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IPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGW EVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVV AEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGA AFEISRDIIAISGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSP GIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAISACD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0989c | grcC2 | - | 100% (325) | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC2 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) |
| M. tuberculosis H37Rv | Rv0562 | grcC1 | e-102 | 57.67% (326) | polyprenyl-diphosphate synthase |
| M. tuberculosis H37Rv | Rv3398c | idsA1 | 1e-18 | 29.03% (248) | multifunctional dimethylallyltransferase/farnesyl |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1016c | grcC2 | 0.0 | 99.69% (325) | polyprenyl-diphosphate synthase |
| M. gilvum PYR-GCK | Mflv_5253 | - | 1e-101 | 57.67% (326) | trans-hexaprenyltranstransferase |
| M. leprae Br4923 | MLBr_02277 | - | 3e-92 | 53.56% (323) | polyprenyl diphosphate synthase component |
| M. abscessus ATCC 19977 | MAB_3928c | - | 4e-91 | 55.56% (324) | polyprenyl-diphosphate synthase GrcC1 |
| M. marinum M | MMAR_0911 | grcC1 | 2e-94 | 55.21% (326) | polyprenyl diphosphate synthetase, GrcC1 |
| M. avium 104 | MAV_4581 | - | 1e-102 | 59.63% (322) | polyprenyl synthetase |
| M. smegmatis MC2 155 | MSMEG_1133 | - | 1e-108 | 60.74% (326) | bifunctional short chain isoprenyl diphosphate synthase |
| M. thermoresistible (build 8) | TH_1767 | - | 1e-100 | 57.67% (326) | bifunctional short chain isoprenyl diphosphate synthase |
| M. ulcerans Agy99 | MUL_0664 | grcC1 | 1e-94 | 55.21% (326) | polyprenyl diphosphate synthetase, GrcC1 |
| M. vanbaalenii PYR-1 | Mvan_0992 | - | 1e-102 | 58.28% (326) | trans-hexaprenyltranstransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5253|M.gilvum_PYR-GCK MRTPANVVAGVDFGDAQFAQDVRDGVARIEALMSEELGRADALMSEAVNH
Mvan_0992|M.vanbaalenii_PYR-1 ------MVAGVDFGDAEFAQDVRDGVARIEALMSEELGKADVLMAEAVQH
MSMEG_1133|M.smegmatis_MC2_155 ------MVAGVDFGDPAFAADVRDGVARIEDLMSDELGKADELMAEAVQH
TH_1767|M.thermoresistible__bu ------VVAGVDLGDPDFAAGVRDGVARIEDLMSSELGKADDLMAEAVQH
MMAR_0911|M.marinum_M MRTSATVVAGVDVGDAEFATTVRDGVASIERLMDAELRGADEVMTDSLLH
MUL_0664|M.ulcerans_Agy99 MRTSATVVAGVDVGDAEFATTVRDGVASIERLMDAELRGADEVMTDSLLH
MLBr_02277|M.leprae_Br4923 -----MVVAGINFGDAAFAATVQDRVVRIEQLMDAELRDTDEVMTESVLH
MAV_4581|M.avium_104 ----------MDFGDPAFAATVRDGVGRIEQLMDTELRSADDIMTELLTH
MAB_3928c|M.abscessus_ATCC_199 -------MAGVDLGDPVFAAKVRDHLAAIETLIVSELGQSDPLLTESVLH
Rv0989c|M.tuberculosis_H37Rv ------MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAH
Mb1016c|M.bovis_AF2122/97 ------MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAH
:..**. *: *:* : * *: ** :* :: : : *
Mflv_5253|M.gilvum_PYR-GCK LFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIELVHLATLYHDDVM
Mvan_0992|M.vanbaalenii_PYR-1 LFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIELVHLATLYHDDVM
MSMEG_1133|M.smegmatis_MC2_155 LFQAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIELVHLATLYHDDVM
TH_1767|M.thermoresistible__bu LFRAGGKRFRPLFTVLSAQLGPEPDAWQVTVAGAVIELVHLATLYHDDVM
MMAR_0911|M.marinum_M LFLAGGKRFRPLFTVLSAQVGPNPGADEVVIAGAVIEMIHLATLYHDDVM
MUL_0664|M.ulcerans_Agy99 LFLAGGKRFRPLFTVLSAQVGPNPGADEVVIAGAVIEMIHLATLYHDDVM
MLBr_02277|M.leprae_Br4923 LFAAGGKRFRPLFTVLSAQIGPRPDAPEVIIAGAVIELVHLASLYHDDVM
MAV_4581|M.avium_104 LFKAGGKRFRPLFTVLSAQIGPDPDAAEVTIAGAVIELVHLATLYHDDVM
MAB_3928c|M.abscessus_ATCC_199 LFHAGGKRFRPLFTVLAAQTGPDPDNDEVILAGAVCELIHLATLYHDDVM
Rv0989c|M.tuberculosis_H37Rv LVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVV
Mb1016c|M.bovis_AF2122/97 LVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVV
*. ***. ********:** *. *. :* :***. *::**.:* ** *:
Mflv_5253|M.gilvum_PYR-GCK DEAQVRRGAPSANARWGNNIAILAGDYLFATASRLTSRLGPEAVRIIADT
Mvan_0992|M.vanbaalenii_PYR-1 DEAQVRRGAPSANARWSNNIAILAGDYLFATASRLVSRLGPDAVRIIADT
MSMEG_1133|M.smegmatis_MC2_155 DEAQMRRGAQSANARWGNNIAILAGDYLFATASRLVSRLGPDAVRVIADT
TH_1767|M.thermoresistible__bu DDAEMRRGAPSANAKWGNSIAILAGDYLFATASRLVSRLGPEAVRVIADT
MMAR_0911|M.marinum_M DEAQVRRGAPSANARWGNNVAILAGDYLLATASRLVSRLGPDAVRIVADT
MUL_0664|M.ulcerans_Agy99 DEAQVRRGAPSANARWGNNVAILAGDYLLATASRLVSRLGPDAVRIVADT
MLBr_02277|M.leprae_Br4923 DEAEVRRGAPSANLRWSNSVAILAGDYLFATASRLVSQLGLDAVRIIADT
MAV_4581|M.avium_104 DEAEVRRGTPTANVRWGNNVAILAGDYLFATASRLVSRLGPEAVQLIAET
MAB_3928c|M.abscessus_ATCC_199 DEAQKRRGVPSANARWGNNVAILAGDYLLATASRLVSRLGPTAVRIVAET
Rv0989c|M.tuberculosis_H37Rv DESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEA
Mb1016c|M.bovis_AF2122/97 DESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEA
*::: * . : * :* *..******* :****:*.*:*. *. ::*::
Mflv_5253|M.gilvum_PYR-GCK FALLVTGQMRETRGAADQVDSVDHYLKVVYEKTACLISASGRFGATFSGS
Mvan_0992|M.vanbaalenii_PYR-1 FALLVTGQMRETRGAADHVDEVDHYLKVVYEKTACLIAASGRFGATFSGA
MSMEG_1133|M.smegmatis_MC2_155 FAQLVTGQMRETRGAADHVDSVDHYLKVVYEKTACLIAASGRFGATFSGA
TH_1767|M.thermoresistible__bu FAQLVTGQMRETRGAADGADPIEHYLKVVYEKTACLISASGRFGATFSGA
MMAR_0911|M.marinum_M FAQLVTGQMRETRGAPEGVDMIEQYLKVVHEKTGCLIGAAGRFGGMFSGA
MUL_0664|M.ulcerans_Agy99 FAQLVTGQMRETRGAPEGVDMIEQYLKVVHEKTGCLIGAAGRFGGMFSGA
MLBr_02277|M.leprae_Br4923 FAQLVTGQMRETRGVPEGADSIEQYLKVVYEKTGCLIGSAGRLGGLFAGA
MAV_4581|M.avium_104 FAQLVTGQMRETRGRKEGSDPIEHYLKVVYEKTACLIAAAGRFGAMFSGA
MAB_3928c|M.abscessus_ATCC_199 FAELVTGQMRETVGVPEGGDETEHYLKVIHEKTGSLIAAAGRFGAMTSRC
Rv0989c|M.tuberculosis_H37Rv FAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGA
Mb1016c|M.bovis_AF2122/97 FAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGA
** *:***** * * . * ::**:*::***..**.::*::*. : .
Mflv_5253|M.gilvum_PYR-GCK DEAQIERLAKLGGIVGTAFQISDDIIDIDSDADESGKVPGTDLREGVHTL
Mvan_0992|M.vanbaalenii_PYR-1 DDEQIERLARLGGIVGTAFQISDDIIDIDSDPDESGKVPGTDLREGVHTL
MSMEG_1133|M.smegmatis_MC2_155 NDEQIERLSRLGGIVGTAFQIADDIIDIDSDPDESGKTPGTDLREGVHTL
TH_1767|M.thermoresistible__bu DEEQVERLARLGGIVGTAFQISDDIIDIESESTESGKTPGTDLREGVHTL
MMAR_0911|M.marinum_M DGEQVERLNRLGGIVGTAFQIADDIIDIDSDTEQSGKLPGTDLREGVRTL
MUL_0664|M.ulcerans_Agy99 DGEQVERLNRLGGIVGTAFQIADDIIDIDSDTEQSGKLPGTDLREGVRTL
MLBr_02277|M.leprae_Br4923 HAEQVERLSRLGSIVGTAFQISDDIIDIDSDYTKSGKLPGTDVREGVRTL
MAV_4581|M.avium_104 DADQVERLSRLGGIVGTAFQISDDIIDIDSDSHESGKLPGTDVREGVHTL
MAB_3928c|M.abscessus_ATCC_199 DDDQIERLSRLGAIVGTAFQISDDIIDIESLTDESGKTPGTDLREGVHTL
Rv0989c|M.tuberculosis_H37Rv AEEQIRRVARLGRMIGAAFEISRDIIAISGD---SATLSGADLGQAVHTL
Mb1016c|M.bovis_AF2122/97 AEEQIRRVARLGRMIGAAFEISRDIIAISGD---SATLSGADLGQAVHTL
*:.*: :** ::*:**:*: *** *.. *.. .*:*: :.*:**
Mflv_5253|M.gilvum_PYR-GCK PVLYALRETGPDADRLRELLAGPVTDDADVAEALRLLRGSQGIRKAKETV
Mvan_0992|M.vanbaalenii_PYR-1 PVLYALRETGPDADRLRELLATPVTDDGDLAEALRLLRASDGITKAKETV
MSMEG_1133|M.smegmatis_MC2_155 PVLYALRETGPDADRLRELLAGPIERDEDVAEALALLRRSPGLTKAKETV
TH_1767|M.thermoresistible__bu PVLYALRETGPEAERLRELVSRPVEDDADLAEALDLLRRSPGMAQATETV
MMAR_0911|M.marinum_M PMLYALRQTGSDGARLRTLLAGPIRDDAEVFEALALLRASPGMDQAKEVL
MUL_0664|M.ulcerans_Agy99 PMLYALRQTGSDGARLRTLLAGPIRDDAEVFEALALLRASPGMDQAKEVL
MLBr_02277|M.leprae_Br4923 PILYALRETGPDSERLRALLAGPVDNDAEVVEALALLRASPGMARARQVL
MAV_4581|M.avium_104 PMVYALREPGPDAARLRELLVGPIDDDEVVAEALTLLRASPGMAKAKQSL
MAB_3928c|M.abscessus_ATCC_199 PMLYALRDTGPDADRLRVLLAAPITDDAEVEEALALLRASEGLAQAKSVV
Rv0989c|M.tuberculosis_H37Rv PMLYALREQTPDTSRLRELLAGPIHDD-HVAEALTLLRCSPGIGKAKNVV
Mb1016c|M.bovis_AF2122/97 PMLYALREQTPDTSRLRELLAGPIHDD-HVAEALTLLRCSPGIGKAKNVV
*::****: .: *** *: *: * : *** *** * *: :* . :
Mflv_5253|M.gilvum_PYR-GCK IGYAQEAQRELDQLPDVPGRQALASLVDYTVNRHG
Mvan_0992|M.vanbaalenii_PYR-1 AAYAREAEQELGQLPAGPGRQALATLVQYTINRHG
MSMEG_1133|M.smegmatis_MC2_155 ASYAAQAREELSHLPECPGRQALAVLVDYTISREG
TH_1767|M.thermoresistible__bu REYATEARSVLAQLPAGPGRDALATLIDFTVNRHG
MMAR_0911|M.marinum_M GQYAARARHELDLLPDVPGRQALAALVDYTVNRHG
MUL_0664|M.ulcerans_Agy99 GQYAARARHELDLLPDVPGRQALAALVDYTVNRHG
MLBr_02277|M.leprae_Br4923 AHYADQASGELAQLPDGPSRDALATLVDYTTNRHG
MAV_4581|M.avium_104 REYAAQAHRELDQLPDVPGRRALQTLVDFTISRHG
MAB_3928c|M.abscessus_ATCC_199 IDYADRAKAELVELPPGDARDALGVLIEYTVRRHG
Rv0989c|M.tuberculosis_H37Rv AAYAAQAREELPYLPDRQPRRALATLIDHAISACD
Mb1016c|M.bovis_AF2122/97 AAYAAQAREELPYLPDRQPRRALATLIDHAVSACD
** .* * ** * ** *::.: .