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M. vanbaalenii PYR-1 Mvan_5025 (-)

annotation: citrate synthase 2
coordinates: 5375117 - 5376232
length: 371

MTAVSKDFVPGLAGVVAFETEIAEPDKDGGALRYRGVDIQDLVSHRVTFGDVWGLLVDGRFGRGLPPAEP
FPLPIHSGDVRVDVQAGLAMLAPIWGYPPILDIEDETARDQLARASVMALSYVAQSARGIYQPAVPQRTV
DECDTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPL
HGGAPARVIPMIEEAERTGDARSVVKGILDRNEKLMGFGHRVYRAEDPRARVLRATAERLQAPRYEVAAA
LEQAALTELRERRPDRAIETNVEFWAAVILDFAQVPPKMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSA
IYVGPEPRSPEAVEGWDLLSH
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_5025--100% (371)citrate synthase 2
M. vanbaalenii PYR-1Mvan_5022gltA3e-3329.50% (383) type II citrate synthase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0913ccitA0.089.65% (367) citrate synthase 2
M. gilvum PYR-GCKMflv_1726-0.091.87% (369) citrate synthase 2
M. tuberculosis H37RvRv0889ccitA0.089.65% (367) citrate synthase 2
M. leprae Br4923MLBr_02130gltA9e-3629.97% (397) type II citrate synthase
M. abscessus ATCC 19977MAB_0932c-0.083.75% (363) citrate synthase 2
M. marinum MMMAR_4643citA0.091.01% (367) citrate synthase II CitA
M. avium 104MAV_1016-0.089.65% (367) citrate synthase 2
M. smegmatis MC2 155MSMEG_5676-0.088.38% (370) citrate synthase 2
M. thermoresistible (build 8)TH_3238-0.088.28% (367) PUTATIVE AMP-dependent synthetase and ligase
M. ulcerans Agy99MUL_0259citA1e-14489.57% (278) citrate synthase 2

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_5025|M.vanbaalenii_PYR-1       -------------------------------------MTAVSKDFVPGLA
Mflv_1726|M.gilvum_PYR-GCK          ------------------------------------MTTSVPKDFVAGLA
Mb0913c|M.bovis_AF2122/97           -------------------------------------MTVVPENFVPGLD
Rv0889c|M.tuberculosis_H37Rv        -------------------------------------MTVVPENFVPGLD
MAV_1016|M.avium_104                -------------------------------------MTVVPENFVPGLE
MMAR_4643|M.marinum_M               -------------------------------------MTVVPEDFVPGLN
MUL_0259|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_5676|M.smegmatis_MC2_155      -------------------------------------MAAVPDDFIAGLE
TH_3238|M.thermoresistible__bu      ---------------------------------------LVPEDFVPGLE
MAB_0932c|M.abscessus_ATCC_199      ----------------------------------MTVAAPLPADFAPGLE
MLBr_02130|M.leprae_Br4923          MADTDDTVTLKYPGGEIDLQIVRATEGNDGIAIVPVLAKTGYTTFDVGYG
                                                                                      

Mvan_5025|M.vanbaalenii_PYR-1       GVVAFETEIAEPDKDGGALRYRGVDIQDLVSHRVTFGDVWGLLVDGRFGR
Mflv_1726|M.gilvum_PYR-GCK          GVVAFETEIAEPDKDGGALRYRGVDIEDLVAHRITFGDVWGLLVDGRFGD
Mb0913c|M.bovis_AF2122/97           GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGS
Rv0889c|M.tuberculosis_H37Rv        GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGS
MAV_1016|M.avium_104                GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQQVTFGDVWALLVDGKFGH
MMAR_4643|M.marinum_M               GVVAFTTEIAEPDKDGGALRYRGVDIEDLVSLRVTFGDVWALLVDGEFGR
MUL_0259|M.ulcerans_Agy99           --------------------------------------------------
MSMEG_5676|M.smegmatis_MC2_155      GVVAFTTEIAEPDKDGGALRYRGVDIEELVDKKVTFADVWGLLVDGRFGN
TH_3238|M.thermoresistible__bu      GVVAFTTEIAEPDKDGGALRYRGVDIEDLVARRVTFADVWALLVDGRFGE
MAB_0932c|M.abscessus_ATCC_199      GVTAFATEIAEPDKDGGSLRYRGVDIEDLVAQRVTFGDVWALLVDGKFGQ
MLBr_02130|M.leprae_Br4923          NTASTKSSITYIDGDAGILRYRGYPIEQLAEK-STFIEVCYLLIYGELPA
                                                                                      

Mvan_5025|M.vanbaalenii_PYR-1       GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYPPIL------------
Mflv_1726|M.gilvum_PYR-GCK          GLTPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYRPLL------------
Mb0913c|M.bovis_AF2122/97           GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLL------------
Rv0889c|M.tuberculosis_H37Rv        GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLL------------
MAV_1016|M.avium_104                GLPPAEPFPLPIHTGDVRVDVQAGLAMLAPIWGYKPLL------------
MMAR_4643|M.marinum_M               GLPPAEPFPLPIHTGDVRVDVQAGLAMLAPIWGYAPLL------------
MUL_0259|M.ulcerans_Agy99           --------------------------MLAPIWGYAPLL------------
MSMEG_5676|M.smegmatis_MC2_155      GLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPML------------
TH_3238|M.thermoresistible__bu      SLAPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYQPML------------
MAB_0932c|M.abscessus_ATCC_199      GLPPAEPFPIPVHTGDVRVDVQAGLAMLAPIWGFEPLL------------
MLBr_02130|M.leprae_Br4923          TDQLAEFTHRIQRHTMLHEDLKRFYDGFPRNAHPMPVLSSVVNALSAYYQ
                                                               :.      *:*            

Mvan_5025|M.vanbaalenii_PYR-1       DIEDETARDQLARASVMALSYVAQSARGIYQPAVPQ--RTVDECDTVTAR
Mflv_1726|M.gilvum_PYR-GCK          DIDDQTARDQLARASVMALSYVAQSARGIYRPAVPQ--RQVDECDTVTAR
Mb0913c|M.bovis_AF2122/97           DIDDATARQQLARASVMALSYVAQSARGIYQPAVPQ--RIIDECSTVTAR
Rv0889c|M.tuberculosis_H37Rv        DIDDATARQQLARASVMALSYVAQSARGIYQPAVPQ--RIIDECSTVTAR
MAV_1016|M.avium_104                DTDDATARDQLARASVMALSYVAQSARGIYQPAVPQ--RVIDECETVTAR
MMAR_4643|M.marinum_M               DIDDATAREQLARASVMALSYVAQSARGIYQPAVPQ--RVIDECSTVTAR
MUL_0259|M.ulcerans_Agy99           DIDDATAREQLARASVMALSYVAQSARGIYQPAVPQ--RVNDECSTVTAR
MSMEG_5676|M.smegmatis_MC2_155      DIDDETAREHLARASVMALSYVAQSARGIYQPAVPQ--RTIDECPTVTAR
TH_3238|M.thermoresistible__bu      DIDDETAREQLARASVMALSYVAQSARGIYQPAVPQ--RLIDECSTVTER
MAB_0932c|M.abscessus_ATCC_199      DTEDSVARSQLARASVMALSYVAQSARGNSLPAVPQ--HIVDECSTVTSR
MLBr_02130|M.leprae_Br4923          DALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNAFSLVEN
                                    *  *   . ::  :::  *: :.  *      :* *     *:. ::. .

Mvan_5025|M.vanbaalenii_PYR-1       FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
Mflv_1726|M.gilvum_PYR-GCK          FMTRWKG------EPDPRHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
Mb0913c|M.bovis_AF2122/97           FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
Rv0889c|M.tuberculosis_H37Rv        FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MAV_1016|M.avium_104                FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MMAR_4643|M.marinum_M               FMTRWQG------EPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGA
MUL_0259|M.ulcerans_Agy99           FMTRWQG------EPDPRHIEAIGAYWVSAAEHGMNASTFTARVIASTGA
MSMEG_5676|M.smegmatis_MC2_155      FMTRWQG------EPDPRHVEAIDAYWVTAAEHGMNASTFTARVIASTGA
TH_3238|M.thermoresistible__bu      FMTRWKG------EPDPXHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
MAB_0932c|M.abscessus_ATCC_199      FMTRWQG------DPDPKHVEAIDAYWVSAAEHGMNASTFTARVIASTGA
MLBr_02130|M.leprae_Br4923          FLRMTFGLPAEPYEPDPEVVRALDMLFILHADHEQNCSTSTVRLVGSSRA
                                    *:    *      :***  :.*:.  ::  *:*  *.** *.*::.*: *

Mvan_5025|M.vanbaalenii_PYR-1       DVAAALSGAIGAMSGPLHGGAPARVIPMIEEAERTG-DARSVVKGILDRN
Mflv_1726|M.gilvum_PYR-GCK          DVAAALSGAVGAMSGPLHGGAPARVIPMIEEAEQTG-DARAVVKGILDRN
Mb0913c|M.bovis_AF2122/97           DVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAG-DARSVVKGILDRG
Rv0889c|M.tuberculosis_H37Rv        DVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAG-DARSVVKGILDRG
MAV_1016|M.avium_104                DVAAALSGAIGAMSGPLHGGAPARVLPMIEEVERTG-DARGLVKKILDSG
MMAR_4643|M.marinum_M               DVAAALSGAIGAMSGPLHGGAPARVLPMIEQVERTG-DARGLVKGILDRG
MUL_0259|M.ulcerans_Agy99           DVAAALSGAIGAMSGPLHGGAPARVLPMIEQVELTG-DARGLVKGILDRG
MSMEG_5676|M.smegmatis_MC2_155      DAAAALSGAVGAMSGPLHGGAPARVLPMIEEVENTG-DARAVVKGILDRG
TH_3238|M.thermoresistible__bu      DVAAALSGAIGAMSGPLHGGAPARVLPMIEEVEKTG-DARKVVTGILDRG
MAB_0932c|M.abscessus_ATCC_199      DVAASLSGAVGAMSGPLHGGAPARVLPMIEQAEKTG-DARGVIRGILDRR
MLBr_02130|M.leprae_Br4923          NLFTSISGGINALWGPLHGGANQAVLEMLEGIRESGDDVGGFVQKVKNCQ
                                    :  :::**.:.*: *******   *: *::  . :* *.  .:  : :  

Mvan_5025|M.vanbaalenii_PYR-1       E--KLMGFGHRVYRAEDPRARVLRATAERLQAPR------YEVAAALEQA
Mflv_1726|M.gilvum_PYR-GCK          E--KLMGFGHRVYRAEDPRARVLRATAERLAAPR------FEVAAALEQA
Mb0913c|M.bovis_AF2122/97           E--KLMGFGHRVYRAEDPRARVLRAAAERLGAPR------YEVAVAVEQA
Rv0889c|M.tuberculosis_H37Rv        E--KLMGFGHRVYRAEDPRARVLRAAAERLGAPR------YEVAVAVEQA
MAV_1016|M.avium_104                D--KLMGFGHRVYRAEDPRARVLRATAERLGAPR------HEVAVALEQA
MMAR_4643|M.marinum_M               E--KLMGFGHRVYRAEDPRARVLRATAERLAAPR------YEVAAALEQA
MUL_0259|M.ulcerans_Agy99           E--KLMGFGHRVYRAEDPRARVLRATAKRLAAPR------YEVAAALEQA
MSMEG_5676|M.smegmatis_MC2_155      D--KLMGFGHRVYRAEDPRARVLRATAQRLGAPR------FEVASALEQA
TH_3238|M.thermoresistible__bu      E--KLMGFGHRVYRAEDPRARVLRETAKRLGAPR------YDVAAALEQA
MAB_0932c|M.abscessus_ATCC_199      E--KLMGFGHRVYRAEDPRARVLRSTAKRLGAAR------YEVAAALEQA
MLBr_02130|M.leprae_Br4923          AGVKLMGFGHRVYKNYDPRARIVKEQADKILVKLGGDDDLLNIAKGLEEA
                                       **********:  *****:::  *.:: .         ::* .:*:*

Mvan_5025|M.vanbaalenii_PYR-1       ALTELRERRPDRAIETNVEFWAAVILDFAQVPPKMMPAMFTCGRTAGWCA
Mflv_1726|M.gilvum_PYR-GCK          ALAELRERRPDRAIETNVEFWAAVILDFAEVPPTMMPAMFTCGRTAGWCA
Mb0913c|M.bovis_AF2122/97           ALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCA
Rv0889c|M.tuberculosis_H37Rv        ALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCA
MAV_1016|M.avium_104                ALAELRERRPDRAIETNVEFWAAVILDFARVPANMMPAMFTCGRTAGWCA
MMAR_4643|M.marinum_M               ALAELRERRPDRAIETNVEFWAAVILDFAGVPANMMPAMFTCGRTAGWCA
MUL_0259|M.ulcerans_Agy99           ALAELRERRPDRAIETNVDFWAAVILDFAGVPANRMPAMFTCGRTVGWCA
MSMEG_5676|M.smegmatis_MC2_155      ALAELRERRPDRAIETNVEFWAAVILDFAQVPASMMPAMFTCGRTAGWCA
TH_3238|M.thermoresistible__bu      ALTELRERRPDRAIETNVEFWAAVILDFAEVPPRMMPAMFTCGRTAGWCA
MAB_0932c|M.abscessus_ATCC_199      ALAELRERRPDRVIETNVEFWAAVILDFAQVPTRMMPAMFTCARTAGWSA
MLBr_02130|M.leprae_Br4923          ALTD--DYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIA
                                    **::  :   :* : .**:*::.::     .*.  :..:*: .*  ** *

Mvan_5025|M.vanbaalenii_PYR-1       HILEQKRLG--KLVRPSAIYVGPEPRSPEAVEGWD-LLSH-----
Mflv_1726|M.gilvum_PYR-GCK          HILEQKRLG--KLVRPSAVYVGPAPRGPESVEGWD-SLTRR----
Mb0913c|M.bovis_AF2122/97           HILEQKRLG--KLVRPSAIYVGPGPRSPESVDGWERVLTTA----
Rv0889c|M.tuberculosis_H37Rv        HILEQKRLG--KLVRPSAIYVGPGPRSPESVDGWERVLTTA----
MAV_1016|M.avium_104                HILEQKRLG--KLVRPSAIYVGPGPRSPESVEGWDRSLTNA----
MMAR_4643|M.marinum_M               HILEQKRLG--KLVRPSAIYVGPAPRTPESVAGWDRVLTTA----
MUL_0259|M.ulcerans_Agy99           HILEQKRLG--KLVRPSAIYVGPAPRTPESVAGWDRVLTTA----
MSMEG_5676|M.smegmatis_MC2_155      HILEQKRLG--KLVRPSAIYVGPEPRSAEAVEGWEKIAAAGSGAA
TH_3238|M.thermoresistible__bu      HILEQKRLG--KLVRPSAVYVGPGPRSVESVEGWETIARP-----
MAB_0932c|M.abscessus_ATCC_199      HIMEQKRLG--KLVRPAALYVGPGPRPIESVEGFGLLHSRVGA--
MLBr_02130|M.leprae_Br4923          HWREMHDEGDSKIGRPRQIYTGYTERDYTAIETR-----------
                                    *  * :  *  *: **  :*.*   *   ::