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M. smegmatis MC2 155 MSMEG_0432 (-)

annotation: bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein
coordinates: 507499 - 508656
length: 385

REPDWAPLTGFRVAVTSARRADELCALLRRRGATVTSAPAITMVPLPDDDELRAHTESLITDPPDIVVAT
TGIGLRGWIAAADGWGLAGELTEALGKARIVSRGPKATGALRAAGLPEEWSPDSESSREVVRYLVEHGVD
GRRIAVQLHGATDDWDPFPEFLDELRVAGAEVVPIRVYRWHPAPPGGEFDQLVAGIAERRFDAVSFTSAP
AVASVLMRATELGLTEQVVSALRTDVHAMCVGPVTARPLVRLGIPTSAPERMRLGALARHITDELPLLQS
RTLRVAGHLLEIRGTCVLVDGVVKSLSPAGMATIRALAHRPGAVVSRFDLLGALPGSGTDTHAVETAVLR
LRTALGDKSIVSTVVKRGYRLAVDDTDTEMARAL*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_0432 - - 100% (385) bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0266c - 1e-160 74.67% (375) bifunctional uroporphyrinogen-III synthetase/response regulator
M. gilvum PYR-GCK Mflv_0380 - 0.0 84.57% (376) bifunctional uroporphyrinogen-III synthetase/response regulator
M. tuberculosis H37Rv Rv0260c - 1e-160 74.67% (375) bifunctional uroporphyrinogen-III synthetase/response regulator
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_3520c - 1e-115 56.91% (369) bifunctional uroporphyrinogen-III synthetase/response regulator
M. marinum M MMAR_0520 - 1e-154 71.16% (371) transcriptional regulatory protein
M. avium 104 MAV_4900 - 1e-157 72.53% (375) bifunctional uroporphyrinogen-III synthetase/response regulator
M. thermoresistible (build 8) TH_0582 - 1e-114 58.22% (371) uroporphyrinogen-III synthetase
M. ulcerans Agy99 MUL_1183 - 1e-153 70.62% (371) bifunctional uroporphyrinogen-III synthetase/response regulator
M. vanbaalenii PYR-1 Mvan_0301 - 0.0 85.90% (376) bifunctional uroporphyrinogen-III synthetase/response regulator

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0380|M.gilvum_PYR-GCK          ----MTDPDWAPLTGFRVAVTSARRADELAALLRRRGATVTSAAAIEMVP
Mvan_0301|M.vanbaalenii_PYR-1       ----MSEPDWAPLTGFRVAVTSARRADELSALLRRRGATVCSAAAIEMVP
MSMEG_0432|M.smegmatis_MC2_155      ----MREPDWAPLTGFRVAVTSARRADELCALLRRRGATVTSAPAITMVP
Mb0266c|M.bovis_AF2122/97           ----MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIA
Rv0260c|M.tuberculosis_H37Rv        ----MAQAHSAPLTGYRIAVTSARRAEELCALLRRQGAEVCSAPAIKMIA
MMAR_0520|M.marinum_M               ----MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIA
MUL_1183|M.ulcerans_Agy99           ----MAQQKSEPLRGYRIAVTSSRRAEELCALLRRHGADVCSAPAINMIA
MAV_4900|M.avium_104                MAPQLAPPDSAPLTGYRIAVTSANRAEELCALLRRNGAEVTSAAAINIIA
MAB_3520c|M.abscessus_ATCC_199      ---MPRNEPERRLDGFTIGVTAARRSEELIALLERRGAAVVHAAAIRIIP
TH_0582|M.thermoresistible__bu      ------------LAGFTVGVTAARRAEELITLLERRGANVVHAPAIRIVP
                                                * *: :.**::.*::** :**.*.** *  *.** ::.

Mflv_0380|M.gilvum_PYR-GCK          LPDDDELRQRTQSLIDAPPDIVIATTGIGFRGWVAAADGWGMAADLTTAL
Mvan_0301|M.vanbaalenii_PYR-1       LPDDDELRQHTRSLIASPPDIVIATTGIGFRGWVAAADGWGMATELTAAL
MSMEG_0432|M.smegmatis_MC2_155      LPDDDELRAHTESLITDPPDIVVATTGIGLRGWIAAADGWGLAGELTEAL
Mb0266c|M.bovis_AF2122/97           LPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESL
Rv0260c|M.tuberculosis_H37Rv        LPDDDELQNNTEALIADPPDILVAHTGIGFRGWLAAAEGWGLANELLESL
MMAR_0520|M.marinum_M               LPEDDELQGNTEALIANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDAL
MUL_1183|M.ulcerans_Agy99           LPEDDELQGNTEALIANPPDILVAHTGIGFRGWVAAAEGWGLAGELVDAL
MAV_4900|M.avium_104                LPEDQELHRHTEAVITQPPDILVAHTGIGFRGWVAAADGWGLAPQLLSAL
MAB_3520c|M.abscessus_ATCC_199      LADDAELRDATELVIANPPDLTVATTGIGFRGWIEAADEWGVADGLKSAL
TH_0582|M.thermoresistible__bu      LVDDDELRRVTAGLIEAPPDLVLVTTGIGFRGWVEAAHGWDVSDELTAAL
                                    * :* **:  *  :*  ***: :. ****:***: **. *.::  *  :*

Mflv_0380|M.gilvum_PYR-GCK          STARIVSRGPKATGALRAAGLPEEWSPESESSRELLHYLVEGGIAGTRIA
Mvan_0301|M.vanbaalenii_PYR-1       SNARIVSRGPKATGALRAAGLPEEWSPESESSRELLHYLVEGGIAGTRIA
MSMEG_0432|M.smegmatis_MC2_155      GKARIVSRGPKATGALRAAGLPEEWSPDSESSREVVRYLVEHGVDGRRIA
Mb0266c|M.bovis_AF2122/97           SSARIISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIA
Rv0260c|M.tuberculosis_H37Rv        SSARIISRGPKATGALRAAGLREEWSPDSESSHEVLEYLLESGVSRTRIA
MMAR_0520|M.marinum_M               SVGRTISRGPKATGELRAAGLREEWSPESESSQEVLEYLLESGVAGQRIA
MUL_1183|M.ulcerans_Agy99           SVGRTISRGPKATGELRAAGLREEWSPESESSQEVLEYLLESGVAGQRIA
MAV_4900|M.avium_104                SQARIVARGPKATGALRAAGLHEEWSPKSESSREVLRYLLDSGVAGKRIA
MAB_3520c|M.abscessus_ATCC_199      ESGRLVARGPKATGAIRQAGLREEWSPASESSAEVLDRLLEEGVEGRRIA
TH_0582|M.thermoresistible__bu      ASTRILARGPKARGAVRQAGLCEEWSPGSESSAEVLQRLLADGVDGLRIA
                                       * ::***** * :* *** ***** **** *::  *:  *:   ***

Mflv_0380|M.gilvum_PYR-GCK          VQLHGATAEWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGDFDQLVAG
Mvan_0301|M.vanbaalenii_PYR-1       VQLHGATADWDPFPEFLDELRAAGAEVVPIRVYRWHPAPRNGEFDQLVAG
MSMEG_0432|M.smegmatis_MC2_155      VQLHGATDDWDPFPEFLDELRVAGAEVVPIRVYRWHPAPPGGEFDQLVAG
Mb0266c|M.bovis_AF2122/97           VQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTG
Rv0260c|M.tuberculosis_H37Rv        VQLHGAADSWDPFPEFLGGLRFAGAQVVPIRVYRWKPAPLGGVFDHLVTG
MMAR_0520|M.marinum_M               IQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVYRWKPTPLGGAFDQLVTE
MUL_1183|M.ulcerans_Agy99           IQLHGAADGWDPFPEFVGGLRAAGAEVVPIRVSRWKPTPLGGAFDQLVTE
MAV_4900|M.avium_104                VQLHGAADGWDPFPEFINGLRSAGAQVMPIHVYRWKPTPAGGEFDQLVAS
MAB_3520c|M.abscessus_ATCC_199      VQLHGAATEWEPIADLCEALTIAGAQVIRVPVYRWEPPEDQRPMDRLISM
TH_0582|M.thermoresistible__bu      VQLHGAASEWEPGTDICEALARAGAQVIKVPVYRWQPAQDCRRGEQLITA
                                    :*****:  *:* .::   *  ***:*: : * **.*.      ::*:: 

Mflv_0380|M.gilvum_PYR-GCK          IAEEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRNGVHAMCVGPVT
Mvan_0301|M.vanbaalenii_PYR-1       IADEKFDAVSFTSAPAVASVLLRATEMGLEAEVLSALRTNVHAMCVGPVT
MSMEG_0432|M.smegmatis_MC2_155      IAERRFDAVSFTSAPAVASVLMRATELGLTEQVVSALRTDVHAMCVGPVT
Mb0266c|M.bovis_AF2122/97           IARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT
Rv0260c|M.tuberculosis_H37Rv        IARRQFDAVTFTSAPAAAAVLERSRELDIEDQLLAALRTDVHAMCVGPVT
MMAR_0520|M.marinum_M               IARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVT
MUL_1183|M.ulcerans_Agy99           IARRQFDAVSFTSAPAAAAVLERGRELDIEEELLEALRNDVHAMCVGPVT
MAV_4900|M.avium_104                VARRQFDAVTFTSAPAGAALLERSRELGIEDQLLQALRSDVHAMCVGPVT
MAB_3520c|M.abscessus_ATCC_199      AINAELDGISFTSAPAVASMLGRAKATGRLDELLAALRARVAPLCVGPVT
TH_0582|M.thermoresistible__bu      ILDADLDAVSFTSAPAVAAVLQRAKTLGVLDDLIAALRTEVAVFCVGPVT
                                         :*.::****** *::* *.   .   ::: ***  *  :******

Mflv_0380|M.gilvum_PYR-GCK          ARPLVRLGVPTSAPERMRLGALARHITDELPLLQARTVRVAGHLLEIRGT
Mvan_0301|M.vanbaalenii_PYR-1       ARPLVRLGVPTSAPERMRLGALARHITDELPLLQTRTVRVAGHLLEIRGT
MSMEG_0432|M.smegmatis_MC2_155      ARPLVRLGIPTSAPERMRLGALARHITDELPLLQSRTLRVAGHLLEIRGT
Mb0266c|M.bovis_AF2122/97           SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGT
Rv0260c|M.tuberculosis_H37Rv        SRPLIRKGVPTSAPERMRLGALARHIAEELPLLGSCTFKAAGHVIEIRGT
MMAR_0520|M.marinum_M               SRPLIRKGVPTSSPERMRLGALARHIAEELPLLGSCTVNAAGHVVDIRGT
MUL_1183|M.ulcerans_Agy99           SRPLIRKGVPTSSPERLRLGALARHIAEELPLLGSCTVNAAGHVVDIRGT
MAV_4900|M.avium_104                AQPLIRAGVPTSSPERMRLGALARHIAQELPPLRSCTLRAAGHQIEIRGT
MAB_3520c|M.abscessus_ATCC_199      AAPLEVLGVPTTQPERARLGALARHIADELTRR-APRFHAGGHIVSVRSC
TH_0582|M.thermoresistible__bu      ATPLRRIGVDARHPQRYRLGALARLITDELPGL-ARQYRAGGHHLSVRNG
                                    : **   *: :  *:* ******* *::**.   :   ...** :.:*. 

Mflv_0380|M.gilvum_PYR-GCK          CVLVDGTVKALSPAAMATIRALALKPGAVVSRTDLLRALPGSGTDTHAVE
Mvan_0301|M.vanbaalenii_PYR-1       CVLVDGTVKELSPSAMATIRALALRPGAVVSRVDLLRALPGSGTDTHAVE
MSMEG_0432|M.smegmatis_MC2_155      CVLVDGVVKSLSPAGMATIRALAHRPGAVVSRFDLLGALPGSGTDTHAVE
Mb0266c|M.bovis_AF2122/97           SVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVD
Rv0260c|M.tuberculosis_H37Rv        SVLVDDSVKPLSPSGMAILRALVHRPGGVVSRGDLLRVLPGDGSDTHAVD
MMAR_0520|M.marinum_M               CVLVDGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVD
MUL_1183|M.ulcerans_Agy99           CVLVDGSIKTLSGSGMAILRALTKRPGDVVARSELLNVLPGNGDDTHAVD
MAV_4900|M.avium_104                CVLVDGAVKSLSGSAMATLRALAARPGDVVARNDLLRVLPGNSNDPHAVD
MAB_3520c|M.abscessus_ATCC_199      GIAVDGETRQISPAGMALMKRLMVRPGQVVSREDLLAALPGGGDDTHAVE
TH_0582|M.thermoresistible__bu      SVEVDGELKVLPPAAMALLRRLLATPGMVVSREELLAELPGGGDETHAVE
                                     : **.  : :. :.** :: *   ** **:* :**  ***.. :.***:

Mflv_0380|M.gilvum_PYR-GCK          TAVLRLRAALGDKKMVSTVVKRGYRLPVDEAFAS-----
Mvan_0301|M.vanbaalenii_PYR-1       TAVLRLRTALGDKKMVSTVVKRGYRLPVDEAFAS-----
MSMEG_0432|M.smegmatis_MC2_155      TAVLRLRTALGDKSIVSTVVKRGYRLAVDDTDTEMARAL
Mb0266c|M.bovis_AF2122/97           TAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV----
Rv0260c|M.tuberculosis_H37Rv        TAVLRLRTALGDKNIVATVVKRGYRLAVDSRHDDV----
MMAR_0520|M.marinum_M               TAVLRLRTALGDKNIIATVVKRGYRLALDTQDDTACT--
MUL_1183|M.ulcerans_Agy99           TAVLRLRTALGDKNIIATVVKRGYRLALDTQDDTACT--
MAV_4900|M.avium_104                TAVLRLRTALGDKNIIATVVKRGYRLAIDTPDGSAWH--
MAB_3520c|M.abscessus_ATCC_199      TAMTRLRAALGAPKVIQTVVKRGYRLAIDPTTIGECHG-
TH_0582|M.thermoresistible__bu      TAMARLRSALSAPQVVQTVVKRGYRLAVDPAAT------
                                    **: ***:**.  .:: *********.:*

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_0432	-	-	100% (385)	bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein