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TGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRVLRDTGYSEETTQEIYLEVWRNASEFDS AKGSALAWLLTMAHRRAVDRVRCEQAGNQREVRYGAANVDPASDVVADLAIAGDERRRVTECLKALTDTQ RQCIELAYYGGLTYVEVSRRLAANLSTIKSRMRDALRSLRNCLDVS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0445c | sigK | - | 100% (187) | RNA polymerase sigma factor SigK |
| M. tuberculosis H37Rv | Rv0735 | sigL | 2e-10 | 24.54% (163) | RNA polymerase sigma factor SigL |
| M. tuberculosis H37Rv | Rv2069 | sigC | 4e-07 | 28.18% (181) | RNA polymerase sigma factor SigC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0453c | sigK | 1e-104 | 100.00% (187) | RNA polymerase sigma factor SigK |
| M. gilvum PYR-GCK | Mflv_1818 | - | 1e-66 | 65.19% (181) | RNA polymerase sigma factor SigK |
| M. leprae Br4923 | MLBr_01076 | sigE | 2e-06 | 26.58% (158) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_2163 | - | 5e-15 | 30.07% (153) | ECF subfamily RNA polymerase sigma factor |
| M. marinum M | MMAR_0766 | sigK | 6e-83 | 81.28% (187) | alternative RNA polymerase sigma factor SigK |
| M. avium 104 | MAV_4431 | - | 2e-12 | 26.79% (168) | RNA polymerase sigma factor SigL |
| M. smegmatis MC2 155 | MSMEG_1486 | - | 9e-13 | 27.22% (169) | RNA polymerase sigma factor SigL |
| M. thermoresistible (build 8) | TH_1729 | sigC | 1e-08 | 27.44% (164) | PROBABLE RNA POLYMERASE SIGMA FACTOR, ECF SUBFAMILY, SIGC |
| M. ulcerans Agy99 | MUL_1400 | sigK | 4e-83 | 81.28% (187) | RNA polymerase sigma factor SigK |
| M. vanbaalenii PYR-1 | Mvan_4927 | - | 7e-68 | 66.67% (183) | RNA polymerase sigma factor SigK |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0445c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0453c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0766|M.marinum_M --------------------------------------------------
MUL_1400|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1818|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4927|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4431|M.avium_104 --------------------------------------------------
MSMEG_1486|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2163|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1729|M.thermoresistible__bu --------------------------------------------------
MLBr_01076|M.leprae_Br4923 MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPT
Rv0445c|M.tuberculosis_H37Rv ------------MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVY
Mb0453c|M.bovis_AF2122/97 ------------MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVY
MMAR_0766|M.marinum_M ------------MTGPPGRSDDLNALLRQIARGERDAFAMFYDHTCTRVY
MUL_1400|M.ulcerans_Agy99 ------------MTGPPGRSDDLNALLRQIARGERDAFAMFYDHTCTRVY
Mflv_1818|M.gilvum_PYR-GCK -----------MADRVLLVTAELDALLRQVARRDADAFAAFYDQTRSRVF
Mvan_4927|M.vanbaalenii_PYR-1 ---MTASVLVGAAARLPLVTAELDALLRQVAQRDAEAFAAFYDQTRARVY
MAV_4431|M.avium_104 ----------------------MVGISRASGTAEAALMKALYDEHAAVLW
MSMEG_1486|M.smegmatis_MC2_155 ----------------------ME-------DPEAAMMRALYDEHATALW
MAB_2163|M.abscessus_ATCC_1997 -------------------------------------MRAFYDEYAGPLH
TH_1729|M.thermoresistible__bu --------------VGLRDDDRVTRLALAAGRGDPAALEQFIRATQRDVW
MLBr_01076|M.leprae_Br4923 IMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVY
: :
Rv0445c|M.tuberculosis_H37Rv GLVMRVLRDTGYSEETTQEIYLEVWRNA---------SEFDSAKGSALAW
Mb0453c|M.bovis_AF2122/97 GLVMRVLRDTGYSEETTQEIYLEVWRNA---------SEFDSAKGSALAW
MMAR_0766|M.marinum_M GLVARVLRDAGYSEETTQEIYLEVWRTA---------SDYDATKGSPLAW
MUL_1400|M.ulcerans_Agy99 GLVARVLRDAGYSEETTQEIYLEVWRTA---------SDYDATKGSPLAW
Mflv_1818|M.gilvum_PYR-GCK GLVTRVLRDPGYSEETTQDVYLQVWRTA---------HNYDPSAGSPLAW
Mvan_4927|M.vanbaalenii_PYR-1 GLITRVLRDPGYSEETTQDVYLQVWRNA---------AGYDPSVGSALSW
MAV_4431|M.avium_104 RYALRLTGDASQSEDVVQETLLRAWQHP---------EVIGDTERSARAW
MSMEG_1486|M.smegmatis_MC2_155 RYALRLTGDPARAEDVVQETLLRAWRHQPDLRTGGGADGIAGPDRSPRAW
MAB_2163|M.abscessus_ATCC_1997 RYVMHLTHDSALAEDIVQEVLLRAWRHP---------TLVNQTEGSARAW
TH_1729|M.thermoresistible__bu RTVAYLA-DPGSADDLTQETFLRAIRSL---------PKFNG-RSSARTW
MLBr_01076|M.leprae_Br4923 WLAYRLSGNQHDAEDLTQETFIRVFRSV-----------QNYQPGTFEGW
: : ::: .*: :.. : : *
Rv0445c|M.tuberculosis_H37Rv LLTMAHRRAVDRVRCEQAGNQREVRYGAANVDPASDVVADLAIAGDERRR
Mb0453c|M.bovis_AF2122/97 LLTMAHRRAVDRVRCEQAGNQREVRYGAANVDPASDVVADLAIAGDERRR
MMAR_0766|M.marinum_M LLTMAHRRAVDRVRAEQAGSQRESRYGAANVDLASDVVADSAIAGDERRR
MUL_1400|M.ulcerans_Agy99 LLTMAHRRAVDRVRAEQAGSQRESRYGAANVDLASDVVADSAIAGDERRR
Mflv_1818|M.gilvum_PYR-GCK LLTLAHRRAVDRVRSEEAASSRDSRYGAATIETPTDHVSDAAILSDERQR
Mvan_4927|M.vanbaalenii_PYR-1 LLTLAHRRAVDRVRSEQAASTRESRYGAISVDPPSDHVADDVLLDDERRR
MAV_4431|M.avium_104 LFTVARNMIIDDRRSARFRNVVGSTDTAGAPEQST---PDEVNAALDRLL
MSMEG_1486|M.smegmatis_MC2_155 LFTVARNMIIDERRSARFRNETDVPDPEQVADHAT---SDQVDTALDRLL
MAB_2163|M.abscessus_ATCC_1997 LFTVAHNLVRDNARSSRFRSEIATAET---PEFAS---PDQVDATLDAWL
TH_1729|M.thermoresistible__bu LLSIARRVVVDQIRHNQSRPRTSYAVDVHTVLDKR----RPDGRFEDIVE
MLBr_01076|M.leprae_Br4923 LHRITTNLFLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPD
* :: . * *
Rv0445c|M.tuberculosis_H37Rv VTECLKALTDTQRQCIELAYYGGLTYVEVSRRLAANLSTIKSRMRDALRS
Mb0453c|M.bovis_AF2122/97 VTECLKALTDTQRQCIELAYYGGLTYVEVSRRLAANLSTIKSRMRDALRS
MMAR_0766|M.marinum_M VVECLDGLTDTQRQCIELAYYGGLTYAEVSQRLATNLSTIKSRMRDALRG
MUL_1400|M.ulcerans_Agy99 VVECLDGLTDTQRQCIELAYYGGLTYAEVSQRLATNLSTIKSRMRDALRG
Mflv_1818|M.gilvum_PYR-GCK VTDCLGALTDTQRECIQLAYYDGLTYAQVSERLATNLATIKSRMRDAIRG
Mvan_4927|M.vanbaalenii_PYR-1 VAGCLDSLTDVQRECIQLAYYDGLTYAQVADRLAANLATIKSRMRDGIRA
MAV_4431|M.avium_104 IADAMAQLSAEHRAVIERSYYRGWTTAQIATDLGIAEGTVKSRLHYAVRA
MSMEG_1486|M.smegmatis_MC2_155 LGTALRQLSDDHRAVIRRAYYQGLTTGQIAAELQIPEGTVKSRLHYAVRA
MAB_2163|M.abscessus_ATCC_1997 VAEALRTLSTDHRAVILRAYYRGSSVADISAELGVPEGTVKSRLHYGVRA
TH_1729|M.thermoresistible__bu IKLLLDGLDTDRRHALLLTQVLGLSYAEAAEVCGCAVGTIRSRVARARDD
MLBr_01076|M.leprae_Br4923 LQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQA
: : * * : * : : . .*::**: .
Rv0445c|M.tuberculosis_H37Rv LRNCLDVS----------------
Mb0453c|M.bovis_AF2122/97 LRNCLDVS----------------
MMAR_0766|M.marinum_M LRNCLDAS----------------
MUL_1400|M.ulcerans_Agy99 LRNCLDAS----------------
Mflv_1818|M.gilvum_PYR-GCK LKRCMGVT----------------
Mvan_4927|M.vanbaalenii_PYR-1 LRKCLGVA----------------
MAV_4431|M.avium_104 LRLTLQELGVTR------------
MSMEG_1486|M.smegmatis_MC2_155 LKLSLQEMGVTR------------
MAB_2163|M.abscessus_ATCC_1997 LRLSLQEMGVTR------------
TH_1729|M.thermoresistible__bu LLQQARPVDRTG------------
MLBr_01076|M.leprae_Br4923 LRDYLLTAHPRDGATTDATHVKSA
*