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VRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTIPAGEVSVLLGPSGTGKSVFL KSLIGLLRPERGSIIIDGTDIIECSAKELYEIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEI RDIVMEKLALVGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYLSQLIMDIN AQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEA TMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEGTH KYAVHEIGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0655 | mkl | - | 100% (359) | POSSIBLE RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER MKL |
| M. tuberculosis H37Rv | Rv2397c | cysA1 | 6e-32 | 33.61% (241) | sulfate-transport ATP-binding protein ABC transporter CysA1 |
| M. tuberculosis H37Rv | Rv3102c | ftsE | 5e-28 | 33.79% (219) | putative cell division ATP-binding protein FTSE (septation |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0674 | mkl | 0.0 | 100.00% (359) | ribonucleotide ABC transporter ATP-binding protein |
| M. gilvum PYR-GCK | Mflv_5099 | - | 1e-166 | 87.50% (328) | ABC transporter related |
| M. leprae Br4923 | MLBr_01892 | - | 1e-179 | 93.15% (336) | ABC transporter ATP-binding protein |
| M. abscessus ATCC 19977 | MAB_3871c | - | 1e-165 | 85.07% (335) | ribonucleotide ABC transporter ATP-binding protein |
| M. marinum M | MMAR_0994 | mkl | 1e-180 | 96.04% (328) | ribonucleotide-transport ATP-binding protein ABC transporter, |
| M. avium 104 | MAV_4504 | - | 1e-178 | 91.94% (335) | ABC transporter, ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_1366 | - | 1e-163 | 87.65% (324) | ABC transporter, ATP-binding protein |
| M. thermoresistible (build 8) | TH_4213 | - | 1e-157 | 87.78% (311) | PUTATIVE ABC transporter-related protein |
| M. ulcerans Agy99 | MUL_0745 | mkl | 1e-179 | 95.73% (328) | ribonucleotide-transport ATP-binding protein ABC transporter, |
| M. vanbaalenii PYR-1 | Mvan_1254 | - | 1e-169 | 87.39% (333) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0655|M.tuberculosis_H37Rv MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTI
Mb0674|M.bovis_AF2122/97 MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTI
MMAR_0994|M.marinum_M -----------------------MGVAIEVNGLTKSFGSSRIWEDVTLTI
MUL_0745|M.ulcerans_Agy99 -----------------------MGVAIEVNGLTKSFGSSRIWEDVTLTI
MLBr_01892|M.leprae_Br4923 ---------------------MPMGVAIEVKGLTKSFGSSRIWEDVTLDI
MAV_4504|M.avium_104 -----------------------MGVAIEVNGLTKSFGSSRIWEDVTLEI
MSMEG_1366|M.smegmatis_MC2_155 -----------------------MGVQIDVTGLSKSFGSSKIWEDVTMSI
MAB_3871c|M.abscessus_ATCC_199 ----------------MLRKERLVGAEVSVEGLTKSFGSQRIWENVTLSL
TH_4213|M.thermoresistible__bu -----------------------------------------------MDI
Mvan_1254|M.vanbaalenii_PYR-1 -----------------------MGIGIQIEGLTKSFGAQRIWEDVTFDL
Mflv_5099|M.gilvum_PYR-GCK -----------------------MGIGIQVEGLTKSFGSQRIWEDVTFDL
: :
Rv0655|M.tuberculosis_H37Rv PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELY
Mb0674|M.bovis_AF2122/97 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELY
MMAR_0994|M.marinum_M PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSILIDGTDIIECSAKELY
MUL_0745|M.ulcerans_Agy99 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSILIDGTDIIECSAKELY
MLBr_01892|M.leprae_Br4923 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSILIDGTDIIECSAKELY
MAV_4504|M.avium_104 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSVVIDGTDILQCSAKELY
MSMEG_1366|M.smegmatis_MC2_155 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIVIDGTDILQCSAKELY
MAB_3871c|M.abscessus_ATCC_199 PPGEVSVLLGPSGTGKSVFLKSLIGLLRPEQGAIYIDGTNIMECSSKELY
TH_4213|M.thermoresistible__bu PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGKIIVDGTNIIDCTAKELY
Mvan_1254|M.vanbaalenii_PYR-1 PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGKIIVDGTNIIECSAKELY
Mflv_5099|M.gilvum_PYR-GCK PAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGKIVVDGTNIIECSAKELY
*.****************************:* : :***:*::*::****
Rv0655|M.tuberculosis_H37Rv EIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLAL
Mb0674|M.bovis_AF2122/97 EIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLAL
MMAR_0994|M.marinum_M EIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLAM
MUL_0745|M.ulcerans_Agy99 EIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLAM
MLBr_01892|M.leprae_Br4923 EIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLQL
MAV_4504|M.avium_104 EIRTLFGVMFQDGALFGSMNLFDNAAFPLREHTKKKESEIRDIVMEKLEL
MSMEG_1366|M.smegmatis_MC2_155 EIRTLFGVLFQDGALFGSMNIYDNTAFPLREHTKKSESEIRKIVMEKLDL
MAB_3871c|M.abscessus_ATCC_199 EIRKLFGVMFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMQKLDV
TH_4213|M.thermoresistible__bu EIRTLFGVMFQDGALFGSMSIYDNTAFPLREHTKKKESEIRKIVMEKLEL
Mvan_1254|M.vanbaalenii_PYR-1 EIRTLFGVMFQDGALFGSMSLYDNTAFPLREHTKKKESEIRQIVMEKLDL
Mflv_5099|M.gilvum_PYR-GCK EIRTLFGVMFQDGALFGSMSLYDNTAFPLREHTKKKESEIRKIVMEKLDL
***.****:**********.::**:**********.*****.***:** :
Rv0655|M.tuberculosis_H37Rv VGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTA
Mb0674|M.bovis_AF2122/97 VGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTA
MMAR_0994|M.marinum_M VGLTGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTA
MUL_0745|M.ulcerans_Agy99 VGLTGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTA
MLBr_01892|M.leprae_Br4923 VGLGGDEKKFPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTA
MAV_4504|M.avium_104 VGLGGDEKKFPGEISGGMRKRASLARALVMDPQIILCDEPDSGLDPVRTA
MSMEG_1366|M.smegmatis_MC2_155 VGMPNDGHKFPGEISGGMRKRAGLARALVLDPEIILCDEPDSGLDPVRTA
MAB_3871c|M.abscessus_ATCC_199 VGLTGHETKFPGEISGGMRKRAGLARSLVLDPQIILCDEPDSGLDPVRTA
TH_4213|M.thermoresistible__bu VGLAGDENKFPGEISGGMRKRAGLARSLVLDPQIILCDEPDSGLDPVRTA
Mvan_1254|M.vanbaalenii_PYR-1 VGLGGDESKFPGEISGGMRKRAGLARSLVLDPQIILCDEPDSGLDPVRTA
Mflv_5099|M.gilvum_PYR-GCK VGLGGDEDKFPGEISGGMRKRAGLARSLVLDPQIILCDEPDSGLDPVRTA
**: .. **************.***:**:**:*****************
Rv0655|M.tuberculosis_H37Rv YLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREV
Mb0674|M.bovis_AF2122/97 YLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREV
MMAR_0994|M.marinum_M YLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREV
MUL_0745|M.ulcerans_Agy99 YLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREV
MLBr_01892|M.leprae_Br4923 YLSQLIMDINAQIDATILIVTHNVNIARTVPDNMGMLFRKHLVMFGPREV
MAV_4504|M.avium_104 YLSQLILDINAQIDATVLIVTHNINIARTVPDNMGMLFRRKLVMFGPREV
MSMEG_1366|M.smegmatis_MC2_155 YLSQLLIDINAQIDATVLIVTHNINIARTVPDNMGMLFRKQLVMFGPREV
MAB_3871c|M.abscessus_ATCC_199 YLSQLLIDINAQIDATILIVTHNINIARTVPDNMGMLYRRNLVMFGPREV
TH_4213|M.thermoresistible__bu YLSQLLIDINAQIDCTILIVTHNINIARTVPDNIGMLFRKRLVMFGPREV
Mvan_1254|M.vanbaalenii_PYR-1 YLSQLLIDINAQIDCTILIVTHNINIARTVPDNMGMLFRKKLVMFGPREV
Mflv_5099|M.gilvum_PYR-GCK YLSQLLIDINAQIDCTILIVTHNINIARTVPDNMGMLFRKHLVMFGPREV
*****::*******.*:******:*********:***:*:.*********
Rv0655|M.tuberculosis_H37Rv LLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEE
Mb0674|M.bovis_AF2122/97 LLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEE
MMAR_0994|M.marinum_M LLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQAMIDAGQHAGGTED
MUL_0745|M.ulcerans_Agy99 LLASDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQAMIDAGQHAGGTED
MLBr_01892|M.leprae_Br4923 LLTSDEPVVRQFLNGRRIGPIGMSEEKDESTMAEEAALLEAGHYAGGAEE
MAV_4504|M.avium_104 LLTSDEPVVKQFLNGRRIGPIGMSEEKDEATMAEEQAALEAGQHAGGVEE
MSMEG_1366|M.smegmatis_MC2_155 LLTSEEPVVKQFLNGRRIGPIGMSEEKDEATAAAEQALVDAGQHDGGVEE
MAB_3871c|M.abscessus_ATCC_199 LLTSDEPVIKQFLNGRRIGPIGMSEEKDEATMAEEQAHLDAGHHDGGVEE
TH_4213|M.thermoresistible__bu LLTSDEPVVRQFLNGRRIGPIGMSEEKDELTMAEEQAMVDAGHHDGGVEE
Mvan_1254|M.vanbaalenii_PYR-1 LLTSDEPVVKQFLNGRRLGPIGMSEEKDESTMAEEQAMADAGHHDGGVEE
Mflv_5099|M.gilvum_PYR-GCK LLTSDEPVVKQFLNGRRIGPIGMSEEKDESTMAEEQAMVDAGHHDGGTEE
**:*:***::*******:*********** * * * * :**:: **.*:
Rv0655|M.tuberculosis_H37Rv IEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEG--
Mb0674|M.bovis_AF2122/97 IEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEG--
MMAR_0994|M.marinum_M IEGVPPQIQATPGMPERKAVARRQARVREMLHTLPKDAQAAILEDLEG--
MUL_0745|M.ulcerans_Agy99 IEGVPPQIQATPGMPERKAVARRQARVREMLHTLPKDAQAAILEDLEG--
MLBr_01892|M.leprae_Br4923 VEGVPPQITVTPGMPKRKAVARRQARVRAMLPTLPKGAQAAILDDLEG--
MAV_4504|M.avium_104 IEGVPPQIVASPGMPERKAVARRQARVREILHTLPQKAQAAILDDLEG--
MSMEG_1366|M.smegmatis_MC2_155 IEGVPPQLQATPGMPERKAVARRKARVREILHTLPPAAQAAILEELDRDQ
MAB_3871c|M.abscessus_ATCC_199 IEGVPPQIQATPGMPERKAVGRRQARVREIMHQLPPNAQAAIQDSFAG--
TH_4213|M.thermoresistible__bu IVGVPPQLTATPGMPERQAVHRRRARVREILHTLPPAAQAAIRDDLEG--
Mvan_1254|M.vanbaalenii_PYR-1 IEGVPPQIQATPGMPERQAVARRQARVREIMHTLPPAAQAAIRDDLEG--
Mflv_5099|M.gilvum_PYR-GCK IEGVPPQVMATPGMPERKAVGRRQARVREIMHTLPPAAQEAIRADLEN--
: *****: .:****:*:** **:**** :: ** ** ** .:
Rv0655|M.tuberculosis_H37Rv ---------------THKYA--VHEIGQ----------------------
Mb0674|M.bovis_AF2122/97 ---------------THKYA--VHEIGQ----------------------
MMAR_0994|M.marinum_M ---------------THR--------------------------------
MUL_0745|M.ulcerans_Agy99 ---------------THR--------------------------------
MLBr_01892|M.leprae_Br4923 ---------------AHNYQ--AHEFGD----------------------
MAV_4504|M.avium_104 ---------------THKYR--AHEVGD----------------------
MSMEG_1366|M.smegmatis_MC2_155 PQLSAPTTQTAATAPVENYD--DSPTGVIEV--------PKQA-------
MAB_3871c|M.abscessus_ATCC_199 ---------------THQYR--VHDFGDEPTGVTTATLAPPQAEQPTQSI
TH_4213|M.thermoresistible__bu ---------------THKYR--ADEFGDSGAGQHRAHEDDAPTASIPVAG
Mvan_1254|M.vanbaalenii_PYR-1 ---------------THQFP--SHQFAGEPAVR---HEDDAPTGRIPVSG
Mflv_5099|M.gilvum_PYR-GCK ---------------TQQTQPYPDGYSDGTTAHHARHDDETPTGRIPVAG
...
Rv0655|M.tuberculosis_H37Rv -----------------
Mb0674|M.bovis_AF2122/97 -----------------
MMAR_0994|M.marinum_M -----------------
MUL_0745|M.ulcerans_Agy99 -----------------
MLBr_01892|M.leprae_Br4923 -----------------
MAV_4504|M.avium_104 -----------------
MSMEG_1366|M.smegmatis_MC2_155 -----------------
MAB_3871c|M.abscessus_ATCC_199 DTSDDDTPTGQIPPVRG
TH_4213|M.thermoresistible__bu EQ---------------
Mvan_1254|M.vanbaalenii_PYR-1 ER---------------
Mflv_5099|M.gilvum_PYR-GCK ER---------------