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LPSCPPAYSEQVRGDGDGWVVSDSGVAYWGRYGAAGLLLRAPRPDGTPAVLLQHRALWSHQGGTWGLPGG ARDSHETPEQTAVRESSEEAGLSAERLEVRATVVTAEVCGVDDTHWTYTTVVADAGELLDTVPNRESAEL RWVAENEVADLPLHPGFAASWQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTPGDADQAPSPLG RRISSLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0413 | mutT3 | - | 100% (217) | POSSIBLE MUTATOR PROTEIN MUTT3 (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE) (8-OXO-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0421 | mutT3 | 1e-128 | 100.00% (217) | 7,8-dihydro-8-oxoguanine-triphosphatase |
| M. gilvum PYR-GCK | Mflv_0199 | - | 2e-69 | 77.78% (162) | NUDIX hydrolase |
| M. leprae Br4923 | MLBr_02299 | - | 9e-05 | 32.53% (83) | hypothetical protein MLBr_02299 |
| M. abscessus ATCC 19977 | MAB_4221c | - | 3e-59 | 57.98% (188) | MutT/NUDIX family mutator protein |
| M. marinum M | MMAR_0716 | mutT3 | 4e-90 | 75.73% (206) | mutator protein MutT3 |
| M. avium 104 | MAV_4747 | - | 8e-93 | 76.56% (209) | hydrolase, NUDIX family protein |
| M. smegmatis MC2 155 | MSMEG_0790 | - | 8e-67 | 76.62% (154) | hydrolase, NUDIX family protein |
| M. thermoresistible (build 8) | TH_2310 | mutT3 | 5e-72 | 74.40% (168) | POSSIBLE MUTATOR PROTEIN MUTT3 |
| M. ulcerans Agy99 | MUL_2807 | mutT3 | 3e-88 | 74.27% (206) | mutator protein MutT3 |
| M. vanbaalenii PYR-1 | Mvan_0706 | - | 1e-72 | 77.71% (166) | NUDIX hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0199|M.gilvum_PYR-GCK -------------------------MQNQVP-RIRRPLPKLVLVRGDGDG
Mvan_0706|M.vanbaalenii_PYR-1 -------------------------MDSGAPNSVTVPYPER--VRGDGDG
MSMEG_0790|M.smegmatis_MC2_155 --------------------------------------------------
Rv0413|M.tuberculosis_H37Rv --------------------------------MPSCPPAYSEQVRGDGDG
Mb0421|M.bovis_AF2122/97 --------------------------------MPSCPPAYSEQVRGDGDG
MMAR_0716|M.marinum_M -------------------------------------------MRGDGDG
MUL_2807|M.ulcerans_Agy99 -------------------------------------------MRGDGDG
MAV_4747|M.avium_104 -------------------------------------------MHGDGDG
TH_2310|M.thermoresistible__bu -------------------------------------------VRGDGDG
MAB_4221c|M.abscessus_ATCC_199 -------------------------------------------MRGDGDG
MLBr_02299|M.leprae_Br4923 MPVSAGCTARVQGTVPLVFDVGPSWLRPLVDNIAVMPGVYQRLLPADVLA
Mflv_0199|M.gilvum_PYR-GCK WVVSA-----SGAAFWGRHGAAGLLLRAP--------GPNGAPAVLLQHR
Mvan_0706|M.vanbaalenii_PYR-1 WVVSE-----AGNAYWGRHGAAGLLLRAP--------GPGGSAAVLLQHR
MSMEG_0790|M.smegmatis_MC2_155 -MMSE-----NGARFWGRHGAAGLLLRAP--------MPGGAAAVLLQHR
Rv0413|M.tuberculosis_H37Rv WVVSD-----SGVAYWGRYGAAGLLLRAP--------RPDGTPAVLLQHR
Mb0421|M.bovis_AF2122/97 WVVSD-----SGVAYWGRYGAAGLLLRAP--------RPDGTPAVLLQHR
MMAR_0716|M.marinum_M WVISE-----SGVHYWGRFGSAGLLLRAP--------RPDGTPAVLLQHR
MUL_2807|M.ulcerans_Agy99 WVISE-----RGVHYWGRFGSAGLLLRAP--------RPDGAAAVLLQHR
MAV_4747|M.avium_104 WVISE-----RGAHYWGRYGAAGLLLRAP--------QPDGTPAVLLQHR
TH_2310|M.thermoresistible__bu WVMSE-----SGARFWGRYGAAGLLLRAP--------RPDGSPAVLLQHR
MAB_4221c|M.abscessus_ATCC_199 WVVAD-----SGARFWGRFGAAGLLLRAP--------LPNGQPAVLLQHR
MLBr_02299|M.leprae_Br4923 IVTAARAIPSVALRRDGREAAVLVLFSGPESGPPDGGAPDDADLLLTVRA
: : . ** .:. :*: .* *.. :* :
Mflv_0199|M.gilvum_PYR-GCK APWSHQGGTWGLPGGARDSHET-PEQAAVREAEEEAGLSPHQLTVRTTVV
Mvan_0706|M.vanbaalenii_PYR-1 APWSHQGGTWGLPGGARDSHET-AEQAAVREAEEEAGLPADQLTVRTTVV
MSMEG_0790|M.smegmatis_MC2_155 APWSHQGGTWALPGGARDSHET-PEQAAVREAHEEAGLPAEQLTVRTTVV
Rv0413|M.tuberculosis_H37Rv ALWSHQGGTWGLPGGARDSHET-PEQTAVRESSEEAGLSAERLEVRATVV
Mb0421|M.bovis_AF2122/97 ALWSHQGGTWGLPGGARDSHET-PEQTAVRESSEEAGLSAERLEVRATVV
MMAR_0716|M.marinum_M AFWSHQGGTWGLPGGARDSHET-PEQTALREAHEEARLPAERLTVRAVTV
MUL_2807|M.ulcerans_Agy99 AFWSHQGGTWGLPGGARDSHET-PEQTALREAHEEARLPAERLTVRAVTV
MAV_4747|M.avium_104 AVWSHQGGTWGLPGGARDSHET-PEETAVREANEEAGLLVDRLAVRASVV
TH_2310|M.thermoresistible__bu AAWSHQGGTWGLPGGARDSHET-AEQAAVREAHEETGLAVELVVVRTAVV
MAB_4221c|M.abscessus_ATCC_199 AWWSHQGGTWALPGGARDSHES-AEEAALREAAEEAGVDPAVMTVRSSVV
MLBr_02299|M.leprae_Br4923 STLRHHAGQAAFPGGASDPTDDGPVATALREAHEETGIDLARLHPLATLE
: *:.* .:**** *. : . :*:**: **: : : :
Mflv_0199|M.gilvum_PYR-GCK TAENSG-----WTYTTVIADATEQ--LVTVPNRESAELRWVAEDEVTNLP
Mvan_0706|M.vanbaalenii_PYR-1 TAEVSG-----WTYTTVIADAGEQ--LATIPNRESAELRWVAEDEVADLP
MSMEG_0790|M.smegmatis_MC2_155 TAEVAGIGGTQWTYTTVIADAAEP--LHTVPNRESAELRWVLEDQVADLP
Rv0413|M.tuberculosis_H37Rv TAEVCGVDDTHWTYTTVVADAGEL--LDTVPNRESAELRWVAENEVADLP
Mb0421|M.bovis_AF2122/97 TAEVCGVDDTHWTYTTVVADAGEL--LDTVPNRESAELRWVAENEVADLP
MMAR_0716|M.marinum_M TARPSG---TAWTYTTVIADTREL--LHAVPDRESAELRWVAEAEVVDFP
MUL_2807|M.ulcerans_Agy99 TARPSG---TAWTYTTVIADTREL--LHAVPDRESAELRWVAEAEVVDFP
MAV_4747|M.avium_104 TAEVAGVGGTRWSYTTVIADADEL--LHTVPNRESAEMRWVAEDEVADLP
TH_2310|M.thermoresistible__bu TAEVAGVGGTHWSYTTVIADAPEM--LETEPNLESAELRWVAEDDVGALP
MAB_4221c|M.abscessus_ATCC_199 TKRIDG--QAHWTYTTVIADAAEL--LPTAANHESTELRWVPEEKIEGMR
MLBr_02299|M.leprae_Br4923 RMFIAP---SRFHVVPVLAYSADPGPVAVVNEAETAIVARVPLCAFINPA
: ..*:* : : : . : *:: : * .
Mflv_0199|M.gilvum_PYR-GCK ---LHPGFAASWARLREVTALIPLMVNPQR--------------------
Mvan_0706|M.vanbaalenii_PYR-1 ---LHPGFAASWERLREVTASIPLLVNPQR--------------------
MSMEG_0790|M.smegmatis_MC2_155 ---LHPGFAASWQRLREVTATIPLLNR-QR--------------------
Rv0413|M.tuberculosis_H37Rv ---LHPGFAASWQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTP
Mb0421|M.bovis_AF2122/97 ---LHPGFAASWQRLRTAPATVPLARCDERRQRLPRTIQIEAGVFLWCTP
MMAR_0716|M.marinum_M ---LHPGFAASWQGLRCAPVTVPLERGDQRRELLPRTVEVEPGVFVWCMP
MUL_2807|M.ulcerans_Agy99 ---LHPGFAASWQGLRCAPVTVPLERGDQRRELLPRTVEVEPGVFVWCMP
MAV_4747|M.avium_104 ---LHPGFAASWHRLRTEPARLPLSHGDERRQYLPRTIEPEDGVFVWCMP
TH_2310|M.thermoresistible__bu ---LHPGFAASWDGLRELIATIPLLTNDPR--------------------
MAB_4221c|M.abscessus_ATCC_199 ---LHPGFKSSWPLLR-VVETLPHASNGFTGAG---TVELESGRYAWQLP
MLBr_02299|M.leprae_Br4923 NRLMVYRRAHGHRWYGPAFLLNDMLVWGFTGQVIAAMLDVAGWAQSWDVT
: .
Mflv_0199|M.gilvum_PYR-GCK -------------------------
Mvan_0706|M.vanbaalenii_PYR-1 -------------------------
MSMEG_0790|M.smegmatis_MC2_155 -------------------------
Rv0413|M.tuberculosis_H37Rv G---DADQAPSPLGRRISSLL----
Mb0421|M.bovis_AF2122/97 G---DADQAPSPLGRRISSLL----
MMAR_0716|M.marinum_M G---DADQVPSQLSPRVISLLEALT
MUL_2807|M.ulcerans_Agy99 G---DADQVPSQLSPRVISLLEALT
MAV_4747|M.avium_104 GDPADTDEASAQLCRRISALLPAPS
TH_2310|M.thermoresistible__bu -------------------------
MAB_4221c|M.abscessus_ATCC_199 -------------------------
MLBr_02299|M.leprae_Br4923 DVREVGEAMALVDSQGDPR------