For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SDMPRDELVDVLIVGAGISGINAAIRLSGAGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHP WHERNTIADGADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDTPAGPTTYRAKFLYLCT GYYNYDDGYTPEFPGVEKFAGRLIHPQHWPDDLDCSGKEITVIGSGATAITLVPSLARAGAKVNMLQRSP SYIYPIARVDAVVDVMRKVFPLSIVQHFARIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPAGYPVD VHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTIDTFTSAGIRLGSGQELPADVIITATGLNLQIF GGIALSVDGSPVDAPNRFIYKGYLIEGVPNAAWSVGYTNASWTLRADLSARAVVRLLDYMDRHGYTHAYP DRHGEELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRIDENMQFGIAKSKAVSS AA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2294c | - | - | 100% (493) | monooxygenase |
| M. abscessus ATCC 19977 | MAB_0103 | - | e-135 | 46.72% (488) | monooxygenase EthA |
| M. abscessus ATCC 19977 | MAB_0985 | - | e-119 | 43.44% (488) | putative monooxygenase EthA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0580c | - | 1e-144 | 50.21% (486) | monooxygenase |
| M. gilvum PYR-GCK | Mflv_4499 | - | 1e-151 | 52.24% (490) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0565c | - | 1e-144 | 50.21% (486) | monooxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 1e-126 | 47.62% (483) | putative monooxygenase |
| M. marinum M | MMAR_0917 | - | 1e-150 | 51.66% (482) | flavin-binding monooxygenase |
| M. avium 104 | MAV_4576 | - | 1e-148 | 51.76% (483) | monooxygenase, flavin-binding family protein |
| M. smegmatis MC2 155 | MSMEG_2038 | - | 1e-151 | 52.52% (476) | monooxygenase, flavin-binding family protein |
| M. thermoresistible (build 8) | TH_2757 | - | 1e-141 | 49.90% (477) | PUTATIVE FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_5026 | ethA | 1e-131 | 48.52% (474) | monooxygenase EthA |
| M. vanbaalenii PYR-1 | Mvan_1867 | - | 1e-148 | 51.54% (487) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0580c|M.bovis_AF2122/97 --------MSVTP-NAG---------CVDVVIVGAGISGLGAAYRIIERN
Rv0565c|M.tuberculosis_H37Rv --------MSVTP-NAG---------CVDVVIVGAGISGLGAAYRIIERN
MMAR_0917|M.marinum_M --------MSVTP-QEAQRT-PVERSLLDVVIVGAGISGLGAAYRLLESN
MAV_4576|M.avium_104 --------MTVTP-QEAADHGAAEADYFDVLIVGAGISGIDAAYRITERN
Mflv_4499|M.gilvum_PYR-GCK --------MDQ---------LYPETESTDVLIVGAGISGIGAAYRIQERN
Mvan_1867|M.vanbaalenii_PYR-1 --------MDQ---------RHSETEFSDVLIIGAGISGIGAAYRIQERN
TH_2757|M.thermoresistible__bu VAEEVIMTLDQGPAVEQSAHHGDAAEYFDVLIIGAGISGIGAAYRIKEKN
MSMEG_2038|M.smegmatis_MC2_155 --------MGAT--------ESDDPAYTDVLIIGAGISGINAAYRIHEKC
MAB_2294c|M.abscessus_ATCC_199 --------MSDMP----------RDELVDVLIVGAGISGINAAIRLSG--
MLBr_00065|M.leprae_Br4923 --------MVVMA----------ETEYLDVVIVGAGISGVSAAWHLQDRC
MUL_5026|M.ulcerans_Agy99 -----------------------MTEHLDVVIVGAGISGVSAAWHLQDRC
**:*:******:.** ::
Mb0580c|M.bovis_AF2122/97 PQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIAD
Rv0565c|M.tuberculosis_H37Rv PQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIAD
MMAR_0917|M.marinum_M PELTYTILERRERIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRREGVAD
MAV_4576|M.avium_104 PQLSYAILERRARIGGTWDLFRYPGVRSDSSIFTLSFPFEPWTRKEGVAD
Mflv_4499|M.gilvum_PYR-GCK PQLTYTVLERRSRIGGTWDLHRYPGIRSDSDIFTLSFPWEPWDRPENVAD
Mvan_1867|M.vanbaalenii_PYR-1 PQLTYTLLERRSRIGGTWDLHRYPGIRSDSDIFTLSFPWEPWTRPENVAD
TH_2757|M.thermoresistible__bu PGVSYAILERRSRIGGTWDLFRYPGIRSDSDILTLSYPWEPWTRPENVAD
MSMEG_2038|M.smegmatis_MC2_155 PGLTYTLLERRERIGGTWDLFRYPGIRSDSDIFTLSYPYEPWTRPENVAD
MAB_2294c|M.abscessus_ATCC_199 AGRSFHIVERRERIGGTWDLFRYPGIRSDSDIYTLSFGYHPWHERNTIAD
MLBr_00065|M.leprae_Br4923 PNKSYVILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRPWTKCQAIAD
MUL_5026|M.ulcerans_Agy99 PTKSYAILEKRAAMGGTWELFRYPGIRSDSDMHTLGFRFRPWTERQAIAD
. :: ::*:* :****:*.****:****.: **.: :.** . : :**
Mb0580c|M.bovis_AF2122/97 GAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQ---NG
Rv0565c|M.tuberculosis_H37Rv GAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQ---NG
MMAR_0917|M.marinum_M GEHIREYLANTAHKYGIDGHIQFNSYVRAADWDSGTDSWTVTFEQ---DG
MAV_4576|M.avium_104 GVHIREYLTATAHKYGIDRHIRFNSYVRSADWDSTSDTWTVTVEDGARDG
Mflv_4499|M.gilvum_PYR-GCK GEDIRQYLVDAARKHGIDRHIHFDTRVLSADWDSTADVWTVRTEC---NG
Mvan_1867|M.vanbaalenii_PYR-1 GEDIRSYLTETAHKHGIDRHIRFDTRVISADWDSGTDTWTVQTEQ---DG
TH_2757|M.thermoresistible__bu GPDIRQYLVDTARKHGIYDNIRFDTHVLSADWDSSTDTWTVQTTE---DG
MSMEG_2038|M.smegmatis_MC2_155 GGDIRAYLTETARKYGIDRHIRFNTHVLSADWDSATDTWTLHTEQ---DG
MAB_2294c|M.abscessus_ATCC_199 GADIRDYLEHAASDYDIDGHITFSAKVTSADFGTDTDIWSVRVDT---PA
MLBr_00065|M.leprae_Br4923 GKPILEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVEN---NG
MUL_5026|M.ulcerans_Agy99 GKPILEYVKGTAAMYGIDKHIRLNQKVISADWSNAQNRWTLQIES---NG
* * *: * :.* * :. * .**:.. : *:: .
Mb0580c|M.bovis_AF2122/97 VHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYT
Rv0565c|M.tuberculosis_H37Rv VHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYT
MMAR_0917|M.marinum_M VQRQCRSRFVFFASGYYNYDQGYTPDFPGIEGFTGTVVHPQHWPADLDYT
MAV_4576|M.avium_104 ERKLYRARFLFFGSGYYNYDEGYTPDFPGIEEFTGTVVHPQHWPEDLDYT
Mflv_4499|M.gilvum_PYR-GCK VPRTYRTRFLFFGTGYYDYDNPYRPEFPGLESFEGPVVHPQHWPEDLDCT
Mvan_1867|M.vanbaalenii_PYR-1 VPHTYRTRFLFFATGYYDYDHPYRPDFPGLDSFSGTVVHPQHWPEDLDYA
TH_2757|M.thermoresistible__bu LPRTYRSRFVFFGTGYYDYDEPYAPEFPGIENFKGEVVHPQHWPESLDYA
MSMEG_2038|M.smegmatis_MC2_155 QPRDYRARFVFFGTGYYNYDEPYTPDFPGINDFRGEVVHPQFWPESLDHT
MAB_2294c|M.abscessus_ATCC_199 GPTTYRAKFLYLCTGYYNYDDGYTPEFPGVEKFAGRLIHPQHWPDDLDCS
MLBr_00065|M.leprae_Br4923 TPRMISCSFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYA
MUL_5026|M.ulcerans_Agy99 AMSAVTCSFLFLCSGYYNYDQGYTPNFAGAQDFAGSIIHPQHWPEDLDYD
*::: :***:*:. * * * * : * * ::***.** .**
Mb0580c|M.bovis_AF2122/97 GKKIVVIGSGATAVTLIPSLTDR-AEKVTMLQRSPTYLISASKYSTFAAV
Rv0565c|M.tuberculosis_H37Rv GKKIVVIGSGATAVTLIPSLTDR-AEKVTMLQRSPTYLISASKYSTFAAV
MMAR_0917|M.marinum_M GKKVVVIGSGATAVTLIPSMAEQ-AAKVTMLQRSPTYLISSSKYSKFAAI
MAV_4576|M.avium_104 GKKVVVIGSGATAVTLLPSLSDR-AAKVTMLQRSPTYLISASKYGKVAAV
Mflv_4499|M.gilvum_PYR-GCK GKKVAVIGSGATAISMIPALAES-AERVTMVQRSPTYLLSGQRINPVVNL
Mvan_1867|M.vanbaalenii_PYR-1 GKNVVVIGSGATAISLIPSLTKQ-AGHVTMLQRSPTYLLSGQRINPVVNL
TH_2757|M.thermoresistible__bu GKRMVVIGSGATAISLIPSLTEQ-AEHVTMLQRTPTYLLSSPRINPVVQA
MSMEG_2038|M.smegmatis_MC2_155 GKRVVVIGSGATAISLVPAMART-AGHVTMLQRSPTYMMSSPRINPAVQA
MAB_2294c|M.abscessus_ATCC_199 GKEITVIGSGATAITLVPSLARA-GAKVNMLQRSPSYIYPIARVDAVVDV
MLBr_00065|M.leprae_Br4923 AKNIVVIGSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAAR
MUL_5026|M.ulcerans_Agy99 GKNVVVIGSGASAVTLVPALANSGAKHVTMLQRSPTYIVSQPERDSIAER
.*.:.******:*::::*::: . :*.*:**:*:*: . . .
Mb0580c|M.bovis_AF2122/97 VRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPE
Rv0565c|M.tuberculosis_H37Rv VRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPE
MMAR_0917|M.marinum_M ARKVLPRKASHLTIRTYNALLEAVLWFLARKLPGFIKWLLRRIAIKNLPA
MAV_4576|M.avium_104 ARKVLPRKPAHLVIRMYSALTEAVFFALSRKAPRLVRWLLRRKAINSLPP
Mflv_4499|M.gilvum_PYR-GCK LRKVPPRKLGYRLAWLYNVLFIVAVYGVARKAPRISRRLIRAVAKHYLPE
Mvan_1867|M.vanbaalenii_PYR-1 LRRVPPRKLGYRLAWLYNVLFIVSVYGIARKAPRFSRKIIRAVAKHYLPE
TH_2757|M.thermoresistible__bu LRKIPPRWLGYRLAWLYNLIFVVAVYAIAKAAPRFSRWFIRTVAKIYLPK
MSMEG_2038|M.smegmatis_MC2_155 IRKVLPRRVAHQVVRVRNAMVQYVAYHLFRAAPRLGRWVIRKATISVLPK
MAB_2294c|M.abscessus_ATCC_199 MRKVFPLSIVQHFARIWLGGFNWIMYQVCRKAPGFAKWFLRRRITKLLPA
MLBr_00065|M.leprae_Br4923 LNRWLPDKYAYTAVRWKNILRQSALYGACQKWPQRMRNILLGHVARRLPK
MUL_5026|M.ulcerans_Agy99 LNRWLPENMAYAMVRWKNVLRQAAVYGACRKWPRRMRKNFMGLAQRQLPE
.: * : : * : : **
Mb0580c|M.bovis_AF2122/97 GYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATG
Rv0565c|M.tuberculosis_H37Rv GYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATG
MMAR_0917|M.marinum_M GYDVDTHFKPNYNPWDQRLCLIPDADLYSAVAGGRAEVVTDHIDHFDATG
MAV_4576|M.avium_104 GYAVDIHFKPRYNPWDQRMCLIPDADLYNAITAGRADVVTDHIDHFDATG
Mflv_4499|M.gilvum_PYR-GCK GYPVDTHFKPRYDPWDQRLCLILSGDFYDAIARGRAEVVTDEIDHIDAHG
Mvan_1867|M.vanbaalenii_PYR-1 GYPVDTHFNPSYDPWDQRLCLILSGDFYDAIAKGRAEVVTDRVDHIDANG
TH_2757|M.thermoresistible__bu DYPVDVHFNPPYDPWDQRLCLILSGDFYKAIREGRATVVTDNIDHIDETG
MSMEG_2038|M.smegmatis_MC2_155 GYPVDVHFKPRYNPWDQRMCLVLDKDIFEGISSGRFDVVTDHIDHFDADG
MAB_2294c|M.abscessus_ATCC_199 GYPVDVHFAPRYNPWDQRVCADTDGDLFEAISNGGVRMVTDTIDTFTSAG
MLBr_00065|M.leprae_Br4923 GYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRFTSTG
MUL_5026|M.ulcerans_Agy99 GYDVRKHFGPHYNPWDQRLCLVPNGDLFRAIRHGQVDVVTDTIDRFTPTG
.* : ** * *:**:**:* . *:: .: * :*** :* : *
Mb0580c|M.bovis_AF2122/97 IALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHML
Rv0565c|M.tuberculosis_H37Rv IALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHML
MMAR_0917|M.marinum_M IALESGRHLDADIIVTATGLQLQALGGVQISLDGTEINPCDRFVYKAHML
MAV_4576|M.avium_104 IALRSGAHLDADIIITATGLQLQALGGATISLDGNEIKTNDRFVYKAHML
Mflv_4499|M.gilvum_PYR-GCK LVLKSGRRIDADVLVTATGLQLQALGGIEISIDGTEVKPADRFVYKEHLL
Mvan_1867|M.vanbaalenii_PYR-1 IVLQSGKRIDADVIVTATGIQLQALGGVVISVDGDEVKPADRFVYKEHLL
TH_2757|M.thermoresistible__bu IVLRSGNRIDADIIVTATGLQLQALGGVRLSIDGEEIKPQDRFVFKEHML
MSMEG_2038|M.smegmatis_MC2_155 IVLTSGNRIDADIVVTATGLQLQALGGITLRVDGDEVKPTERFVYKEFLL
MAB_2294c|M.abscessus_ATCC_199 IRLGSGQELPADVIITATGLNLQIFGGIALSVDGSPVDAPNRFIYKGYLI
MLBr_00065|M.leprae_Br4923 IRLKSGNELRADIIVTATGLNLQLFGGAVATVDGQPVDLAQTMSYKGMML
MUL_5026|M.ulcerans_Agy99 IRLNSGQQLPADIIVTATGLNLQLFGGAAVTVDGESVDLTKAMAYKGMML
: * ** .: **:::****::** :** :** :. . : :* ::
Mb0580c|M.bovis_AF2122/97 EDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDE
Rv0565c|M.tuberculosis_H37Rv EDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDE
MMAR_0917|M.marinum_M EGVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAANGYTHAYPDRGNE
MAV_4576|M.avium_104 EDVPNLFWCVGYTNASWTLRADITARATAKLLEHMTTHGYTHAYPHRGNE
Mflv_4499|M.gilvum_PYR-GCK EDVPNLAWCVGYINASWTLRADLTARAVAKLLAHMDSHGYTHAYPHLGGV
Mvan_1867|M.vanbaalenii_PYR-1 EDVPNMAWCVGYINASWTLRADLTARAVAKLLAYMDSHGYTHAYPHLGGT
TH_2757|M.thermoresistible__bu EDVPNLAWCIGYINASWTLRADLTARAFARLIAHMRKHGYTHGYPHLGDT
MSMEG_2038|M.smegmatis_MC2_155 EDVPNMAWCIGYTNASWTLRADMTAKAVAKLLAYMGSHGYTHAYPHKGST
MAB_2294c|M.abscessus_ATCC_199 EGVPNAAWSVGYTNASWTLRADLSARAVVRLLDYMDRHGYTHAYPDRHGE
MLBr_00065|M.leprae_Br4923 SGLPNMIYTVGYTNASWTLKADLVSEFFCRLLNYMNANDFDTVAVEYPGS
MUL_5026|M.ulcerans_Agy99 SGLPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDANDYESVVVERPGS
..:** : :** ******:**: :. :*: :* :.. . .
Mb0580c|M.bovis_AF2122/97 PMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRI-
Rv0565c|M.tuberculosis_H37Rv PMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRI-
MMAR_0917|M.marinum_M AMPEKPSWDIQAGYVLRSLHALPKSGTKRPWNVRQNYFADAIDYRFDRI-
MAV_4576|M.avium_104 PMTEKPSWDINAGYVLRSVHALPKSGTKRPWNVRQNYLADAIDYRFDRI-
Mflv_4499|M.gilvum_PYR-GCK PMEEKPAWNINAGYVHRAPHVLPKSGTHRPWNVRHNYVLDAVDQRFDRI-
Mvan_1867|M.vanbaalenii_PYR-1 SMPEKPAWNINAGYVHRAVHVLPKSGTHRPWNVRHNYVLDAIDHRVDRI-
TH_2757|M.thermoresistible__bu PMKEKPAWNINAGYVKRALHALPKSGTRRPWNVRHNYLLDVVDHRFDRI-
MSMEG_2038|M.smegmatis_MC2_155 PIAEKRTWDLEAGYIQRSEHALPRSGTKRPWHVRHNYLLDAIDHRFDRI-
MAB_2294c|M.abscessus_ATCC_199 ELEARPFFNLSSGYVTRGDAHMPRSGVSGPWAIRHNYVLDFLAFHRDRI-
MLBr_00065|M.leprae_Br4923 DVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLRDIRLIRRGKVA
MUL_5026|M.ulcerans_Agy99 DVQECPFMEFTPGYVLRVIDELPKQGSRKPWRLNQDYLRDIHLIRRGKID
: :: .**: * :*:.* ** :.::*. * : .::
Mb0580c|M.bovis_AF2122/97 EEAMVFGAA-------------------------------
Rv0565c|M.tuberculosis_H37Rv EEAMVFGAA-------------------------------
MMAR_0917|M.marinum_M DEAMMFGRAADRAPLAG-----------------------
MAV_4576|M.avium_104 EEAMVFGRAADRAALAG-----------------------
Mflv_4499|M.gilvum_PYR-GCK DESMVFGRVSPKLHSSSEMSSEDLLERNFGA---------
Mvan_1867|M.vanbaalenii_PYR-1 EESMVFGRAASKSPSSSDIPGEDLLEGKVVG---------
TH_2757|M.thermoresistible__bu DESMVFGRVGAPLKQPA-----------------------
MSMEG_2038|M.smegmatis_MC2_155 DESMVFGRAPAAVQVPASAPSPAPPSAPRAGASAVEPAAS
MAB_2294c|M.abscessus_ATCC_199 DENMQFGIAKSKAVSSAA----------------------
MLBr_00065|M.leprae_Br4923 DEGLLFAKKTTPVTV-------------------------
MUL_5026|M.ulcerans_Agy99 DEGLRFAKKPVAVPV-------------------------
:* : *.