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MSEAYIIDAVRTAVGKRNGALSKVHPLDLGAATFKGLFDRVDVDPDAIDDVYMGVLDAIGGQAGNAGRLA WLAGGYPEEVPGATVDRQCGSSQQAISFAAQAVMSGTADLIVAGGFQNMSQIPISAAMLVGKEYGFTSPT AESEGWLHRYGDQEISQFRGAEMIAEKWDISREEMERFALSSHEKAFAAIRNGHFDNEIIPVGDFRVDEG PRESTLEKLASLNPLVEGGRLTAALASQISDGGSATLVASERAVKAHGLTPRARVHHISARGDDPVFMLT GPIPATRYALEKTGLTMDDIDVVEINEAFAPVVLAWAKELDVDLKKVNPNGGAMALGHPLGATGAKLFAT MLNELERTGGRYGLQTMCEGGGTANVTIIERL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0600 | - | - | 100% (382) | acetyl-CoA acetyltransferase |
| M. abscessus ATCC 19977 | MAB_3455c | - | 9e-97 | 48.40% (405) | putative acyl-CoA thiolase |
| M. abscessus ATCC 19977 | MAB_0902 | - | 5e-73 | 41.58% (404) | beta-ketoadipyl-CoA thiolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3586c | fadA6 | 1e-179 | 79.02% (386) | acetyl-CoA acetyltransferase |
| M. gilvum PYR-GCK | Mflv_1484 | - | 1e-175 | 78.44% (385) | acetyl-CoA acetyltransferase |
| M. tuberculosis H37Rv | Rv3556c | fadA6 | 1e-179 | 79.02% (386) | acetyl-CoA acetyltransferase |
| M. leprae Br4923 | MLBr_02162 | fadA | 3e-70 | 39.90% (411) | acetyl-CoA acetyltransferase |
| M. marinum M | MMAR_5045 | fadA6_1 | 1e-177 | 79.27% (386) | acetyl-CoA acetyltransferase FadA6_1 |
| M. avium 104 | MAV_0604 | - | 0.0 | 80.57% (386) | acetyl-CoA acetyltransferase |
| M. smegmatis MC2 155 | MSMEG_6008 | - | 0.0 | 80.89% (382) | acetyl-CoA acetyltransferase |
| M. thermoresistible (build 8) | TH_2071 | fadA6 | 1e-180 | 79.79% (386) | PROBABLE ACETYL-CoA ACETYLTRANSFERASE FADA6 |
| M. ulcerans Agy99 | MUL_4119 | fadA6_1 | 1e-177 | 79.02% (386) | acetyl-CoA acetyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5282 | - | 1e-175 | 78.53% (382) | acetyl-CoA acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6008|M.smegmatis_MC2_155 ---MPEAYIIDAVRTPVGK-KNGSLAQVHPIDLGVHVFRSIFDRV-DVDP
TH_2071|M.thermoresistible__bu -MAVSEAYVIDAVRTPTGK-RNGSLAALHPIDLGVHAFRGIFDRN-DVDP
Mb3586c|M.bovis_AF2122/97 ---MTEAYVIDAVRTAVGK-RGGALAGIHPVDLGALAWRGLLDRT-DIDP
Rv3556c|M.tuberculosis_H37Rv ---MTEAYVIDAVRTAVGK-RGGALAGIHPVDLGALAWRGLLDRT-DIDP
MAV_0604|M.avium_104 ---MPEAYVIDAVRTAVGK-RGGSLAGIHPVDLGALGWRGLLDRV-DVDP
MMAR_5045|M.marinum_M ---MPEAYVIDAVRTAVGK-RGGALAGVHPVDLGALGWRGLLDRV-DVDP
MUL_4119|M.ulcerans_Agy99 ---MPEAYVIDAVRTAVGK-RGGALAGVHPVDLGALGWRGLLDRV-DVDP
Mflv_1484|M.gilvum_PYR-GCK MAVASEAYVIDAVRTAVGK-RNGSLAGVHPVDLGAAAWRGLFERN-DVDP
Mvan_5282|M.vanbaalenii_PYR-1 ---MAEAYVIDAVRTAIGK-RNGSLAGMHPVDLGAAGWRGLFARN-DVDP
MAB_0600|M.abscessus_ATCC_1997 ---MSEAYIIDAVRTAVGK-RNGALSKVHPLDLGAATFKGLFDRV-DVDP
MLBr_02162|M.leprae_Br4923 --MSEEAFIYEAIRTPRGKQKNGSLHEVKPVSLVVGLVEELRKRNPDLDE
**:: :*:**. ** :.*:* ::*:.* . . : * *:*
MSMEG_6008|M.smegmatis_MC2_155 GAVDDVIVGCVDAIGGQAGNIGRNAWLAAGYPEEVPGVTVDRQCGSSQQA
TH_2071|M.thermoresistible__bu AAVDDVVVGCVDAIGGQAGNIGRLMWLAAGYPEEVPGVTVDRQCGSSQQA
Mb3586c|M.bovis_AF2122/97 AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
Rv3556c|M.tuberculosis_H37Rv AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
MAV_0604|M.avium_104 AAVDDVIAGCVDAIGAQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
MMAR_5045|M.marinum_M AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
MUL_4119|M.ulcerans_Agy99 AAVDDVIAGCVDAIGGQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
Mflv_1484|M.gilvum_PYR-GCK GAVDDVIAGCVDAIGPQAGNIARLSWLAAGFPEEVPGVTVDRQCGSSQQA
Mvan_5282|M.vanbaalenii_PYR-1 GAVDDVIAGCVDAIGPQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQA
MAB_0600|M.abscessus_ATCC_1997 DAIDDVYMGVLDAIGGQAGNAGRLAWLAGGYPEEVPGATVDRQCGSSQQA
MLBr_02162|M.leprae_Br4923 NLISDVILGCVSPVGDQGGDIARATVLAAGLPVTAGGVQLNRFCASGLEA
:.** * :..:* *.*: .* **.* * . *. ::* *.*. :*
MSMEG_6008|M.smegmatis_MC2_155 ISFGAQAIMSGTADIILAGGMQNMSWVPISSAMIVGKELGFSTPTAESEY
TH_2071|M.thermoresistible__bu ISFGAQAIMSGTADIILAGGVQNMSQIPISSAMIVGKEFGFTSPTNESKY
Mb3586c|M.bovis_AF2122/97 ISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQ
Rv3556c|M.tuberculosis_H37Rv ISFGAQAIMSGTADVIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQ
MAV_0604|M.avium_104 ISFGAQAIMSGTADLIVAGGVQNMSQIPISSAMTVGEQFGFTSPTNESKQ
MMAR_5045|M.marinum_M ISFGAQAIMSGTADLIVAGGMQNMSQIPISSAMIVGEQFGFSSPTNESKQ
MUL_4119|M.ulcerans_Agy99 ISFGAQAIMSGTADLIVAGGMQNMSQIPISSAMIVGEQFGFSSPTNESKQ
Mflv_1484|M.gilvum_PYR-GCK ISFGAQAIMSGTADLIVAGGMQNMSQIPISSAMTVAEQFGFTSPTNESKS
Mvan_5282|M.vanbaalenii_PYR-1 ISFGAQAILSGTADLIVAGGMQNMSQIPISSAMIVGEQFGFTSPTNESKS
MAB_0600|M.abscessus_ATCC_1997 ISFAAQAVMSGTADLIVAGGFQNMSQIPISAAMLVGKEYGFTSPTAESEG
MLBr_02162|M.leprae_Br4923 VNTAAQKVRSGWDDLVLAGGVESMSRVPMGSD---GGAMGLDPATN----
:. .** : ** *:::***.:.** :*:.: . *: ..*
MSMEG_6008|M.smegmatis_MC2_155 WRHRYGDQEISQFRGSELIAERWDISREEMEQFALSSHQRAFAAIRAGHF
TH_2071|M.thermoresistible__bu WLHRYGDQEISQFRGAEMIAERWEISREDMERYALTSHERALAAIRAGRF
Mb3586c|M.bovis_AF2122/97 WLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAGHF
Rv3556c|M.tuberculosis_H37Rv WLHRYGDQEISQFRGSELIAEKWNLSREEMERYSLTSHERAFAAIRAGHF
MAV_0604|M.avium_104 WLHRYGDQEISQFRGSELIAEKWNLSREEMERYALTSHERAFAAIRGGHF
MMAR_5045|M.marinum_M WLHRYGDQEISQFRGSEMIAEKWNLSREEMEQYALTSHARAFAAIRGGRF
MUL_4119|M.ulcerans_Agy99 WLHRYGDQEISQFRGSEMIAEKWNLSREEMEQYALTSHARAFAAIRGGRF
Mflv_1484|M.gilvum_PYR-GCK WLHRYGDQEISQFRGSELIAEKWNLSREEMEQYALMSHHRAQAAIRAGHF
Mvan_5282|M.vanbaalenii_PYR-1 WLHRYGDQEISQFRGAEMIAEKWDISREDMEQFALTSNQRAQAAIRAGHF
MAB_0600|M.abscessus_ATCC_1997 WLHRYGDQEISQFRGAEMIAEKWDISREEMERFALSSHEKAFAAIRNGHF
MLBr_02162|M.leprae_Br4923 ----YDVMFVPQGIGADLIATIEGFSRDDVDVYALRSQEKAAAAWSGGYF
*. :.* *:::** :**:::: ::* *: :* ** * *
MSMEG_6008|M.smegmatis_MC2_155 DNEIVPV----GDFGVD--EGPR-ETTLEKMAALQPLVE-----GGR---
TH_2071|M.thermoresistible__bu DNEIIGVPVDGGEFRID--ETPR-ETSLEKMAALPTLTE-----GGR---
Mb3586c|M.bovis_AF2122/97 ENEIITVETESGPFRVD--EGPR-ESSLEKMAGLQPLVE-----GGR---
Rv3556c|M.tuberculosis_H37Rv ENEIITVETESGPFRVD--EGPR-ESSLEKMAGLQPLVE-----GGR---
MAV_0604|M.avium_104 DNEIITVETESGPFRVD--EGPR-ESSLEKMAGLKPLVE-----GGR---
MMAR_5045|M.marinum_M DNEILSVETESGPFRVD--EGPR-ESSLEKMAGLKTLVE-----GGR---
MUL_4119|M.ulcerans_Agy99 DNEILSVETESGPFRVD--EGPR-ESSLEKMAGLKTLVE-----GGR---
Mflv_1484|M.gilvum_PYR-GCK ENEIIPVQTDGAGFATD--EGPR-DTSLEKMAGLKTLVE-----GGR---
Mvan_5282|M.vanbaalenii_PYR-1 ENEIIDVD----GFRVD--ECPR-ETTLEKMAGLKTLVD-----GGR---
MAB_0600|M.abscessus_ATCC_1997 DNEIIPVG----DFRVD--EGPR-ESTLEKLASLNPLVE-----GGR---
MLBr_02162|M.leprae_Br4923 AKSVVPVRDQNGLLILDHDEHMRPDTSKEGLAKLKPAFEGLAAMGGFDDV
:.:: * : * * * ::: * :* * . : **
MSMEG_6008|M.smegmatis_MC2_155 --------------LTAALASQISDGASAVLLASEQAVKEHNLKPRARIH
TH_2071|M.thermoresistible__bu --------------MTAAVASQISDGASAVLLASEKAVKEHKLKPRARIH
Mb3586c|M.bovis_AF2122/97 --------------LTAAMASQISDGASAVLLASERAVKDHGLRPRARIH
Rv3556c|M.tuberculosis_H37Rv --------------LTAAMASQISDGASAVLLASERAVKDHGLRPRARIH
MAV_0604|M.avium_104 --------------LTAAMASQISDGASAVLLASERAVKDHGLQPRARIH
MMAR_5045|M.marinum_M --------------LTAAMASQISDGASAVLLASEQAVKDHGLTPRARIH
MUL_4119|M.ulcerans_Agy99 --------------LTAAMASQISDGASAVLLASEQAVKDHGLTPRARIH
Mflv_1484|M.gilvum_PYR-GCK --------------LTAAMASQISDGASAVLLASEDAVKAHGLKPRARIH
Mvan_5282|M.vanbaalenii_PYR-1 --------------LTAAMASQISDGASAVLLASENAVKVHNLKPRARIH
MAB_0600|M.abscessus_ATCC_1997 --------------LTAALASQISDGGSATLVASERAVKAHGLTPRARVH
MLBr_02162|M.leprae_Br4923 ALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSEAVGKSQGLTPRARMV
*.. :* * **.: .::.** . * : * ****:
MSMEG_6008|M.smegmatis_MC2_155 HISARGADPVMMLTGPIPATEYALKKTGLSIDDIDTVEINEAFAPVVLAW
TH_2071|M.thermoresistible__bu HISARGDDPVLMLTGPIPATRYALEKTGLSMDDIDVVEINEAFAPVVIAW
Mb3586c|M.bovis_AF2122/97 HISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAW
Rv3556c|M.tuberculosis_H37Rv HISARAADPVFMLTGPIPATRYALDKTGLAIDDIDTVEINEAFAPVVMAW
MAV_0604|M.avium_104 HISARAADPVFMLTGPIPATRYALDKTGLSIDDIDTVEINEAFAPVVLAW
MMAR_5045|M.marinum_M HISARAADPVFMLTGPIPATRHALEKTGLSIDDIATVEINEAFAPVVLAW
MUL_4119|M.ulcerans_Agy99 HISARAADPVFMLTGPIPATRHALEKTGLSIDDIATVEINEAFAPVVLAW
Mflv_1484|M.gilvum_PYR-GCK HISARGADPVFMLTGPIPATRYALDKTGLTIDDIDTVEINEAFAPVVQAW
Mvan_5282|M.vanbaalenii_PYR-1 HISARGADPVFMLTGPIPATQYALDRAGLTIEDIDTVEINEAFAPVVQAW
MAB_0600|M.abscessus_ATCC_1997 HISARGDDPVFMLTGPIPATRYALEKTGLTMDDIDVVEINEAFAPVVLAW
MLBr_02162|M.leprae_Br4923 ATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKF
:: . ***:***** ***. .*.::**:::** .*:*****.** :
MSMEG_6008|M.smegmatis_MC2_155 IKDLKADPEKVNPNGGAIALGHPLGATGAKLFATMLNTLERTGGRYGLQT
TH_2071|M.thermoresistible__bu EKELKVDHAKVNPNGGAIALGHPLGATGAKLFATMLNELERTGGRYGLQT
Mb3586c|M.bovis_AF2122/97 LKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQT
Rv3556c|M.tuberculosis_H37Rv LKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELERIGGRYGLQT
MAV_0604|M.avium_104 LKEIKADPEKVNPNGGAIALGHPLGATGAKLFATMLNELERIGGRYGLQT
MMAR_5045|M.marinum_M LKEIKADPEKVNPNGGAIALGHPLGATGAKLFTTMLNELDRVGGRYGLQT
MUL_4119|M.ulcerans_Agy99 LKEIKADPEKVNPNGGAIALGHPLGATGAKLFTTMLNELDRVGGRYGLHT
Mflv_1484|M.gilvum_PYR-GCK LKETKADPEKVNPSGGAIALGHPLGATGAKLFATMLNTLERTGGRYGLQT
Mvan_5282|M.vanbaalenii_PYR-1 LKETKADPEKVNPNGGAIALGHPLGATGAKLFATMLNTLERTGGRYGLQT
MAB_0600|M.abscessus_ATCC_1997 AKELDVDLKKVNPNGGAMALGHPLGATGAKLFATMLNELERTGGRYGLQT
MLBr_02162|M.leprae_Br4923 QKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERCNARRALVT
*: . *:* .***:*:********* :: **:. *:* ..* .* *
MSMEG_6008|M.smegmatis_MC2_155 MCEGGGTANVTIIERL-
TH_2071|M.thermoresistible__bu MCEGGGTANVTIIERL-
Mb3586c|M.bovis_AF2122/97 MCEGGGTANVTIIERL-
Rv3556c|M.tuberculosis_H37Rv MCEGGGTANVTIIERL-
MAV_0604|M.avium_104 MCEGGGTANVTIIERL-
MMAR_5045|M.marinum_M MCEGGGTANVTIIERL-
MUL_4119|M.ulcerans_Agy99 MCEGGGTANVTIIERL-
Mflv_1484|M.gilvum_PYR-GCK MCEGGGTANVTIIERLS
Mvan_5282|M.vanbaalenii_PYR-1 MCEGGGTANVTIIERL-
MAB_0600|M.abscessus_ATCC_1997 MCEGGGTANVTIIERL-
MLBr_02162|M.leprae_Br4923 LCIGAGMGVATIIERV-
:* *.* . .*****: