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M. tuberculosis H37Rv Rv0354c (PPE7)

annotation: PPE FAMILY PROTEIN
coordinates: 424269 - 424694
length: 141

SVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPIDTAFTQTLDFAGSGTVGAFPFGFGWQQ
SPGFFNSTTTPSSGFFNSGAGGASGFLNDAAAAVSGLGNVFTETSGFFNAGGVGIRASKTSATCCRAGRT
*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0354cPPE7-100% (141)PPE FAMILY PROTEIN
M. tuberculosis H37RvRv0304cPPE53e-2047.57% (103) PPE family protein
M. tuberculosis H37RvRv0355cPPE84e-1245.98% (87) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0362cPPE82e-71100.00% (125) PPE family protein
M. gilvum PYR-GCK-----
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_0642-3e-5267.67% (133) PPE family protein
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_0965-6e-0537.18% (78) PPE family protein
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         MSFAVLPPEINSARLYVGAGLAPMLDAAAAWDGLADELGSAAASFSAVTA
MMAR_0642|M.marinum_M             MNFAVLPPEINSARLTIGAGLGPMLEAANAWQGLAGELGSAASAFSSVTT
MUL_0965|M.ulcerans_Agy99         MNFIMLPPEINSARIFAGAGVGPTLAAAAAWDALAADLASAAQSFAAITV
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GLAGSSWLGAASTAMTGAAAPYLGWLSAAAAQAQQAATQTRLAAAAFEAA
MMAR_0642|M.marinum_M             DLVSGGWQGAASTAMASAAAPYLKWLTTAAAQAGQAATQVRLAAAAFEAA
MUL_0965|M.ulcerans_Agy99         GLVGEAWQGAAATAMAAAARPYASWLGTAAARAAVTAAQANAAAAVFEAA
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LAATVHPAIISANRALFVSLVVSNLLGQNAPAIAATEAAYEQMWAQDVAA
MMAR_0642|M.marinum_M             LAATVHPAAISANRSQFVSLVVSNLLGQNAPAIAAAEAAYEQMWAQDVAA
MUL_0965|M.ulcerans_Agy99         QAATAHPELVAANRNQLVSLVVSNLFGQNAPAIASTEAAYDQLWAQDVAA
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         MFGYHAGASAAVSALTPFGQALPTVAGGGALVSAAAAQVTTRVFRNLGLA
MMAR_0642|M.marinum_M             MFGYRSGAESIAAALTPFPLQAAG----------------SVVTANLGFA
MUL_0965|M.ulcerans_Agy99         MAGYHSGASAVAAQLAPWQQALRT--------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NVGEGNVGNGNVGNFNLGSANIGNGNIGSGNIGSSNIGFGNVGPGLTAAL
MMAR_0642|M.marinum_M             NVGFRNFGNGNVGDYNLGSGNLGSENVGSSNIGSGNIGFGNSGPALTAAL
MUL_0965|M.ulcerans_Agy99         ---------------------------LQNRVAGATTALPPPGPAAAAAL
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NNIGFGNTGSNNIGFGNTGSNNIGFGNTGDGNRGIGLTGSGLLGFGGLNS
MMAR_0642|M.marinum_M             NNIGFGNTGSNNIGFGNTGNNNIGFGNTGDNNRGIGLTGTGQFGLGGLNS
MUL_0965|M.ulcerans_Agy99         P-------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GTGNIGLFNSGTGNVGIGNSGTGNWGIGNSGNSYNTGFGNSGDANTGFFN
MMAR_0642|M.marinum_M             GSGNIGLFNSGTGNFGIGNSGTGNWGIGNSGNSYNTGIGNSGDANTGFFN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SGIANTGVGNAGNYNTGSYNPGNSNTGGFNMGQYNTGYLNSGNYNTGLAN
MMAR_0642|M.marinum_M             AGVANTGIGNVGSYNTGGFNPGDANTGGFNTGSYNTGYLNRGDYNTGVAN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SGNVNTGAFITGNFNNGFLWRGDHQGLIFGSPGFFNSTSAPSSGFFNSGA
MMAR_0642|M.marinum_M             FGNVNTGALNTGDYNNGFLWRGDNQGLIFGEPGFGNSTTVPSSGFFNSGE
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GSASGFLNSGANNSGFFNSSSGAIGNSGLANAGVLVSGVINSGNTVSGLF
MMAR_0642|M.marinum_M             GSASGFFNSGANNSGFFNDSSGPIGNSGFANTGVLQSGLVNSGNTISGLL
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NMSLVAITTPALISGFFNTGSNMSGFFGGPPVFNLGLANRGVVNILGNAN
MMAR_0642|M.marinum_M             NSSLVPITTPAYISGVLNTGSNLAGFLLGPTLFNIGFANDGVGNILAHAN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         IGNYNILGSGNVGDFNILGSGNLGSQNILGSGNVGSFNIGSGNIG-----
MMAR_0642|M.marinum_M             VGNYNIGGNGNVGDYNIFGSGNAGSYNIFGSGNIGSLNLGSGNFGGTNFG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         -----VFNVGSGSLGNYNIGSGNLGIYNIGFGNVGDYNVGFGNAGDFNQG
MMAR_0642|M.marinum_M             SGNIGSLNLGSANIGSYNIGSASLGSYNVGFGNLGDYNTGFGNAGSYNQG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         FANTGNNNIGFANTGNNNIGIGLSGDNQQGFNIASG-------WNSGTGN
MMAR_0642|M.marinum_M             LANTGSNNAGFANTGNGNIGIGLTGDGQIGIGALNSGIGNAGLFNSGTDN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SGLFNSGTNNVGIFNAGTGNVGIANSGTGNWGIGNPGTDNTGILNAGSYN
MMAR_0642|M.marinum_M             VGLFNSGSGNIGIGNSGSGNTGLLNAGVANWGLENPGTANTGIGNAGQYN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TGILNAGDFNTGFYNTGSYNTGGFNVGNTNTGNFNVGDTNTGSYNPGDTN
MMAR_0642|M.marinum_M             TGLHNVGAANTGFYNNGSYNTGGFNVGSTNTGSFDAGSANTGNFNPGDTN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TGFFNPGNVNTGAFDTGDFNNGFLVAGDNQGQIAIDLSVTTPFIPINEQM
MMAR_0642|M.marinum_M             TGSYNPGNVNTGFFDTGNYNNGFFVTSDNQGQIAINLSVTTPHIPIDVQS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         VIDVHNVMTFGGNMITVTEASTVFPQTFYLSGLFFFGPVNLSASTLTVPT
MMAR_0642|M.marinum_M             IVPVNQVYTLGGNTIQVSEAGSVFPRTYYLGGLFFLGPINLGASTLTIPT
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         ITLTIGGPTVTVPISIVGALESRTITFLKIDPAPGIGNSTTNPSSGFFNS
MMAR_0642|M.marinum_M             VTIALGGPSTNIPISIVGAVESRTITFLDIPAAPGFGNTTAGPSSGFFNA
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GTGGTSGFQNVGGGSSGVWNSGLSSAIGNSGFQNLGSLQSGWANLGNSVS
MMAR_0642|M.marinum_M             GTGGNSGFANFGAASSGLWNSG-VAAAGNSGVQNFGSLASGWANLGNTLS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GFFNTSTVNLSTPANVSGLNNIGTNLSGVFRGPTGTIFNAGLANLGQLNI
MMAR_0642|M.marinum_M             GFYNTSTANLAAPANLSGLFNVGTDLAGVLRDANGTILNLGLADLGHLNV
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GSANLGDFNLGSGNVGSFNVFSGNQGSYNIGPANLGNYNIGFANLGN---
MMAR_0642|M.marinum_M             GSGNVGDFNVGSANIGSANFGFGNVGSDNLGSGNIGSGNIGFGNAGARLT
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         ---YNIGFGNAGDFNQGFANTGNNNIGFANTGNNNIGIGLSGDNQQGFNF
MMAR_0642|M.marinum_M             DAFNNIGFGNTGDNNIGFGNTGNGNFGFGNTGNGNIGIGLTGAGQRGVNF
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         AGGWNSGTANIGLFNSGTNNVGIGNSGTGNWGIGNSGSGNTGIGNTGSTN
MMAR_0642|M.marinum_M             AGGLNSGSGNIGLFNSGTNNVGIGNSGTGNWGIGNSGSLNTGFGNAGSTN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TGFFNTGIVNTGVANAGSYNTGWYNTGDTNTGIANLGDFNTGFYNTGNFS
MMAR_0642|M.marinum_M             TGLFNTGMVNTGIANVGDYNTGWFNTGDVNTGAANRGDYNTGWYNTGNYS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TGFANQGDIATGAFITGDMGNGAFWRGDQQGLFSAGYRVHVPEIPAHVTV
MMAR_0642|M.marinum_M             TGFANAGNIDTGLLISGDMGNGFAWRGDQQGQVSASYVIHVPEIPAHVDA
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         EVPVNIPITASFTNTVYSGITLEQINFGFTIDIAGIPLLAGAISKAVLPP
MMAR_0642|M.marinum_M             SAPINIPLTANFTNTLYSGITMEDINFGFTVAIGPLPVLTGTIDSVTLAP
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         ITGTGPAITVNIGDPGGSTAIRIPATASVGPFDVTFVNIAATTGFFNATT
MMAR_0642|M.marinum_M             ITATGPAISFNIGDPKGTTVVSIPATASLGPVDWTIFDIPAVTGLFNSTS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         DPSSGFFNGGPGTVSGIANIGANISGFQNVANSATSGFNNYGSLQSGLAN
MMAR_0642|M.marinum_M             SPSSGFFNGGTGTVSGIANFGGDISGFQNFGTSALSGFKNVGSLQSGLLN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LGDTVSGVFNTGIGAPANVSGMFNIGSNLAGFFHDQATGMSMFNLGLGNI
MMAR_0642|M.marinum_M             IGDTVSGLFNTGIGTPANVSGVSNIGTTLAGIFVDQASGMSTFSLGLADI
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GQFNVGFSNVGDSNAGLANIGSFNLGSGNLGSFNVFGGNQGSYNIGPANL
MMAR_0642|M.marinum_M             GQANVGFGNTGDFNLGFANLGDENLGLGNSGFNNLGLANLGNFNVGSANL
MUL_0965|M.ulcerans_Agy99         ---------------GAAAVGFPVLHIGNIGFANLSVGNIGDYNLGSGNT
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GNYNIGLGNLGSYNFGFGNAGDFNLGFANTGNNNIGFANTGNNNIGIGLS
MMAR_0642|M.marinum_M             GGYNIGSSNLGDYNVGFGNAGGFNQGLANSGNNNIGLFNTGNNNIGIGLT
MUL_0965|M.ulcerans_Agy99         GSFNLGSGNIGDASLGSGNAGDSNVGFGNFGSNNVGIGNNGNNNIGIGLN
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GDNQQGFNFAGGWNSGSGNSGLFNSGTNNIGLFNSGTGNIGIGNSGTGNW
MMAR_0642|M.marinum_M             GDNQQGFNFGGGLNSGTGNTGLFNSGTNNTGIFNSGTNNTGIFNSGNANW
MUL_0965|M.ulcerans_Agy99         GDDLIG---IGALNSGAGNLGFGNSGTNNIGFFNSGDNNIGFFNSGSGNF
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GIANTGDTNTGIFNTGDVNTGLLNAGNVNTGIFNTGHYNTGSFNAGSFNT
MMAR_0642|M.marinum_M             GIGNTGVTNTGVFNSGQINTGLWNAGNVNTGIGNPGNYNTGSFNTGSFNT
MUL_0965|M.ulcerans_Agy99         GFENAGDINTGFWNGRDTNTGFGNSG------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         AGFNPGSYNTGYLNTGSYNTGLANSGDVNTGGFITGNYSNGFWWRGDYQG
MMAR_0642|M.marinum_M             AGLNPGDYNTGYLNSGNYNTGFANSGDVNTGAFISGNYSNGLLWRGDYQG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LAGISQTITVPDTAVPVKLHVPIFLDIPVTGTLGTFTVHGFRFPEITGDI
MMAR_0642|M.marinum_M             LWGIDYAITIPDTAIPLNLDVPVYLDIPITGTLGVFTVDGFTIPASTVEL
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         FLIGIPFNAATLDAFSFPNISIVLPNIGINLGSGPDPLIDIAGTGGLLPI
MMAR_0642|M.marinum_M             DIVGIGFKAVHVSAIKFPNLELGLPAIDINIGTGPEPLIHIVGTGGLLPI
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         KIPLIDIPAAPGFGNSTTTPSSGFFNAGTGTVSGVGNVGSNSSGFFDLTS
MMAR_0642|M.marinum_M             KIPIIDIAAAPGFGNSTTTASSGFFNTGSGTASGFGNTGGNNSGFFNLAS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GSSGISGVQNFGELISGGFNFGNTVSGLVNASTLGLSMPANLSGGGNVGA
MMAR_0642|M.marinum_M             GSSGISGYQNLGDLVSGMSNLGNSVSGFFNTSSLGVSIPADISGAANIGT
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TVAGFVNNTQILNLGFGNVGSGNVGHGNIGDSNVGLGNLGNANVGHGNIG
MMAR_0642|M.marinum_M             NIAGFFNDNPIGNLGIANLGNGNIGDGNIGSNNAGFGNVGANNFGSGNIG
MUL_0965|M.ulcerans_Agy99         ----------LSNFGFGNSGVNNVGAGNGGSSNVGLG-------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SFNVFSGNRGSYNIGPANLGNYNIGLGNLGSYNFGFGNAGDFNLGFANSG
MMAR_0642|M.marinum_M             SFNFLSGNHGTYNFGLGNLGDYNVGLANLGDYNVGFGNAGSLNQGFANTG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SNNIGFANTGNNNIGIGLSGHNQQGFGSWN---SGTANTGLFNSGTNNIG
MMAR_0642|M.marinum_M             DHNIGIGNTGNNNIGIGLTGDNQVGINLAGGLNSGTGNAGLFNSGTNNTG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LFNSGTGNIGIGNSGIGNTGIGNPGVGNTGLGNSGTGNWGLWNPGTGNMG
MMAR_0642|M.marinum_M             IFNSGTGNTGIFNSGTANWGIGNSGTANSGIANSGSTNWGLWNPGTGNTG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         VANVGTYNTGGYNVGSTNTGIANVGIANTGSYNTGSTNTGSFNDGDFNTG
MMAR_0642|M.marinum_M             IANAGDYNTGLYNAGHTNTGLANPTDYNTGFFNTGDYNTGLANAGNYNTG
MUL_0965|M.ulcerans_Agy99         --NAGLLNTGSFNSGKFNTGDFNSGSMNTGYFNSSGHNTGLGNSGFTNTG
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         FYNTGDYNTGFYNTGDVNTGAFIGGNFSNGAFWQSDHQGQWGAHYAITVP
MMAR_0642|M.marinum_M             FFNTGDYNTGLANTGDVNTGAFISGNYSNGMFWRGDYQGLVGAHYEIFIP
MUL_0965|M.ulcerans_Agy99         FFNSGDLNTGMGSPEDQ---------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         QIPLLNFSLNIPVNIPIHLDFGTLAVNGFQIPAITLRALGVTHFSVGPII
MMAR_0642|M.marinum_M             EFPVLNFDLNIPVDIPIYLDLGSLALNGFTIPTITIDALSITDFKIGPIT
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         VPRIAGTLPVIDINIGDPGGSSSIPITITSGAGPVVIPLLDIPPAPGFGN
MMAR_0642|M.marinum_M             IPTIKGILPVIDINIGNPDGSSSIPIAIRSGLGPISIVLLDIPAAPGFGN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         STTGPSSGFFNSGTGSSSGFGNVGANNSGFWNTAFAGIGNSGLQNFGSLQ
MMAR_0642|M.marinum_M             STSAPSSGFFNSGTGTASGFGNVGANNSGFWNTGFGDIGSSGLQNYGQQL
MUL_0965|M.ulcerans_Agy99         --SVANSGFRN---------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SGWANLGNTVSGFYNTSAADFATPANLSGLSNVGADLTGVLRGPNGSTFN
MMAR_0642|M.marinum_M             SGWANLGNTVSGWYNSSTADLPTAANLSGFFNIGTELSGVLRDSAGTIFN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         AGLANLGQFNVGSANLGSANLGSANLGNSNVGFGNIGNANIGGANIGDFN
MMAR_0642|M.marinum_M             AGLGDLGQLNLGSGNVGDFNVGSANIGSFNVGFGNVGADNLGSGNIGSGN
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         VGIANTGPGLTAAVNNIGIGNTGNYNIGVGNTGNYNIGFGNTGNNNIGIG
MMAR_0642|M.marinum_M             IGFGNAGAGLTEAFNNIGFGNVGDTNIGFGNTGNGNLGFGNTGNGNIGIG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LSGDNQIGFGPLNAGIANMGLFNLGDNNFGMANAGNFNQGIANTGNNNIG
MMAR_0642|M.marinum_M             LSGDGQIGFGPLNDGVGNAGLFNLGDFNTGLANAGNDNQGWSNTGNNNIG
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LFNTGNNNVGIGLTGDGLSGFSSLNSGAGNTGFFNSGTANTGLFNSGTGN
MMAR_0642|M.marinum_M             LFNTGDNNVGIGLTGDGRVGFGSLSSGAGNTGFFNSGTSNAGMFNSGTGN
MUL_0965|M.ulcerans_Agy99         -------------------------AGSGNSGFNNTGSFSSGFFNSTNSN
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         TGLFNSGTGNVGIGNMGTGGFGVGLSGDSQVGIGGTNSGSFNIGLFNSGT
MMAR_0642|M.marinum_M             VGFFNSGTGNVGIGNMGTGGIGIGLQGDNLVGIGGLNSGSFNVGLFNSGT
MUL_0965|M.ulcerans_Agy99         SEFLNAG-------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GNVGIGNSGTGNVGIGNTGTGNTGIGNSGNYNTGLLNAGLVNTGIANPGN
MMAR_0642|M.marinum_M             GNVGIGNSGTGNWGIGNSGSHNSGIGNTGSYNTGLFNSGSFNTGIANPGN
MUL_0965|M.ulcerans_Agy99         --------GTVNSGINNSGNTNAGIGNLGDDNFGLFNNGTFNTGAGNSSG
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         HNTGLFNIGTFNTGIANPGHYNTGSYNTGSYNTGMANAGDYGTGAFITGS
MMAR_0642|M.marinum_M             FNTGLFNIGVFNTGIANPGDYNTGFYNTGDYNTGLANIGNFDTGAFITGN
MUL_0965|M.ulcerans_Agy99         GAVFPYTSGLFNSGNGSSGVFNAGDEQSGFFGT-----------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         MNNGLLWRADRQGLLAANYTITIERPAAFLNVDIPVNIPITGDITNVSIP
MMAR_0642|M.marinum_M             MANGVFWRADSMGQLSAHYAITVNRIPAFMTIDAPVNIPITGTITDISIP
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         AITFPRIDASGSVDIGILSGTVLAPVGPITLHGGDASAPLDTPIEIDFGP
MMAR_0642|M.marinum_M             AVTFPKVPATGKVDLAIISGTVIAPIGPITIHGGDASAPLNTPIVIDFGT
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         SPAINLNIGKPDGSTVINIVGGAGAGPISIPIIDLRPAPGFFNATTGPSS
MMAR_0642|M.marinum_M             QPALQLNLGNPDGSTVVHVGGYFNFGPGQIPLIDIKPAAGFFNATTGPSS
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GFLNWGAGSASGLLNF-GNNSGLYNFATSSMGNSGFQNYGSLQSGWANLG
MMAR_0642|M.marinum_M             GFFNLGDGSASGFANVGANNSGIWNVATAALGNSGFQNIGSQQSGLANLG
MUL_0965|M.ulcerans_Agy99         --------------------SGLVLTGTDGLAATTTSGLPALDLPAPNLG
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NSISGIYNTGLGAPANVSGLLNIGTNLAGWLQNGPTETTFSVGLANLGFW
MMAR_0642|M.marinum_M             NAISGFLNTGGATPANLSGFQNIGTDLAGWYRNGPDATTFSFGIANPGFW
MUL_0965|M.ulcerans_Agy99         -------------------------------------------IGNAGVG
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NLGSANIGNYNLGSANIGVYNLGSANIGDFNLGSANIGDFNLGSANIGSS
MMAR_0642|M.marinum_M             NVGSANIGSYNLGNANIGVSNFGFGNLGSANLGSANLGGFNLGSANIGSH
MUL_0965|M.ulcerans_Agy99         NLGLGNIGDYNLGSGNTGDANFGSGNIGALNLGSGNHGDANLGFG-----
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         NIGFGNVGPGLTAAIGNIGFGNTGNGNIGIGNTGTGNIGFGNTGNGNIGI
MMAR_0642|M.marinum_M             NFGFANTGPALSDAIGNIGFGNTGSYNIGFGNTGNGNLGFANTGDGNIGI
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GLTGDTMTGFGGWNSGTGNIGLFNSGTGNIGFGNSGTGNWGIGNSGDYNT
MMAR_0642|M.marinum_M             GLAGDTMTGFGGWNSGSGNIGLFNSGTNNIGFGNSGTGNWGIGNSGSYNT
MUL_0965|M.ulcerans_Agy99         -------------NTGDNNIGLFNSGDNNVGFFNSGGANFGLANSGDTNT
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GIGNTGSTNSGFFNTGLVNTGIGNSGDYNTGLFNAGNTNTGSFNPGDYNT
MMAR_0642|M.marinum_M             GIGNTGTTNTGFFNSGMVNTGIGNAGNYNTGCYNTGDFNTGSFNPGDYNT
MUL_0965|M.ulcerans_Agy99         GLWNAGSTNTGFGNAGSADFGFGNAGDRNMGFGNAGAANMGAGNSGSYNT
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         GGFNPGNYNTGYFNPGNSNTGFANSGDVNTGAFNSGNYSNGFFWRGDYQG
MMAR_0642|M.marinum_M             GGFNPGNYNTGYFNEGNSNTGLANSGNVNTGAFISGNYSNGLLWRGDYQG
MUL_0965|M.ulcerans_Agy99         GSFNSGTLNTGDFNGGDHNTGWGNSGNTNTGG------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      --------------------------------------------------
Mb0362c|M.bovis_AF2122/97         LGGFAYQSAVSEIPWSYDIGSNIEIPIEGDINAITQDAFTIDEFEIPIKL
MMAR_0642|M.marinum_M             LLGFTYESTVPAIPWNIGVHSDIDIPITGAINTITQDMFTIAEFEIPISL
MUL_0965|M.ulcerans_Agy99         --------------------------------------------------
                                                                                    

Rv0354c|M.tuberculosis_H37Rv      -MSVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPIDTAFT
Mb0362c|M.bovis_AF2122/97         RVSVCVIYIPFKGCVKHVSVTIPITTEHLGPYEIDASTINPDQPIDTAFT
MMAR_0642|M.marinum_M             ETTICLIYVPFVGCVLHVSVTVPITTEHVGPFVIDPSVINPQSPINTAIT
MUL_0965|M.ulcerans_Agy99         -INSGDLNTGFGSSADQAVTNSGFGNNGSGNSGFNN-TGDTNSGFHNANT
                                    .   :   * ... :. ..  : .:  *   ::  . :.:. :..* *

Rv0354c|M.tuberculosis_H37Rv      QTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSSGFFNSGAGGASGFLN
Mb0362c|M.bovis_AF2122/97         QTLDFAGSGTVGAFPFGFGWQQSPGFFNSTTTPSSGFFNSGAGGASGFLN
MMAR_0642|M.marinum_M             DTIDFSDAGTVGPATFGFNWQQSPGFFNSSDTPSSGFFNSGAGGASGLLN
MUL_0965|M.ulcerans_Agy99         SALFSGHSGLLNAGGSQSVGINNTGSFN-TVLFNTGFR--TAGIANSATN
                                  .::  . :* :..        :..* ** :   .:**    ** *..  *

Rv0354c|M.tuberculosis_H37Rv      DAAAAVSGLGNVFTETSGFFNAGGVG------------------------
Mb0362c|M.bovis_AF2122/97         DAAAAVSGLGNVFTETSGFFNAGGVGNSGFQNFGNLLSGWANLGNTVSGF
MMAR_0642|M.marinum_M             DAQGAVSGIGNAFLESSGFFNAGGPGLSGLQNVGTLESGWANFGNSLSGI
MUL_0965|M.ulcerans_Agy99         GLLTATSGVANSGNNSSGGFNA----------------------------
                                  .   *.**:.*   ::** ***                            

Rv0354c|M.tuberculosis_H37Rv      ----IRASKTSATCCRAGRT--------------
Mb0362c|M.bovis_AF2122/97         YNTSMLDLATQALISGFGNHGARLSGILNNGSGP
MMAR_0642|M.marinum_M             YNTSILNLMAQAFVSGLGNTGHELSGFLNDAMA-
MUL_0965|M.ulcerans_Agy99         ------NPDQSGFFN-------------------
                                            ..