For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TVATTTRRRLDPVTFEVLKNAFVTSVDLMSEQILRTCYSFVIYSRDFSSALCDAQGNTVMQGSQDIAVHV GTLHFQCKAVLEEFSGDINPGDVFCVNDPYRGGTHLNDVSFIRPIFADNELIGFAQNKGHWADIGGSVPG SFDVTATEHFAEGLRITPVRIWHEGRFLGDVAKLLVANTRAPEISMGDLHAQAEATGVCEREIHRLVAKY GRETVVEAMAEVQDYVERIVRQRVADLPDGEWVTEDFLDSDPSKPEGMVPIRVKMTIKGDQLSYDLSGSA PAVASFLNCGYGTAFSGIVAGTKTFFPDVPLNSGLYAAITTDIGPEGTVVNAGWPVAVTGFCSGPYEKIM NAIFELWSGIMPERAIACSFNLEYLLVGGRDARGDDRPFFMWYDWMAGGWGGRSTKDGSTATAPVFGVGL AVQPCEGQERLTPVLTTKHAIIPDSGGPGLHRGGCGVTKGGTLTDCENTVMSYCCDRSRSVTWGIEGGLP SIPHGVWLNRGTAEEQFLGSVFSNVAVQAGDTFERPSAGGGGLGDPLRRAPEEVLEDVIDGYVTIAGAAR DYGVVITPIDPEIDEYEIDRGATEALRTEIRAARRKWLDTDPEEVAERFRDGELDTFDLLRRYGVIVDWG TGELLPNTTKQFRDLLHVRAASHWD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3973 | - | - | 100% (656) | N-methylhydantoinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0272c | oplA | 5e-41 | 27.43% (536) | 5-oxoprolinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0266c | oplA | 5e-41 | 27.43% (536) | 5-oxoprolinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_4899 | - | 8e-35 | 23.95% (593) | hydantoinase B/oxoprolinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0272c|M.bovis_AF2122/97 MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDAAVAGIR
Rv0266c|M.tuberculosis_H37Rv MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDNPARYRDAAVAGIR
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4899|M.vanbaalenii_PYR-1 ----------------MTTVNERPAG------KLTATEQRWVDQFMDETT
Mb0272c|M.bovis_AF2122/97 ALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAY
Rv0266c|M.tuberculosis_H37Rv ALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALRIAY
MSMEG_3973|M.smegmatis_MC2_155 -------------------MTVATTTRRRLDPVTFEVLKNAFVTSVDLMS
Mvan_4899|M.vanbaalenii_PYR-1 LFLGPDPEIMRSHRISERSLHEEVAIAAGVDRLQVERIRKRIAGALDEGY
: . . : . : ::
Mb0272c|M.bovis_AF2122/97 QNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQA
Rv0266c|M.tuberculosis_H37Rv QNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRAPDLEALGEKMRQA
MSMEG_3973|M.smegmatis_MC2_155 EQILRTCYSFVIYSRDFSSALCDAQGNTVMQG------------------
Mvan_4899|M.vanbaalenii_PYR-1 EMCEAQGAAPGAKWGDLTTAIYTGSGDVSYLS------------------
: : : . . .
Mb0272c|M.bovis_AF2122/97 HADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLV
Rv0266c|M.tuberculosis_H37Rv HADGIRAVAVVCLHSYLYPGHEREIGTLAQRIGFAQISLSSEVSPLMKLV
MSMEG_3973|M.smegmatis_MC2_155 ---------------------SQDIAVHVGTLHFQCKAVLEEFS------
Mvan_4899|M.vanbaalenii_PYR-1 ---------------------CHGVIAFSAILHHPIRYIMKYWKD-----
: : . : . : . .
Mb0272c|M.bovis_AF2122/97 PRGDTTVVDAYLSPVLRRYINQVADQMRGVRLMFMQSNGGLAQAGHFRGK
Rv0266c|M.tuberculosis_H37Rv PRGDTTVVDAYLSPVLRRYINQVADQMRGVRLMFMQSNGGLAQAGHFRGK
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------GDINPGDVFCVN
Mvan_4899|M.vanbaalenii_PYR-1 -----------------------------------EPTVGINPGDGFIHN
.: .. * :
Mb0272c|M.bovis_AF2122/97 DAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHYAGEYERVFT
Rv0266c|M.tuberculosis_H37Rv DAILSGPAGGIVGMVRMSALAGFDHVIGFDMGGTSTDVSHYAGEYERVFT
MSMEG_3973|M.smegmatis_MC2_155 DPYRGGTHLNDVSFIRP--IFADNELIGFAQN------------------
Mvan_4899|M.vanbaalenii_PYR-1 DARFGNVHNTDQSMIMP--IIRDDEIIAWVAA------------------
*. .. .:: : :.:*.:
Mb0272c|M.bovis_AF2122/97 TQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSAGADPGPACYR
Rv0266c|M.tuberculosis_H37Rv TQVAGVRLRAPMLDIHTVAAGGGSILHFDGSRYRVGPDSAGADPGPACYR
MSMEG_3973|M.smegmatis_MC2_155 -------------KGHWADIGGSVPGSFDVTATEHFAEGLRITPVRIWHE
Mvan_4899|M.vanbaalenii_PYR-1 -------------TIHEGENGACEPGGMPSGSETAFDDGLRMSPFKIVER
* *. : :. * .
Mb0272c|M.bovis_AF2122/97 GGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRGFTDLAADI
Rv0266c|M.tuberculosis_H37Rv GGGPLCVTDANVMLGRIQPTHFPSVFGPSGDQPLDAGTVRRGFTDLAADI
MSMEG_3973|M.smegmatis_MC2_155 G----------RFLGDVAKLLVANTRAP-----------EISMGDLHAQA
Mvan_4899|M.vanbaalenii_PYR-1 G----------ELRRDLLTFLQHSVRDP-----------KLQLADLKVKI
* : : .. * . : ** ..
Mb0272c|M.bovis_AF2122/97 AARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGG
Rv0266c|M.tuberculosis_H37Rv AARTGDDRSPEQVAEGYLRIAVANMANAVKKISVQKGHDVTRYALTTFGG
MSMEG_3973|M.smegmatis_MC2_155 EATGVCEREIHRLVAKYGRETVVEAMAEVQDYVER---------------
Mvan_4899|M.vanbaalenii_PYR-1 TAVRKIMERIDKVIDEVGVDTFVAALRTTVEDVDA---------------
* . .:: :.. . .
Mb0272c|M.bovis_AF2122/97 AGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLG
Rv0266c|M.tuberculosis_H37Rv AGGQHACAVADALGIRTVLIPPMAGVLSALGIGLADTTAMREQSVEIPLG
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------IVRQRVADLPDG
Mvan_4899|M.vanbaalenii_PYR-1 --------------------------------------EVRRRIAELPDG
:*.: .::* *
Mb0272c|M.bovis_AF2122/97 PAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIP
Rv0266c|M.tuberculosis_H37Rv PAAPQRLASVAESLERAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIP
MSMEG_3973|M.smegmatis_MC2_155 EWVTEDFLDSDPSKPEGMVPIRVKMTIKGD--------QLSYDLSGSAPA
Mvan_4899|M.vanbaalenii_PYR-1 TYRFDQFMDS-TLKENILIKFACKITVKGD--------HMTVDLRGTGPE
: : . . . : *: :: : .:.
Mb0272c|M.bovis_AF2122/97 VQLAEIET-MATAFESSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQ
Rv0266c|M.tuberculosis_H37Rv VQLAEIET-MATAFESSHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQ
MSMEG_3973|M.smegmatis_MC2_155 VASFLNCG-YGTAFSGIVAGTKTFFPDVPLNSGLYAAITTDIGPEGTVVN
Mvan_4899|M.vanbaalenii_PYR-1 ILNRAINSPLCSVKSMMMQAILAFWWPDLPRCTAAMSCIDIISDEGTWAD
: :. . . :* . : : :
Mb0272c|M.bovis_AF2122/97 LGDQANDTTGSSETVR--IYSNGLWRDAPLRRREAMRPGDVLTGPAIIAE
Rv0266c|M.tuberculosis_H37Rv LGDQANDTTGSSETVR--IYSNGLWRDAPLRRREAMRPGDVLTGPAIIAE
MSMEG_3973|M.smegmatis_MC2_155 AGWPVAVTGFCSGPYE--KIMNAIFELWSG----------IMPERAIACS
Mvan_4899|M.vanbaalenii_PYR-1 ASYDAPMGQSLQASFRGFSCMQALYSRMSFSTP-------HKYSNVVANW
. . . . . :.:: . .:
Mb0272c|M.bovis_AF2122/97 ANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAGFEAGFEADPVL
Rv0266c|M.tuberculosis_H37Rv ANATTVVDDGWQATMTETGHLLAQRVVTPPRPDAATRAGFEAGFEADPVL
MSMEG_3973|M.smegmatis_MC2_155 FNLEYLLVGGRDARGDDRPFFMWYDWMAGGWGGRSTKDG-----------
Mvan_4899|M.vanbaalenii_PYR-1 FNQINTFLWGGITQHGDMVGNLCADLNGMPGGAKPFHDG-----------
* . * : : : . : *
Mb0272c|M.bovis_AF2122/97 LEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDGNLVANAP
Rv0266c|M.tuberculosis_H37Rv LEIFNNLFMSIAEQMGFRLEATAQSVNIRERLDFSCALFDPDGNLVANAP
MSMEG_3973|M.smegmatis_MC2_155 ---------STATAPVFGVGLAVQPCEGQERLTP---VLTTKHAIIPDSG
Mvan_4899|M.vanbaalenii_PYR-1 ---------EDAVSPLFCAMADTAEQEVMEEEVPFMQLVAKR--LVRDNM
. * * . : *. :. :: :
Mb0272c|M.bovis_AF2122/97 HIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITP
Rv0266c|M.tuberculosis_H37Rv HIPVHLGSMGTTVKEVIRRRLSGMKPGDVYAVNDPYHGGTHLPDITVITP
MSMEG_3973|M.smegmatis_MC2_155 GPGLHRGGCGVTKGGTLTDCEN----------------------------
Mvan_4899|M.vanbaalenii_PYR-1 GFGKFTGGMGYEMIVAAEGTPQWG--------------------------
. *. * . .
Mb0272c|M.bovis_AF2122/97 VFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLA
Rv0266c|M.tuberculosis_H37Rv VFNTGGEDVLFFVASRGHHAEIGGITPGSMPADSREIHEEGVLFDNWLLA
MSMEG_3973|M.smegmatis_MC2_155 -------TVMSYCCDRSRSVTWG--IEGGLPS-----IPHGVWLN-----
Mvan_4899|M.vanbaalenii_PYR-1 -----FMTVTSGAKFSSIYGMYGGYGCGTYPLAMVKGTNVYEHFRRDNKK
* . * * * :
Mb0272c|M.bovis_AF2122/97 ENGRFREAETRRLLTEAPFGSRNPDTNLADLRA------QIAANQKGVDE
Rv0266c|M.tuberculosis_H37Rv ENGRFREAETRRLLTEAPFGSRNPDTNLADLRA------QIAANQKGVDE
MSMEG_3973|M.smegmatis_MC2_155 -RGTAEEQFLGSVFSNVAVQAG------DTFER------PSAGGGGLGDP
Mvan_4899|M.vanbaalenii_PYR-1 FDLSIEKVMNERPFPDGRYSTYHMGLQFDLAKDGELYMISQGAGGGYGDP
.: :.: : . ... *
Mb0272c|M.bovis_AF2122/97 VGKMIDHFGRDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMDSGATI
Rv0266c|M.tuberculosis_H37Rv VGKMIDHFGRDVVAAYMRHVQDNAEEAVRRVIDRLDNGAYRYRMDSGATI
MSMEG_3973|M.smegmatis_MC2_155 LRRAPEEVLEDVIDGYVTIAG--AARDYGVVITPIDPEIDEYEIDRGATE
Mvan_4899|M.vanbaalenii_PYR-1 LERLPESVVRDAELGRISQKVAEDIFGVRYEPKTFRLDVAGTEAARAAAR
: : : . .*. . : : . .*:
Mb0272c|M.bovis_AF2122/97 AVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVLYVFRTLVADD
Rv0266c|M.tuberculosis_H37Rv AVRITVDRAARSATIDFTGTSAQLDTNFNAPTSVVNAAVLYVFRTLVADD
MSMEG_3973|M.smegmatis_MC2_155 ALRTEIRAARR----------KWLDTDPEEVAERFRDGELDTFDLLRRYG
Mvan_4899|M.vanbaalenii_PYR-1 KNRLQRGKPFAAFCEEFVTPEPPKDLPYYGSWGTWTDENQDITATVHSID
* . * : .
Mb0272c|M.bovis_AF2122/97 IP-LNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALFAALG
Rv0266c|M.tuberculosis_H37Rv IP-LNDGCLRPLRIVVPEGSMLAPTHPAAVVAGNVETSQAITGALFAALG
MSMEG_3973|M.smegmatis_MC2_155 VI-VDWGTGELLPNTTKQFRDLLHVRAASHWD------------------
Mvan_4899|M.vanbaalenii_PYR-1 GPERVCAPLSALPIVMVPDRREVKIGKLEARIAELEAKHGEKVTRLT---
. * .
Mb0272c|M.bovis_AF2122/97 VQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNSRL
Rv0266c|M.tuberculosis_H37Rv VQAEGSGTMNNVTFGNERHQYYETVGSGSGAGDGYHGASVVQTHMTNSRL
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4899|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 TDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTL
Rv0266c|M.tuberculosis_H37Rv TDPEVLEWRYPVLLREFAVRQGSGGAGRWRGGDGAVRRLEFTEPMTVSTL
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4899|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 SGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVI
Rv0266c|M.tuberculosis_H37Rv SGHRRVRPYGMAGGSPGELGRNRVERADGSTVELAGCGSTHVEPGDTLVI
MSMEG_3973|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_4899|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 ETPGGGGYGPASTSARRRR
Rv0266c|M.tuberculosis_H37Rv ETPGGGGYGPASTSARRRR
MSMEG_3973|M.smegmatis_MC2_155 -------------------
Mvan_4899|M.vanbaalenii_PYR-1 -------------------