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VGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDAAVAGIRALLANGEAGTRVDAVRMGTTV ATNALLERTGERTLLVITRGFGDALRIAYQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLE ALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLVPRGDTTVVDAY LSPVLRRYINQVADQMRGVRLMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVIGFDM GGTSTDVSHYAGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSAGADPGPACYRG GGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIA VANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMR EQSVEIPLGPAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMAT AFESSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVRIYSNGLWRDAPLRRRE AMRPGDVLTGPAIIAEANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIF NNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVIRRRLSGM KPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLF DNWLLAENGRFREAETRRLLTEAPFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHV QDNAEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVL YVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNN VTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSGGAGRWRG GDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVIE TPGGGGYGPASTSARRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0266c | oplA | - | 100% (1209) | PROBABLE 5-OXOPROLINASE OPLA (5-OXO-L-PROLINASE) (PYROGLUTAMASE) (5-OPASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0272c | oplA | 0.0 | 100.00% (1209) | 5-oxoprolinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_3973 | - | 1e-40 | 27.43% (536) | N-methylhydantoinase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4898 | - | 6e-52 | 26.65% (713) | 5-oxoprolinase (ATP-hydrolyzing) |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0266c|M.tuberculosis_H37Rv MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDN---PARYRDAAVA
Mb0272c|M.bovis_AF2122/97 MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDN---PARYRDAAVA
Mvan_4898|M.vanbaalenii_PYR-1 ----MKRISVDIGGTFTDCFFVWDDIYVDAKALTTHHNLAIGFNDALDLA
MSMEG_3973|M.smegmatis_MC2_155 ----MTVATTTRRRLDPVTFEVLKNAFVTSVDLMSEQILRTCYSFVIYSR
. . . : : : * :.:
Rv0266c|M.tuberculosis_H37Rv GIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALR
Mb0272c|M.bovis_AF2122/97 GIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALR
Mvan_4898|M.vanbaalenii_PYR-1 CKRAGLDRSTVLSEVDSVRYATTLGTNALIERNGPKVAAIVTHGFEDTIP
MSMEG_3973|M.smegmatis_MC2_155 DFSSALCDAQGNTVMQGSQDIAVHVGTLHFQCKAVLEEFSGDINPGDVFC
: * . : ::. : :. . :: .. . *.:
Rv0266c|M.tuberculosis_H37Rv IA----------YQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRA
Mb0272c|M.bovis_AF2122/97 IA----------YQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRA
Mvan_4898|M.vanbaalenii_PYR-1 LSRGRGYGEGLDYGMQQNLPAAERPEPLVPRAMIRSVKERVNSAGKIVAR
MSMEG_3973|M.smegmatis_MC2_155 VN--------DPYRGGTHLNDVSFIRPIFADNELIGFAQ-NKGHWADIGG
: * .: * . : . : .. :
Rv0266c|M.tuberculosis_H37Rv PDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQ------R
Mb0272c|M.bovis_AF2122/97 PDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQ------R
Mvan_4898|M.vanbaalenii_PYR-1 LDAEDVRTVVRELVDAGAEAIVVSLVNATENPEHELAIQEIILDEFPPHE
MSMEG_3973|M.smegmatis_MC2_155 SVPGSFDVTATEHFAEGLRITPVRIWHEGRFLGDVAKLLVANT------R
. : * . * : . : .
Rv0266c|M.tuberculosis_H37Rv IGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR
Mb0272c|M.bovis_AF2122/97 IGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR
Mvan_4898|M.vanbaalenii_PYR-1 LGAIPVLLGHQVSGRKGEYVRATSTIIDGYLHEIMFHALAQLSSNLRDFG
MSMEG_3973|M.smegmatis_MC2_155 APEISMGDLHAQAEATGVCEREIHRLVAKYGRETVVEAMAEVQDYVERIV
: : * :: * : . : :: . :. .
Rv0266c|M.tuberculosis_H37Rv ----LMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVI
Mb0272c|M.bovis_AF2122/97 ----LMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVI
Mvan_4898|M.vanbaalenii_PYR-1 YDKPMLVIHNSGGMAQMNSTDALQTIHSGPIAGVGAAEHLSNETGIGHVI
MSMEG_3973|M.smegmatis_MC2_155 R--------QRVADLPDGEWVTEDFLDSDPSKPEGMVPIRVKMTIKGDQL
. . . : : *.* : .. :
Rv0266c|M.tuberculosis_H37Rv GFDMGGTSTDVSHY--AGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSI
Mb0272c|M.bovis_AF2122/97 GFDMGGTSTDVSHY--AGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSI
Mvan_4898|M.vanbaalenii_PYR-1 ATDMGGTSFDIGLVPEGGVKHYDFLPTIDRWLVSVPMVHLDTLGAGGGSI
MSMEG_3973|M.smegmatis_MC2_155 SYDLSGSAPAVASF-LNCGYGTAFSGIVAGTKTFFPDVPLN-SGLYAAIT
. *:.*:: :. * : * : :. . ..
Rv0266c|M.tuberculosis_H37Rv LHFD--GSRYRVGPDSAGADPGPACY-RGGGPLCVTDANVMLGRIQPTHF
Mb0272c|M.bovis_AF2122/97 LHFD--GSRYRVGPDSAGADPGPACY-RGGGPLCVTDANVMLGRIQPTHF
Mvan_4898|M.vanbaalenii_PYR-1 ASYDRIHNSVKIGPKSAGSNPGPACYDRGGLKPTVTDADLLLGYLDPDNY
MSMEG_3973|M.smegmatis_MC2_155 TDIGPEGTVVNAGWPVAVTGFCSGPYEKIMNAIFELWSGIMPERAIACSF
. . . * * :. .. * : :.:: . :
Rv0266c|M.tuberculosis_H37Rv PSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIAV
Mb0272c|M.bovis_AF2122/97 PSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIAV
Mvan_4898|M.vanbaalenii_PYR-1 ANGYIKLNP--------KRSLFAIEEELCDHLDMD--PIDVARVIKDGVD
MSMEG_3973|M.smegmatis_MC2_155 NLEYLLVGGR--DARGDDRPFFMWYDWMAGGWGGRSTKDGSTATAPVFGV
: . * : :. . :
Rv0266c|M.tuberculosis_H37Rv ANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPP
Mb0272c|M.bovis_AF2122/97 ANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPP
Mvan_4898|M.vanbaalenii_PYR-1 EQMAIGIGKELRVRGYLPEDFTMLAYGGNGPLHACGVARHAGIKRVLAPP
MSMEG_3973|M.smegmatis_MC2_155 GLAVQPCEGQERLTPVLTTKHAIIPDSGGPGLHRGGCG----------VT
. .:: . .* * . . .
Rv0266c|M.tuberculosis_H37Rv MAGVLSALGIGLADTTAMREQSVEIPLGPAAP-------QRLASVAESLE
Mb0272c|M.bovis_AF2122/97 MAGVLSALGIGLADTTAMREQSVEIPLGPAAP-------QRLASVAESLE
Mvan_4898|M.vanbaalenii_PYR-1 FSSVFSACGAGNMKQLHFHERGVHVTMYNATTRALFEDYDEFNSVVSELE
MSMEG_3973|M.smegmatis_MC2_155 KGGTLTDCENTVMSYCCDRSRSVTWGIEGGLP--------SIPHGVWLNR
...:: . :.:.* : . . : . .
Rv0266c|M.tuberculosis_H37Rv RAARAELLDEGVPGERIRVVRRVHLRYEG-TDTAIPVQLAEIETMATAFE
Mb0272c|M.bovis_AF2122/97 RAARAELLDEGVPGERIRVVRRVHLRYEG-TDTAIPVQLAEIETMATAFE
Mvan_4898|M.vanbaalenii_PYR-1 ARGCEDLIRQGFSAEDVKFRLELDMRYGN-QLLTQAVALSDINRING---
MSMEG_3973|M.smegmatis_MC2_155 GTAEEQFLGSVFSNVAVQAGDTFERPSAGGGGLGDPLRRAPEEVLED---
. ::: . .. :: .. . .: : : :
Rv0266c|M.tuberculosis_H37Rv SSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETV
Mb0272c|M.bovis_AF2122/97 SSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETV
Mvan_4898|M.vanbaalenii_PYR-1 ---------------VGDVLEIIKT----------FGDVYSHRFGASSAA
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------VIDGYVTIAGAA
. : :.
Rv0266c|M.tuberculosis_H37Rv RIYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTE
Mb0272c|M.bovis_AF2122/97 RIYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTE
Mvan_4898|M.vanbaalenii_PYR-1 PEAG---------IRCSTIRVASYVDGDVVNFEP----------------
MSMEG_3973|M.smegmatis_MC2_155 RDYG------------VVITPIDPEIDEYEIDRG----------------
. .: . . .
Rv0266c|M.tuberculosis_H37Rv TGHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGF
Mb0272c|M.bovis_AF2122/97 TGHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGF
Mvan_4898|M.vanbaalenii_PYR-1 ---LEHGGARTAPAPAGTRKAYFIG--IDDPIETPVYD------------
MSMEG_3973|M.smegmatis_MC2_155 ----ATEALRTEIRAARRKWLDTDPEEVAERFRDGELDT-----------
* . : . :
Rv0266c|M.tuberculosis_H37Rv RLEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVI
Mb0272c|M.bovis_AF2122/97 RLEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVI
Mvan_4898|M.vanbaalenii_PYR-1 ------------------EKALTPDSVIVG-----PAIVTTENTTFLVEP
MSMEG_3973|M.smegmatis_MC2_155 ------------------FDLLRRYGVIVDWG--TGELLPNTTKQFRDLL
: . :* : . . .
Rv0266c|M.tuberculosis_H37Rv RRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRG
Mb0272c|M.bovis_AF2122/97 RRRLSGMKPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRG
Mvan_4898|M.vanbaalenii_PYR-1 GWRLEPTAQGAVWFLQD---------------------------------
MSMEG_3973|M.smegmatis_MC2_155 HVRAASHWD-----------------------------------------
*
Rv0266c|M.tuberculosis_H37Rv HHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAETRRLLTEA
Mb0272c|M.bovis_AF2122/97 HHAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAETRRLLTEA
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv PFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDN
Mb0272c|M.bovis_AF2122/97 PFGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDN
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv AEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQ
Mb0272c|M.bovis_AF2122/97 AEEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQ
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv LDTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAP
Mb0272c|M.bovis_AF2122/97 LDTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAP
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv THPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYET
Mb0272c|M.bovis_AF2122/97 THPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYET
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv VGSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSG
Mb0272c|M.bovis_AF2122/97 VGSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSG
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv GAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRV
Mb0272c|M.bovis_AF2122/97 GAGRWRGGDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRV
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Rv0266c|M.tuberculosis_H37Rv ERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTSARRRR
Mb0272c|M.bovis_AF2122/97 ERADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTSARRRR
Mvan_4898|M.vanbaalenii_PYR-1 ---------------------------------------------
MSMEG_3973|M.smegmatis_MC2_155 ---------------------------------------------