FASAIDGRV Mvan_1594|M.vanbaalenii_PYR-1 AAAIDSLG--ILRADDLNFLWLPLAHAFGKVMLALPLLVG-FPTAIDGRV Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 RTIAAALPDVRPTVWGAVPRVWEKLKAGIEFTVARETDEMKRQALAWAMS MMAR_2370|M.marinum_M RAIVSALPDVRPTVWGAVPRVWEKLKAGIEFTISHETDEMKKQALIWAMS MUL_1546|M.ulcerans_Agy99 RAIVSALPDVRPTVWGAVPRVWEKLKAGIEFTISHETDEMKKYALIWAMS MAV_3221|M.avium_104 RAIAAALPDVRPTVWAAVPRIWEKLKAGIEFTVANEQDEATRAALQWAMS MAB_1865|M.abscessus_ATCC_1997 KAVLSALTDVRPTLFLGVPRVWVKAKMGLDAALQ-EAGPLRRTLAHWAIG MSMEG_3131|M.smegmatis_MC2_155 TRLIPMLSDVQPEIFFAPPRIWEKLRAITASDLESGADKFR--------- Mflv_2962|M.gilvum_PYR-GCK KNLVPMFAVFQPTLVVSVPRVFEKVYN---TAELNAETGGKGKIFTAAAN MLBr_00887|M.leprae_Br4923 KNLLPMLAVFKPTVVVSVPRVFEKVYN---TAEQNAANEGKSRIFAMAAQ TH_4043|M.thermoresistible__bu DKIVENMGVVRPTFMGAAPRIFEKAHA----KVVTSQKGVKKKLFDAAFS Mvan_1594|M.vanbaalenii_PYR-1 DRIVDNLAAVRPTFMAAAPRIFEKAHARI-QAVVADEGGLKKRLFDWAVN Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 VAGKRANALLAGESMSDQLVAEWAKADESVLSKLRERLGFGELRWALSGA MMAR_2370|M.marinum_M VAAKRAEAMLADEPMSAEVVDEWTKADELVLSKLRERLGFGELRWAVSGA MUL_1546|M.ulcerans_Agy99 VAAKRAEAMLADEPMSAEVVDEWTKADELVLSKLRERLGFGELRWAVSGA MAV_3221|M.avium_104 VAAQRAAALVAGEQIPDELATEWARADKLVLSKLRERLGFGELRWAVSGA MAB_1865|M.abscessus_ATCC_1997 VGRRKARASSAGARLSALDNMTHALADRLVLSSIRARMGLDRVKVGASGA MSMEG_3131|M.smegmatis_MC2_155 ---------------------------------VRRNTGLARIEVALTGA Mflv_2962|M.gilvum_PYR-GCK TAIEYSKALDSGG-PGLVLKLKHALFDKLVYGKLRAALG-GRCHAAISGG MLBr_00887|M.leprae_Br4923 TAVEWSEASHRGG-PGLLLRARHAVFDRLVYRKLRAALG-GDCHASVSGG TH_4043|M.thermoresistible__bu VGREVDRRRFAGEKVPLPMQLAHGLFDRLVFSKIREVFG-GRIKFMISGA Mvan_1594|M.vanbaalenii_PYR-1 VGIEVSRAREGGATPSRLLALQHAIADRLVLSTIRERFG-GRLRFFVSAA Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 APIPKETLAFFAGIGIPIAEIWGMSELSCVATASHPRDGRLGTVGKLLPG MMAR_2370|M.marinum_M APIPKETLGFFCGIGIPITEIWGMSELSCVATASHPRDARLGSVGKLLPG MUL_1546|M.ulcerans_Agy99 APIPKETLGFFCGIGIPITEIWGMSELSCVATASHPRDARLGSVAKLLPG MAV_3221|M.avium_104 APIPKETLAFFAGIGIPIAEVWGMSELSCVAAVSHPRDARLGSVGKLLPG MAB_1865|M.abscessus_ATCC_1997 APIPVEVHEFLLALGIPICEGYGMTECTCAGTINRASRIKIGSVGIPAPG MSMEG_3131|M.smegmatis_MC2_155 APCPTGVVEYFHKLGVPLRETYGMSETAGPVLIADVDD--VGSVGRPLPG Mflv_2962|M.gilvum_PYR-GCK APLGARLGHFYRGVGLSIYEGYGLTETSAAITVNRVGDLRVGSVGKLVPG MLBr_00887|M.leprae_Br4923 APLGARLGHFYRGVGLTIHEGYGLTETSAAITLNQAGNVKVGTVGNLLPG TH_4043|M.thermoresistible__bu APLNRDIAEWFHAAGLLILEGYGLTETAAGAFINRPDNYRLGTVGQVFDG Mvan_1594|M.vanbaalenii_PYR-1 APLNRDIARWFDAIGIIVLEGYGLTETAAASFINRPGAYRFGTVGIPFPG Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 LQGKIAEDGEYLVRGPLVMKGYRKEPAKTAEAIDSDGWLHTGDVFDIDSD MMAR_2370|M.marinum_M LEGKIADDGEYLVRGPLVMKGYRKEAAKTAEAIDEDGWLHTGDIFDVDAD MUL_1546|M.ulcerans_Agy99 LEGKIADDGEYLVRGPLVMKGYRKEAAKTAEAIDEDGWLHTGDIFDVDAD MAV_3221|M.avium_104 LEGKIADDGEFLVRGPLVMKGYRKEPAKTAEAIDADGWLHTGDILEADAQ MAB_1865|M.abscessus_ATCC_1997 VEVSLGPDGEVLLRGKNIMRGYRKMPEKTAETVDPEGWLHTGDIGEIDAE MSMEG_3131|M.smegmatis_MC2_155 NEVRVADDGELLIRGPSVMARYRDRPDATAEALDERGWLHTGDVARIDGC Mflv_2962|M.gilvum_PYR-GCK NSMRLGEDGELLVRGGVVFNGYWGNEEETRAVFT-DGWFHTGDLGAIDDD MLBr_00887|M.leprae_Br4923 NSMRIADDGELLVRGNVVFSGYWHNEQGTIEAFT-EGWFKTGDLGAIDED TH_4043|M.thermoresistible__bu AQVRIADSGEVQIKGPNVMEGYHNLPDKTAEAITPDGWLRTGDKGELDAD Mvan_1594|M.vanbaalenii_PYR-1 TEVKIAADGEILLRSPGVMTAYHDLPEATARALDADGWFYTGDIGEIDDD Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 GYLRVVDRKKELIINAAGKNMSPANIENTILAA-CPMVGVMMAIGDGRTY MMAR_2370|M.marinum_M GYLRVVDRKKELIINAAGKNMSPANIENTILAA-CPMVGVLIAIGDGRPY MUL_1546|M.ulcerans_Agy99 GYLRVVDRKKELIINAAGNYMSPANIENTILAA-CPMVGVLIAIGDGRPY MAV_3221|M.avium_104 GYLRVVDRKKELIINAAGKNMSPANIENAILAA-CPMIGVMITIGDGRPY MAB_1865|M.abscessus_ATCC_1997 GYLKIVDRKKEIIINEAGKNMSPTNIENAITAN-TPLAGPVAVIGDRRPY MSMEG_3131|M.smegmatis_MC2_155 GRVRIVDRKKDLIINSSGKNMSPANIEARVREFGSPLVEHACVIGDGRPY Mflv_2962|M.gilvum_PYR-GCK GFLTIVGRKKEIIVTAGGKNVAPAQLED-RLR-AHPLISQAMAVGDQQPF MLBr_00887|M.leprae_Br4923 GFLTITGRKKEIIVTAGGKNVAPALLED-QLR-AHPLISQALVVGDAKPF TH_4043|M.thermoresistible__bu GFLTITGRIKDLFKTSGGKYIAPPAIEG-RFMALCPYAGHMLVFGEARNF Mvan_1594|M.vanbaalenii_PYR-1 GFLRITDRKKDLFKTSQGKYVAPSAVAA-AFKAVCPYVSEIIVYGEERPY Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 NTALLVFDADSLGPYAAQRG-L-DASPAALAADPEVIARIAAGVAEGNAK MMAR_2370|M.marinum_M NTALLVFDADSVGPYAAQHG-ISDASPAALAADPAVIARIAAGVVEGNAK MUL_1546|M.ulcerans_Agy99 NTALLVFDANLVGPYAAQHG-ISDASPAALAADPAVIARIAAGVVEGNAK MAV_3221|M.avium_104 NTALLVFDADSVGPYAARHG-LSDASPAALAADPDVIAQIAAGVAAGNAK MAB_1865|M.abscessus_ATCC_1997 NTALITLDPEALARFAERHG-LTGRQSE-LAESPVVRAAIDECVQNANRS MSMEG_3131|M.smegmatis_MC2_155 NVALIVVDP---------------AQAENFPTAEHLHTAVGAYVGRANAR Mflv_2962|M.gilvum_PYR-GCK IAALITVDTEAFPGWKERHHKASDASVADLADDPDLLAEIELAVKDANQA MLBr_00887|M.leprae_Br4923 VGALITIDPEAFNGWKQRNSKAADAAIGDLTTDPDLVAEVDAAVKQANLS TH_4043|M.thermoresistible__bu CVALITVDPDAIADWAKENG-LGDKSYRELVESEEVKQLIGGYVDQLNSE Mvan_1594|M.vanbaalenii_PYR-1 CVALVSLDGEAITDWAAKNG-LENLSYAELARHDATRELIAGYVDELNEQ Rv1549|M.tuberculosis_H37Rv -------------------------------------------------- Mb1576|M.bovis_AF2122/97 LSRVEQIKRFRILPTLWEPGGDEITLTMKLKRRRIAAKYSAEIEELYASE MMAR_2370|M.marinum_M LSRVEQIKRFRILPTLWEPGGDEITLTMKLKRRPIVTKYAAEIEELYAAK MUL_1546|M.ulcerans_Agy99 LSRVEQIKRFRILPTLWEPGGDEITLTMKLKRRPIVTKYAAEIEELYAAK MAV_3221|M.avium_104 LSRVEQIKRFRILPTLWEPGGDEITLTMKLKRKPIMAKYAEEIEQLYADP MAB_1865|M.abscessus_ATCC_1997 LSRVEQIKTFTVLPDVWEPGSEYLTPTTKLRRKPIEEHYCEVIDAMY--- MSMEG_3131|M.smegmatis_MC2_155 LSRVEQIKRFVVLTTQWLPGSDELTPTMKLKRSQIAKKYTAEIDALYSAA Mflv_2962|M.gilvum_PYR-GCK VSKAEAIRKFRILPVDFTEDTGELTPTLKVKRKVVAEKFAADIEALYAKG MLBr_00887|M.leprae_Br4923 VSHAESIRKFRILPVDFTEQTGELTPTMKVKRNVVAQKFASDIEAIYEKD TH_4043|M.thermoresistible__bu LNRWETIKKWALLPSDLSIEGGELTPSLKVKRAVVEEKNKELLDSFYS-- Mvan_1594|M.vanbaalenii_PYR-1 LNRWEQVKRFALLDRELSIAAGDLTPSLKAKRNVIVKNFADTIAELYA-- Rv1549|M.tuberculosis_H37Rv ----------------- Mb1576|M.bovis_AF2122/97 LRPQVYEPAAVPSTQPA MMAR_2370|M.marinum_M PGPHVHEPASAATVQPA MUL_1546|M.ulcerans_Agy99 PGPHVHEPASAATVQPA MAV_3221|M.avium_104 PPPEVHEPAAAAVQPV- MAB_1865|M.abscessus_ATCC_1997 ----------------- MSMEG_3131|M.smegmatis_MC2_155 PTEAVPT---------- Mflv_2962|M.gilvum_PYR-GCK ----------------- MLBr_00887|M.leprae_Br4923 ----------------- TH_4043|M.thermoresistible__bu ----------------- Mvan_1594|M.vanbaalenii_PYR-1 -----------------