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AQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIALPDDDELQNNTEALIADPPDILVAH TGIGFRGWLAAAEGWGLANELLESLSSARIISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVS RTRIAVQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTGIARRQFDAVTFTSAP AAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVTSRPLIRKGVPTSAPERMRLGALARHIAEELPLLGS CTFKAAGHVIEIRGTSVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVDTAVLR LRTALGDKNIVATVVKRGYRLAVDSRHDDV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0260c | - | - | 100% (381) | bifunctional uroporphyrinogen-III synthetase/response regulator domain protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0266c | - | 0.0 | 100.00% (381) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. gilvum PYR-GCK | Mflv_0380 | - | 1e-150 | 71.00% (369) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3520c | - | 1e-111 | 55.59% (367) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. marinum M | MMAR_0520 | - | 1e-180 | 83.11% (379) | transcriptional regulatory protein |
| M. avium 104 | MAV_4900 | - | 1e-166 | 78.19% (376) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. smegmatis MC2 155 | MSMEG_0432 | - | 1e-160 | 74.67% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. thermoresistible (build 8) | TH_0582 | - | 1e-107 | 55.86% (367) | uroporphyrinogen-III synthetase |
| M. ulcerans Agy99 | MUL_1183 | - | 1e-179 | 82.59% (379) | bifunctional uroporphyrinogen-III synthetase/response regulator |
| M. vanbaalenii PYR-1 | Mvan_0301 | - | 1e-154 | 72.00% (375) | bifunctional uroporphyrinogen-III synthetase/response regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0380|M.gilvum_PYR-GCK ----MTDPDWAPLTGFRVAVTSARRADELAALLRRRGATVTSAAAIEMVP
Mvan_0301|M.vanbaalenii_PYR-1 ----MSEPDWAPLTGFRVAVTSARRADELSALLRRRGATVCSAAAIEMVP
MSMEG_0432|M.smegmatis_MC2_155 ----MREPDWAPLTGFRVAVTSARRADELCALLRRRGATVTSAPAITMVP
Rv0260c|M.tuberculosis_H37Rv ----MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIA
Mb0266c|M.bovis_AF2122/97 ----MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIA
MMAR_0520|M.marinum_M ----MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIA
MUL_1183|M.ulcerans_Agy99 ----MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIA
MAV_4900|M.avium_104 MAPQLAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSAAAINIIA
MAB_3520c|M.abscessus_ATCC_199 ---MPRNEPERRLDGFTIGVTAARRSEELIALLERRGAAVVHAAAIRIIP
TH_0582|M.thermoresistible__bu ------------LAGFTVGVTAARRAEELITLLERRGANVVHAPAIRIVP
* *: :.**::.*::** :**.*.** * *.** ::.
Mflv_0380|M.gilvum_PYR-GCK LPDDDELRQRTQSLIDAPPDIVIATTGIGFRGWVAAADGWGMAADLTTAL
Mvan_0301|M.vanbaalenii_PYR-1 LPDDDELRQHTRSLIASPPDIVIATTGIGFRGWVAAADGWGMATELTAAL
MSMEG_0432|M.smegmatis_MC2_155 LPDDDELRAHTESLITDPPDIVVATTGIGLRGWIAAADGWGLAGELTEAL
Rv0260c|M.tuberculosis_H37Rv LPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESL
Mb0266c|M.bovis_AF2122/97 LPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESL
MMAR_0520|M.marinum_M LPEDDELQGNTEALIANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDAL
MUL_1183|M.ulcerans_Agy99 LPEDDELQGNTEALIANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDAL
MAV_4900|M.avium_104 LPEDQELHRHTEAVITQPPDILVAHTGIGFRGWVAAADGWGLAPQLLSAL
MAB_3520c|M.abscessus_ATCC_199 LADDAELRDATELVIANPPDLTVATTGIGFRGWIEAADEWGVADGLKSAL
TH_0582|M.thermoresistible__bu LVDDDELRRVTAGLIEAPPDLVLVTTGIGFRGWVEAAHGWDVSDELTAAL
* :* **: * :* ***: :. ****:***: **. *.:: * :*
Mflv_0380|M.gilvum_PYR-GCK STARIVSRGPKATGALRAAGLPEEWSPESESSRELLHYLVEGGIAGTRIA
Mvan_0301|M.vanbaalenii_PYR-1 SNARIVSRGPKATGALRAAGLPEEWSPESESSRELLHYLVEGGIAGTRIA
MSMEG_0432|M.smegmatis_MC2_155 GKARIVSRGPKATGALRAAGLPEEWSPDSESSREVVRYLVEHGVDGRRIA
Rv0260c|M.tuberculosis_H37Rv SSARIISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIA
Mb0266c|M.bovis_AF2122/97 SSARIISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIA
MMAR_0520|M.marinum_M SVGRTISRGPKATGELRAAGLREEWSPESESSQEVLEYLLESGVAGQRIA
MUL_1183|M.ulcerans_Agy99 SVGRTISRGPKATGELRAAGLREEWSPESESSQEVLEYLLESGVAGQRIA
MAV_4900|M.avium_104 SQARIVARGPKATGALRAAGLHEEWSPKSESSREVLRYLLDSGVAGKRIA
MAB_3520c|M.abscessus_ATCC_199 ESGRLVARGPKATGAIRQAGLREEWSPASESSAEVLDRLLEEGVEGRRIA
TH_0582|M.thermoresistible__bu ASTRILARGPKARGAVRQAGLCEEWSPGSESSAEVLQRLLADGVDGLRIA
* ::***** * :* *** ***** **** *:: *: *: ***
Mflv_0380|M.gilvum_PYR-GCK VQLHGATAEWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGDFDQLVAG
Mvan_0301|M.vanbaalenii_PYR-1 VQLHGATADWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGEFDQLVAG
MSMEG_0432|M.smegmatis_MC2_155 VQLHGATDDWDPFPEFLDELRVAGAEVVPIRVYRWHPAPPGGEFDQLVAG
Rv0260c|M.tuberculosis_H37Rv VQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTG
Mb0266c|M.bovis_AF2122/97 VQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTG
MMAR_0520|M.marinum_M IQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVYRWKPTPLGGAFDQLVTE
MUL_1183|M.ulcerans_Agy99 IQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVSRWKPTPLGGAFDQLVTE
MAV_4900|M.avium_104 VQLHGAADGWDPFPEFINGLRSAGAQVMPIHVYRWKPTPAGGEFDQLVAS
MAB_3520c|M.abscessus_ATCC_199 VQLHGAATEWEPIADLCEALTIAGAQVIRVPVYRWEPPEDQRPMDRLISM
TH_0582|M.thermoresistible__bu VQLHGAASEWEPGTDICEALARAGAQVIKVPVYRWQPAQDCRRGEQLITA
:*****: *:* .:: * ***:*: : * **.*. ::*::
Mflv_0380|M.gilvum_PYR-GCK IAEEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRNGVHAMCVGPVT
Mvan_0301|M.vanbaalenii_PYR-1 IADEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRTNVHAMCVGPVT
MSMEG_0432|M.smegmatis_MC2_155 IAERRFDAVSFTSAPAVASVLMRATELGLTEQVVSALRTDVHAMCVGPVT
Rv0260c|M.tuberculosis_H37Rv IARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT
Mb0266c|M.bovis_AF2122/97 IARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT
MMAR_0520|M.marinum_M IARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVT
MUL_1183|M.ulcerans_Agy99 IARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVT
MAV_4900|M.avium_104 VARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAMCVGPVT
MAB_3520c|M.abscessus_ATCC_199 AINAELDGISFTSAPAVASMLGRAKATGRLDELLAALRARVAPLCVGPVT
TH_0582|M.thermoresistible__bu ILDADLDAVSFTSAPAVAAVLQRAKTLGVLDDLIAALRTEVAVFCVGPVT
:*.::****** *::* *. . ::: *** * :******
Mflv_0380|M.gilvum_PYR-GCK ARPLVRLGVPTSAPERMRLGALARHITDELPLLQARTVRVAGHLLEIRGT
Mvan_0301|M.vanbaalenii_PYR-1 ARPLVRLGVPTSAPERMRLGALARHITDELPLLQTRTVRVAGHLLEIRGT
MSMEG_0432|M.smegmatis_MC2_155 ARPLVRLGIPTSAPERMRLGALARHITDELPLLQSRTLRVAGHLLEIRGT
Rv0260c|M.tuberculosis_H37Rv SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGT
Mb0266c|M.bovis_AF2122/97 SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGT
MMAR_0520|M.marinum_M SRPLIRKGVPTSSPERMRLGALARHIAEELPLLGSCTVNAAGHVVDIRGT
MUL_1183|M.ulcerans_Agy99 SRPLIRKGVPTSSPERLRLGALARHIAEELPLLGSCTVNAAGHVVDIRGT
MAV_4900|M.avium_104 AQPLIRAGVPTSSPERMRLGALARHIAQELPPLRSCTLRAAGHQIEIRGT
MAB_3520c|M.abscessus_ATCC_199 AAPLEVLGVPTTQPERARLGALARHIADELTRR-APRFHAGGHIVSVRSC
TH_0582|M.thermoresistible__bu ATPLRRIGVDARHPQRYRLGALARLITDELPGL-ARQYRAGGHHLSVRNG
: ** *: : *:* ******* *::**. : ...** :.:*.
Mflv_0380|M.gilvum_PYR-GCK CVLVDGTVKALSPAAMATIRALALKPGAVVSRTDLLRALPGSGTDTHAVE
Mvan_0301|M.vanbaalenii_PYR-1 CVLVDGTVKELSPSAMATIRALALRPGAVVSRVDLLRALPGSGTDTHAVE
MSMEG_0432|M.smegmatis_MC2_155 CVLVDGVVKSLSPAGMATIRALAHRPGAVVSRFDLLGALPGSGTDTHAVE
Rv0260c|M.tuberculosis_H37Rv SVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVD
Mb0266c|M.bovis_AF2122/97 SVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVD
MMAR_0520|M.marinum_M CVLVDGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVD
MUL_1183|M.ulcerans_Agy99 CVLVDGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVD
MAV_4900|M.avium_104 CVLVDGAVKSLSGSAMATLRALAARPGDVVARNDLLRVLPGNSNDPHAVD
MAB_3520c|M.abscessus_ATCC_199 GIAVDGETRQISPAGMALMKRLMVRPGQVVSREDLLAALPGGGDDTHAVE
TH_0582|M.thermoresistible__bu SVEVDGELKVLPPAAMALLRRLLATPGMVVSREELLAELPGGGDETHAVE
: **. : :. :.** :: * ** **:* :** ***.. :.***:
Mflv_0380|M.gilvum_PYR-GCK TAVLRLRAALGDKKMVSTVVKRGYRLPVDEAFAS-----
Mvan_0301|M.vanbaalenii_PYR-1 TAVLRLRTALGDKKMVSTVVKRGYRLPVDEAFAS-----
MSMEG_0432|M.smegmatis_MC2_155 TAVLRLRTALGDKSIVSTVVKRGYRLAVDDTDTEMARAL
Rv0260c|M.tuberculosis_H37Rv TAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV----
Mb0266c|M.bovis_AF2122/97 TAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV----
MMAR_0520|M.marinum_M TAVLRLRTALGDKNIIATVVKRGYRLALDTQDDTACT--
MUL_1183|M.ulcerans_Agy99 TAVLRLRTALGDKNIIATVVKRGYRLALDTQDDTACT--
MAV_4900|M.avium_104 TAVLRLRTALGDKNIIATVVKRGYRLAIDTPDGSAWH--
MAB_3520c|M.abscessus_ATCC_199 TAMTRLRAALGAPKVIQTVVKRGYRLAIDPTTIGECHG-
TH_0582|M.thermoresistible__bu TAMARLRSALSAPQVVQTVVKRGYRLAVDPAAT------
**: ***:**. .:: *********.:*