For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
CAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAGDAVTLHRILSS MERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPV DSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGK YIPRLGGMAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGG PIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1043c | - | - | 100% (341) | hypothetical protein Rv1043c |
| M. tuberculosis H37Rv | Rv3671c | - | 3e-08 | 26.19% (168) | membrane-associated serine protease |
| M. tuberculosis H37Rv | Rv0125 | pepA | 3e-07 | 29.82% (171) | serine protease PepA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1072c | - | 0.0 | 99.41% (341) | hypothetical protein Mb1072c |
| M. gilvum PYR-GCK | Mflv_1376 | - | 6e-07 | 25.44% (169) | colicin V production protein |
| M. leprae Br4923 | MLBr_02298 | - | 3e-11 | 30.36% (168) | putative membrane-associated serine protease |
| M. abscessus ATCC 19977 | MAB_0421 | - | 2e-07 | 24.40% (168) | membrane-associated serine protease |
| M. marinum M | MMAR_5159 | - | 1e-08 | 26.63% (169) | membrane-associated serine protease |
| M. avium 104 | MAV_0459 | - | 5e-10 | 26.35% (167) | serine protease |
| M. smegmatis MC2 155 | MSMEG_5486 | - | 7e-07 | 25.64% (234) | peptidase S1 and S6, chymotrypsin/Hap |
| M. thermoresistible (build 8) | TH_1677 | - | 2e-07 | 26.94% (193) | Trypsin |
| M. ulcerans Agy99 | MUL_4245 | - | 7e-08 | 26.67% (165) | membrane-associated serine protease |
| M. vanbaalenii PYR-1 | Mvan_5430 | - | 9e-07 | 25.15% (167) | colicin V production protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1376|M.gilvum_PYR-GCK -----MNSSQWLDIAILAVAMLAAVSGWRSGAPGSLMALVGVVLGAGAGI
Mvan_5430|M.vanbaalenii_PYR-1 -----MNSSQWLDISILALALIAAISGWRSGAPGSLLALVGVALGAAAGI
MAB_0421|M.abscessus_ATCC_1997 ---MNLNPSQWLDIGVIAVAFIAAVSGWRSGALGSLMSFVGVILGAVAGI
MMAR_5159|M.marinum_M --MNSMTPSQWLDIAVLAVAFIAAVSGWRSGALGSMLSFAGVLLGAIAGV
MUL_4245|M.ulcerans_Agy99 --MNSMTPSQWLDIAVLAVAFIAAVSGWRSGALGSMLSFAGVLLGAIAGV
MAV_0459|M.avium_104 MNLNSMTPSQWLDVAVLAVAFIAAISGWRSGALGSLLSFVGVLLGAIAGV
MLBr_02298|M.leprae_Br4923 --MSSMTLSEWLDIAVLAVAFIAAISGWRSGALGSLLSLIGVLFGAMAGV
Rv1043c|M.tuberculosis_H37Rv -----MCAHQFFG--LVHNPVVAAAIGKPEPPP------VDSDIGLPTTV
Mb1072c|M.bovis_AF2122/97 -----MCAHQFFG--LVHNPVVAAAIGKPEPPP------VDSDIGLPTTV
MSMEG_5486|M.smegmatis_MC2_155 -------MTNHPRYSQQPDPRTGATPGYPGGRPDPYQQTSQYDWRYAQQV
TH_1677|M.thermoresistible__bu -----MGAHRLVRRPWLYLIALVATLGLLSPAFP------------VTSV
. * * :
Mflv_1376|M.gilvum_PYR-GCK LLAPHVVDHISGPRTKLFATLFLILVLVVIGEIAGVVLGRAVRGAIRNPG
Mvan_5430|M.vanbaalenii_PYR-1 LLAPHVVSHISGPRTKLFVTLFLILALVVIGEIAGVVLGRAVRGAIRSPG
MAB_0421|M.abscessus_ATCC_1997 MLAPHVVANIEGSRTKLFASLLLILVLVVIGEVAGVVLGRAMRGAIRNRV
MMAR_5159|M.marinum_M LLAPHIVSHINAPRAKLFAALFLILGLVVVGEVAGVVLGRAVRGAIRNRP
MUL_4245|M.ulcerans_Agy99 LLAPHIVSHINAPRAKLFAALFLILGLVVVGEVAGVVLGRAVRGAIRNRP
MAV_0459|M.avium_104 LLAPHLVSHIAAPRAKLFAALFLILALVVIGEVAGVVLGRAVRGAIRSRS
MLBr_02298|M.leprae_Br4923 LLVPHVVSHISAPRAKLFAALFLILALVVIGEVVGVVLGRAVRSANRSRT
Rv1043c|M.tuberculosis_H37Rv PFEPWSVADFSR----------YLSTLGLPAAGDAVTLHRILSSMERAG-
Mb1072c|M.bovis_AF2122/97 PFEPWSVADFSR----------YLSTLGLPAAGDAVTLHRILSSMERAG-
MSMEG_5486|M.smegmatis_MC2_155 QQAPQSPQTHQTQPGFRPAYDPYRAPSTAQPVAIPAKKRSRAGLAAGALA
TH_1677|M.thermoresistible__bu AQPPDVLAAASR----------------VEPAVARIDTRIDYQRAIGVG-
*
Mflv_1376|M.gilvum_PYR-GCK LRIVDSVVGVALQLVLVLTAAWLLGTALVSS-PQPNLAAAVSGSRVIAEV
Mvan_5430|M.vanbaalenii_PYR-1 LRVADSVVGVALQLVLVLTAAWLLGTALVSS-PQPNLAAAVQGSKVIAEV
MAB_0421|M.abscessus_ATCC_1997 LRTGDSVVGVVLQVAAVLVAAWLLSIPMQSS-NQPNISAAARESKVLSQV
MMAR_5159|M.marinum_M IRVIDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAQV
MUL_4245|M.ulcerans_Agy99 IRVIDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAQV
MAV_0459|M.avium_104 IRTVDSVIGVGVQLVVVLTAAWLLATPLTQSKDQPELAAAVRGSRVLAKV
MLBr_02298|M.leprae_Br4923 VRLVDSVIGVGVQLIVVLTAAWLLATPLTQSKEQPELASAVRGSRALASV
Rv1043c|M.tuberculosis_H37Rv -----------------------LLLPLGWDPRLPVMGQKYISQGAISKG
Mb1072c|M.bovis_AF2122/97 -----------------------LLLPLGWDPRLPVMGQKYISQGTISKG
MSMEG_5486|M.smegmatis_MC2_155 VAVVSAGIGGGVATLVHNESPQLGSPAIGAAPTVPAAALPAGSVEQVAAK
TH_1677|M.thermoresistible__bu -----------------------AGIVLHPNGEVLTNFHVVQGADTITAT
: ::
Mflv_1376|M.gilvum_PYR-GCK DAVAPDWLRSVPDRMS------------SVWENAGLHDVLKPFGPTPVAA
Mvan_5430|M.vanbaalenii_PYR-1 DSVAPSWLRSVPNRLS------------ALWETAGLHDVLKPFGPTPVAE
MAB_0421|M.abscessus_ATCC_1997 DKYAPDQLRKVPNDLS------------KLLDTSGLPSVLQPFGKTPIAA
MMAR_5159|M.marinum_M NEVAPTWLKTVPKRLS------------GLLNTSGLPAVLEPFSRTPVIP
MUL_4245|M.ulcerans_Agy99 NAVAPTWLKTVPKRLS------------GLLNTSGLPAVLEPFSRTPVIP
MAV_0459|M.avium_104 NEVAPPWLKTVPKRLS------------ALLNTSGLPAVLEPFSRTPVIP
MLBr_02298|M.leprae_Br4923 NEVAPPWLKTVPKRLS------------ALLNTSGLPAVLEPFSRTPVLP
Rv1043c|M.tuberculosis_H37Rv QRGGNLWLSEVFGAEL------------IIPSYNAVTVQLAGHDDAGNPV
Mb1072c|M.bovis_AF2122/97 QRGGNLWLSEVFGAEL------------IIPSYNAVTVQLAGHDDAGNPV
MSMEG_5486|M.smegmatis_MC2_155 VVPSVVKLETDLGRASEEGSGIILTADGLILTNNHVVAAAKGDGPGPAAQ
TH_1677|M.thermoresistible__bu VNGQPFPAELIGYNRR----------------QDIAVLQLHGAAGLPVAP
Mflv_1376|M.gilvum_PYR-GCK VDAPDPALATSPVVNQ-----TRSSVVKVKGVAQSCQKVLEGTGFVVAPN
Mvan_5430|M.vanbaalenii_PYR-1 IDPPDPSLATSPVVNT-----TRSSVVKVRGVAQSCQKVLEGTGFVVAPN
MAB_0421|M.abscessus_ATCC_1997 VDAPDATLADGPVVRG-----SEPSVVKIKGIARSCQKSLEGTGFVIAPH
MMAR_5159|M.marinum_M VASPDPALARNPVVEA-----TAPSVLKIRSLAPSCQKVLEGSGFVIAPD
MUL_4245|M.ulcerans_Agy99 VASPDPALARNPVVEA-----TAPSVLKIRSLAPSCQKVLEGSGFVIAPD
MAV_0459|M.avium_104 VASPDPELASNPVVQA-----TAPSVVKVRSLAPSCQKVLEGSGFVIAPD
MLBr_02298|M.leprae_Br4923 VASPDPALVDNPVVLA-----TQPSVVKIRSVAPSCQKVLEGTGFVVSLD
Rv1043c|M.tuberculosis_H37Rv DSWGTGLVVDHNHVIT-----NKHVVTGLAGTS---------AGLSVYPS
Mb1072c|M.bovis_AF2122/97 DSWGTGLVVDHNHVIT-----NKHVVTGLAGTS---------AGLSVYPS
MSMEG_5486|M.smegmatis_MC2_155 TKVTFADGTTRPFTVVGTDPSSDIAVVRAQDVSGLTPITLGSSANLRVGQ
TH_1677|M.thermoresistible__bu IGDSDNLAPGEPVVALG--------------------------------N
.
Mflv_1376|M.gilvum_PYR-GCK RVMSNAHVVAGSDTVTVEVDGQEYTAGVVSYDPNADISILDVPDLPSVPL
Mvan_5430|M.vanbaalenii_PYR-1 RVMSNAHVVAGSDSVTVEVDGQTYDAGVVSYDPNADISILDVPNLPSAPL
MAB_0421|M.abscessus_ATCC_1997 RVMSNAHVVAGTNSVTVESAGQTYDASVVSYDPNADISILAVPDMPAAPL
MMAR_5159|M.marinum_M RVMTNAHVVAGANSVQVFASGKPLDATVVSYDPSVDIAILAVPGLPPPPL
MUL_4245|M.ulcerans_Agy99 RVMTNAHVVAGANSVQVFASGKPLDATVVSYDPSVDIAILAVPGLPPPPL
MAV_0459|M.avium_104 RVMTNAHVVAGSNSVQIYASGNPLDATVVSYDPSVDIAILAVPNLPPPPL
MLBr_02298|M.leprae_Br4923 RVMTNAHVVAGSDGVQVYASGNPFDATVVSYDPSVDIAILAVPHLPPAPL
Rv1043c|M.tuberculosis_H37Rv SNHAEAELVNFSGTAHPHP---TLDVAVIKFEMPEGKYIPRLGGMAFR--
Mb1072c|M.bovis_AF2122/97 SNHAEAELVNFSGTAHPHP---TLDVAVIKFEMPEGKYIPRLGGMAFR--
MSMEG_5486|M.smegmatis_MC2_155 DVVAIGSPLGLEGTVTTGIVSALNRPVAAGGDTRNQNTVLDAIQTDAAIN
TH_1677|M.thermoresistible__bu ANGTHAPLTRETGTVTEFGRTVTAEDTLTGSSEE----LSGLFEFAAPVR
: . . . . :
Mflv_1376|M.gilvum_PYR-GCK QFVDALAQTGTDGIVLGYPGGGDFTATPARVREVIELNGPDIYRS-TTVT
Mvan_5430|M.vanbaalenii_PYR-1 QFVDAEAQPGTDGIVMGYPGGGEFTATPARVREVIELNGPDIYRS-TTVT
MAB_0421|M.abscessus_ATCC_1997 VFASKPAKTGDDAIVLGYPGGGDYKASPARVREIIELKGPDIYRS-ITVT
MMAR_5159|M.marinum_M IFAEREAPTGTNVVVLGYPGGGNFTATPARIREAIRLSGPDIYRNPQPVT
MUL_4245|M.ulcerans_Agy99 IFAEREAPTGTNVVVLGYPGGGNFTATPARIREATRLSGPDIYRNLQPVT
MAV_0459|M.avium_104 PFAQTEAKTGASVVVLGYPGGGNFTATPARIRELIKLSGPDIYRDPAPVT
MLBr_02298|M.leprae_Br4923 RFDDTKAKPGTNVVMLGYPGGGNFTATSARIRQAIKLTGPDIYRGLAPVT
Rv1043c|M.tuberculosis_H37Rv -----DPDWADEVYVFGYPR-VPMTAEMAITVQRGEVVNP--AATTIPGR
Mb1072c|M.bovis_AF2122/97 -----DPDWADEVYVFGYPR-VPMTAEMAITVQRGEVVNP--AATTIPCR
MSMEG_5486|M.smegmatis_MC2_155 PGNSGGALVNMNGELVGINSAIATMGGDSPNAQSGSIGLGFAIPVDQAKR
TH_1677|M.thermoresistible__bu AGDSGGPVVNTAGEVVGITTAASVSFRMGPGGRGFAIPINDAMAIADQIR
. :.* . . :
Mflv_1376|M.gilvum_PYR-GCK REVYTIRGTVRQGNSGGPMVNRQ-------GKVLGVVFGAAVDDIDTGFV
Mvan_5430|M.vanbaalenii_PYR-1 REVYTIRGTVKQGNSGGPMINRQ-------GRVLGVVFGAAVDDVDTGFV
MAB_0421|M.abscessus_ATCC_1997 REVYTVRGSVLQGNSGGPLIDTE-------GRVLGVVFGAAIDDDDTGFA
MMAR_5159|M.marinum_M RDVYTIRANVEQGDSGGPLIDLN-------GQVLGVVFGAAVDDPDTGFV
MUL_4245|M.ulcerans_Agy99 RDVYTIRANVEQGDSGGPLIDLN-------GQVLGVVFGAAVDDPDTGFV
MAV_0459|M.avium_104 RDVYTIRASVEQGNSGGPLIDLN-------GQVLGVVFGAAVDDPDTGFV
MLBr_02298|M.leprae_Br4923 RDVYTIRATVEQGNSGGPLIDLN-------GRVLGVVFGAAVDDSETGFV
Rv1043c|M.tuberculosis_H37Rv QKIFLYSAIARPGNSGGPIVAQD-------GRVIGLVVEDSAEAPSTGTG
Mb1072c|M.bovis_AF2122/97 QKIFLYSAIARPGNSGGPIVAQD-------GRVIGLVVEDSAEAPSTGTG
MSMEG_5486|M.smegmatis_MC2_155 IADELIQNGVASHASLGVQVANDRSSD--GAKIVEVNDGGAAAAAGLPSG
TH_1677|M.thermoresistible__bu ARVPSDSVHIGPPTLLGVGVRTAPLRTRPGVLIQDVLRGGPAEAAGLRSG
* : : : .
Mflv_1376|M.gilvum_PYR-GCK LTADEVAAQMA--RVGNV---DLVPTGTCISSG-----------------
Mvan_5430|M.vanbaalenii_PYR-1 LTADEVARQMA--KVGNV---ERVATGTCISAG-----------------
MAB_0421|M.abscessus_ATCC_1997 LTAKQVKDQLA--KADLA---DPVATGSCVSAAEANRPTEQPVNGPQSPV
MMAR_5159|M.marinum_M LTSGEVASQLA--RIGAT---ERVATGSCVS-------------------
MUL_4245|M.ulcerans_Agy99 LTSGEVASQLA--RIGAT---ERVATGSCVS-------------------
MAV_0459|M.avium_104 LTADEVAGQLA--KIGET---KTVGTGSCVS-------------------
MLBr_02298|M.leprae_Br4923 LTAEEVSHRLT--EIGETQ--EAVATGACVS-------------------
Rv1043c|M.tuberculosis_H37Rv PNAAPFYRGIP--SSEVIRALDELDFGGIVEMDTLP--------------
Mb1072c|M.bovis_AF2122/97 PNAAPFYRGIP--SSEVIRALDELDFGGIVEMDTLP--------------
MSMEG_5486|M.smegmatis_MC2_155 VVVTKVDDRVIGSADALVAAVRSKAPGEKVTLTYLDQAGKPQTVDVTLGK
TH_1677|M.thermoresistible__bu DILIELDGTRLDSATTLTYTLDRHYPGDVVDLVWIDASGQTRTGKATLTA
. * :
Mflv_1376|M.gilvum_PYR-GCK -----
Mvan_5430|M.vanbaalenii_PYR-1 -----
MAB_0421|M.abscessus_ATCC_1997 PGKAP
MMAR_5159|M.marinum_M -----
MUL_4245|M.ulcerans_Agy99 -----
MAV_0459|M.avium_104 -----
MLBr_02298|M.leprae_Br4923 -----
Rv1043c|M.tuberculosis_H37Rv -----
Mb1072c|M.bovis_AF2122/97 -----
MSMEG_5486|M.smegmatis_MC2_155 AEQ--
TH_1677|M.thermoresistible__bu HL---