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MKRISVDIGGTFTDCFFVWDDIYVDAKALTTHHNLAIGFNDALDLACKRAGLDRSTVLSEVDSVRYATTL GTNALIERNGPKVAAIVTHGFEDTIPLSRGRGYGEGLDYGMQQNLPAAERPEPLVPRAMIRSVKERVNSA GKIVARLDAEDVRTVVRELVDAGAEAIVVSLVNATENPEHELAIQEIILDEFPPHELGAIPVLLGHQVSG RKGEYVRATSTIIDGYLHEIMFHALAQLSSNLRDFGYDKPMLVIHNSGGMAQMNSTDALQTIHSGPIAGV GAAEHLSNETGIGHVIATDMGGTSFDIGLVPEGGVKHYDFLPTIDRWLVSVPMVHLDTLGAGGGSIASYD RIHNSVKIGPKSAGSNPGPACYDRGGLKPTVTDADLLLGYLDPDNYANGYIKLNPKRSLFAIEEELCDHL DMDPIDVARVIKDGVDEQMAIGIGKELRVRGYLPEDFTMLAYGGNGPLHACGVARHAGIKRVLAPPFSSV FSACGAGNMKQLHFHERGVHVTMYNATTRALFEDYDEFNSVVSELEARGCEDLIRQGFSAEDVKFRLELD MRYGNQLLTQAVALSDINRINGVGDVLEIIKTFGDVYSHRFGASSAAPEAGIRCSTIRVASYVDGDVVNF EPLEHGGARTAPAPAGTRKAYFIGIDDPIETPVYDEKALTPDSVIVGPAIVTTENTTFLVEPGWRLEPTA QGAVWFLQD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4898 | - | - | 100% (709) | 5-oxoprolinase (ATP-hydrolyzing) |
| M. vanbaalenii PYR-1 | Mvan_4896 | - | 3e-68 | 29.56% (707) | hydantoinase/oxoprolinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0272c | oplA | 2e-52 | 26.65% (713) | 5-oxoprolinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0266c | oplA | 2e-52 | 26.65% (713) | 5-oxoprolinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0272c|M.bovis_AF2122/97 MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDN---PARYRDAAVA
Rv0266c|M.tuberculosis_H37Rv MVGAGWHFWVDRGGTFTDVVARRPDGRLLTHKLLSDN---PARYRDAAVA
Mvan_4898|M.vanbaalenii_PYR-1 ----MKRISVDIGGTFTDCFFVWDDIYVDAKALTTHHNLAIGFNDALDLA
:: ** ****** . * : :: * :.: . :*
Mb0272c|M.bovis_AF2122/97 GIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALR
Rv0266c|M.tuberculosis_H37Rv GIRALLANGEAGTRVDAVRMGTTVATNALLERTGERTLLVITRGFGDALR
Mvan_4898|M.vanbaalenii_PYR-1 CKRAGLDRSTVLSEVDSVRYATTLGTNALIERNGPKVAAIVTHGFEDTIP
** * .. . :.**:** .**:.****:**.* :. ::*:** *::
Mb0272c|M.bovis_AF2122/97 IA----------YQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRA
Rv0266c|M.tuberculosis_H37Rv IA----------YQNRPRIFDRRIVLPEMLYERVVEVDERVTADGRVLRA
Mvan_4898|M.vanbaalenii_PYR-1 LSRGRGYGEGLDYGMQQNLPAAERPEPLVPRAMIRSVKERVNSAGKIVAR
:: * : .: . * : : .*.***.: *:::
Mb0272c|M.bovis_AF2122/97 PDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQ------R
Rv0266c|M.tuberculosis_H37Rv PDLEALGEKMRQAHADGIRAVAVVCLHSYLYPGHEREIGTLAQ------R
Mvan_4898|M.vanbaalenii_PYR-1 LDAEDVRTVVRELVDAGAEAIVVSLVNATENPEHELAIQEIILDEFPPHE
* * : :*: * .*:.* ::: * ** * : .
Mb0272c|M.bovis_AF2122/97 IGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR
Rv0266c|M.tuberculosis_H37Rv IGFAQISLSSEVSPLMKLVPRGDTTVVDAYLSPVLRRYINQVADQMRGVR
Mvan_4898|M.vanbaalenii_PYR-1 LGAIPVLLGHQVSGRKGEYVRATSTIIDGYLHEIMFHALAQLSSNLRDFG
:* : *. :** *. :*::*.** :: : : *::.::*..
Mb0272c|M.bovis_AF2122/97 ----LMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVI
Rv0266c|M.tuberculosis_H37Rv ----LMFMQSNGGLAQAGHFRGKDAILSGPAGGIVGMVRMSALAGFDHVI
Mvan_4898|M.vanbaalenii_PYR-1 YDKPMLVIHNSGGMAQMNSTDALQTIHSGPIAGVGAAEHLSNETGIGHVI
::.::..**:** . . ::* *** .*: . ::* :*:.***
Mb0272c|M.bovis_AF2122/97 GFDMGGTSTDVSHY--AGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSI
Rv0266c|M.tuberculosis_H37Rv GFDMGGTSTDVSHY--AGEYERVFTTQVAGVRLRAPMLDIHTVAAGGGSI
Mvan_4898|M.vanbaalenii_PYR-1 ATDMGGTSFDIGLVPEGGVKHYDFLPTIDRWLVSVPMVHLDTLGAGGGSI
. ****** *:. .* . * . : : .**:.:.*:.******
Mb0272c|M.bovis_AF2122/97 LHFD--GSRYRVGPDSAGADPGPACY-RGGGPLCVTDANVMLGRIQPTHF
Rv0266c|M.tuberculosis_H37Rv LHFD--GSRYRVGPDSAGADPGPACY-RGGGPLCVTDANVMLGRIQPTHF
Mvan_4898|M.vanbaalenii_PYR-1 ASYDRIHNSVKIGPKSAGSNPGPACYDRGGLKPTVTDADLLLGYLDPDNY
:* . ::**.***::****** *** ****:::** ::* ::
Mb0272c|M.bovis_AF2122/97 PSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIAV
Rv0266c|M.tuberculosis_H37Rv PSVFGPSGDQPLDAGTVRRGFTDLAADIAARTGDDRSPEQVAEGYLRIAV
Mvan_4898|M.vanbaalenii_PYR-1 ANGYIKLNP--------KRSLFAIEEELCDHLDMD--PIDVARVIKDGVD
.. : . :*.: : ::. : . * * :**. .
Mb0272c|M.bovis_AF2122/97 ANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPP
Rv0266c|M.tuberculosis_H37Rv ANMANAVKKISVQKGHDVTRYALTTFGGAGGQHACAVADALGIRTVLIPP
Mvan_4898|M.vanbaalenii_PYR-1 EQMAIGIGKELRVRGYLPEDFTMLAYGGNGPLHACGVARHAGIKRVLAPP
:** .: * :*: ::: ::** * ***.** **: ** **
Mb0272c|M.bovis_AF2122/97 MAGVLSALGIGLADTTAMREQSVEIPLGPAAP-------QRLASVAESLE
Rv0266c|M.tuberculosis_H37Rv MAGVLSALGIGLADTTAMREQSVEIPLGPAAP-------QRLASVAESLE
Mvan_4898|M.vanbaalenii_PYR-1 FSSVFSACGAGNMKQLHFHERGVHVTMYNATTRALFEDYDEFNSVVSELE
::.*:** * * . ::*:.*.:.: *:. :.: **...**
Mb0272c|M.bovis_AF2122/97 RAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFES
Rv0266c|M.tuberculosis_H37Rv RAARAELLDEGVPGERIRVVRRVHLRYEGTDTAIPVQLAEIETMATAFES
Mvan_4898|M.vanbaalenii_PYR-1 ARGCEDLIRQGFSAEDVKFRLELDMRYGNQLLTQAVALSDINRING----
. :*: :*...* ::. .:.:** . : .* *::*: :
Mb0272c|M.bovis_AF2122/97 SHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVR
Rv0266c|M.tuberculosis_H37Rv SHRALYTFLLDRPLIAEAISVEATGLTDQPDLSQLGDQANDTTGSSETVR
Mvan_4898|M.vanbaalenii_PYR-1 --------------VGDVLEIIKT----------FGDVYSHRFGASSAAP
:.:.:.: * :** .. *:*.:.
Mb0272c|M.bovis_AF2122/97 IYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTET
Rv0266c|M.tuberculosis_H37Rv IYSNGLWRDAPLRRREAMRPGDVLTGPAIIAEANATTVVDDGWQATMTET
Mvan_4898|M.vanbaalenii_PYR-1 EAG---------IRCSTIRVASYVDGDVVNFEP-----------------
. * .::* .. : * .: *.
Mb0272c|M.bovis_AF2122/97 GHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFR
Rv0266c|M.tuberculosis_H37Rv GHLLAQRVVTPPRPDAATRAGFEAGFEADPVLLEIFNNLFMSIAEQMGFR
Mvan_4898|M.vanbaalenii_PYR-1 --LEHGGARTAPAPAGTRKAYFIG--IDDPIETPVYD-------------
* . *.* * .: :* * . **: :::
Mb0272c|M.bovis_AF2122/97 LEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVIR
Rv0266c|M.tuberculosis_H37Rv LEATAQSVNIRERLDFSCALFDPDGNLVANAPHIPVHLGSMGTTVKEVIR
Mvan_4898|M.vanbaalenii_PYR-1 -----------------EKALTPDSVIVG-----PAIVTTENTTFLVEPG
: **. :*. *. : : .**.
Mb0272c|M.bovis_AF2122/97 RRLSGMKPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRGH
Rv0266c|M.tuberculosis_H37Rv RRLSGMKPGDVYAVNDPYHGGTHLPDITVITPVFNTGGEDVLFFVASRGH
Mvan_4898|M.vanbaalenii_PYR-1 WRLEPTAQGAVWFLQD----------------------------------
**. * *: ::*
Mb0272c|M.bovis_AF2122/97 HAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAETRRLLTEAP
Rv0266c|M.tuberculosis_H37Rv HAEIGGITPGSMPADSREIHEEGVLFDNWLLAENGRFREAETRRLLTEAP
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 FGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDNA
Rv0266c|M.tuberculosis_H37Rv FGSRNPDTNLADLRAQIAANQKGVDEVGKMIDHFGRDVVAAYMRHVQDNA
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 EEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQL
Rv0266c|M.tuberculosis_H37Rv EEAVRRVIDRLDNGAYRYRMDSGATIAVRITVDRAARSATIDFTGTSAQL
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 DTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPT
Rv0266c|M.tuberculosis_H37Rv DTNFNAPTSVVNAAVLYVFRTLVADDIPLNDGCLRPLRIVVPEGSMLAPT
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 HPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYETV
Rv0266c|M.tuberculosis_H37Rv HPAAVVAGNVETSQAITGALFAALGVQAEGSGTMNNVTFGNERHQYYETV
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 GSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSGG
Rv0266c|M.tuberculosis_H37Rv GSGSGAGDGYHGASVVQTHMTNSRLTDPEVLEWRYPVLLREFAVRQGSGG
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 AGRWRGGDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRVE
Rv0266c|M.tuberculosis_H37Rv AGRWRGGDGAVRRLEFTEPMTVSTLSGHRRVRPYGMAGGSPGELGRNRVE
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0272c|M.bovis_AF2122/97 RADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTSARRRR
Rv0266c|M.tuberculosis_H37Rv RADGSTVELAGCGSTHVEPGDTLVIETPGGGGYGPASTSARRRR
Mvan_4898|M.vanbaalenii_PYR-1 --------------------------------------------