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MQLGNQNTMRFAGRPQRFRQSAYPLFNPNSAIALGHPFGGSGARLMTTVLHHMPDKGIRYGLQTMCEGRG QANATIVELL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1135A | - | - | 100% (80) | POSSIBLE ACETYL-CoA ACETYLTRANSFERASE (ACETOACETYL-CoA THIOLASE) |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 6e-14 | 63.64% (55) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv1074c | fadA3 | 4e-10 | 52.00% (50) | acetyl-CoA acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1167 | - | 9e-44 | 100.00% (80) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_2116 | - | 2e-19 | 76.36% (55) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 1e-06 | 41.67% (48) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_0600 | - | 2e-13 | 60.00% (55) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_4318 | fadA6_3 | 4e-21 | 81.82% (55) | acetyl-CoA acetyltransferase FadA6_3 |
| M. avium 104 | MAV_1276 | - | 6e-22 | 85.45% (55) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_5199 | - | 2e-19 | 76.36% (55) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_0264 | fadA6 | 3e-20 | 80.00% (55) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_0971 | fadA6_3 | 6e-21 | 80.00% (55) | acetyl-CoA acetyltransferase FadA6_3 |
| M. vanbaalenii PYR-1 | Mvan_4589 | - | 2e-19 | 76.36% (55) | acetyl-CoA acetyltransferases |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1135A|M.tuberculosis_H37Rv --------------------------------------------------
Mb1167|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4318|M.marinum_M -MAEAVIVEAVRSPVGK-RNGALSGVHPADLSAQVLNGLADK-AGIDPEI
MUL_0971|M.ulcerans_Agy99 -MAEAVIVEAVRSPVGK-RNGALSGVHPADLSAQVLNGLADK-AGIDPEI
MAV_1276|M.avium_104 -MAEAVIVEAVRSPIGK-RNGGLSGVHPAELSAQVLNGLVDK-AGVDPGI
Mflv_2116|M.gilvum_PYR-GCK -MAEAVIVEAVRSAVGK-RNGALAGIHPAELSAQVLNGLVER-AGVDPAL
Mvan_4589|M.vanbaalenii_PYR-1 -MAEAVIVEAVRAPVGK-RNGALSGVHPAELSAQVLNGLVER-AGVDPAL
MSMEG_5199|M.smegmatis_MC2_155 -MAEAVIVEAVRSPVGK-RNGALSGIHPAELSAQVLNGLVER-AGVDPAL
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 -MSEAYIIDAVRTAVGK-RNGALSKVHPLDLGAATFKGLFDR-VDVDPDA
MLBr_02162|M.leprae_Br4923 MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDLDENL
Rv1135A|M.tuberculosis_H37Rv --------------------------------------------------
Mb1167|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4318|M.marinum_M VDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQQSVH
MUL_0971|M.ulcerans_Agy99 VDDVIWGCVMQAGEQALDIARTSLLTAGWPETVPGVTVDRQCGSSQQSVH
MAV_1276|M.avium_104 VDDVIWGCVMQAGEQALDIGRTALLTAGWPETVPGVTVDRQCGSSQQSIH
Mflv_2116|M.gilvum_PYR-GCK VDDVIWGCVMQAGEQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSLH
Mvan_4589|M.vanbaalenii_PYR-1 VDDVIWGCVMQAGEQALDIARTAALSAGWPETVAGVTVDRQCGSSQQTLN
MSMEG_5199|M.smegmatis_MC2_155 VDDVIWGCVMQAGEQALDIARTAVLSAGWPETVPGVTVDRQCGSSQQSLH
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 IDDVYMGVLDAIGGQAGNAGRLAWLAGGYPEEVPGATVDRQCGSSQQAIS
MLBr_02162|M.leprae_Br4923 ISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLEAVN
Rv1135A|M.tuberculosis_H37Rv --------------------------------------------------
Mb1167|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4318|M.marinum_M FAAAGVVAGHYDVVVAGGVESMSRTPMGSS-LANGGRP-------YSQTF
MUL_0971|M.ulcerans_Agy99 FAAAGVVAGHYDVVVAGGVESMSRTPMGSS-LANGGRP-------YSQTF
MAV_1276|M.avium_104 FAAAGVIAGHYDVVVAGGVESMSRTPMGAS-LANGGRP-------YPQAF
Mflv_2116|M.gilvum_PYR-GCK FAVAGVIAGHYDVVVAGGVESMSRTPMGSS-LANGGNP-------YGESF
Mvan_4589|M.vanbaalenii_PYR-1 FAVAGVIAGHYDVVVAGGVESMSRTPMGSS-LANGGNP-------YGESF
MSMEG_5199|M.smegmatis_MC2_155 FAVAGVVAGHYDVVVAGGVESMSRTPMGSS-LANGGNP-------YGESF
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 FAAQAVMSGTADLIVAGGFQNMSQIPISAA-MLVGKEYGFTSPTAESEGW
MLBr_02162|M.leprae_Br4923 TAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDP------------
Rv1135A|M.tuberculosis_H37Rv --------------------------------------------------
Mb1167|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4318|M.marinum_M LERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSGAFD
MUL_0971|M.ulcerans_Agy99 LERYDGRIPNQGLGAEMIAEQWGLSRTMLDEFSLMSHEKAAAAQDSGAFD
MAV_1276|M.avium_104 LDRYQGQIPNQGIGAEMIAEKWGFDRTALDEFSLASHEKAAAAQDSGAFD
Mflv_2116|M.gilvum_PYR-GCK KARYA-QTPNQGVGAEMIAEQWGLSRTQLDEFSLRSHEKAAAAQDSGAFK
Mvan_4589|M.vanbaalenii_PYR-1 KARYA-QTPNQGVGAEMIAEQWGFSRTQLDEFSLRSHEKAAAAQDSGAFK
MSMEG_5199|M.smegmatis_MC2_155 KARYD-KTPNQGVGAEMIAEQWGFSRTQLDEFSLRSHEKAAAAQDSGAFS
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 LHRYGDQEISQFRGAEMIAEKWDISREEMERFALSSHEKAFAAIRNGHFD
MLBr_02162|M.leprae_Br4923 ATNYDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGGYFA
Rv1135A|M.tuberculosis_H37Rv ---------------------------------------------M----
Mb1167|M.bovis_AF2122/97 ---------------------------------------------M----
MMAR_4318|M.marinum_M DQIVGIK--DQDGN--PVLKDEGIRRGTPMEKMAALKPAFKEDGVI----
MUL_0971|M.ulcerans_Agy99 DQIVGIK--DQDGN--PVLKDEGIRRGTPMEKMAALKPAFKEDGVI----
MAV_1276|M.avium_104 DQIVGIK--DQDGN--VVLKDEGIRRGTPMEKMASLKPAFKEDGVI----
Mflv_2116|M.gilvum_PYR-GCK DQIVGIKTKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFREDGVI----
Mvan_4589|M.vanbaalenii_PYR-1 DQIVGIKTKDADGNDTVVLEDGGIRRGGTVESMAKIKPAFKEDGVI----
MSMEG_5199|M.smegmatis_MC2_155 DQIVGIKTKDADGNDTVVLEDGGIRRGGTIEAMAGIKPAFKEDGVI----
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 NEIIPVGDFRVDEG----------PRESTLEKLASLNP-LVEGGRL----
MLBr_02162|M.leprae_Br4923 KSVVPVRD---QNGLLILDHDEHMRPDTSKEGLAKLKPAFEGLAAMGGFD
Rv1135A|M.tuberculosis_H37Rv -----------------QLGNQ----------------------------
Mb1167|M.bovis_AF2122/97 -----------------QLGNQ----------------------------
MMAR_4318|M.marinum_M -----------------HAGNSSQISDGSAALLFMSAEKAKSLGMKPIAR
MUL_0971|M.ulcerans_Agy99 -----------------HAGNSSQISDGSAALLFMSAEKAKSLGMKPIAK
MAV_1276|M.avium_104 -----------------HAGNSSQISDGSAAILFMSAEKAKELGLKPIAK
Mflv_2116|M.gilvum_PYR-GCK -----------------HAGNSSQISDGSAALLLMSAEKAKDLGLKPLAK
Mvan_4589|M.vanbaalenii_PYR-1 -----------------HAGNSSQISDGSAALLIMSAEKAKELGCKPLAK
MSMEG_5199|M.smegmatis_MC2_155 -----------------HAGNSSQISDGSAALLITSAEKAKELGLKPIAK
TH_0264|M.thermoresistible__bu --------------------------------------------------
MAB_0600|M.abscessus_ATCC_1997 -----------------TAALASQISDGGSATLVASERAVKAHGLTPRAR
MLBr_02162|M.leprae_Br4923 DVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRAR
Rv1135A|M.tuberculosis_H37Rv -NTMRFAGRP-------------QRFRQS--------AYPL---------
Mb1167|M.bovis_AF2122/97 -NTMRFAGRP-------------QRFRQS--------AYPL---------
MMAR_4318|M.marinum_M VHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNEAFAPVPL
MUL_0971|M.ulcerans_Agy99 VHTAVLAGADPVIMLTAPIPATQKVLKRSGLSIGDIGAYEVNEAFAPVPL
MAV_1276|M.avium_104 VHTATLAGADPVIMLTAPIPATQKVLKKSGLSIDDIGVYEVNEAFAPVPM
Mflv_2116|M.gilvum_PYR-GCK VHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPM
Mvan_4589|M.vanbaalenii_PYR-1 VHTAVLAGADPVIMLTAPIPATQKALKKSGLSVDQIGAFEVNEAFAPVPM
MSMEG_5199|M.smegmatis_MC2_155 VHTAVLAGADPVIMLTAPIPATQKALKKSGLSLDQIGAFEVNEAFAPVPM
TH_0264|M.thermoresistible__bu -------------------------------------VFEVNEAFAPVPM
MAB_0600|M.abscessus_ATCC_1997 VHHISARGDDPVFMLTGPIPATRYALEKTGLTMDDIDVVEINEAFAPVVL
MLBr_02162|M.leprae_Br4923 MVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVL
:
Rv1135A|M.tuberculosis_H37Rv ------------FNPNS-AIALGHPFGGSGARLMTTVLHHMPDKGIRYGL
Mb1167|M.bovis_AF2122/97 ------------FNPNS-AIALGHPFGGSGARLMTTVLHHMPDKGIRYGL
MMAR_4318|M.marinum_M AWLRDIGADENRLNPNGGAIALGHPLGGSGARLMTTLLYHMRDNGIRYGL
MUL_0971|M.ulcerans_Agy99 AWLCDIGADENRLNPNGGAIALGHPLGGSGARVMTTLLYHMRDNGIRYGL
MAV_1276|M.avium_104 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTLLYHMRDKGIRYGL
Mflv_2116|M.gilvum_PYR-GCK AWLKDIGADETKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
Mvan_4589|M.vanbaalenii_PYR-1 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
MSMEG_5199|M.smegmatis_MC2_155 AWLKDIGADEKKLNPNGGAIALGHPLGGSGARILTTLLYHMRDNNIQYGL
TH_0264|M.thermoresistible__bu AWLKDIGADEKKLNPNGGAIALGHPLGGSGARIMTTMLYHMRANGIRYGL
MAB_0600|M.abscessus_ATCC_1997 AWAKELDVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGGRYGL
MLBr_02162|M.leprae_Br4923 KFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERCNARRAL
.* *. *:*:***:*.:** :: *:: .: . : .*
Rv1135A|M.tuberculosis_H37Rv QTMCEGRGQANATIVELL
Mb1167|M.bovis_AF2122/97 QTMCEGRGQANATIVELL
MMAR_4318|M.marinum_M QTMCEGGGQANATVLELL
MUL_0971|M.ulcerans_Agy99 QTMCEGGGQANATVLELL
MAV_1276|M.avium_104 QTMCEGGGQANATIVELL
Mflv_2116|M.gilvum_PYR-GCK QTMCEGGGQANATILELL
Mvan_4589|M.vanbaalenii_PYR-1 QTMCEGGGQANATILELL
MSMEG_5199|M.smegmatis_MC2_155 QTMCEGGGQANATILELL
TH_0264|M.thermoresistible__bu QTMCEGGGQANATILELL
MAB_0600|M.abscessus_ATCC_1997 QTMCEGGGTANVTIIERL
MLBr_02162|M.leprae_Br4923 VTLCIGAGMGVATIIERV
*:* * * . .*::* :